Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Homo sapiens | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.32 nM | Agonist activity at human recombinant CB2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay | ChEMBL. | 18006322 |
EC50 (functional) | = 0.32 nM | Agonist activity at human recombinant CB2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay | ChEMBL. | 18006322 |
Emax (functional) | = 96 % | Agonist activity at human recombinant CB2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay relative to CP55940 | ChEMBL. | 18006322 |
Emax (functional) | = 96 % | Agonist activity at human recombinant CB2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay relative to CP55940 | ChEMBL. | 18006322 |
IC50 (binding) | = 1.7 nM | Displacement of [3H]CP55940 from human recombinant CB2 receptor expressed in CHO cells | ChEMBL. | 18006322 |
IC50 (binding) | = 1.7 nM | Displacement of [3H]CP55940 from human recombinant CB2 receptor expressed in CHO cells | ChEMBL. | 18006322 |
IC50 (binding) | = 940 nM | Displacement of [3H]CP55940 from human recombinant CB1 receptor expressed in CHO cells | ChEMBL. | 18006322 |
IC50 (binding) | = 940 nM | Displacement of [3H]CP55940 from human recombinant CB1 receptor expressed in CHO cells | ChEMBL. | 18006322 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.