Detailed information for compound 516327

Basic information

Technical information
  • TDR Targets ID: 516327
  • Name: N-(3-oxo-1,2,4-thiadiazol-5-yl)benzamide
  • MW: 221.236 | Formula: C9H7N3O2S
  • H donors: 2 H acceptors: 2 LogP: 1.17 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1)Nc1s[nH]c(=O)n1
  • InChi: 1S/C9H7N3O2S/c13-7(6-4-2-1-3-5-6)10-9-11-8(14)12-15-9/h1-5H,(H2,10,11,12,13,14)
  • InChiKey: KDLAEQAKUHJGTN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-keto-1,2,4-thiadiazol-5-yl)benzamide
  • MLS000736063
  • N-(3-hydroxy-1,2,4-thiadiazol-5-yl)benzenecarboxamide
  • SMR000338613
  • 3M-519S

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references
Plasmodium falciparum M17 leucyl aminopeptidase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Chlamydia trachomatis cytosol aminopeptidase Get druggable targets OG5_127293 All targets in OG5_127293
Leishmania donovani cytosolic leucyl aminopeptidase Get druggable targets OG5_127293 All targets in OG5_127293
Cryptosporidium parvum putative leucine aminopeptidase; of possible plant or bacterial origin Get druggable targets OG5_127293 All targets in OG5_127293
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Babesia bovis leucine aminopeptidase, putative Get druggable targets OG5_127293 All targets in OG5_127293
Plasmodium knowlesi M17 leucyl aminopeptidase, putative Get druggable targets OG5_127293 All targets in OG5_127293
Neospora caninum Probable cytosol aminopeptidase, related Get druggable targets OG5_127293 All targets in OG5_127293
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase Get druggable targets OG5_127293 All targets in OG5_127293
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum M17 leucyl aminopeptidase Get druggable targets OG5_127293 All targets in OG5_127293
Plasmodium vivax M17 leucyl aminopeptidase, putative Get druggable targets OG5_127293 All targets in OG5_127293
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus leucine aminopeptidase protein Get druggable targets OG5_127293 All targets in OG5_127293
Plasmodium yoelii putative leucine aminopeptidase Get druggable targets OG5_127293 All targets in OG5_127293
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii leucyl aminopeptidase LAP Get druggable targets OG5_127293 All targets in OG5_127293
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 Get druggable targets OG5_127293 All targets in OG5_127293
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 Get druggable targets OG5_127293 All targets in OG5_127293
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 Get druggable targets OG5_127293 All targets in OG5_127293
Theileria parva leucine aminopeptidase, putative Get druggable targets OG5_127293 All targets in OG5_127293
Cryptosporidium hominis leucine aminopeptidase Get druggable targets OG5_127293 All targets in OG5_127293
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative Get druggable targets OG5_127293 All targets in OG5_127293
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis leucine aminopeptidase protein Get druggable targets OG5_127293 All targets in OG5_127293
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense metallo-peptidase, Clan MF, Family M17, putative Get druggable targets OG5_127293 All targets in OG5_127293
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative Get druggable targets OG5_127293 All targets in OG5_127293
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium leprae Probable cytosol aminopeptidase PepB Get druggable targets OG5_127293 All targets in OG5_127293
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable aminopeptidase PepB Get druggable targets OG5_127293 All targets in OG5_127293
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 Get druggable targets OG5_127293 All targets in OG5_127293
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei M17 leucyl aminopeptidase, putative Get druggable targets OG5_127293 All targets in OG5_127293
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense cytosolic leucyl aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17, putative Get druggable targets OG5_127293 All targets in OG5_127293
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans leucyl aminopeptidase Get druggable targets OG5_127293 All targets in OG5_127293
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 Get druggable targets OG5_127293 All targets in OG5_127293
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0068 0.5062 0.5044
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.3494 0.3494
Echinococcus multilocularis bloom syndrome protein 0.0024 0.1435 0.1321
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.2029 0.2052
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0025 0.1589 0.1589
Leishmania major hypothetical protein, conserved 0.0022 0.1294 0.1309
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.7047 0.7125
Plasmodium falciparum protein disulfide isomerase 0.0008 0.0148 0.015
Schistosoma mansoni tsg101-related 0.0046 0.3291 0.467
Echinococcus multilocularis smad 0.0008 0.0171 0.0023
Treponema pallidum DNA ligase (lig) 0.001 0.0307 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0449 0.0438
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.106 0.0936
Brugia malayi hypothetical protein 0.001 0.0307 0.0307
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0307 0.0232
Schistosoma mansoni DNA helicase recq5 0.001 0.0312 0.0443
Toxoplasma gondii leucyl aminopeptidase LAP 0.0127 0.9891 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.106 0.1072
Onchocerca volvulus 0.0033 0.2172 0.2767
Schistosoma mansoni hypothetical protein 0.0015 0.0779 0.1106
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0312 0.0168
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0544 0.0576
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.1033 0.1465
Trypanosoma brucei polo-like protein kinase 0.0092 0.7047 0.7125
Echinococcus granulosus Smad4 0.0008 0.0171 0.0023
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0022 0.1294 0.1309
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0171 0.0023
Echinococcus granulosus dna polymerase kappa 0.0019 0.106 0.0936
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.106 0.1072
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0127 0.9891 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0544 0.055
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.7047 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.106 0.1072
Schistosoma mansoni intermediate filament proteins 0.0033 0.2172 0.3082
Toxoplasma gondii protein disulfide isomerase 0.0008 0.0148 0.015
Schistosoma mansoni kinase 0.0047 0.3347 0.4749
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0942 0.0942
Echinococcus granulosus nibrin 0.001 0.0307 0.0163
Loa Loa (eye worm) intermediate filament protein 0.0033 0.2172 0.2172
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0449 0.0454
Brugia malayi MH2 domain containing protein 0.0117 0.9033 0.9033
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.1531 0.1548
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.106 0.1072
Schistosoma mansoni hypothetical protein 0.0033 0.2237 0.3175
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0583 0.0589
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.1531 0.1548
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.106 0.1072
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0307 0.0307
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0942 0.0942
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.7047 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0801 0.0671
Loa Loa (eye worm) RecQ helicase 0.0024 0.1435 0.1435
Echinococcus multilocularis lamin 0.0033 0.2172 0.2078
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.106 0.1323
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0068 0.5062 0.5044
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0046 0.3291 0.4555
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0307 0.0311
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.7047 0.7125
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0307 0.0311
Entamoeba histolytica hypothetical protein 0.0011 0.0449 0.0437
Loa Loa (eye worm) hypothetical protein 0.001 0.0307 0.0307
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.1531 0.1548
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0025 0.1589 0.1589
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.106 0.0936
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.1531 0.1548
Echinococcus multilocularis GPCR, family 2 0.0015 0.0779 0.0648
Schistosoma mansoni tsg101-related 0.0057 0.4136 0.5869
Brugia malayi hypothetical protein 0.0016 0.0819 0.0819
Schistosoma mansoni DNA helicase recq1 0.001 0.0312 0.0443
Brugia malayi cytosol aminopeptidase 0.0025 0.1589 0.1589
Entamoeba histolytica hypothetical protein 0.0011 0.0449 0.0437
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0449 0.0454
Schistosoma mansoni hypothetical protein 0.0015 0.0779 0.1106
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0127 0.9891 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0801 0.0809
Echinococcus granulosus leucyl aminopeptidase 0.0025 0.1589 0.1479
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0449 0.0454
Loa Loa (eye worm) hypothetical protein 0.001 0.0312 0.0312
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0171 0.0023
Loa Loa (eye worm) hypothetical protein 0.001 0.0307 0.0307
Leishmania major DNA polymerase eta, putative 0.0031 0.2029 0.2052
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.3494 0.3494
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0307 0.0232
Giardia lamblia Protein disulfide isomerase PDI2 0.0008 0.0148 0.021
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.106 0.1072
Loa Loa (eye worm) hypothetical protein 0.0015 0.0753 0.0753
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0307 0.0232
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0307 0.0311
Leishmania major DNA polymerase kappa, putative 0.0019 0.106 0.1072
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.1531 0.1548
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.7047 0.7047
Brugia malayi transglutaminase 0.0008 0.0148 0.0148
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0449 0.0454
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0307 0.0307
Giardia lamblia DINP protein human, muc B family 0.0019 0.106 0.1504
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.3089 0.3123
Trypanosoma brucei protein disulfide isomerase 0.0008 0.0148 0.015
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.106 0.1072
Loa Loa (eye worm) Smad1 0.0008 0.0171 0.0171
Entamoeba histolytica hypothetical protein 0.001 0.0307 0.023
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0025 0.1589 0.1607
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.1531 0.1548
Schistosoma mansoni leucine aminopeptidase 0.0025 0.1589 0.2255
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.106 0.1072
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0583 0.0589
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0022 0.1294 0.1309
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0171 0.0171
Echinococcus granulosus leucine aminopeptidase protein 0.0127 0.9891 1
Echinococcus multilocularis nibrin 0.001 0.0307 0.0163
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0449 0.0454
Brugia malayi hypothetical protein 0.001 0.0307 0.0307
Trichomonas vaginalis hypothetical protein 0.0033 0.2221 0.3005
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0544 0.0574
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0449 0.0454
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.9033 0.9033
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.106 0.1072
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0423 0.0283
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0449 0.0454
Entamoeba histolytica hypothetical protein 0.0011 0.0449 0.0437
Schistosoma mansoni hypothetical protein 0.0011 0.0423 0.0601
Plasmodium falciparum M17 leucyl aminopeptidase 0.0127 0.9891 1
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.7047 1
Trypanosoma brucei aminopeptidase, putative 0.0025 0.1589 0.1607
Brugia malayi hypothetical protein 0.0025 0.1531 0.1531
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0127 0.9891 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0779 0.0648
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.0312 0.0443
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.7047 0.7047
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.106 0.1072
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0449 0.0454
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0307 0.0232
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0449 0.0454
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.106 0.1504
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0025 0.1589 0.1607
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0025 0.1589 0.2255
Echinococcus granulosus GPCR family 2 0.0015 0.0779 0.0648
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.1203 0.1216
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0449 0.0438
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0025 0.1589 0.1607
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.1435 0.1866
Chlamydia trachomatis cytosol aminopeptidase 0.0127 0.9891 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0312 0.0168
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0127 0.9891 1
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0127 0.9891 1
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0025 0.1589 0.1607
Loa Loa (eye worm) hypothetical protein 0.0033 0.2172 0.2172
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.106 0.1323
Schistosoma mansoni smad1 5 8 and 0.0008 0.0171 0.0242
Loa Loa (eye worm) hypothetical protein 0.0044 0.3089 0.3089
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0025 0.1589 0.1589
Loa Loa (eye worm) hypothetical protein 0.001 0.0307 0.0307
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.106 0.106
Leishmania major protein disulfide isomerase 0.0008 0.0148 0.015
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0025 0.1589 0.1589
Echinococcus granulosus lamin dm0 0.0033 0.2172 0.2078
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0307 0.0232
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.106 0.1504
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.2237 0.2237
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.7047 0.7125
Echinococcus granulosus leucyl aminopeptidase 0.0025 0.1589 0.1479
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0312 0.0312
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0307 0.0232
Schistosoma mansoni hypothetical protein 0.0015 0.0779 0.1106
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0025 0.1589 0.1607
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0779 0.0648
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.2172 0.2172
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.3248 0.4493
Echinococcus granulosus replication factor c subunit 1 0.001 0.0307 0.0163
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0025 0.1589 0.1607
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.106 0.1072
Trichomonas vaginalis protein disulfide isomerase, putative 0.0008 0.0148 0.0001
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0307 0.023
Entamoeba histolytica hypothetical protein 0.0011 0.0449 0.0437
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0127 0.9891 1
Onchocerca volvulus 0.0033 0.2172 0.2767
Mycobacterium ulcerans leucyl aminopeptidase 0.0127 0.9891 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0544 0.055
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.106 0.1072
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0171 0.0171
Schistosoma mansoni hypothetical protein 0.0015 0.0779 0.1106
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.2172 0.2172
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0779 0.0648
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.7047 1
Echinococcus granulosus intermediate filament protein 0.0033 0.2172 0.2078
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.7047 0.7081
Loa Loa (eye worm) hypothetical protein 0.0016 0.0801 0.0801
Leishmania major hypothetical protein, conserved 0.0025 0.1531 0.1548
Brugia malayi MH1 domain containing protein 0.0008 0.0171 0.0171
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0312 0.0312
Echinococcus multilocularis dna polymerase eta 0.0044 0.3089 0.3019
Echinococcus granulosus smad 0.0008 0.0171 0.0023
Schistosoma mansoni topbp1 0.001 0.0307 0.0436
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.3494 0.3494
Brugia malayi MH1 domain containing protein 0.0008 0.0171 0.0171
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0307 0.0311
Loa Loa (eye worm) hypothetical protein 0.0032 0.2124 0.2124
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0779 0.0779
Brugia malayi probable protein disulfide-isomerase 0.0008 0.0148 0.0148
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0307 0.0311
Schistosoma mansoni smad 0.0008 0.0171 0.0242
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0312 0.0168
Loa Loa (eye worm) hypothetical protein 0.0015 0.0779 0.0779
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.3089 0.3089
Loa Loa (eye worm) hypothetical protein 0.0118 0.9149 0.9149
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.7047 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0075 0.0075
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.7047 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0449 0.0454
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0127 0.9891 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.1531 0.1531
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0307 0.0311
Echinococcus multilocularis leucyl aminopeptidase 0.0025 0.1589 0.1479
Schistosoma mansoni lamin 0.0033 0.2172 0.3082
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0127 0.9891 1
Brugia malayi DKFZp564C0469 protein 0.001 0.0307 0.0307
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0423 0.0283
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.106 0.1072
Brugia malayi topoisomerase 0.001 0.0307 0.0307
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0307 0.0232
Trypanosoma cruzi bloodstream- specific protein 2 precursor 0.0008 0.0148 0.015
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0307 0.0311
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0312 0.0316
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.106 0.1072
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.106 0.1072
Echinococcus multilocularis leucyl aminopeptidase 0.0025 0.1589 0.1479
Schistosoma mansoni smad1 5 8 and 0.0008 0.0171 0.0242
Schistosoma mansoni tsg101-related 0.0057 0.4136 0.5869
Schistosoma mansoni smad1 5 8 and 0.0008 0.0171 0.0242
Echinococcus granulosus bloom syndrome protein 0.0024 0.1435 0.1321
Loa Loa (eye worm) hypothetical protein 0.0068 0.5062 0.5062
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0449 0.0454
Schistosoma mansoni topbp1 0.001 0.0307 0.0436
Loa Loa (eye worm) Pdia4 protein 0.0008 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.001 0.0307 0.0307
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0307 0.0311
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.3248 0.4493
Echinococcus multilocularis leucine aminopeptidase protein 0.0127 0.9891 1
Echinococcus multilocularis leucyl aminopeptidase 0.0025 0.1589 0.1479
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.1435 0.1435
Loa Loa (eye worm) hypothetical protein 0.001 0.0307 0.0307
Schistosoma mansoni Probable protein disulfide-isomerase ER-60 precursor (ERP60) 0.0008 0.0148 0.021
Leishmania major DNA polymerase eta, putative 0.0044 0.3089 0.3123
Brugia malayi protein disulphide isomerase 0.0008 0.0148 0.0148
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.7047 1
Brugia malayi intermediate filament protein 0.0033 0.2172 0.2172
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0816 0.0825
Trypanosoma brucei unspecified product 0.0019 0.106 0.1072
Brugia malayi Smad1 0.0008 0.0171 0.0171
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0779 0.0779
Plasmodium vivax protein disulfide isomerase, putative 0.0008 0.0148 0.015
Loa Loa (eye worm) hypothetical protein 0.001 0.0307 0.0307
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.9033 0.9033
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0779 0.0648
Loa Loa (eye worm) hypothetical protein 0.0033 0.2237 0.2237
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.106 0.1322
Trichomonas vaginalis protein disulfide isomerase, putative 0.0008 0.0148 0.0001
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0544 0.055
Echinococcus multilocularis musashi 0.0033 0.2172 0.2078
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0307 0.0232
Echinococcus granulosus lamin 0.0033 0.2172 0.2078
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.7047 1
Echinococcus multilocularis lamin dm0 0.0033 0.2172 0.2078
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0025 0.1589 0.1589
Loa Loa (eye worm) hypothetical protein 0.0049 0.3494 0.3494
Schistosoma mansoni lamin 0.0033 0.2172 0.3082
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0307 0.0232
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0307 0.0311
Brugia malayi MH2 domain containing protein 0.0008 0.0171 0.0171
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0801 0.0671
Echinococcus granulosus dna polymerase eta 0.0044 0.3089 0.3019
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0449 0.0454
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0312 0.0168
Loa Loa (eye worm) protein disulfide isomerase 0.0008 0.0148 0.0148
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0025 0.1589 0.1607
Schistosoma mansoni Smad4 0.0008 0.0171 0.0242
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0449 0.0454
Loa Loa (eye worm) hypothetical protein 0.0015 0.0753 0.0753
Brugia malayi hypothetical protein 0.0068 0.5062 0.5062
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.106 0.1072
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0171 0.0023
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.7047 1
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0307 0.0436
Trypanosoma brucei unspecified product 0.0013 0.0583 0.0589
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.3089 0.3123
Giardia lamblia Replication factor C, subunit 1 0.001 0.0307 0.0436
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.2029 0.2052
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.106 0.106
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0025 0.1589 0.1479
Schistosoma mansoni protein disulfide-isomerase er-60 precursor (erp60) 0.0008 0.0148 0.021
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.7047 0.7081
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0312 0.0316
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.106 0.1072
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0779 0.0779
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.0312 0.0316
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.1435 0.1866
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0312 0.0312
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0171 0.0242
Loa Loa (eye worm) STAT protein 0.0129 1 1
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0307 0.0232
Schistosoma mansoni protein disulfide-isomerase 0.0008 0.0148 0.021
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.106 0.1072
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0307 0.0311
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0171 0.0023
Schistosoma mansoni DNA polymerase eta 0.0044 0.3089 0.4384
Trichomonas vaginalis protein disulfide isomerase, putative 0.0008 0.0148 0.0001
Brugia malayi MH2 domain containing protein 0.0008 0.0171 0.0171
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.7047 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.1531 0.1548
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.106 0.1072
Trypanosoma brucei unspecified product 0.0013 0.0583 0.0589
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0307 0.0163
Schistosoma mansoni DNA ligase IV 0.001 0.0307 0.0436
Echinococcus multilocularis Smad4 0.0008 0.0171 0.0023
Echinococcus multilocularis dna polymerase kappa 0.0019 0.106 0.0936
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0449 0.0454
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0583 0.0589
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.106 0.1072
Loa Loa (eye worm) transglutaminase 0.0008 0.0148 0.0148
Giardia lamblia Kinase, PLK 0.0092 0.7047 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 18.13 um PUBCHEM_BIOASSAY: Inhibitors of Plasmodium falciparum M17- Family Leucine Aminopeptidase (M17LAP). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 50 um PUBCHEM_BIOASSAY: Dose Response Confirmation for Calpain Inhibitors. (Class of assay: confirmatory) [Related pubchem assays: 1236 (Primary screen preceding this confirmatory assay.)] ChEMBL. No reference
IC50 (binding) > 100 uM Inhibition of rabbit recombinant GSK3beta ChEMBL. 17919914
Potency (functional) = 0.0282 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.9285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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