Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0117 | 0.0478 | 0.0478 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0117 | 0.0478 | 0.0478 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0117 | 0.0478 | 0.0478 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0117 | 0.0478 | 0.0478 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0117 | 0.0478 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0117 | 0.0478 | 0.0478 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0478 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0117 | 0.0478 | 0.0478 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0117 | 0.0478 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0117 | 0.0478 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0619 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0117 | 0.0478 | 0.0542 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0117 | 0.0478 | 0.0542 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0117 | 0.0478 | 0.0478 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0478 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0117 | 0.0478 | 0.0478 |
Brugia malayi | ecdysteroid receptor | 0.0117 | 0.0478 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0117 | 0.0478 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0478 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0117 | 0.0478 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0117 | 0.0478 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0117 | 0.0478 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.0142 | 0.0955 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0117 | 0.0478 | 0.0542 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0117 | 0.0478 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0117 | 0.0478 | 0.0478 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0117 | 0.0478 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0478 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0117 | 0.0478 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0117 | 0.0478 | 0.0478 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0117 | 0.0478 | 0.0542 |
Brugia malayi | nuclear receptor NHR-88 | 0.0117 | 0.0478 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0117 | 0.0478 | 0.0478 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0117 | 0.0478 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0117 | 0.0478 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0117 | 0.0478 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0117 | 0.0478 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0117 | 0.0478 | 0.0478 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0117 | 0.0478 | 0.0542 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0117 | 0.0478 | 0.0478 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0117 | 0.0478 | 0.0542 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0117 | 0.0478 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0117 | 0.0478 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0117 | 0.0478 | 0.0478 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0117 | 0.0478 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0478 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0117 | 0.0478 | 0.0542 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0117 | 0.0478 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0117 | 0.0478 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0117 | 0.0478 | 1 |
Onchocerca volvulus | 0.0117 | 0.0478 | 1 | |
Brugia malayi | steroid hormone receptor | 0.0117 | 0.0478 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0117 | 0.0478 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0117 | 0.0478 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0117 | 0.0478 | 0.0478 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0117 | 0.0478 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0117 | 0.0478 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0117 | 0.0478 | 0.0478 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0557 | 0.8827 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0117 | 0.0478 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0117 | 0.0478 | 0.0478 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0117 | 0.0478 | 0.0542 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0478 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0117 | 0.0478 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0117 | 0.0478 | 0.0478 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0117 | 0.0478 | 0.0478 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0117 | 0.0478 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0117 | 0.0478 | 0.0478 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0478 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0117 | 0.0478 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0117 | 0.0478 | 0.0542 |
Schistosoma mansoni | hypothetical protein | 0.0142 | 0.0955 | 0.0955 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0478 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 128 ug ml-1 | Minimum inhibitory concentration against Neisseria meningitides 69480 | ChEMBL. | 14998336 |
MIC (functional) | = 128 ug ml-1 | Minimum inhibitory concentration against Micrococcus luteus ATCC8340 | ChEMBL. | 14998336 |
MNEC (binding) | = 4 ug ml-1 | Maximum noneffective concentration of the compound against E. coli DNA gyrase | ChEMBL. | 14998336 |
MNEC (binding) | = 4 ug ml-1 | Maximum noneffective concentration of the compound against E. coli DNA gyrase | ChEMBL. | 14998336 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.