Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, alpha | 451 aa | 372 aa | 25.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0176 | 0.1523 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.1523 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.1523 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0301 | 0.9282 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 21 nM | Effect on human TRalpha transactivation activity in HeLa cells by luciferase reporter assay | ChEMBL. | 17988877 |
EC50 (binding) | = 21 nM | Effect on human TRalpha transactivation activity in HeLa cells by luciferase reporter assay | ChEMBL. | 17988877 |
EC50 (binding) | = 105 nM | Effect on human TRalpha transactivation activity in U2OS cells by luciferase reporter assay | ChEMBL. | 17988877 |
EC50 (binding) | = 105 nM | Effect on human TRalpha transactivation activity in U2OS cells by luciferase reporter assay | ChEMBL. | 17988877 |
EC50 (binding) | = 216 nM | Effect on human TRbeta transactivation activity in HeLa cells by luciferase reporter assay | ChEMBL. | 17988877 |
EC50 (binding) | = 216 nM | Effect on human TRbeta transactivation activity in HeLa cells by luciferase reporter assay | ChEMBL. | 17988877 |
EC50 (binding) | = 2000 nM | Effect on human TRbeta transactivation activity in U2OS cells by luciferase reporter assay | ChEMBL. | 17988877 |
EC50 (binding) | = 2000 nM | Effect on human TRbeta transactivation activity in U2OS cells by luciferase reporter assay | ChEMBL. | 17988877 |
Kd (binding) | = 24 nM | Displacement of [125I]T3 from human TRalpha receptor | ChEMBL. | 17988877 |
Kd (binding) | = 24 nM | Displacement of [125I]T3 from human TRalpha receptor | ChEMBL. | 17988877 |
Kd (binding) | = 36 nM | Displacement of [125I]T3 from human TRbeta receptor | ChEMBL. | 17988877 |
Kd (binding) | = 36 nM | Displacement of [125I]T3 from human TRbeta receptor | ChEMBL. | 17988877 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.