Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0047 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0047 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0047 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0047 | 0.1828 | 0.8189 |
Plasmodium vivax | vivapain-2 | 0.0047 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0047 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0047 | 0.1828 | 0.1828 |
Loa Loa (eye worm) | fibroinase | 0.0047 | 0.1828 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0047 | 0.1828 | 0.8189 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0047 | 0.1828 | 0.1828 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0033 | 0.0582 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0047 | 0.1828 | 0.8189 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0047 | 0.1828 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0047 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0047 | 0.1828 | 0.8189 |
Onchocerca volvulus | 0.0047 | 0.1828 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0047 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0047 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0033 | 0.0582 | 0.2606 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0047 | 0.1828 | 0.1828 |
Entamoeba histolytica | cysteine protease, putative | 0.0047 | 0.1828 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0047 | 0.1828 | 0.8189 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1828 | 0.1323 |
Onchocerca volvulus | 0.0047 | 0.1828 | 1 | |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0047 | 0.1828 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0047 | 0.1828 | 0.8189 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0141 | 1 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0047 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0033 | 0.0582 | 0.2606 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0047 | 0.1828 | 0.8189 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0047 | 0.1828 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0141 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0047 | 0.1828 | 0.1828 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0052 | 0.2232 | 0.2232 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0047 | 0.1828 | 0.1828 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0033 | 0.0582 | 0.0582 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0141 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0047 | 0.1828 | 0.8189 |
Echinococcus granulosus | cathepsin l1 | 0.0047 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0047 | 0.1828 | 0.8189 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0047 | 0.1828 | 0.1828 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0047 | 0.1828 | 0.1828 |
Onchocerca volvulus | 0.0047 | 0.1828 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0047 | 0.1828 | 0.1828 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0047 | 0.1828 | 0.8189 |
Onchocerca volvulus | Cathepsin F homolog | 0.0047 | 0.1828 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0047 | 0.1828 | 0.1828 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0047 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0047 | 0.1828 | 0.8189 |
Onchocerca volvulus | 0.0047 | 0.1828 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0047 | 0.1828 | 0.1828 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0052 | 0.2232 | 1 |
Onchocerca volvulus | 0.0047 | 0.1828 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0047 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0033 | 0.0582 | 0.0582 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0047 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0047 | 0.1828 | 0.8189 |
Giardia lamblia | Cathepsin B precursor | 0.0052 | 0.2232 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0052 | 0.2232 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0033 | 0.0582 | 0.0582 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0141 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0047 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0047 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0047 | 0.1828 | 0.8189 |
Loa Loa (eye worm) | cathepsin B | 0.0052 | 0.2232 | 0.1752 |
Brugia malayi | Cathepsin L-like precursor | 0.0033 | 0.0582 | 0.0582 |
Echinococcus granulosus | cathepsin l1 | 0.0033 | 0.0582 | 0.0582 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0047 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0047 | 0.1828 | 0.8189 |
Giardia lamblia | Cathepsin B precursor | 0.0052 | 0.2232 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0047 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0047 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0047 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0047 | 0.1828 | 0.8189 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0047 | 0.1828 | 0.1323 |
Brugia malayi | cathepsin L-like precursor | 0.0033 | 0.0582 | 0.0582 |
Brugia malayi | Cathepsin L-like precursor | 0.0047 | 0.1828 | 0.1828 |
Onchocerca volvulus | 0.0047 | 0.1828 | 1 | |
Echinococcus granulosus | cathepsin b | 0.0141 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0052 | 0.2232 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0047 | 0.1828 | 0.1323 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0047 | 0.1828 | 1 |
Echinococcus granulosus | cathepsin b | 0.0141 | 1 | 1 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0052 | 0.2232 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0047 | 0.1828 | 0.8189 |
Plasmodium vivax | vivapain-2 | 0.0047 | 0.1828 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0033 | 0.0582 | 0.0582 |
Echinococcus multilocularis | cysteine protease | 0.0047 | 0.1828 | 0.1828 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0047 | 0.1828 | 0.1828 |
Onchocerca volvulus | Cathepsin L homolog | 0.0047 | 0.1828 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0047 | 0.1828 | 0.1828 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0047 | 0.1828 | 0.1828 |
Onchocerca volvulus | 0.0047 | 0.1828 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0047 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0047 | 0.1828 | 0.8189 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0047 | 0.1828 | 0.1828 |
Onchocerca volvulus | Cathepsin L homolog | 0.0047 | 0.1828 | 1 |
Toxoplasma gondii | cathepsin B | 0.0052 | 0.2232 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0047 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0047 | 0.1828 | 0.8189 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0141 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0052 | 0.2232 | 0.2232 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0047 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0047 | 0.1828 | 0.8189 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0047 | 0.1828 | 0.1828 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0047 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0047 | 0.1828 | 0.8189 |
Loa Loa (eye worm) | ctsf protein | 0.0047 | 0.1828 | 0.1323 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0047 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0047 | 0.1828 | 0.8189 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0141 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0141 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 1.98 | Antifungal activity against Magnaporthe grisea infected rice plant assessed as logarithm of fungal control value at 100 ppm after 5 days | ChEMBL. | 18299194 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.