Detailed information for compound 516624

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 419.695 | Formula: C18H13Cl3N6
  • H donors: 0 H acceptors: 4 LogP: 5.14 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)c1nnnn1C
  • InChi: 1S/C18H13Cl3N6/c1-10-16(18-22-24-25-26(18)2)23-27(15-8-7-13(20)9-14(15)21)17(10)11-3-5-12(19)6-4-11/h3-9H,1-2H3
  • InChiKey: GUGPQXDMATZXEW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Cannabinoid CB1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0026 0.0784 0.0783
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.0026 0.0784 0.1505
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.4351 0.836
Loa Loa (eye worm) hypothetical protein 0.0026 0.0816 0.0825
Entamoeba histolytica recQ family DNA helicase 0.0014 0.0268 0.0108
Echinococcus granulosus uridine phosphorylase 1 0.0026 0.0784 0.1505
Entamoeba histolytica serine/threonine protein kinase, putative 0.0063 0.2498 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.1248 0.1248
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.1248 0.2397
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.1248 0.419
Echinococcus granulosus lamin 0.0026 0.081 0.1555
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.4351 0.836
Plasmodium falciparum glutathione reductase 0.0046 0.1699 0.6287
Trypanosoma brucei NIMA-related protein kinase 0.0063 0.2498 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0679 0.1842
Echinococcus multilocularis bloom syndrome protein 0.004 0.1431 0.2749
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0024 0.0703 0.2038
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0026 0.0784 0.2313
Giardia lamblia Sgs1 DNA helicase, putative 0.0028 0.0882 0.1103
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.1248 0.2003
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0346 0.1386
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0936 0.1798
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0936 0.1502
Echinococcus granulosus methylthioadenosine phosphorylase 0.0026 0.0784 0.1505
Trypanosoma brucei Serine/threonine-protein kinase NEK16, putative 0.0063 0.2498 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.4351 0.836
Brugia malayi intermediate filament protein 0.0026 0.081 0.0818
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0123 0.5205 0.5205
Treponema pallidum pfs protein (pfs) 0.0026 0.0784 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.8741 0.883
Mycobacterium ulcerans purine nucleoside phosphorylase 0.0123 0.5205 1
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0026 0.0784 0.2396
Echinococcus granulosus intermediate filament protein 0.0026 0.081 0.1555
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0346 0.0665
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.2498 0.2498
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.003 0.0996 0.3264
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0882 0.0891
Mycobacterium tuberculosis Probable reductase 0.0104 0.4351 0.836
Chlamydia trachomatis AMP nucleosidase 0.0026 0.0784 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0177 0.0179
Echinococcus multilocularis purine nucleoside phosphorylase 0.0123 0.5205 1
Toxoplasma gondii NEK kinase 0.0063 0.2498 1
Loa Loa (eye worm) RecQ helicase 0.004 0.1431 0.1445
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0346 0.0352
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0028 0.0882 0.1695
Leishmania major protein kinase, putative,serine/threonine-protein kinase Nek1, putative 0.0063 0.2498 1
Loa Loa (eye worm) uridine phosphorylase 0.0026 0.0784 0.0792
Echinococcus granulosus purine nucleoside phosphorylase 0.0123 0.5205 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0346 0.0352
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0037 0.1317 0.4513
Schistosoma mansoni DNA helicase recq1 0.0028 0.0882 0.1416
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0346 0.1386
Trypanosoma brucei trypanothione reductase 0.0046 0.1699 0.6287
Toxoplasma gondii NEK kinase 0.0063 0.2498 1
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0026 0.0784 0.09
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0346 0.0346
Echinococcus multilocularis musashi 0.0026 0.081 0.1555
Loa Loa (eye worm) hypothetical protein 0.0014 0.0268 0.0271
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0346 0.0352
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0026 0.0784 0.2396
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0026 0.0784 0.2313
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.4878 0.9372
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.1248 0.4456
Echinococcus granulosus bloom syndrome protein 0.004 0.1431 0.2749
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0026 0.0784 0.2396
Brugia malayi Pre-SET motif family protein 0.0029 0.0936 0.0945
Toxoplasma gondii Purine nucleoside phosphorylase 0.0026 0.0784 0.2313
Trichomonas vaginalis DNA helicase recq1, putative 0.004 0.1431 0.1431
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.1248 0.1261
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0346 0.035
Leishmania major trypanothione reductase 0.0046 0.1699 0.6802
Entamoeba histolytica recQ family helicase, putative 0.003 0.0996 0.3337
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.2141 0.3435
Plasmodium vivax serine/threonine-protein kinase NEK4, putative 0.0063 0.2498 1
Leishmania major methylthioadenosine phosphorylase, putative 0.0026 0.0784 0.3137
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.2498 0.2498
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.2141 0.4112
Loa Loa (eye worm) glutathione reductase 0.0046 0.1699 0.1716
Toxoplasma gondii phosphorylase family protein 0.0026 0.0784 0.2313
Echinococcus multilocularis purine nucleoside phosphorylase 0.0098 0.405 0.7782
Trypanosoma cruzi Serine/threonine-protein kinase NEK11, putative 0.0063 0.2498 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0346 0.1386
Schistosoma mansoni methylthioadenosine phosphorylase 0.0026 0.0784 0.1258
Schistosoma mansoni blooms syndrome DNA helicase 0.0014 0.0268 0.043
Loa Loa (eye worm) hypothetical protein 0.0013 0.0199 0.0201
Echinococcus granulosus inosine guanosine and xanthosine phosphorylase 0.0098 0.405 0.7782
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0123 0.5205 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.0123 0.5205 1
Toxoplasma gondii thioredoxin reductase 0.0046 0.1699 0.6418
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0028 0.0882 0.0891
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0028 0.0882 0.2491
Schistosoma mansoni lamin 0.0026 0.081 0.1299
Onchocerca volvulus 0.0026 0.081 0.081
Mycobacterium ulcerans bifunctional Mta/Sah nucleosidase Mtn 0.0026 0.0784 0.1505
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0028 0.0882 0.1695
Giardia lamblia UPL-1 0.0026 0.0784 0.09
Schistosoma mansoni purine nucleoside phosphorylase 0.0123 0.5205 0.8353
Schistosoma mansoni lamin 0.0026 0.081 0.1299
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0882 0.2755
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0199 0.0382
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0346 1
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0026 0.0784 0.2396
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.1248 0.2397
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.0123 0.5205 1
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.1248 0.1248
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0936 0.1502
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0026 0.0784 0.09
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0123 0.5205 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.4351 0.836
Plasmodium falciparum NIMA related kinase 4 0.0063 0.2498 1
Schistosoma mansoni methylthioadenosine phosphorylase 0.0026 0.0784 0.1258
Toxoplasma gondii NEK kinase 0.0063 0.2498 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0227 0.9899 1
Schistosoma mansoni uridine phosphorylase 0.0026 0.0784 0.1258
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.1699 0.6418
Trypanosoma cruzi Serine/threonine-protein kinase NEK16, putative 0.0063 0.2498 1
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.2498 0.2498
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0882 0.0891
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0026 0.0784 0.2396
Loa Loa (eye worm) hypothetical protein 0.0026 0.081 0.0818
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0346 0.0665
Echinococcus multilocularis purine nucleoside phosphorylase 0.0123 0.5205 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.2141 0.4113
Loa Loa (eye worm) hypothetical protein 0.0036 0.1248 0.1261
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.1248 0.1248
Onchocerca volvulus 0.0029 0.0936 0.0936
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.4878 0.9372
Echinococcus granulosus purine nucleoside phosphorylase 0.0123 0.5205 1
Echinococcus multilocularis lamin dm0 0.0026 0.081 0.1555
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0026 0.0784 0.2396
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0346 0.0352
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0026 0.0784 0.2313
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.1248 0.2397
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0936 0.1798
Plasmodium vivax SET domain protein, putative 0.0029 0.0936 0.3071
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0346 0.0665
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.1248 0.4395
Trichomonas vaginalis set domain proteins, putative 0.0229 1 1
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0026 0.0784 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0346 0.0456
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0346 0.0352
Echinococcus granulosus purine nucleoside phosphorylase 0.0123 0.5205 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0346 0.1386
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0261 0.0264
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0026 0.0784 0.0783
Mycobacterium tuberculosis Hypothetical protein 0.0026 0.0784 0.1505
Echinococcus multilocularis lamin 0.0026 0.081 0.1555
Echinococcus granulosus purine nucleoside phosphorylase 0.0123 0.5205 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0346 0.0352
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.1248 0.2397
Echinococcus multilocularis uridine phosphorylase 1 0.0026 0.0784 0.1505
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.4856 0.4905
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.1248 0.4395
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0346 0.0346
Brugia malayi MTAP 0.0026 0.0784 0.0792
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0936 0.1798
Trypanosoma cruzi NIMA-related kinase, putative 0.0063 0.2498 1
Echinococcus granulosus serine:threonine protein kinase Nek1 0.0062 0.2425 0.4659
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.4878 0.9372
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.003 0.0996 0.3018
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.4351 0.836
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0346 0.0352
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.1248 0.2003
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0026 0.0784 0.0783
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.2141 0.4113
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0156 0.0158
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0156 0.0158
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.003 0.0996 0.3986
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.2141 0.2162
Plasmodium falciparum NIMA related kinase 2 0.0063 0.2498 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0261 0.0264
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.2141 0.4112
Brugia malayi MH2 domain containing protein 0.0116 0.4856 0.4905
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.1248 0.1856
Trichomonas vaginalis DNA helicase recq, putative 0.003 0.0996 0.0996
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0026 0.0784 0.2313
Onchocerca volvulus 0.0026 0.081 0.081
Toxoplasma gondii phosphorylase family protein 0.0026 0.0784 0.2313
Mycobacterium tuberculosis Conserved hypothetical protein 0.0026 0.0784 0.1505
Brugia malayi glutathione reductase 0.0046 0.1699 0.1716
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0026 0.0784 0.0792
Leishmania major serine/threonine-protein kinase, putative 0.0063 0.2498 1
Trypanosoma brucei uridine phosphorylase 0.0026 0.0784 0.2032
Loa Loa (eye worm) hypothetical protein 0.0029 0.0936 0.0945
Loa Loa (eye worm) intermediate filament protein 0.0026 0.081 0.0818
Brugia malayi follicle stimulating hormone receptor 0.0227 0.9899 1
Echinococcus granulosus purine nucleoside phosphorylase 0.0123 0.5205 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.081 0.0818
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0026 0.0784 0.0783
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.2141 0.8569
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0026 0.0784 0.2313
Loa Loa (eye worm) hypothetical protein 0.0026 0.0788 0.0796
Echinococcus multilocularis purine nucleoside phosphorylase 0.0123 0.5205 1
Echinococcus granulosus purine nucleoside phosphorylase 0.0123 0.5205 1
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0123 0.5205 0.5205
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0026 0.0784 0.1505
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0936 0.1502
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0026 0.0784 0.1505
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0026 0.0784 0.0783
Echinococcus multilocularis purine nucleoside phosphorylase 0.0123 0.5205 1
Trypanosoma cruzi protein kinase, putative 0.0062 0.2425 0.9673
Schistosoma mansoni methylthioadenosine phosphorylase 0.0026 0.0784 0.1258
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.2498 0.2498
Plasmodium falciparum thioredoxin reductase 0.0046 0.1699 0.6287
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.1248 0.2397
Brugia malayi Thioredoxin reductase 0.0046 0.1699 0.1716
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0346 0.0352
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0882 0.2755
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0784 0.0783
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0026 0.0784 0.2032
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0028 0.0882 0.1695
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.2141 0.4113
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0784 0.0783
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0346 0.0352
Trypanosoma brucei Serine/threonine-protein kinase NEK11, putative 0.0063 0.2498 1
Brugia malayi uridine phosphorylase family protein 0.0026 0.0784 0.0792
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0936 0.1502
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.4351 0.836
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0346 1
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.1699 0.1716
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0026 0.0784 0.0783
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.4856 0.4905
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0028 0.0882 0.1695
Brugia malayi Bloom's syndrome protein homolog 0.004 0.1431 0.1445
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.1699 0.3264
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0346 0.0456
Echinococcus granulosus lamin dm0 0.0026 0.081 0.1555
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.1699 0.3264
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0346 0.0665
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0346 0.0665
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.1699 0.3264
Trypanosoma cruzi Serine/threonine-protein kinase NEK11, putative 0.0063 0.2498 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.405 0.4092
Brugia malayi Pre-SET motif family protein 0.0202 0.8741 0.883
Treponema pallidum uridine phosphorylase (udp) 0.0026 0.0784 1
Plasmodium vivax glutathione reductase, putative 0.0046 0.1699 0.6457
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0346 0.0556
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.4878 0.9372
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.1248 0.2397
Giardia lamblia Kinase, NEK 0.0063 0.2498 0.4429
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0346 0.0665
Mycobacterium leprae probable uridine phosphorylase 0.0026 0.0784 0.1505
Echinococcus granulosus purine nucleoside phosphorylase 0.0123 0.5205 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0199 0.0382
Plasmodium vivax serine/threonine-protein kinase Nek1, putative 0.0063 0.2498 1
Schistosoma mansoni uridine phosphorylase 0.0026 0.0784 0.1258
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.1248 0.4996
Echinococcus multilocularis purine nucleoside phosphorylase 0.0098 0.405 0.7782
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0346 0.0352
Schistosoma mansoni intermediate filament proteins 0.0026 0.081 0.1299
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.1972 0.1992
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0346 0.0352
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0888 0.1706
Leishmania major protein kinase, putative 0.0063 0.2498 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0026 0.0792 0.1271
Leishmania major nucleoside phosphorylase-like protein 0.0026 0.0784 0.3137
Schistosoma mansoni purine nucleoside phosphorylase 0.0123 0.5205 0.8353
Echinococcus multilocularis serine:threonine protein kinase Nek1 0.0062 0.2425 0.4659
Treponema pallidum ATP-dependent DNA helicase 0.0014 0.0268 0.3416
Trichomonas vaginalis STE family protein kinase 0.0063 0.2498 0.2498
Echinococcus multilocularis purine nucleoside phosphorylase 0.0123 0.5205 1
Echinococcus granulosus purine nucleoside phosphorylase 0.0123 0.5205 1
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0026 0.0784 0.2396
Loa Loa (eye worm) hypothetical protein 0.0028 0.0882 0.0891
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.2498 0.4009
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0026 0.0784 0.0783
Schistosoma mansoni DNA helicase recq5 0.0028 0.0882 0.1416
Treponema pallidum NADH oxidase 0.0016 0.0346 0.4419
Plasmodium falciparum purine nucleoside phosphorylase 0.0026 0.0784 0.2032
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0123 0.5205 0.5258
Trichomonas vaginalis DNA helicase recq, putative 0.004 0.1431 0.1431
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0936 0.2996
Entamoeba histolytica hypothetical protein 0.0026 0.0784 0.2396
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.081 0.0818
Loa Loa (eye worm) hypothetical protein 0.0012 0.0177 0.0179
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.1699 0.6457

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1060 nM Inhibition of cannabinoid CB1 receptor in Sprague-Dawley rat brain ChEMBL. 18337096
IC50 (binding) = 1060 nM Inhibition of cannabinoid CB1 receptor in Sprague-Dawley rat brain ChEMBL. 18337096

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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