Detailed information for compound 516788

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 425.4 | Formula: C19H15F4N3O2S
  • H donors: 1 H acceptors: 1 LogP: 4.34 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cc1cs/c(=N\c2ccc(cc2)F)/n1C)Nc1ccc(cc1)OC(F)(F)F
  • InChi: 1S/C19H15F4N3O2S/c1-26-15(11-29-18(26)25-14-4-2-12(20)3-5-14)10-17(27)24-13-6-8-16(9-7-13)28-19(21,22)23/h2-9,11H,10H2,1H3,(H,24,27)/b25-18-
  • InChiKey: COKNCJVVZMHKFW-BWAHOGKJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.003 0.1533 0.5
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.003 0.1533 0.5
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.003 0.1533 0.5464
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0047 0.2806 1
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0604 0.2152
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0047 0.2806 1
Toxoplasma gondii hypothetical protein 0.0017 0.0604 0.2152
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0047 0.2806 1
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0047 0.2806 1
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0047 0.2806 1
Brugia malayi Methionine aminopeptidase protein type I 0.0047 0.2806 1
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0047 0.2806 1
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0047 0.2806 1
Leishmania major hypothetical protein, conserved 0.0017 0.0604 0.2152
Treponema pallidum methionine aminopeptidase (map) 0.003 0.1533 0.5
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.003 0.1533 0.5464
Plasmodium falciparum HP12 protein homolog, putative 0.0017 0.0604 0.2152
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.003 0.1533 1
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0047 0.2806 1
Onchocerca volvulus 0.0009 0 0.5
Trypanosoma brucei methionine aminopeptidase, putative 0.0047 0.2806 1
Plasmodium vivax hypothetical protein, conserved 0.0017 0.0604 0.2152
Toxoplasma gondii methionine aminopeptidase 0.003 0.1533 0.5464
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.003 0.1533 0.5
Plasmodium vivax methionine aminopeptidase 1a, putative 0.003 0.1533 0.5464
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0604 0.2152
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.003 0.1533 0.5464
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0047 0.2806 1
Chlamydia trachomatis methionine aminopeptidase 0.003 0.1533 0.5
Mycobacterium ulcerans epoxide hydrolase EphA 0.0145 1 1
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.003 0.1533 1
Toxoplasma gondii methionine aminopeptidase 0.0047 0.2806 1
Loa Loa (eye worm) methionine aminopeptidase type I 0.0047 0.2806 1

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 0.9 Antifungal activity against Magnaporthe grisea infected rice plant assessed as logarithm of fungal control value at 100 ppm after 5 days ChEMBL. 18299194

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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