Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0189 | 1 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0117 | 0.2291 | 0.2291 |
Giardia lamblia | Hypothetical protein | 0.0168 | 0.7709 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0189 | 1 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0189 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0189 | 1 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0168 | 0.7709 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0189 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0189 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0189 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0189 | 1 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0117 | 0.2291 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0189 | 1 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0189 | 1 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0189 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0189 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0189 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0189 | 1 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0189 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0189 | 1 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0189 | 1 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0189 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0189 | 1 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0189 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0189 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.039 uM | Inhibition of chymotrypsin-like activity of 20S proteasome (unknown origin) | ChEMBL. | 18294845 |
IC50 (binding) | = 0.052 uM | In vivo inhibition of chymotrypsin-like activity of 20S proteasome (unknown origin) | ChEMBL. | 18294845 |
IC50 (binding) | = 0.286 uM | Inhibition of trypsin-like activity of 20S proteasome (unknown origin) | ChEMBL. | 18294845 |
IC50 (binding) | = 0.473 uM | In vivo inhibition of trypsin-like activity of 20S proteasome (unknown origin) | ChEMBL. | 18294845 |
IC50 (binding) | > 10 uM | Inhibition of post acidic active site of 20S proteasome (unknown origin) | ChEMBL. | 18294845 |
IC50 (binding) | > 10 uM | In vivo inhibition of post acidic active site of 20S proteasome (unknown origin) | ChEMBL. | 18294845 |
t1/2 (ADMET) | > 360 min | Half life in human plasma | ChEMBL. | 18294845 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.