Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin 3 (5-HT3) receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carboxylesterase 5A | 0.0067 | 0.2559 | 0.2484 |
Schistosoma mansoni | chromobox protein | 0.0073 | 0.2963 | 0.2893 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.2559 | 0.5905 |
Echinococcus multilocularis | acetylcholinesterase | 0.0067 | 0.2559 | 0.2484 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0067 | 0.2559 | 0.2484 |
Brugia malayi | chromobox protein homolog 3 | 0.0041 | 0.0804 | 0.1692 |
Echinococcus granulosus | acetylcholinesterase | 0.0067 | 0.2559 | 0.2484 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0804 | 0.1692 |
Onchocerca volvulus | 0.0032 | 0.0209 | 0.1201 | |
Loa Loa (eye worm) | carboxylesterase | 0.0067 | 0.2559 | 0.5905 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0209 | 0.0264 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0067 | 0.2559 | 0.2484 |
Echinococcus multilocularis | geminin | 0.0178 | 1 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0073 | 0.2963 | 0.2893 |
Echinococcus granulosus | chromobox protein 1 | 0.0073 | 0.2963 | 0.2893 |
Brugia malayi | Carboxylesterase family protein | 0.0067 | 0.2559 | 0.5905 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0804 | 0.2714 |
Trichomonas vaginalis | chromobox protein, putative | 0.0044 | 0.1013 | 0.3419 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.2559 | 0.5905 |
Brugia malayi | Carboxylesterase family protein | 0.0067 | 0.2559 | 0.5905 |
Echinococcus multilocularis | acetylcholinesterase | 0.0067 | 0.2559 | 0.2484 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.0804 | 0.7712 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.4264 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0073 | 0.2963 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.4264 | 1 |
Schistosoma mansoni | eyes absent homolog | 0.0093 | 0.4264 | 0.4207 |
Trichomonas vaginalis | chromobox protein, putative | 0.0073 | 0.2963 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0804 | 0.2714 |
Brugia malayi | hypothetical protein | 0.0093 | 0.4264 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0067 | 0.2559 | 0.5905 |
Schistosoma mansoni | chromobox protein | 0.0073 | 0.2963 | 0.2893 |
Echinococcus multilocularis | chromobox protein 1 | 0.0073 | 0.2963 | 0.2893 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0044 | 0.1013 | 1 |
Brugia malayi | Heterochromatin protein 1 | 0.0073 | 0.2963 | 0.6876 |
Trichomonas vaginalis | chromobox protein, putative | 0.0044 | 0.1013 | 0.3419 |
Echinococcus multilocularis | chromobox protein 1 | 0.0073 | 0.2963 | 0.2893 |
Echinococcus granulosus | acetylcholinesterase | 0.0067 | 0.2559 | 0.2484 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 1 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0073 | 0.2963 | 0.6876 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = -9.15 | Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes. | ChEMBL. | 1992112 |
Log IC50 (binding) | = 9.15 | Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes. | ChEMBL. | 1992112 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.