Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.5133 | 0.5133 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.824 | 0.824 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0099 | 0.824 | 0.824 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.4565 | 0.8893 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.1527 | 0.2976 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0099 | 0.824 | 0.824 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.1527 | 0.3346 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.1527 | 0.1527 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.4565 | 0.8893 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0016 | 0 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.1527 | 0.1527 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.5133 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.4565 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.4565 | 0.4565 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.4565 | 0.4565 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.4565 | 0.8893 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.1527 | 0.1527 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0099 | 0.824 | 0.824 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.4565 | 0.4565 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.1527 | 0.3346 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.1527 | 0.2976 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.1527 | 0.3346 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.4565 | 0.4565 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.1527 | 0.3346 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.4565 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.4565 | 0.8893 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.1527 | 0.2976 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.4565 | 0.4565 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.5133 | 0.5133 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1527 | 0.1527 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.1527 | 0.2976 |
Brugia malayi | RNA binding protein | 0.0062 | 0.4565 | 0.4565 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.1527 | 0.3346 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.1527 | 0.3346 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.4565 | 0.8893 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Decrease (functional) | = -13 % | Bradycardic activity measured as a percentage decrease of heart rate after 5 mg/kg intravenous administration in anesthetized rats | ChEMBL. | 2261014 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.