Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0149 | 0.5885 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0149 | 0.5885 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.013 | 0.5058 | 0.8595 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.013 | 0.5058 | 0.8595 |
Schistosoma mansoni | thyroid hormone receptor | 0.0149 | 0.5885 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.013 | 0.5058 | 1 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.024 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Inhibition of PDE4B (unknown origin) | ChEMBL. | 18304812 | |
Activity (binding) | 0 | Inhibition of PDE4B (unknown origin) | ChEMBL. | 18304812 |
IC50 (binding) | Inhibition of PDE3A (unknown origin) | ChEMBL. | 18304812 | |
IC50 (binding) | 0 | Inhibition of PDE3A (unknown origin) | ChEMBL. | 18304812 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.