Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0032 | 0.2561 | 0.5 | |
Loa Loa (eye worm) | intermediate filament protein | 0.0032 | 0.2561 | 0.2561 |
Echinococcus multilocularis | lamin dm0 | 0.0032 | 0.2561 | 0.2353 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0271 | 0.0271 |
Schistosoma mansoni | lamin | 0.0032 | 0.2561 | 0.2353 |
Brugia malayi | TAR-binding protein | 0.0074 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0032 | 0.2561 | 0.2353 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.246 | 0.246 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.4015 | 0.4015 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0032 | 0.2561 | 0.2561 |
Echinococcus granulosus | intermediate filament protein | 0.0032 | 0.2561 | 0.2353 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.724 | 0.724 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.724 | 0.724 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0271 | 0.0271 |
Echinococcus multilocularis | musashi | 0.0032 | 0.2561 | 0.2353 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0271 | 0.0271 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.4015 | 0.4015 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 1 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0271 | 0.0271 |
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 1 | 1 |
Onchocerca volvulus | 0.0032 | 0.2561 | 0.5 | |
Brugia malayi | intermediate filament protein | 0.0032 | 0.2561 | 0.2561 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0032 | 0.2561 | 0.2561 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.2561 | 0.2561 |
Echinococcus multilocularis | lamin | 0.0032 | 0.2561 | 0.2353 |
Echinococcus granulosus | lamin dm0 | 0.0032 | 0.2561 | 0.2353 |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.724 | 0.724 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.724 | 0.724 |
Schistosoma mansoni | intermediate filament proteins | 0.0032 | 0.2561 | 0.2353 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0032 | 0.2561 | 0.2353 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.4015 | 0.3848 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.17 uM | Antiproliferative activity against Lck (unknown origin) transformed mouse BaF3 cells after 48 hrs by luciferase assay | ChEMBL. | 18353642 |
IC50 (functional) | = 0.17 uM | Antiproliferative activity against Lck (unknown origin) transformed mouse BaF3 cells after 48 hrs by luciferase assay | ChEMBL. | 18353642 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 18353642 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.