Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Adenosine deaminase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Dictyostelium discoideum | adenosine deaminase-related growth factor | Adenosine deaminase | 363 aa | 299 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | adenosine deaminase, putative | 0.0104 | 0.4257 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0232 | 1 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0104 | 0.4257 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0204 | 0.8741 | 0.8836 |
Plasmodium falciparum | adenosine deaminase | 0.0104 | 0.4257 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1136 | 0.0227 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0104 | 0.4257 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0227 | 0.977 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0936 | 0.2198 |
Brugia malayi | adenosine monophosphate deaminase | 0.0034 | 0.1136 | 0.0227 |
Onchocerca volvulus | 0.0034 | 0.1136 | 0.0221 | |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0888 | 0.2086 |
Treponema pallidum | adenosine deaminase | 0.0104 | 0.4257 | 1 |
Loa Loa (eye worm) | AMP deaminase | 0.0034 | 0.1136 | 0.0227 |
Schistosoma mansoni | adenosine deaminase-related | 0.0104 | 0.4257 | 1 |
Echinococcus granulosus | AMP deaminase 2 | 0.0034 | 0.1136 | 0.267 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0034 | 0.1136 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0034 | 0.1136 | 0.5 |
Schistosoma mansoni | adenosine deaminase | 0.0104 | 0.4257 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0104 | 0.4257 | 0.3664 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0034 | 0.1136 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0104 | 0.4257 | 1 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0008 | 0 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0104 | 0.4257 | 0.4257 |
Trypanosoma cruzi | AMP deaminase 2, putative | 0.0034 | 0.1136 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.0034 | 0.1136 | 0.5 |
Plasmodium vivax | adenosine/AMP deaminase, putative | 0.0034 | 0.1136 | 0.0604 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.2749 | 0.2053 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0936 | 0.2198 |
Schistosoma mansoni | AMP deaminase | 0.0034 | 0.1136 | 0.267 |
Leishmania major | adenine aminohydrolase | 0.0104 | 0.4257 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0034 | 0.1136 | 0.5 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0936 | 0.2198 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0204 | 0.8741 | 0.8836 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.4257 | 0.3759 |
Toxoplasma gondii | AMP deaminase | 0.0034 | 0.1136 | 0.0604 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0936 | 0.2198 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.0034 | 0.1136 | 0.0221 |
Brugia malayi | Adenosine/AMP deaminase family protein | 0.0104 | 0.4257 | 0.3759 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.2749 | 0.2053 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0104 | 0.4257 | 0.4257 |
Mycobacterium ulcerans | adenosine deaminase | 0.0104 | 0.4257 | 1 |
Echinococcus granulosus | adenosine deaminase | 0.0104 | 0.4257 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.0034 | 0.1136 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0936 | 0.2198 |
Echinococcus multilocularis | AMP deaminase 2 | 0.0034 | 0.1136 | 0.267 |
Echinococcus multilocularis | adenosine deaminase | 0.0104 | 0.4257 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0936 | 0.2198 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0034 | 0.1136 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0104 | 0.4257 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.2749 | 0.2053 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0936 | 0.2198 |
Brugia malayi | follicle stimulating hormone receptor | 0.0227 | 0.977 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0102 | 0.4161 | 0.9775 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.2749 | 0.2053 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0104 | 0.4257 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.0102 | 0.4161 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0104 | 0.4257 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.32 uM | Inhibitory activity against calf intestinal Adenosine deaminase (ADA) | ChEMBL. | 10780907 |
Ki (binding) | = 0.32 uM | Inhibitory activity against calf intestinal Adenosine deaminase (ADA) | ChEMBL. | 10780907 |
Ki (binding) | = 1.5 uM | Inhibitory activity against porcine heart Adenylate deaminase (AMPDA) | ChEMBL. | 10780907 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.