Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | dihydrofolate reductase | 0.4111 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.4111 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.4111 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.4111 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0401 | 0.0667 | 0.0155 |
Echinococcus granulosus | dihydrofolate reductase | 0.4111 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0401 | 0.0667 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0401 | 0.0667 | 0.0155 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.4111 | 1 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0401 | 0.0667 | 0.0155 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1572 | 0.3613 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0401 | 0.0667 | 0.0155 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1572 | 0.3613 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.4111 | 1 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0401 | 0.0667 | 0.0155 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1572 | 0.3613 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.4111 | 1 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1572 | 0.3613 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.4111 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0401 | 0.0667 | 0.0155 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0401 | 0.0667 | 0.0155 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0401 | 0.0667 | 0.0155 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1572 | 0.3613 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1572 | 0.3613 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Increase (functional) | = 108 % | Effect on Maxi-K-Mediated outward current in Xenopus laevis oocytes expressing cloned mSlo maxi-K channels at 20 uM | ChEMBL. | 11906290 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.