Detailed information for compound 518319

Basic information

Technical information
  • TDR Targets ID: 518319
  • Name: [(2R)-1-hydroxy-3-(5-methyl-2,4-dioxopyrimidi n-1-yl)propan-2-yl]oxymethylphosphonic acid
  • MW: 294.198 | Formula: C9H15N2O7P
  • H donors: 4 H acceptors: 6 LogP: -2.91 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@@H](Cn1cc(C)c(=O)[nH]c1=O)OCP(=O)(O)O
  • InChi: 1S/C9H15N2O7P/c1-6-2-11(9(14)10-8(6)13)3-7(4-12)18-5-19(15,16)17/h2,7,12H,3-5H2,1H3,(H,10,13,14)(H2,15,16,17)/t7-/m1/s1
  • InChiKey: NXSCESRMUVPASQ-SSDOTTSWSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(1R)-1-(hydroxymethyl)-2-(5-methyl-2,4-dioxo-pyrimidin-1-yl)ethoxy]methylphosphonic acid
  • [(1R)-1-(hydroxymethyl)-2-(5-methyl-2,4-dioxo-1-pyrimidinyl)ethoxy]methylphosphonic acid
  • [(2R)-1-hydroxy-3-(5-methyl-2,4-dioxo-pyrimidin-1-yl)propan-2-yl]oxymethylphosphonic acid
  • [(1R)-1-[(2,4-diketo-5-methyl-pyrimidin-1-yl)methyl]-2-hydroxy-ethoxy]methylphosphonic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0187 0.0183
Brugia malayi orphan nuclear receptor NR2E1 0.008 0.0427 0.0559
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0395 0.3066 0.4963
Schistosoma mansoni jun-related protein 0.0146 0.0977 0.0973
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0169 0.1176 0.19
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.0216 0.1568 0.2432
Mycobacterium tuberculosis Probable reductase 0.0114 0.0716 0.1033
Schistosoma mansoni lozenge 0.0061 0.0267 0.0262
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0033 0.0038
Entamoeba histolytica hypothetical protein 0.0074 0.0381 1
Brugia malayi Nuclear hormone receptor E75 0.008 0.0427 0.0559
Loa Loa (eye worm) hypothetical protein 0.0103 0.0621 0.0823
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0249 0.3234
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.0344 0.5155
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0169 0.1176 0.1553
Brugia malayi Thioredoxin reductase 0.005 0.0178 0.023
Brugia malayi nuclear hormone receptor family member nhr-6 0.008 0.0427 0.0559
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0114 0.0716 0.1033
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0249 0.0264
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0395 0.3066 0.4963
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0178 0.0281
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0381 0.0377
Entamoeba histolytica hypothetical protein 0.0074 0.0381 1
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0097 0.015
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.0344 0.0551
Loa Loa (eye worm) follicle stimulating hormone receptor 0.093 0.7549 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0427 0.0565
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.0981 0.1584
Schistosoma mansoni nuclear hormone receptor 0.008 0.0427 0.0422
Brugia malayi Nuclear hormone receptor E75 0.008 0.0427 0.0559
Echinococcus multilocularis snurportin 1 0.0297 0.2249 0.364
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0338 0.0541
Leishmania major trypanothione reductase 0.005 0.0178 0.1805
Schistosoma mansoni nuclear hormone receptor 0.008 0.0427 0.0422
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0338 0.0448
Brugia malayi bZIP transcription factor family protein 0.0179 0.1258 0.1661
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0089 0.0507 0.0503
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0981 0.0977
Loa Loa (eye worm) hypothetical protein 0.0089 0.0507 0.0671
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0181 1
Echinococcus granulosus nuclear factor of activated T cells 5 0.0152 0.1029 0.1661
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.0344 0.874
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0181 0.1868
Schistosoma mansoni steroid hormone receptor ad4bp 0.0169 0.1176 0.1172
Schistosoma mansoni RAR-like nuclear receptor 0.0169 0.1176 0.1172
Mycobacterium tuberculosis Probable dehydrogenase 0.0114 0.0716 0.1033
Onchocerca volvulus 0.0169 0.1176 0.3071
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0088 0.0135
Loa Loa (eye worm) CYP4Cod1 0.0062 0.028 0.0371
Echinococcus granulosus netrin receptor unc 5 0.003 0.0005 0.0001
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0179 0.1258 0.2032
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0127 0.0824 0.1209
Echinococcus multilocularis jun protein 0.0179 0.1258 0.2032
Onchocerca volvulus Bile acid receptor homolog 0.0169 0.1176 0.3071
Onchocerca volvulus 0.008 0.0427 0.1106
Brugia malayi hypothetical protein 0.0074 0.0381 0.0499
Onchocerca volvulus Netrin receptor homolog 0.003 0.0005 0.0002
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.0216 0.1568 0.2432
Onchocerca volvulus 0.0051 0.0187 0.0479
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0114 0.0716 0.1033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.0981 0.1584
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0127 0.0824 0.1209
Loa Loa (eye worm) cytochrome P450 family protein 0.0062 0.028 0.0371
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0169 0.1176 0.1172
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0169 0.1176 0.1172
Loa Loa (eye worm) cytochrome P450 family protein 0.0062 0.028 0.0371
Echinococcus granulosus FTZ F1 alpha 0.0169 0.1176 0.19
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0249 0.0396
Loa Loa (eye worm) hypothetical protein 0.0089 0.0507 0.0671
Loa Loa (eye worm) hypothetical protein 0.008 0.0427 0.0565
Brugia malayi Nuclear hormone receptor-like 1 0.0089 0.0507 0.0666
Loa Loa (eye worm) DR-78 0.008 0.0427 0.0565
Schistosoma mansoni nuclear hormone receptor 0.0169 0.1176 0.1172
Brugia malayi nuclear receptor RXR 0.0089 0.0507 0.0666
Loa Loa (eye worm) hypothetical protein 0.0089 0.0507 0.0671
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0088 0.0117
Brugia malayi Nuclear hormone receptor-like 1 0.0089 0.0507 0.0666
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0114 0.0716 0.1033
Echinococcus multilocularis thymidine phosphorylase 0.0765 0.6172 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0169 0.1176 0.19
Trichomonas vaginalis CMGC family protein kinase 0.0099 0.0585 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0427 0.0565
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0169 0.1176 0.19
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0222 0.162 0.1616
Brugia malayi Protein-tyrosine phosphatase containing protein 0.069 0.554 0.7337
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.008 0.0427 0.0684
Trichomonas vaginalis CMGC family protein kinase 0.0099 0.0585 1
Echinococcus multilocularis tumor protein p63 0.0351 0.2696 0.4364
Echinococcus multilocularis nuclear receptor nhr 48 0.008 0.0427 0.0684
Mycobacterium ulcerans thymidine phosphorylase 0.0765 0.6172 1
Echinococcus multilocularis FTZ F1 alpha 0.0169 0.1176 0.19
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0103 0.0621 0.0617
Loa Loa (eye worm) hypothetical protein 0.008 0.0427 0.0565
Loa Loa (eye worm) hypothetical protein 0.0169 0.1176 0.1558
Brugia malayi hypothetical protein 0.008 0.0427 0.0559
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0178 0.1805
Schistosoma mansoni thyroid hormone receptor 0.0564 0.4485 0.4482
Brugia malayi nuclear hormone receptor 0.008 0.0427 0.0559
Trypanosoma brucei trypanothione reductase 0.005 0.0178 0.1805
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0249 0.0396
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0169 0.1176 0.1553
Brugia malayi ecdysteroid receptor 0.0169 0.1176 0.1553
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0152 0.1029 0.1661
Plasmodium falciparum thioredoxin reductase 0.005 0.0178 0.9658
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0099 0.0585 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0099 0.0585 0.0775
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0338 0.0334
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0099 0.0585 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0169 0.1176 0.1553
Brugia malayi hypothetical protein 0.0089 0.0507 0.0666
Loa Loa (eye worm) hypothetical protein 0.0048 0.0161 0.0213
Echinococcus granulosus ecdysone induced protein 78C 0.0169 0.1176 0.19
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0089 0.0507 0.0503
Echinococcus multilocularis Protein lozenge 0.0061 0.0267 0.0425
Loa Loa (eye worm) hypothetical protein 0.0089 0.0507 0.0671
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0338 0.0334
Brugia malayi hypothetical protein 0.0051 0.0181 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0169 0.1176 0.1553
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0179 0.1258 0.2032
Brugia malayi nuclear receptor NHR-67 0.008 0.0427 0.0559
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0099 0.0585 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.0344 0.034
Echinococcus granulosus geminin 0.0176 0.1231 0.1988
Loa Loa (eye worm) hypothetical protein 0.008 0.0427 0.0565
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.0344 0.0551
Giardia lamblia Kinase, CMGC MAPK 0.0099 0.0585 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0088 0.5
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0169 0.1176 0.1553
Schistosoma mansoni coup transcription factor 0.0169 0.1176 0.1172
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0169 0.1176 0.19
Brugia malayi TAR-binding protein 0.0069 0.0338 0.0442
Brugia malayi Steroid receptor seven-up type 2 0.0169 0.1176 0.1553
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0169 0.1176 0.19
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0338 0.0334
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0169 0.1176 0.3071
Echinococcus multilocularis Nuclear hormone receptor HR96 0.008 0.0427 0.0684
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.0765 0.6172 1
Brugia malayi RNA, U transporter 1 0.0079 0.0421 0.0552
Plasmodium vivax glutathione reductase, putative 0.005 0.0178 0.9658
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0169 0.1176 0.19
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0249 0.0264
Toxoplasma gondii thioredoxin reductase 0.005 0.0178 0.1805
Loa Loa (eye worm) hypothetical protein 0.0169 0.1176 0.1558
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0097 0.015
Echinococcus granulosus Ankyrin 0.003 0.0008 0.0005
Onchocerca volvulus 0.0141 0.0935 0.244
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.0216 0.1568 1
Loa Loa (eye worm) RNA binding protein 0.0069 0.0338 0.0448
Trypanosoma brucei cytochrome P450, putative 0.0062 0.028 0.387
Schistosoma mansoni hypothetical protein 0.0297 0.2249 0.2246
Echinococcus multilocularis netrin receptor unc 5 0.003 0.0005 0.0001
Brugia malayi hypothetical protein 0.0033 0.0031 0.0035
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0089 0.0507 0.0671
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.003 0.0005 0.0007
Brugia malayi RNA binding protein 0.0069 0.0338 0.0442
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0169 0.1176 0.1558
Schistosoma mansoni hypothetical protein 0.0146 0.0977 0.0973
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.008 0.0427 0.0684
Loa Loa (eye worm) hypothetical protein 0.0169 0.1176 0.1558
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.008 0.0427 0.1106
Brugia malayi Death domain containing protein 0.003 0.0005 0.0001
Trichomonas vaginalis CMGC family protein kinase 0.0099 0.0585 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0169 0.1176 0.1172
Schistosoma mansoni ap endonuclease 0.0039 0.0088 0.0084
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0344 0.5155
Echinococcus granulosus Nuclear hormone receptor HR96 0.008 0.0427 0.0684
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0169 0.1176 0.19
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.069 0.554 0.8975
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0169 0.1176 0.19
Brugia malayi nuclear receptor NHR-88 0.008 0.0427 0.0559
Schistosoma mansoni hypothetical protein 0.0395 0.3066 0.3063
Loa Loa (eye worm) protein-tyrosine phosphatase 0.069 0.554 0.7338
Brugia malayi Cytochrome P450 family protein 0.0066 0.0314 0.0411
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0169 0.1176 0.1172
Loa Loa (eye worm) steroid hormone receptor 0.0169 0.1176 0.1558
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0099 0.0585 1
Onchocerca volvulus 0.0096 0.0565 0.147
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0249 0.0264
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0088 0.0135
Brugia malayi nuclear receptor RXR 0.008 0.0427 0.0559
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.008 0.0427 0.0559
Brugia malayi nuclear receptor NHR-88 0.0169 0.1176 0.1553
Loa Loa (eye worm) hypothetical protein 0.0485 0.3819 0.5059
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0103 0.0621 0.0617
Trichomonas vaginalis CMGC family protein kinase 0.0099 0.0585 1
Schistosoma mansoni hypothetical protein 0.0074 0.0381 0.0377
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0169 0.1176 0.1172
Brugia malayi Cytochrome P450 family protein 0.0062 0.028 0.0366
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0089 0.0507 0.0814
Echinococcus granulosus Nuclear hormone receptor HR96 0.008 0.0427 0.0684
Brugia malayi conserved hypotetical protein 0.008 0.0427 0.0559
Brugia malayi glutathione reductase 0.005 0.0178 0.023
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0099 0.0585 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0427 0.0565
Schistosoma mansoni hypothetical protein 0.0176 0.1231 0.1227
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0178 0.0147
Loa Loa (eye worm) cytochrome P450 family protein 0.0066 0.0314 0.0416
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0088 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0146 0.0981 0.13
Loa Loa (eye worm) hypothetical protein 0.0169 0.1176 0.1558
Echinococcus granulosus nuclear receptor 2DBD gamma 0.008 0.0427 0.0684
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.0981 0.1584
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.008 0.0427 0.0684
Echinococcus granulosus death domain containing protein 0.003 0.0005 0.0001
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.003 0.0005 0.0001
Echinococcus multilocularis geminin 0.0176 0.1231 0.1988
Brugia malayi hypothetical protein 0.0141 0.0935 0.1234
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0178 0.0235
Brugia malayi nuclear hormone receptor 0.0169 0.1176 0.1553
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.008 0.0427 0.0422
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0249 0.0264
Loa Loa (eye worm) hypothetical protein 0.0033 0.0033 0.0044
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0169 0.1176 0.19
Loa Loa (eye worm) glutathione reductase 0.005 0.0178 0.0235
Onchocerca volvulus Protein ultraspiracle homolog 0.0169 0.1176 0.3071
Leishmania major hypothetical protein, conserved 0.0051 0.0181 0.1868
Loa Loa (eye worm) hypothetical protein 0.0036 0.0063 0.0083
Loa Loa (eye worm) hypothetical protein 0.003 0.0005 0.0007
Loa Loa (eye worm) nuclear receptor NHR-67 0.008 0.0427 0.0565
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.0981 0.1584
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.0585 0.0581
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0178 0.0281
Schistosoma mansoni netrin receptor unc5 0.003 0.0005 0.0001
Schistosoma mansoni nuclear receptor 0.008 0.0427 0.0422
Echinococcus multilocularis Nuclear hormone receptor HR96 0.008 0.0427 0.0684
Loa Loa (eye worm) hypothetical protein 0.0169 0.1176 0.1558
Brugia malayi Trypsin family protein 0.0103 0.0621 0.0818
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0114 0.0716 0.1033
Entamoeba histolytica hypothetical protein 0.0074 0.0381 1
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0181 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0008 0.001
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.008 0.0427 0.1106
Echinococcus granulosus thymidine phosphorylase 0.0765 0.6172 1
Brugia malayi hypothetical protein 0.0485 0.3819 0.5057
Loa Loa (eye worm) hypothetical protein 0.008 0.0427 0.0565
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0169 0.1176 0.1553
Brugia malayi MAP kinase sur-1 0.0099 0.0585 0.077
Echinococcus multilocularis thyroid hormone receptor alpha 0.0564 0.4485 0.7264
Loa Loa (eye worm) hypothetical protein 0.008 0.0427 0.0565
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0127 0.0824 0.1257
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0099 0.0585 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0169 0.1176 0.1553
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0338 0.0334
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0062 0.028 0.0316
Onchocerca volvulus 0.0485 0.3819 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0089 0.0507 0.0814
Trypanosoma cruzi cytochrome P450, putative 0.0062 0.028 0.387
Loa Loa (eye worm) hypothetical protein 0.0174 0.1217 0.1612
Echinococcus granulosus mitogen activated protein kinase 3 0.0099 0.0585 0.0941
Entamoeba histolytica hypothetical protein 0.0074 0.0381 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0181 0.1868
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0169 0.1176 0.1558
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0169 0.1176 0.19
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0169 0.1176 0.1558
Brugia malayi Immunoglobulin I-set domain containing protein 0.003 0.0005 0.0001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0381 0.0611
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0169 0.1176 0.1558
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0161 0.0213
Schistosoma mansoni hypothetical protein 0.003 0.0005 0.0001
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 0.2249 0.298
Brugia malayi tailless protein 0.008 0.0427 0.0559
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0169 0.1176 0.19
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.003 0.0008 0.0003
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0344 0.5155
Schistosoma mansoni zinc finger protein 0.008 0.0427 0.0422
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0169 0.1176 0.1553
Loa Loa (eye worm) hypothetical protein 0.003 0.0005 0.0006
Echinococcus multilocularis mitogen activated protein kinase 0.0099 0.0585 0.0941
Loa Loa (eye worm) hypothetical protein 0.0051 0.0187 0.0248
Loa Loa (eye worm) hypothetical protein 0.0089 0.0507 0.0671
Echinococcus granulosus tar DNA binding protein 0.0069 0.0338 0.0541
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0338 0.0448
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.0344 0.045
Brugia malayi Protein kinase domain containing protein 0.0031 0.0013 0.0011
Echinococcus granulosus jun protein 0.0179 0.1258 0.2032
Loa Loa (eye worm) hypothetical protein 0.008 0.0427 0.0565
Echinococcus multilocularis Ankyrin 0.003 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.008 0.0427 0.0565
Onchocerca volvulus 0.0103 0.0621 0.1617
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0161 0.0207
Onchocerca volvulus 0.008 0.0427 0.1106
Brugia malayi photoreceptor-specific nuclear receptor 0.0169 0.1176 0.1553
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0981 0.0977
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.008 0.0427 0.0422
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0169 0.1176 0.1553
Trypanosoma cruzi cytochrome P450, putative 0.0062 0.028 0.387
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0169 0.1176 0.19
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.003 0.0005 0.0001
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0146 0.0981 0.1295
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.0344 0.0456
Mycobacterium tuberculosis Probable oxidoreductase 0.0127 0.0824 0.1209
Schistosoma mansoni retinoic acid receptor RXR 0.0169 0.1176 0.1172
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0249 0.0244
Loa Loa (eye worm) hypothetical protein 0.0169 0.1176 0.1558
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0169 0.1176 0.1553
Brugia malayi hypothetical protein 0.0089 0.0507 0.0666
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0344 0.5155
Schistosoma mansoni nuclear receptor 0.008 0.0427 0.0422
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0169 0.1176 0.1553
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0169 0.1176 0.1172
Loa Loa (eye worm) hypothetical protein 0.0169 0.1176 0.1558
Echinococcus granulosus thyroid hormone receptor alpha 0.008 0.0427 0.0684
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0169 0.1176 0.1558
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0005 0.0006
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.069 0.554 0.8975
Loa Loa (eye worm) hypothetical protein 0.0169 0.1176 0.1558
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0338 0.0334
Leishmania major cytochrome p450-like protein 0.0062 0.028 0.387
Loa Loa (eye worm) hypothetical protein 0.008 0.0427 0.0565
Plasmodium falciparum glutathione reductase 0.005 0.0178 0.9658
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0169 0.1176 0.1553
Schistosoma mansoni ankyrin 23/unc44 0.003 0.0005 0.0001
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.069 0.554 0.5538
Echinococcus multilocularis mitogen activated protein kinase 3 0.0099 0.0585 0.0941
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0099 0.0585 1
Schistosoma mansoni ap endonuclease 0.0039 0.0088 0.0084
Trypanosoma brucei protein kinase, putative 0.0099 0.0585 1
Loa Loa (eye worm) runx1 0.0061 0.0267 0.0353
Loa Loa (eye worm) nuclear receptor nhr-7B 0.008 0.0427 0.0565
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0178 0.9658
Schistosoma mansoni nuclear receptor nhr-48 0.008 0.0427 0.0422
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0249 0.0244
Brugia malayi Uncoordinated protein 44 0.003 0.0005 0.0001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.008 0.0427 0.0684
Echinococcus granulosus snurportin 1 0.0297 0.2249 0.364
Schistosoma mansoni hypothetical protein 0.0033 0.0033 0.0029
Brugia malayi nuclear hormone receptor family member odr-7 0.008 0.0427 0.0559
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0181 0.1868
Brugia malayi Cytochrome P450 family protein 0.0062 0.028 0.0366
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0338 0.0442
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0099 0.0585 1
Brugia malayi ecdysone receptor 0.008 0.0427 0.0559
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0088 0.0111
Loa Loa (eye worm) nuclear hormone receptor 0.008 0.0427 0.0565
Schistosoma mansoni thyroid hormone receptor 0.0564 0.4485 0.4482
Loa Loa (eye worm) hypothetical protein 0.0103 0.0621 0.0823
Echinococcus granulosus tumor protein p63 0.0351 0.2696 0.4364
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0981 0.0977
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0249 0.3234
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0169 0.1176 0.1553
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0181 0.1868
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0181 1
Schistosoma mansoni hypothetical protein 0.0176 0.1231 0.1227
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0169 0.1176 0.1558
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0161 0.0207
Brugia malayi hypothetical protein 0.008 0.0427 0.0559
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0169 0.1176 0.19
Echinococcus granulosus nuclear receptor nhr 48 0.008 0.0427 0.0684
Brugia malayi follicle stimulating hormone receptor 0.093 0.7549 1
Brugia malayi Nuclear hormone receptor-like 1 0.0169 0.1176 0.1553
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0169 0.1176 0.1558
Brugia malayi steroid hormone receptor 0.0169 0.1176 0.1553
Loa Loa (eye worm) hypothetical protein 0.008 0.0427 0.0565
Echinococcus granulosus mitogen activated protein kinase 0.0099 0.0585 0.0941
Loa Loa (eye worm) hypothetical protein 0.008 0.0427 0.0565
Loa Loa (eye worm) hypothetical protein 0.0051 0.0181 0.024
Loa Loa (eye worm) intermediate filament protein 0.003 0.0005 0.0006
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0169 0.1176 0.19
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0381 0.0611
Loa Loa (eye worm) hypothetical protein 0.0485 0.3819 0.5059

Activities

Activity type Activity value Assay description Source Reference
Ratio (binding) = 0.31 Inhibition of Sprague-Dawley rat lymphoma thymidine phosphorylase assessed as ratio of phosphorolysis in presence of drug to control at 10 umol/l ChEMBL. 18221873
Ratio (binding) = 0.84 Inhibition of human placental thymidine phosphorylase assessed as ratio of phosphorolysis in presence of drug to control at 10 umol/l ChEMBL. 18221873
Ratio (binding) = 0.84 Inhibition of human thymidine phosphorylase expressed in V79 cells assessed as ratio of phosphorolysis in presence of drug to control at 10 umol/l ChEMBL. 18221873
Ratio (binding) = 0.98 Inhibition of Escherichia coli thymidine phosphorylase assessed as ratio of phosphorolysis in prescence of drug to control at 10 umol/l ChEMBL. 18221873
Ratio (binding) = 0.31 Inhibition of Sprague-Dawley rat lymphoma thymidine phosphorylase assessed as ratio of phosphorolysis in presence of drug to control at 10 umol/l ChEMBL. 18221873
Ratio (binding) = 0.84 Inhibition of human thymidine phosphorylase expressed in V79 cells assessed as ratio of phosphorolysis in presence of drug to control at 10 umol/l ChEMBL. 18221873
Ratio (binding) = 0.84 Inhibition of human placental thymidine phosphorylase assessed as ratio of phosphorolysis in presence of drug to control at 10 umol/l ChEMBL. 18221873
Ratio (binding) = 0.98 Inhibition of Escherichia coli thymidine phosphorylase assessed as ratio of phosphorolysis in prescence of drug to control at 10 umol/l ChEMBL. 18221873

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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