Detailed information for compound 518390

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 452.572 | Formula: C23H28N6O2S
  • H donors: 0 H acceptors: 4 LogP: 3.84 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1nc2c(o1)cc1c(c2)CCN(CC1)CCCSc1nnc(n1C)c1ocnc1C
  • InChi: 1S/C23H28N6O2S/c1-4-20-25-18-12-16-6-9-29(10-7-17(16)13-19(18)31-20)8-5-11-32-23-27-26-22(28(23)3)21-15(2)24-14-30-21/h12-14H,4-11H2,1-3H3
  • InChiKey: UALAMQRWRIVLLQ-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dopamine receptor D3 Starlite/ChEMBL References
Homo sapiens histamine receptor H1 Starlite/ChEMBL References
Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 2 Starlite/ChEMBL References
Homo sapiens dopamine receptor D2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum Potassium voltage-gated channel subfamily H member 2, putative Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) voltage and ligand gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog Get druggable targets OG5_128858 All targets in OG5_128858
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus multilocularis potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein dopamine receptor D3 400 aa 392 aa 19.9 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Toxoplasma gondii oxidoreductase, putative 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0716 0.121
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0013 0.0302 0.0302
Brugia malayi beta-lactamase 0.0007 0.01 0.0098
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.016 0.577 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Mycobacterium tuberculosis Probable reductase 0.0017 0.0473 0.0738
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Entamoeba histolytica hypothetical protein, conserved 0.016 0.577 1
Schistosoma mansoni serine/threonine protein kinase 0.0006 0.0059 0.0102
Schistosoma mansoni serine/threonine protein kinase 0.0006 0.0059 0.0102
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0287 0.0287
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0012 0.0287 0.0497
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0009 0.0181 0.0313
Echinococcus multilocularis hyperpolarization activated cyclic 0.0009 0.016 0.016
Schistosoma mansoni histamine h1 receptor 0.0012 0.0287 0.0497
Echinococcus multilocularis allatostatin A receptor 0.0012 0.0287 0.0287
Schistosoma mansoni carbonyl reductase 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0212 0.0282
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.014 0.5051 1
Brugia malayi mbt repeat family protein 0.001 0.0187 0.0249
Onchocerca volvulus 0.016 0.577 1
Trypanosoma cruzi cytochrome P450, putative 0.0007 0.0096 0.0079
Onchocerca volvulus Putative nachr subunit 0.0013 0.0306 0.0446
Onchocerca volvulus 0.0012 0.0287 0.0411
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0013 0.0306 0.0531
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.1641 0.2844
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0287 0.0287
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0022 0.064 0.1984
Schistosoma mansoni opsin-like receptor 0.0012 0.0287 0.0497
Loa Loa (eye worm) hypothetical protein 0.0007 0.01 0.0138
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0006 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0287 0.0287
Entamoeba histolytica protein kinase, putative 0.0021 0.0606 0.097
Echinococcus multilocularis oxidoreductase 0.016 0.577 0.577
Treponema pallidum cyclic nucleotide binding protein 0.0006 0.0051 0.0002
Onchocerca volvulus 0.016 0.577 1
Schistosoma mansoni short chain dehydrogenase 0.016 0.577 1
Trypanosoma brucei oxidoreductase-like protein 0.016 0.577 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0.0287 0.0497
Schistosoma mansoni hypothetical protein 0.0061 0.2095 0.3631
Echinococcus granulosus G protein coupled receptor 139 0.0012 0.0287 0.0287
Echinococcus granulosus g protein coupled receptor 0.0012 0.0287 0.0287
Schistosoma mansoni neuropeptide f receptor 76f 0.0012 0.0287 0.0497
Schistosoma mansoni hypothetical protein 0.0024 0.0716 0.1241
Echinococcus granulosus glycine receptor subunit alpha 1 0.0013 0.0306 0.0306
Leishmania major metacaspase, putative 0.001 0.0212 0.0281
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0012 0.0287 0.0463
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.0376 0.0568
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0006 0.0051 0.0051
Brugia malayi phosphofructokinase 0.0022 0.064 0.104
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.016 0.0278
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0006 0.0051 0.0089
Echinococcus granulosus hypothetical protein 0.016 0.577 0.577
Schistosoma mansoni nAChR subunit 0.0013 0.0306 0.0531
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.001 0.0212 0.0282
Schistosoma mansoni caspase-3 (C14 family) 0.001 0.0212 0.0368
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0012 0.0287 0.0287
Leishmania major quinonoid dihydropteridine reductase 0.016 0.577 1
Onchocerca volvulus 0.0013 0.0306 0.0446
Echinococcus granulosus steroid dehydrogenase 0.016 0.577 0.577
Brugia malayi Serotonin receptor 0.0012 0.0287 0.0424
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0013 0.0306 0.0497
Leishmania major quinonoid dihydropteridine reductase 0.016 0.577 1
Trypanosoma cruzi metacaspase, putative 0.001 0.0212 0.0281
Brugia malayi oxidoreductase 0.016 0.577 1
Echinococcus granulosus zinc finger protein 0.0005 0.0004 0.0004
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0006 0.0051 0.0089
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0015 0.0376 0.0567
Plasmodium falciparum glutathione reductase 0.0008 0.0113 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0287 0.0497
Brugia malayi hypothetical protein 0.0024 0.0716 0.1174
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0007 0.01 0.0085
Echinococcus multilocularis serotonin receptor 0.0012 0.0287 0.0287
Trypanosoma cruzi hypothetical protein, conserved 0.016 0.577 1
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.001 0.0212 0.0212
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.016 0.577 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.001 0.0212 0.0282
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.016 0.577 1
Trichomonas vaginalis phosphofructokinase, putative 0.0022 0.064 0.103
Trypanosoma brucei short-chain dehydrogenase, putative 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.01 0.0138
Loa Loa (eye worm) cytochrome P450 family protein 0.0007 0.0096 0.0132
Loa Loa (eye worm) hypothetical protein 0.0007 0.01 0.0138
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.0306 0.0458
Echinococcus granulosus patatin phospholipase domain containing protein 0.0006 0.0051 0.0051
Onchocerca volvulus 0.0012 0.0287 0.0411
Schistosoma mansoni 3-dehydroquinate synthase 0.0055 0.1864 0.323
Schistosoma mansoni nAChR subunit 0.0013 0.0306 0.0531
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0015 0.0376 0.0567
Onchocerca volvulus 0.016 0.577 1
Onchocerca volvulus 0.016 0.577 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0306 0.0458
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.016 0.0278
Onchocerca volvulus 0.016 0.577 1
Mycobacterium ulcerans ketoacyl reductase 0.016 0.577 1
Loa Loa (eye worm) oxidoreductase 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.016 0.577 1
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0287 0.0463
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0009 0.016 0.016
Leishmania major dehydrogenase-like protein 0.016 0.577 1
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.001 0.0212 0.0212
Schistosoma mansoni short chain dehydrogenase 0.016 0.577 1
Schistosoma mansoni hypothetical protein 0.0012 0.0287 0.0497
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0287 0.0497
Schistosoma mansoni neuropeptide receptor 0.0012 0.0287 0.0497
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0012 0.0287 0.0287
Echinococcus granulosus nAChR subunit 0.0013 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0029 0.0926 0.1605
Schistosoma mansoni sex comb on midleg homolog 0.001 0.0187 0.0324
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0015 0.0376 0.0618
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.001 0.0212 0.0282
Echinococcus granulosus neuropeptide receptor A26 0.0012 0.0287 0.0287
Echinococcus granulosus oxidoreductase 0.016 0.577 0.577
Plasmodium vivax SET domain protein, putative 0.0006 0.0054 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0021 0.0606 0.0606
Trichomonas vaginalis AGC family protein kinase 0.0021 0.0606 0.097
Loa Loa (eye worm) MBCTL1 0.0011 0.0236 0.0374
Plasmodium falciparum histone acetyltransferase GCN5 0.0008 0.0123 0.0126
Schistosoma mansoni short chain dehydrogenase 0.016 0.577 1
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.016 0.577 1
Toxoplasma gondii carbonyl reductase 1, putative 0.016 0.577 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0287 0.0287
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0006 0.0051 0.0013
Loa Loa (eye worm) hypothetical protein 0.001 0.0212 0.0333
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.138 0.2324
Mycobacterium tuberculosis Probable dehydrogenase 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Mycobacterium tuberculosis Probable oxidoreductase 0.016 0.577 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.016 0.577 1
Onchocerca volvulus 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Brugia malayi Dopamine receptor 0.0012 0.0287 0.0424
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0013 0.0306 0.0458
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0015 0.0376 0.0567
Echinococcus multilocularis G-protein coupled receptor, putative 0.0012 0.0287 0.0287
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0007 0.01 0.0085
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0013 0.0306 0.0531
Trypanosoma brucei short-chain dehydrogenase, putative 0.016 0.577 1
Brugia malayi AKH receptor 0.0012 0.0287 0.0424
Trypanosoma brucei cytochrome P450, putative 0.0007 0.0096 0.0079
Toxoplasma gondii oxidoreductase, putative 0.016 0.577 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0012 0.0287 0.0463
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.016 0.577 1
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.016 0.577 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Loa Loa (eye worm) oxidoreductase 0.016 0.577 1
Brugia malayi putative neuropeptide receptor NPR1 0.0012 0.0287 0.0424
Trichomonas vaginalis phosphofructokinase, putative 0.0022 0.064 0.103
Schistosoma mansoni hypothetical protein 0.0012 0.0287 0.0497
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Echinococcus multilocularis nAChR subunit 0.0013 0.0306 0.0306
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.001 0.0212 0.0282
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.016 0.577 1
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.0006 0.0051 0.0001
Echinococcus multilocularis apoptotic protease activating factor 1 0.0024 0.0716 0.0716
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0022 0.064 0.1029
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0013 0.0306 0.0306
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0011 0.0236 0.0236
Trypanosoma brucei trypanothione reductase 0.0008 0.0113 0.0109
Schistosoma mansoni hypothetical protein 0.0012 0.0287 0.0497
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.016 0.577 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0009 0.016 0.016
Echinococcus multilocularis neuropeptide receptor A26 0.0012 0.0287 0.0287
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0012 0.0287 0.0287
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.001 0.0212 0.0282
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0013 0.0306 0.0531
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0009 0.016 0.016
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0013 0.0306 0.0497
Onchocerca volvulus 0.0012 0.0287 0.0411
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0006 0.0051 0.0089
Trichomonas vaginalis penicillin-binding protein, putative 0.0007 0.01 0.0086
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Schistosoma mansoni ap endonuclease 0.0015 0.0376 0.0651
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.016 0.577 1
Onchocerca volvulus 0.0012 0.0287 0.0411
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.016 0.577 1
Mycobacterium ulcerans short-chain dehydrogenase 0.016 0.577 1
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.016 0.577 1
Schistosoma mansoni short chain dehydrogenase 0.016 0.577 1
Treponema pallidum cyclic nucleotide binding protein 0.0006 0.0051 0.0002
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0006 0.0051 0.0001
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0287 0.0287
Onchocerca volvulus 0.0012 0.0287 0.0411
Echinococcus multilocularis SAM and MBT domain containing protein 0.001 0.0187 0.0187
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Brugia malayi beta-lactamase family protein 0.0007 0.01 0.0098
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0287 0.0287
Echinococcus granulosus carbonyl reductase 1 0.016 0.577 0.577
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.016 0.577 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0013 0.0306 0.0306
Echinococcus multilocularis zinc finger protein 0.0005 0.0004 0.0004
Mycobacterium tuberculosis Conserved protein 0.0007 0.01 0.0085
Mycobacterium tuberculosis Probable lipase LipD 0.0007 0.01 0.0085
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.1489 0.2554
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0006 0.0051 0.0001
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0017 0.0473 0.0738
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0013 0.0306 0.0458
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.016 0.577 1
Schistosoma mansoni amine GPCR 0.0012 0.0287 0.0497
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.016 0.577 1
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0086 0.302 1
Mycobacterium leprae 3-dehydroquinate synthase AroB 0.0055 0.1864 0.3169
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Echinococcus granulosus retinol dehydrogenase 11 0.016 0.577 0.577
Loa Loa (eye worm) cytochrome P450 family protein 0.0007 0.0096 0.0132
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.016 0.577 0.577
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Trichomonas vaginalis short-chain dehydrogenase, putative 0.016 0.577 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0011 0.0236 0.0236
Trichomonas vaginalis short-chain dehydrogenase, putative 0.016 0.577 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0022 0.064 0.1077
Onchocerca volvulus 0.016 0.577 1
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0287 0.0287
Brugia malayi Retinol dehydrogenase 12 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Mycobacterium ulcerans carveol-like dehydrogenase 0.016 0.577 1
Echinococcus granulosus hypothetical protein 0.016 0.577 0.577
Schistosoma mansoni steroid dehydrogenase 0.016 0.577 1
Loa Loa (eye worm) GABA receptor subunit 0.0013 0.0306 0.0497
Trypanosoma cruzi short chain dehydrogenase, putative 0.016 0.577 1
Echinococcus multilocularis retinol dehydrogenase 11 0.016 0.577 0.577
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.016 0.577 1
Onchocerca volvulus 0.0012 0.0287 0.0411
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.016 0.577 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.016 0.577 1
Brugia malayi GnHR receptor homolog 0.0012 0.0287 0.0424
Brugia malayi hypothetical protein 0.0012 0.0287 0.0424
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0022 0.064 0.1029
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0287 0.0463
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0006 0.0051 0.0013
Leishmania major ATP-dependent phosphofructokinase 0.0022 0.064 0.1029
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.0306 0.0458
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0007 0.01 0.0173
Echinococcus multilocularis conserved hypothetical protein 0.016 0.577 0.577
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.016 0.577 1
Entamoeba histolytica hypothetical protein 0.016 0.577 1
Echinococcus multilocularis orexin receptor type 2 0.0012 0.0287 0.0287
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.016 0.577 1
Toxoplasma gondii exonuclease III APE 0.0015 0.0376 0.0568
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0051 0.0001
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0006 0.0051 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.01 0.0085
Schistosoma mansoni short chain dehydrogenase 0.016 0.577 1
Echinococcus multilocularis somatostatin receptor 0.0012 0.0287 0.0287
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.016 0.577 1
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Trypanosoma cruzi short-chain dehydrogenase, putative 0.016 0.577 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0015 0.0376 0.0568
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.138 0.2324
Leishmania major quinonoid dihydropteridine reductase 0.016 0.577 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0017 0.0473 0.0738
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0013 0.0306 0.0458
Trichomonas vaginalis AGC family protein kinase 0.0021 0.0606 0.097
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0029 0.0926 0.0926
Onchocerca volvulus 0.0007 0.01 0.0085
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.016 0.577 1
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0287 0.0287
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.016 0.577 1
Brugia malayi follicle stimulating hormone receptor 0.0012 0.0287 0.0424
Onchocerca volvulus 0.016 0.577 1
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0006 0.0051 0.0051
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0009 0.016 0.016
Echinococcus multilocularis neuropeptide FF receptor 2 0.0012 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0006 0.0051 0.0054
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.014 0.5051 0.8742
Onchocerca volvulus Sepiapterin reductase homolog 0.016 0.577 1
Mycobacterium tuberculosis Possible oxidoreductase 0.016 0.577 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.001 0.0212 0.0282
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0012 0.0287 0.0287
Trypanosoma brucei metacaspase MCA2 0.001 0.0212 0.0281
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0012 0.0287 0.0287
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.127 0.2174
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0007 0.01 0.0138
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0287 0.0287
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0007 0.01 0.0098
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0012 0.0287 0.0424
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0009 0.016 0.016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0006 0.0054 0.0094
Trypanosoma cruzi hypothetical protein, conserved 0.016 0.577 1
Brugia malayi Dopamine receptor protein 1 0.0012 0.0287 0.0424
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0006 0.0051 0.0001
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Echinococcus granulosus retinol dehydrogenase 11 0.016 0.577 0.577
Leishmania major quinonoid dihydropteridine reductase 0.016 0.577 1
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0012 0.0287 0.0411
Brugia malayi 6-phosphofructokinase 0.0022 0.064 0.104
Brugia malayi hypothetical protein 0.0012 0.0287 0.0424
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0212 0.0282
Brugia malayi Dopamine receptor protein 2 0.0012 0.0287 0.0424
Schistosoma mansoni steroid dehydrogenase 0.016 0.577 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0212 0.0282
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0013 0.0306 0.0306
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0012 0.0287 0.0497
Brugia malayi Cytochrome P450 family protein 0.0007 0.0096 0.0092
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0008 0.0113 0.0109
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0012 0.0287 0.0497
Mycobacterium ulcerans hypothetical protein 0.0007 0.01 0.0085
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0006 0.0051 0.0013
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Echinococcus granulosus neuropeptide s receptor 0.0012 0.0287 0.0287
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.016 0.577 0.577
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.001 0.0212 0.0368
Loa Loa (eye worm) hypothetical protein 0.016 0.577 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.016 0.577 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0013 0.0306 0.0497
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0012 0.0287 0.0497
Leishmania major hypothetical protein, conserved 0.0007 0.01 0.0085
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.016 0.0278
Leishmania major hypothetical protein, conserved 0.016 0.577 1
Brugia malayi G protein-coupled receptor 0.0012 0.0287 0.0424
Trichomonas vaginalis short-chain dehydrogenase, putative 0.016 0.577 1
Leishmania major oxidoreductase-like protein 0.016 0.577 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0012 0.0287 0.0463
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0287 0.0497
Brugia malayi Egg laying defective protein 4 0.0006 0.0059 0.0026
Mycobacterium ulcerans ketoacyl reductase 0.016 0.577 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0287 0.0287
Trypanosoma cruzi hypothetical protein, conserved 0.016 0.577 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0287 0.0497
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0007 0.0099 0.0099
Schistosoma mansoni short chain dehydrogenase 0.016 0.577 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0019 0.0545 0.0863
Treponema pallidum catabolite gene activator 0.0006 0.0051 0.0002
Mycobacterium tuberculosis Possible ketoacyl reductase 0.016 0.577 1
Echinococcus granulosus SAM and MBT domain containing protein 0.001 0.0187 0.0187
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0273 1 1
Brugia malayi Cation transporter family protein 0.0013 0.0306 0.0458
Brugia malayi mbt repeat family protein 0.001 0.0187 0.0249
Loa Loa (eye worm) hypothetical protein 0.0014 0.0358 0.0586
Onchocerca volvulus 0.0012 0.0287 0.0411
Treponema pallidum exodeoxyribonuclease (exoA) 0.0015 0.0376 0.1094
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0013 0.0306 0.0306
Brugia malayi Bromodomain containing protein 0.0016 0.0416 0.0649
Echinococcus multilocularis glycine receptor subunit beta 0.0013 0.0306 0.0306
Onchocerca volvulus 0.0012 0.0287 0.0411
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.016 0.577 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.016 0.577 1
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0009 0.016 0.016
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Mycobacterium tuberculosis Probable oxidoreductase 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.016 0.577 1
Schistosoma mansoni myosin xvIII 0.0012 0.0287 0.0497
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0021 0.0606 0.1017
Loa Loa (eye worm) dehydrogenase 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Giardia lamblia Short-chain dehydrogenase, putative 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0118 0.0169
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.016 0.577 1
Leishmania major quinonoid dihydropteridine reductase 0.016 0.577 1
Onchocerca volvulus 0.016 0.577 1
Echinococcus granulosus caspase 2 0.0034 0.1096 0.1096
Echinococcus granulosus peptide allatostatin:somatostatin 0.0012 0.0287 0.0287
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0006 0.0051 0.0054
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0013 0.0306 0.0306
Mycobacterium ulcerans esterase/lipase LipP 0.0007 0.01 0.0085
Echinococcus multilocularis thioredoxin glutathione reductase 0.0008 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Trypanosoma cruzi hypothetical protein, conserved 0.016 0.577 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0287 0.0287
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0006 0.0054 0.0094
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0287 0.0287
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0012 0.0287 0.0463
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0009 0.0167 0.0203
Schistosoma mansoni growth hormone secretagogue receptor 0.0012 0.0287 0.0497
Brugia malayi G protein-coupled receptor F59B2.13 0.0012 0.0287 0.0424
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0012 0.0287 0.0287
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.016 0.0278
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0006 0.0051 0.0001
Trypanosoma cruzi metacaspase 5, putative 0.001 0.0212 0.0281
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.016 0.577 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0013 0.0306 0.0531
Loa Loa (eye worm) oxidoreductase 0.016 0.577 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0009 0.0167 0.0203
Onchocerca volvulus Neuropeptide F receptor homolog 0.0012 0.0287 0.0411
Schistosoma mansoni 60S ribosomal protein L21 0.0007 0.0094 0.0162
Echinococcus multilocularis polycomb protein SCMH1 0.001 0.0187 0.0187
Schistosoma mansoni steroid dehydrogenase 0.016 0.577 1
Echinococcus granulosus nAChR subunit 0.0013 0.0306 0.0306
Loa Loa (eye worm) thioredoxin reductase 0.0008 0.0113 0.0162
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0006 0.0051 0.0089
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0006 0.0046 0.0046
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Mycobacterium ulcerans dehydrogenase/reductase 0.016 0.577 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.016 0.577 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.004 0.1338 0.1338
Loa Loa (eye worm) hypothetical protein 0.0007 0.01 0.0138
Schistosoma mansoni amine GPCR 0.0012 0.0287 0.0497
Schistosoma mansoni steroid dehydrogenase 0.016 0.577 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0013 0.0312 0.0312
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.1489 0.2523
Giardia lamblia Hypothetical protein 0.016 0.577 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0306 0.0458
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.016 0.577 1
Trypanosoma cruzi cytochrome P450, putative 0.0007 0.0096 0.0079
Trichomonas vaginalis phosphofructokinase, putative 0.0022 0.064 0.103
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.016 0.577 1
Onchocerca volvulus 0.0047 0.1591 0.2693
Trypanosoma cruzi oxidoreductase-like protein, putative 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Loa Loa (eye worm) hypothetical protein 0.0034 0.1096 0.187
Echinococcus multilocularis carbonyl reductase 1 0.016 0.577 0.577
Schistosoma mansoni short chain dehydrogenase 0.016 0.577 1
Onchocerca volvulus 0.001 0.0187 0.0237
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0006 0.0051 0.0051
Echinococcus granulosus thioredoxin glutathione reductase 0.0008 0.0117 0.0117
Echinococcus granulosus serotonin receptor 0.0012 0.0287 0.0287
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0312 0.0542
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0376 0.0568
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0007 0.0096 0.0079
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.016 0.577 1
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.016 0.577 1
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0287 0.0287
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.014 0.5051 0.8742
Leishmania major hypothetical protein, conserved 0.016 0.577 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0007 0.0099 0.0099
Schistosoma mansoni steroid dehydrogenase 0.016 0.577 1
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0013 0.0306 0.0306
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Schistosoma mansoni hypothetical protein 0.0012 0.0287 0.0497
Schistosoma mansoni serine/threonine protein kinase 0.0006 0.0059 0.0102
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Plasmodium falciparum metacaspase-like protein 0.001 0.0212 0.0282
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.016 0.577 1
Brugia malayi Cell death protein 3 precursor 0.0034 0.1096 0.1837
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.016 0.577 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0012 0.0287 0.0424
Leishmania major hypothetical protein, conserved 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0187 0.0289
Loa Loa (eye worm) oxidoreductase 0.016 0.577 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0009 0.0167 0.0203
Schistosoma mansoni neurotransmitter gated ion channel 0.0013 0.0306 0.0531
Mycobacterium tuberculosis Probable oxidoreductase 0.016 0.577 1
Schistosoma mansoni short chain dehydrogenase 0.016 0.577 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.016 0.577 1
Schistosoma mansoni short chain dehydrogenase 0.016 0.577 1
Schistosoma mansoni short chain dehydrogenase 0.016 0.577 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0287 0.0287
Leishmania major short chain dehydrogenase/reductase, putative 0.016 0.577 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0287 0.0497
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Loa Loa (eye worm) hypothetical protein 0.0009 0.0181 0.0279
Loa Loa (eye worm) hypothetical protein 0.0009 0.0161 0.0245
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0013 0.0312 0.0312
Mycobacterium ulcerans short-chain dehydrogenase 0.016 0.577 1
Schistosoma mansoni biogenic amine receptor 0.0012 0.0287 0.0497
Echinococcus multilocularis voltage gated potassium channel 0.0013 0.0312 0.0312
Schistosoma mansoni nAChR subunit 0.0013 0.0306 0.0531
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0012 0.0287 0.0287
Loa Loa (eye worm) oxidoreductase 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0287 0.0287
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0015 0.0376 0.0568
Onchocerca volvulus 0.0012 0.0287 0.0411
Leishmania major short chain dehydrogenase, putative 0.016 0.577 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0287 0.0287
Onchocerca volvulus 0.0013 0.0306 0.0446
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0006 0.0051 0.0089
Schistosoma mansoni amine GPCR 0.0012 0.0287 0.0497
Brugia malayi acetyltransferase, GNAT family protein 0.0029 0.0926 0.1541
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.016 0.577 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0212 0.0282
Trichomonas vaginalis short-chain dehydrogenase, putative 0.016 0.577 1
Treponema pallidum catabolite gene activator (Crp) 0.0006 0.0051 0.0002
Echinococcus granulosus 6 phosphofructokinase 0.0022 0.064 0.064
Toxoplasma gondii ABC1 family protein 0.0007 0.01 0.0086
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.016 0.577 1
Schistosoma mansoni adenoreceptor 0.0012 0.0287 0.0497
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0287 0.0497
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0006 0.0051 0.0001
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0287 0.0287
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0606 0.1049
Trypanosoma brucei metacaspase 0.001 0.0212 0.0281
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0046 0.154 0.2604
Plasmodium falciparum thioredoxin reductase 0.0008 0.0113 0.011
Leishmania major 3-keto-dihydrosphingosine reductase 0.016 0.577 1
Schistosoma mansoni steroid dehydrogenase 0.016 0.577 1
Trichomonas vaginalis AGC family protein kinase 0.0021 0.0606 0.097
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0287 0.0497
Entamoeba histolytica phosphofructokinase, putative 0.0022 0.064 0.103
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.016 0.577 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0013 0.0306 0.0306
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0006 0.0059 0.0059
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0006 0.0051 0.0051
Brugia malayi hypothetical protein 0.0012 0.0287 0.0424
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0006 0.0051 0.0051
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0011 0.0236 0.0335
Mycobacterium tuberculosis Probable oxidoreductase 0.016 0.577 1
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0287 0.0287
Mycobacterium ulcerans short-chain dehydrogenase 0.016 0.577 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0012 0.0287 0.0287
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0376 0.0568
Echinococcus multilocularis steroid dehydrogenase 0.016 0.577 0.577
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0013 0.0306 0.0458
Mycobacterium tuberculosis Probable oxidoreductase 0.016 0.577 1
Schistosoma mansoni ap endonuclease 0.0015 0.0376 0.0651
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.016 0.577 1
Mycobacterium tuberculosis 3-dehydroquinate synthase AroB 0.0055 0.1864 0.3169
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.1641 0.2844
Echinococcus granulosus caspase 0.001 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Echinococcus multilocularis neuropeptide s receptor 0.0012 0.0287 0.0287
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0006 0.0054 0.0006
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Mycobacterium ulcerans ketoacyl reductase 0.016 0.577 1
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0006 0.0059 0.0014
Entamoeba histolytica short chain dehydrogenase family protein 0.016 0.577 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.0306 0.0458
Mycobacterium ulcerans lipase LipD 0.0007 0.01 0.0085
Onchocerca volvulus 0.0006 0.0054 0.0005
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0306 0.0458
Echinococcus granulosus endonuclease exonuclease phosphatase 0.004 0.1338 0.1338
Trichomonas vaginalis phosphofructokinase, putative 0.0022 0.064 0.103
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0013 0.0306 0.0458
Echinococcus granulosus histone acetyltransferase KAT2B 0.0028 0.0879 0.0879
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Onchocerca volvulus 0.0012 0.0287 0.0411
Leishmania major hypothetical protein, conserved 0.016 0.577 1
Loa Loa (eye worm) dehydrogenase 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.001 0.0212 0.0294
Schistosoma mansoni zinc finger protein 0.0005 0.0004 0.0008
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0009 0.0181 0.0181
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.016 0.577 1
Mycobacterium tuberculosis Conserved protein 0.0007 0.01 0.0085
Schistosoma mansoni amine GPCR 0.0012 0.0287 0.0497
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0011 0.0236 0.0236
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0013 0.0306 0.0497
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Schistosoma mansoni voltage-gated potassium channel 0.0007 0.0094 0.0162
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0013 0.0306 0.0458
Loa Loa (eye worm) hypothetical protein 0.016 0.577 1
Mycobacterium ulcerans short-chain dehydrogenase 0.016 0.577 1
Leishmania major cytochrome p450-like protein 0.0007 0.0096 0.0079
Echinococcus granulosus neuropeptide receptor 0.0012 0.0287 0.0287
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0287 0.0287
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.0306 0.0458
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0013 0.0306 0.0458
Schistosoma mansoni neuropeptide receptor 0.0012 0.0287 0.0497
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0012 0.0287 0.0463
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0006 0.0051 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0287 0.0497
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0017 0.0473 0.0738
Brugia malayi larval opioid receptor 0.0012 0.0287 0.0424
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Echinococcus multilocularis glycine receptor subunit beta 0.0013 0.0306 0.0306
Echinococcus granulosus carbonyl reductase 1 0.016 0.577 0.577
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0006 0.0051 0.0001
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.1489 0.1489
Echinococcus granulosus somatostatin receptor 0.0012 0.0287 0.0287
Mycobacterium tuberculosis Probable dehydrogenase 0.0017 0.0473 0.0738
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0013 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.001 0.0187 0.0324
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0006 0.0051 0.0001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.016 0.577 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.016 0.577 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0287 0.0287
Brugia malayi N-terminal motif family protein 0.0006 0.0051 0.0013
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0287 0.0287
Trichomonas vaginalis D-aminoacylase, putative 0.0007 0.01 0.0086
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.016 0.577 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0012 0.0287 0.0287
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Brugia malayi neuropeptide F receptor 0.0012 0.0287 0.0424
Echinococcus granulosus voltage gated potassium channel 0.0013 0.0312 0.0312
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.016 0.577 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0287 0.0287
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0021 0.0606 0.0606
Mycobacterium tuberculosis Possible oxidoreductase 0.016 0.577 1
Onchocerca volvulus 0.0012 0.0287 0.0411
Trichomonas vaginalis penicillin-binding protein, putative 0.0007 0.01 0.0086
Brugia malayi sulfakinin receptor protein 0.0012 0.0287 0.0424
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0287 0.0463
Entamoeba histolytica short chain dehydrogenase family protein 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Echinococcus multilocularis expressed conserved protein 0.0006 0.0059 0.0059
Loa Loa (eye worm) CYP4Cod1 0.0007 0.0096 0.0132
Echinococcus granulosus alpha 1A adrenergic receptor 0.0012 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0013 0.0312 0.0508
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0013 0.0312 0.0469
Echinococcus multilocularis beta LACTamase domain containing family member 0.0007 0.01 0.01
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0012 0.0287 0.0497
Mycobacterium ulcerans oxidoreductase 0.016 0.577 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0287 0.0497
Plasmodium falciparum steroid dehydrogenase, putative 0.016 0.577 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0.0287 0.0287
Trypanosoma brucei hypothetical protein, conserved 0.0007 0.01 0.0085
Trypanosoma brucei short-chain dehydrogenase, putative 0.016 0.577 1
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.016 0.577 0.577
Brugia malayi hypothetical protein 0.016 0.577 1
Loa Loa (eye worm) LGC-31 protein 0.0013 0.0306 0.0497
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0013 0.0306 0.0458
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0287 0.0497
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.0306 0.0458
Loa Loa (eye worm) beta-lactamase 0.0007 0.01 0.0138
Schistosoma mansoni sex comb on midleg homolog 0.001 0.0187 0.0324
Loa Loa (eye worm) hypothetical protein 0.0011 0.0236 0.0374
Mycobacterium tuberculosis Probable esterase LipL 0.0007 0.01 0.0085
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0012 0.0287 0.0287
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0006 0.0051 0.0089
Leishmania major hypothetical protein, conserved 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Mycobacterium ulcerans oxidoreductase 0.016 0.577 1
Echinococcus multilocularis retinol dehydrogenase 11 0.016 0.577 0.577
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.016 0.577 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0.0287 0.0287
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0312 0.0542
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0287 0.0463
Schistosoma mansoni short chain dehydrogenase 0.016 0.577 1
Loa Loa (eye worm) ACC-1 protein 0.0013 0.0306 0.0497
Brugia malayi ORL1-like opioid receptor 0.0012 0.0287 0.0424
Schistosoma mansoni bromodomain containing protein 0.0013 0.0329 0.057
Chlamydia trachomatis UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0086 0.302 0.5938
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0007 0.01 0.0173
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0.0287 0.0497
Mycobacterium tuberculosis Probable oxidoreductase 0.016 0.577 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.016 0.577 1
Trichomonas vaginalis set domain proteins, putative 0.0047 0.1591 0.2694
Echinococcus granulosus WW domain containing oxidoreductase 0.016 0.577 0.577
Brugia malayi Cation transporter family protein 0.0013 0.0306 0.0458
Brugia malayi neuropeptide F receptor 0.0012 0.0287 0.0424
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.016 0.577 0.577
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0287 0.0497
Trypanosoma cruzi short-chain dehydrogenase, putative 0.016 0.577 1
Brugia malayi RE15519p 0.0012 0.0287 0.0424
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0013 0.0306 0.0531
Echinococcus multilocularis carbonyl reductase 1 0.016 0.577 0.577
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0006 0.0051 0.0089
Trichomonas vaginalis short-chain dehydrogenase, putative 0.016 0.577 1
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Schistosoma mansoni 6-phosphofructokinase 0.0022 0.064 0.1109
Plasmodium vivax metacaspase 1, putative 0.001 0.0212 0.0282
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Plasmodium vivax hypothetical protein, conserved 0.016 0.577 1
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0086 0.302 0.519
Giardia lamblia Reductase, putative 0.016 0.577 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0009 0.016 0.0192
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0006 0.0054 0.0054
Entamoeba histolytica phosphofructokinase, putative 0.0022 0.064 0.103
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0013 0.0306 0.0306
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.016 0.577 1
Leishmania major quinonoid dihydropteridine reductase 0.016 0.577 1
Leishmania major quinonoid dihydropteridine reductase 0.016 0.577 1
Onchocerca volvulus 0.0012 0.0287 0.0411
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.016 0.577 0.577
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0015 0.0376 0.0567
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0012 0.0287 0.0497
Leishmania major short chain dehydrogenase-like protein 0.016 0.577 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0012 0.0287 0.0463
Trypanosoma cruzi oxidoreductase-like protein, putative 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Brugia malayi hypothetical protein 0.0012 0.0287 0.0424
Brugia malayi hypothetical protein 0.0012 0.0287 0.0424
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0012 0.0287 0.0497
Echinococcus granulosus carbonyl reductase 1 0.016 0.577 0.577
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0013 0.0306 0.0306
Trypanosoma cruzi metacaspase, putative 0.001 0.0212 0.0281
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.016 0.577 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0009 0.0167 0.0203
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0287 0.0287
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.001 0.0212 0.0282
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.0376 0.0567
Brugia malayi Tachykinin-like peptides receptor 99D 0.0012 0.0287 0.0424
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.016 0.577 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.016 0.577 1
Echinococcus granulosus cGMP dependent protein kinase 0.0006 0.0059 0.0059
Echinococcus granulosus cGMP dependent protein kinase 1 0.0006 0.0059 0.0059
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.001 0.0187 0.0237
Brugia malayi putative neuropeptide receptor 0.0012 0.0287 0.0424
Loa Loa (eye worm) ACC-1 protein 0.0013 0.0306 0.0497
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.016 0.577 1
Schistosoma mansoni nAChR subunit 0.0013 0.0306 0.0531
Trichomonas vaginalis esterase, putative 0.0007 0.01 0.0086
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0013 0.0306 0.0497
Schistosoma mansoni hypothetical protein 0.0006 0.0051 0.0089
Plasmodium vivax steroid dehydrogenase, putative 0.016 0.577 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0287 0.0287
Schistosoma mansoni caspase-7 (C14 family) 0.0034 0.1096 0.1899
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.016 0.577 0.577
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.016 0.577 1
Mycobacterium ulcerans 3-dehydroquinate synthase 0.0055 0.1864 0.3169
Schistosoma mansoni short chain dehydrogenase 0.016 0.577 1
Trichomonas vaginalis D-aminoacylase, putative 0.0007 0.01 0.0086
Echinococcus granulosus g-protein coupled receptor 0.0012 0.0287 0.0287
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0022 0.064 0.1029
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0212 0.0282
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.016 0.577 1
Trichomonas vaginalis steroid dehydrogenase, putative 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0013 0.0306 0.0306
Brugia malayi Cyclic-nucleotide gated cation channel 0.0009 0.016 0.0203
Schistosoma mansoni carbonyl reductase 0.016 0.577 1
Brugia malayi hypothetical protein 0.016 0.577 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0013 0.0306 0.0531
Brugia malayi Dehydrogenases, short chain protein 2 0.016 0.577 1
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0013 0.0306 0.0497
Schistosoma mansoni steroid dehydrogenase 0.016 0.577 1
Echinococcus multilocularis sex peptide receptor 0.0012 0.0287 0.0287
Echinococcus granulosus apoptotic protease activating factor 1 0.0024 0.0716 0.0716
Mycobacterium ulcerans dehydrogenase 0.016 0.577 1
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.016 0.577 1
Schistosoma mansoni steroid dehydrogenase 0.016 0.577 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0013 0.0306 0.0306
Brugia malayi Bromodomain containing protein 0.0008 0.0143 0.0174
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.001 0.0212 0.0282
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0012 0.0287 0.0424
Loa Loa (eye worm) oxidoreductase 0.016 0.577 1
Onchocerca volvulus 0.0007 0.01 0.0085
Mycobacterium tuberculosis Probable hydrolase 0.0007 0.01 0.0085
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0019 0.0545 0.0863
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Echinococcus multilocularis transient receptor potential cation channel 0.016 0.577 0.577
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.016 0.577 1
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Brugia malayi Thioredoxin reductase 0.0008 0.0113 0.0121
Toxoplasma gondii thioredoxin reductase 0.0008 0.0113 0.011
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.016 0.577 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0017 0.0473 0.0738
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.1489 0.1489
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.016 0.577 1
Chlamydia trachomatis dehyroquinate synthase 0.0055 0.1864 0.3626
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Brugia malayi Pre-SET motif family protein 0.0042 0.1378 0.233
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0013 0.0306 0.0306
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.016 0.577 1
Schistosoma mansoni short chain dehydrogenase 0.016 0.577 1
Onchocerca volvulus 0.0024 0.0716 0.1163
Schistosoma mansoni short chain dehydrogenase 0.016 0.577 1
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.016 0.577 1
Brugia malayi excitatory GABA receptor EXP-1A 0.0013 0.0306 0.0458
Trypanosoma brucei short-chain dehydrogenase, putative 0.016 0.577 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0009 0.016 0.016
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.001 0.0212 0.0282
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0009 0.016 0.016
Onchocerca volvulus 0.016 0.577 1
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0006 0.0051 0.0089
Mycobacterium ulcerans beta-lactamase 0.0007 0.01 0.0085
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Loa Loa (eye worm) hypothetical protein 0.0007 0.01 0.0138
Echinococcus granulosus glycine receptor subunit beta 0.0013 0.0306 0.0306
Echinococcus granulosus g protein coupled receptor 0.0012 0.0287 0.0287
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0287 0.0287
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.016 0.577 0.577
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0012 0.0287 0.0424
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0007 0.01 0.0085
Brugia malayi Dehydrogenases, short chain protein 30 0.016 0.577 1
Mycobacterium leprae Probable oxidoreductase 0.016 0.577 1
Loa Loa (eye worm) AGC/PKG protein kinase 0.0006 0.0059 0.0066
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.016 0.577 1
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.016 0.577 0.577
Echinococcus multilocularis carbonyl reductase 1 0.016 0.577 0.577
Mycobacterium tuberculosis Probable oxidoreductase 0.0019 0.0545 0.0863
Leishmania major pteridine reductase 1 0.016 0.577 1
Mycobacterium tuberculosis Probable lipase LipE 0.0007 0.01 0.0085
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0006 0.0051 0.0001
Loa Loa (eye worm) hypothetical protein 0.0006 0.0051 0.0054
Trypanosoma cruzi hypothetical protein, conserved 0.016 0.577 1
Loa Loa (eye worm) acetyltransferase 0.0029 0.0926 0.1575
Mycobacterium tuberculosis Conserved protein 0.0007 0.01 0.0085
Schistosoma mansoni steroid dehydrogenase 0.016 0.577 1
Schistosoma mansoni neuropeptide receptor 0.0012 0.0287 0.0497
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Schistosoma mansoni opsin-like receptor 0.0012 0.0287 0.0497
Onchocerca volvulus Cell death protein 3 homolog 0.0034 0.1096 0.1826
Echinococcus granulosus histone acetyltransferase MYST2 0.0011 0.0236 0.0236
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0006 0.0051 0.0001
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.016 0.577 1
Echinococcus multilocularis carbonyl reductase 1 0.016 0.577 0.577
Trypanosoma cruzi trypanothione reductase, putative 0.0008 0.0113 0.0109
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0009 0.0181 0.0313
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.016 0.577 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Plasmodium vivax thioredoxin reductase, putative 0.0008 0.0113 0.011
Echinococcus multilocularis retinol dehydrogenase 13 0.016 0.577 0.577
Mycobacterium ulcerans 6-phosphofructokinase 0.0022 0.064 0.1029
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0287 0.0287
Entamoeba histolytica hypothetical protein 0.0013 0.0306 0.0447
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0007 0.01 0.01
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0012 0.0287 0.0287
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0013 0.0306 0.0531
Echinococcus granulosus fmrfamide receptor 0.0012 0.0287 0.0287
Brugia malayi exodeoxyribonuclease III family protein 0.0015 0.0376 0.0579
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0287 0.0287
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.001 0.0212 0.0282
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.001 0.0212 0.0282
Mycobacterium tuberculosis 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) 0.0055 0.1864 0.3169
Loa Loa (eye worm) glutathione reductase 0.0008 0.0113 0.0162
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.01 0.0085
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0009 0.0176 0.027
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.016 0.577 1
Schistosoma mansoni short-chain dehydrogenase/reductase 0.016 0.577 1
Brugia malayi Pre-SET motif family protein 0.0006 0.0054 0.0018
Schistosoma mansoni nAChR subunit 0.0013 0.0306 0.0531
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0012 0.0287 0.0287
Onchocerca volvulus 0.0013 0.0306 0.0446
Loa Loa (eye worm) oxidoreductase 0.016 0.577 1
Schistosoma mansoni carbonyl reductase 0.016 0.577 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0042 0.1378 0.2361
Echinococcus granulosus carbonyl reductase 1 0.016 0.577 0.577
Echinococcus granulosus orexin receptor type 2 0.0012 0.0287 0.0287
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0306 0.0458
Loa Loa (eye worm) mbt repeat family protein 0.001 0.0187 0.0289
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.016 0.0278
Brugia malayi Cation transporter family protein 0.0013 0.0306 0.0458
Trypanosoma brucei Metacaspase-4 0.001 0.0212 0.0281
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.014 0.5051 0.8742
Echinococcus multilocularis caspase 8 0.001 0.0212 0.0212
Echinococcus granulosus neuropeptide FF receptor 2 0.0012 0.0287 0.0287
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0006 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0086 0.302 0.4901
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0019 0.0545 0.0863
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0021 0.0606 0.1017
Schistosoma mansoni myelin transcription factor 1 myt1 0.0011 0.0236 0.0409
Echinococcus multilocularis G protein coupled receptor 139 0.0012 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Schistosoma mansoni short chain dehydrogenase 0.016 0.577 1
Brugia malayi Cytochrome P450 family protein 0.0007 0.0096 0.0092
Brugia malayi beta-lactamase family protein 0.0007 0.01 0.0098
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Leishmania major trypanothione reductase 0.0008 0.0113 0.0109
Echinococcus granulosus hyperpolarization activated cyclic 0.0009 0.016 0.016
Brugia malayi hypothetical protein 0.0012 0.0287 0.0424
Echinococcus multilocularis 6 phosphofructokinase 0.0022 0.064 0.064
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0287 0.0287
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0287 0.0497
Mycobacterium ulcerans short-chain type oxidoreductase 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0012 0.0287 0.0287
Schistosoma mansoni amine GPCR 0.0012 0.0287 0.0497
Schistosoma mansoni nAChR subunit 0.0013 0.0306 0.0531
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.016 0.577 1
Echinococcus multilocularis caspase 2 0.0034 0.1096 0.1096
Onchocerca volvulus 0.0012 0.0287 0.0411
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0015 0.0376 0.0376
Schistosoma mansoni biogenic amine receptor 0.0012 0.0287 0.0497
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Echinococcus granulosus polycomb protein SCMH1 0.001 0.0187 0.0187
Trypanosoma cruzi metacaspase, putative 0.001 0.0212 0.0281
Brugia malayi glutathione reductase 0.0008 0.0113 0.0121
Echinococcus granulosus g protein coupled receptor 0.0012 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.016 0.577 1
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.016 0.577 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0013 0.0306 0.0458
Onchocerca volvulus 0.0007 0.01 0.0085
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0287 0.0497
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0007 0.01 0.0085
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0009 0.016 0.0192
Echinococcus granulosus glycine receptor subunit beta 0.0013 0.0306 0.0306
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0287 0.0497
Giardia lamblia Histone acetyltransferase GCN5 0.0008 0.0123 0.0126
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.016 0.577 1
Trypanosoma cruzi short chain dehydrogenase, putative 0.016 0.577 1
Onchocerca volvulus 0.016 0.577 1
Trypanosoma brucei metacaspase 5, putative 0.001 0.0212 0.0281
Schistosoma mansoni biogenic amine receptor 0.0012 0.0287 0.0497
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0012 0.0287 0.0424
Echinococcus multilocularis steroid dehydrogenase 0.016 0.577 0.577
Brugia malayi 6-phosphofructokinase 0.0022 0.064 0.104
Plasmodium falciparum metacaspase 1 0.001 0.0212 0.0282
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Echinococcus granulosus allatostatin A receptor 0.0012 0.0287 0.0287
Schistosoma mansoni opsin-like receptor 0.0012 0.0287 0.0497
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0015 0.0376 0.0567
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.016 0.577 1
Brugia malayi Protein kinase domain containing protein 0.0021 0.0606 0.0981
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.001 0.0212 0.0282
Brugia malayi Melatonin receptor type 1A 0.0012 0.0287 0.0424
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.016 0.577 1
Onchocerca volvulus 0.0012 0.0287 0.0411
Onchocerca volvulus 0.0012 0.0287 0.0411
Loa Loa (eye worm) oxidoreductase 0.016 0.577 1
Trichomonas vaginalis D-aminoacylase, putative 0.0007 0.01 0.0086
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0013 0.0306 0.0306
Leishmania major short chain dehydrogenase, putative 0.016 0.577 1
Plasmodium vivax hypothetical protein, conserved 0.001 0.0212 0.0282
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0287 0.0287
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0013 0.0306 0.0306
Mycobacterium leprae Probable lipase LipE 0.0007 0.01 0.0085
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.016 0.577 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0006 0.0051 0.0001
Schistosoma mansoni caspase-7 (C14 family) 0.001 0.0212 0.0368
Entamoeba histolytica hypothetical protein, conserved 0.016 0.577 1
Onchocerca volvulus 0.0013 0.0306 0.0446
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Echinococcus granulosus histone acetyltransferase KAT2B 0.0009 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0015 0.0376 0.0376
Leishmania major protein kinase, putative 0.0006 0.0059 0.0013
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0287 0.0287
Schistosoma mansoni 6-phosphofructokinase 0.0022 0.064 0.1109
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.01 0.0138
Onchocerca volvulus 0.0012 0.0287 0.0411
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0006 0.0051 0.0001
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0013 0.0306 0.0531
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Echinococcus granulosus cGMP dependent protein kinase 1 0.0006 0.0059 0.0059
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.016 0.577 1
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0013 0.0306 0.0306
Echinococcus granulosus sex peptide receptor 0.0012 0.0287 0.0287
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0006 0.0051 0.0051
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0006 0.0051 0.0089
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Brugia malayi hypothetical protein 0.0012 0.0287 0.0424
Trypanosoma cruzi hypothetical protein, conserved 0.016 0.577 1
Plasmodium vivax hypothetical protein, conserved 0.0007 0.01 0.0086
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Mycobacterium leprae conserved hypothetical protein 0.0007 0.01 0.0085
Echinococcus granulosus hypothetical protein 0.0012 0.0287 0.0287
Brugia malayi phosphoinositide-dependent protein kinase I 0.0021 0.0606 0.0981
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0009 0.016 0.0243
Leishmania major protein kinase, putative 0.0006 0.0059 0.0013
Onchocerca volvulus 0.0012 0.0287 0.0411
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.016 0.577 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.016 0.577 1
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0006 0.0051 0.0089
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0013 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.016 0.577 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0017 0.0473 0.0738
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0287 0.0287
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0009 0.016 0.0243
Onchocerca volvulus 0.016 0.577 1
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0006 0.0051 0.0089
Plasmodium vivax glutathione reductase, putative 0.0008 0.0113 0.011
Trypanosoma brucei metacaspase MCA3 0.001 0.0212 0.0281
Trichomonas vaginalis short-chain dehydrogenase, putative 0.016 0.577 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.016 0.0278
Brugia malayi Serotonin receptor 0.0012 0.0287 0.0424
Schistosoma mansoni steroid dehydrogenase 0.016 0.577 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0012 0.0287 0.0287
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0022 0.064 0.1029
Onchocerca volvulus 0.0013 0.0306 0.0446
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0287 0.0497
Echinococcus granulosus histone lysine methyltransferase setb 0.0009 0.0181 0.0181
Trypanosoma cruzi metacaspase 5, putative 0.001 0.0212 0.0281
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.016 0.577 1
Onchocerca volvulus 0.0013 0.0306 0.0446
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.0376 0.0568
Loa Loa (eye worm) TYRA-2 protein 0.0012 0.0287 0.0463
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.016 0.577 1
Brugia malayi G-protein coupled receptor 0.0012 0.0287 0.0424
Schistosoma mansoni retinal dehydrogenase 0.016 0.577 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0012 0.0287 0.0497
Echinococcus granulosus tachykinin peptides receptor 99D 0.0012 0.0287 0.0287
Onchocerca volvulus 0.0013 0.0306 0.0446
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0013 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0287 0.0497
Echinococcus granulosus caspase 8 0.001 0.0212 0.0212
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0287 0.0287
Loa Loa (eye worm) phosphofructokinase 0.0022 0.064 0.1077
Echinococcus multilocularis g-protein coupled receptor 0.0012 0.0287 0.0287
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.016 0.577 1
Entamoeba histolytica phosphofructokinase, putative 0.0022 0.064 0.103
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0306 0.0458
Schistosoma mansoni neuropeptide receptor 0.0012 0.0287 0.0497
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0013 0.0306 0.0306
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0006 0.0051 0.0089
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.016 0.577 0.577
Echinococcus granulosus neuropeptide receptor 0.0012 0.0287 0.0287
Brugia malayi dehydrogenases, short chain protein 9 0.016 0.577 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0006 0.0051 0.0051
Echinococcus multilocularis serotonin receptor 0.0012 0.0287 0.0287
Trypanosoma brucei short-chain dehydrogenase, putative 0.016 0.577 1
Brugia malayi G-protein coupled receptor 0.0012 0.0287 0.0424
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0013 0.0306 0.0306
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Leishmania major short chain dehydrogenase/reductase, putative 0.016 0.577 1
Trypanosoma cruzi metacaspase, putative 0.001 0.0212 0.0281
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0006 0.0051 0.0051
Brugia malayi dehydrogenases, short chain protein 2 0.016 0.577 1
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0009 0.016 0.016
Onchocerca volvulus 0.0013 0.0306 0.0446
Plasmodium falciparum cGMP-dependent protein kinase 0.0006 0.0059 0.0014
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0008 0.0123 0.0126
Echinococcus multilocularis caspase 0.001 0.0212 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0212 0.0282
Loa Loa (eye worm) 6-phosphofructokinase 0.0022 0.064 0.1077
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.016 0.577 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0006 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0009 0.016 0.0243
Onchocerca volvulus 0.016 0.577 1
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.016 0.577 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0306 0.0458
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.016 0.577 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.016 0.577 1
Brugia malayi hypothetical protein 0.0012 0.0287 0.0424
Echinococcus multilocularis nAChR subunit 0.0013 0.0306 0.0306
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0012 0.0287 0.0497
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Echinococcus granulosus dro:myosuppressin receptor 0.0012 0.0287 0.0287
Brugia malayi hypothetical protein 0.0012 0.0287 0.0424
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0013 0.0302 0.0302
Schistosoma mansoni nAChR subunit 0.0013 0.0306 0.0531
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.016 0.577 1
Loa Loa (eye worm) oxidoreductase 0.016 0.577 1
Brugia malayi hypothetical protein 0.0012 0.0287 0.0424
Trichomonas vaginalis bromodomain-containing protein, putative 0.0009 0.0167 0.0203
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5.2 Displacement of [3H]Dofetilide from human ERG ChEMBL. 18248991
Ki (functional) > 5.5 Antagonist activity at histamine H1 receptor (unknown origin) by FLIPR assay ChEMBL. 18248991
Ki (functional) > 6.3 Antagonist activity at dopamine D2 receptor (unknown origin) by GTPgammaS binding assay ChEMBL. 18248991
Ki (functional) = 7.5 Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay ChEMBL. 18248991
Log IC50 (binding) = 5.2 Displacement of [3H]Dofetilide from human ERG ChEMBL. 18248991
Log Ki (functional) < 5.5 Antagonist activity at histamine H1 receptor (unknown origin) by FLIPR assay ChEMBL. 18248991
Log Ki (functional) < 6.3 Antagonist activity at dopamine D2 receptor (unknown origin) by GTPgammaS binding assay ChEMBL. 18248991
Log Ki (functional) = 7.5 Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay ChEMBL. 18248991
Ratio (binding) = 100 Selectivity for human dopamine D3 receptor over human ERG ChEMBL. 18248991

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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