TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 600.658 | Formula: C34H36N2O8
H donors: 2 H acceptors: 4 LogP: 5.5 Rotable bonds: 13
Rule of 5 violations (Lipinski): 2
SMILES: COc1cc(ccc1OCCCCCOc1cc2NC(=O)[C@H]3N(C(=O)c2cc1OC)CCC3)/C=C/C(=O)c1ccccc1O
InChi: 1S/C34H36N2O8/c1-41-30-19-22(12-14-28(38)23-9-4-5-11-27(23)37)13-15-29(30)43-17-6-3-7-18-44-32-21-25-24(20-31(32)42-2)34(40)36-16-8-10-26(36)33(39)35-25/h4-5,9,11-15,19-21,26,37H,3,6-8,10,16-18H2,1-2H3,(H,35,39)/b14-12+/t26-/m0/s1
InChiKey: AKDHCVUHTNCVLX-FIUWIIBXSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2547	0.2718
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.013	0.3181	1
Mycobacterium tuberculosis	Probable reductase	0.0117	0.2722	0.8342
Brugia malayi	Pre-SET motif family protein	0.0225	0.6542	0.7646
Brugia malayi	Tubulin beta-1 chain	0.0279	0.8428	1
Loa Loa (eye worm)	glutathione reductase	0.0051	0.0415	0.0078
Plasmodium falciparum	tubulin gamma chain	0.0144	0.3669	0.4061
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0193	0.5408	0.5209
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0117	0.2722	0.8342
Leishmania major	beta tubulin	0.0279	0.8428	1
Trichomonas vaginalis	conserved hypothetical protein	0.0158	0.4163	0.4939
Mycobacterium tuberculosis	Probable oxidoreductase	0.013	0.3181	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0279	0.8428	0.8375
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0117	0.2722	0.8342
Leishmania major	alpha tubulin	0.0193	0.5408	0.6231
Echinococcus multilocularis	tubulin gamma 1 chain	0.0144	0.3669	0.3396
Giardia lamblia	NADPH oxidoreductase, putative	0.0158	0.4163	0.4402
Trichomonas vaginalis	tubulin beta chain, putative	0.0279	0.8428	1
Giardia lamblia	Beta tubulin	0.0279	0.8428	1
Entamoeba histolytica	tubulin family protein	0.0279	0.8428	1
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0143	0.3648	0.3374
Echinococcus granulosus	beta tubulin	0.0279	0.8428	0.8375
Loa Loa (eye worm)	tubulin beta chain	0.0062	0.0809	0.0566
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0112	0.2547	0.3022
Echinococcus multilocularis	tubulin subunit beta	0.0279	0.8428	0.836
Brugia malayi	tubulin alpha-2 chain	0.0193	0.5408	0.6231
Loa Loa (eye worm)	thioredoxin reductase	0.0051	0.0415	0.0078
Trypanosoma brucei	alpha tubulin	0.0193	0.5408	0.6231
Leishmania major	beta tubulin	0.0279	0.8428	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0279	0.8428	1
Toxoplasma gondii	beta-1 tubulin, putative	0.0279	0.8428	1
Leishmania major	alpha tubulin	0.0193	0.5408	0.6231
Trichomonas vaginalis	conserved hypothetical protein	0.0158	0.4163	0.4939
Trypanosoma brucei	zeta tubulin, putative	0.0062	0.0809	0.0492
Leishmania major	beta tubulin	0.0279	0.8428	1
Echinococcus multilocularis	tubulin alpha 3 chain	0.0193	0.5408	0.5209
Leishmania major	alpha tubulin	0.0193	0.5408	0.6231
Loa Loa (eye worm)	hypothetical protein	0.0131	0.3213	0.3542
Echinococcus granulosus	alpha tubulin	0.0193	0.5408	0.5218
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0158	0.4163	0.4939
Plasmodium falciparum	tubulin epsilon chain, putative	0.0144	0.3669	0.4061
Schistosoma mansoni	alpha tubulin	0.0193	0.5408	0.5237
Echinococcus multilocularis	tubulin alpha	0.0144	0.3669	0.3396
Plasmodium vivax	tubulin epsilon chain, putative	0.0144	0.3669	0.4061
Trichomonas vaginalis	conserved hypothetical protein	0.0158	0.4163	0.4939
Echinococcus granulosus	tubulin alpha	0.0144	0.3669	0.3402
Trypanosoma cruzi	beta tubulin, putative	0.0279	0.8428	1
Schistosoma mansoni	tubulin subunit alpha	0.0193	0.5408	0.5237
Echinococcus granulosus	tubulin alpha 1C chain	0.0193	0.5408	0.5218
Leishmania major	alpha tubulin	0.0193	0.5408	0.6231
Brugia malayi	Tubulin alpha-2 chain	0.0193	0.5408	0.6231
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0193	0.5408	0.6416
Echinococcus granulosus	tubulin alpha 3 chain	0.0193	0.5408	0.5218
Schistosoma mansoni	tubulin subunit epsilon	0.0144	0.3669	0.3257
Trichomonas vaginalis	tubulin alpha chain, putative	0.0144	0.3669	0.4354
Leishmania major	beta tubulin	0.0279	0.8428	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0193	0.5408	0.5218
Loa Loa (eye worm)	BEN-1 protein	0.0279	0.8428	1
Leishmania major	beta tubulin	0.0279	0.8428	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0193	0.5408	0.6416
Schistosoma mansoni	tubulin subunit beta	0.0279	0.8428	0.8676
Brugia malayi	Tubulin alpha chain	0.0062	0.0809	0.0492
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0062	0.0809	0.1424
Echinococcus granulosus	Tubulin beta 2C chain	0.0279	0.8428	0.8375
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0193	0.5408	0.5209
Echinococcus multilocularis	tubulin alpha chain	0.0193	0.5408	0.5209
Trichomonas vaginalis	tubulin alpha chain, putative	0.0081	0.1474	0.1749
Trypanosoma cruzi	tubulin gamma chain	0.0144	0.3669	0.4061
Echinococcus multilocularis	Tubulin beta 2C chain	0.0279	0.8428	0.836
Echinococcus granulosus	tubulin epsilon chain	0.0144	0.3669	0.3402
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0193	0.5408	0.626
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0193	0.5408	0.6416
Treponema pallidum	cell division protein FtsZ	0.0062	0.0809	0.5
Echinococcus granulosus	tubulin alpha chain	0.0193	0.5408	0.5218
Echinococcus multilocularis	tubulin epsilon chain	0.0144	0.3669	0.3396
Entamoeba histolytica	tubulin family protein	0.0279	0.8428	1
Leishmania major	alpha tubulin	0.0193	0.5408	0.6231
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0193	0.5408	0.6416
Leishmania major	alpha tubulin	0.0193	0.5408	0.6231
Echinococcus granulosus	tubulin beta 1 chain	0.0279	0.8428	0.8375
Trypanosoma brucei	zeta tubulin	0.0062	0.0809	0.0492
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0279	0.8428	1
Leishmania major	beta tubulin	0.0279	0.8428	1
Leishmania major	beta tubulin	0.0279	0.8428	1
Echinococcus multilocularis	ankyrin repeat protein	0.0312	0.9591	0.9574
Entamoeba histolytica	tubulin alpha chain, putative	0.0193	0.5408	0.6416
Trichomonas vaginalis	tubulin beta chain, putative	0.0193	0.5408	0.6416
Trichomonas vaginalis	tubulin beta chain, putative	0.0193	0.5408	0.6416
Trichomonas vaginalis	conserved hypothetical protein	0.0158	0.4163	0.4939
Brugia malayi	Tubulin alpha-2 chain	0.0193	0.5408	0.6231
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0062	0.0809	0.0492
Echinococcus multilocularis	Tubulin beta 2C chain	0.0279	0.8428	0.836
Trypanosoma cruzi	epsilon tubulin, putative	0.0144	0.3669	0.4061
Brugia malayi	Tubulin alpha chain	0.0193	0.5408	0.6231
Schistosoma mansoni	tubulin subunit beta	0.0279	0.8428	0.8676
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0062	0.0809	0.0492
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.008	0.1439	0.107
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0143	0.3648	0.338
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0117	0.2722	0.8342
Echinococcus granulosus	Tubulin beta 2C chain	0.0279	0.8428	0.8375
Schistosoma mansoni	tubulin subunit beta	0.0279	0.8428	0.8676
Leishmania major	beta tubulin	0.0279	0.8428	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0279	0.8428	0.836
Trypanosoma brucei	beta tubulin	0.0279	0.8428	1
Echinococcus multilocularis	tubulin subunit TubB	0.0193	0.5408	0.5209
Echinococcus granulosus	tubulin alpha chain	0.0193	0.5408	0.5218
Trichomonas vaginalis	tubulin alpha chain, putative	0.0081	0.1474	0.1749
Loa Loa (eye worm)	tubulin beta-1 chain	0.0279	0.8428	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0117	0.2722	0.8342
Schistosoma mansoni	tubulin subunit beta	0.0279	0.8428	0.8676
Echinococcus granulosus	beta tubulin	0.0279	0.8428	0.8375
Echinococcus granulosus	tubulin alpha chain	0.0193	0.5408	0.5218
Leishmania major	epsilon tubulin, putative	0.0144	0.3669	0.4061
Trichomonas vaginalis	conserved hypothetical protein	0.0158	0.4163	0.4939
Leishmania major	beta tubulin	0.0279	0.8428	1
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0279	0.8428	0.836
Echinococcus multilocularis	Tubulin beta 2C chain	0.0279	0.8428	0.836
Brugia malayi	beta-tubulin, identical	0.0279	0.8428	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0193	0.5408	0.5218
Trypanosoma cruzi	zeta tubulin, putative	0.0062	0.0809	0.0492
Schistosoma mansoni	alpha tubulin	0.0193	0.5408	0.5237
Trichomonas vaginalis	set domain proteins, putative	0.0256	0.7637	0.9061
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0158	0.4163	0.4939
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.013	0.3181	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0193	0.5408	0.6416
Trichomonas vaginalis	tubulin, putative	0.0081	0.1474	0.1749
Schistosoma mansoni	tubulin subunit beta	0.0279	0.8428	0.8676
Plasmodium falciparum	tubulin beta chain	0.0279	0.8428	1
Giardia lamblia	Gamma tubulin	0.0144	0.3669	0.3754
Echinococcus granulosus	Tubulin alpha 1 chain	0.0193	0.5408	0.5218
Mycobacterium ulcerans	cell division protein FtsZ	0.0062	0.0809	0.5
Trichomonas vaginalis	tubulin gamma chain, putative	0.0062	0.0809	0.0959
Loa Loa (eye worm)	tubulin beta chain	0.0279	0.8428	1
Schistosoma mansoni	tubulin subunit gamma	0.0144	0.3669	0.3257
Trypanosoma brucei	beta tubulin	0.0279	0.8428	1
Brugia malayi	tubulin alpha chain - mouse	0.0193	0.5408	0.6231
Trichomonas vaginalis	tubulin, putative	0.0279	0.8428	1
Trypanosoma brucei	epsilon tubulin	0.0144	0.3669	0.4061
Echinococcus multilocularis	beta tubulin	0.0279	0.8428	0.836
Echinococcus multilocularis	tubulin alpha chain	0.0193	0.5408	0.5209
Leishmania major	beta tubulin	0.0279	0.8428	1
Trypanosoma brucei	epsilon tubulin	0.0144	0.3669	0.4061
Mycobacterium tuberculosis	Probable dehydrogenase	0.0117	0.2722	0.8342
Echinococcus multilocularis	tubulin delta chain	0.0062	0.0809	0.0411
Entamoeba histolytica	tubulin gamma chain	0.0144	0.3669	0.4354
Echinococcus multilocularis	tubulin alpha chain	0.0193	0.5408	0.5209
Echinococcus multilocularis	beta tubulin	0.0279	0.8428	0.836
Echinococcus multilocularis	tubulin alpha chain	0.0193	0.5408	0.5209
Schistosoma mansoni	tubulin subunit beta	0.0279	0.8428	0.8676
Schistosoma mansoni	alpha tubulin	0.0193	0.5408	0.5237
Leishmania major	alpha tubulin	0.0193	0.5408	0.6231
Trichomonas vaginalis	conserved hypothetical protein	0.0158	0.4163	0.4939
Plasmodium vivax	tubulin gamma chain, putative	0.0144	0.3669	0.4061
Echinococcus multilocularis	sodium channel protein	0.008	0.1439	0.1068
Loa Loa (eye worm)	tubulin alpha chain	0.0193	0.5408	0.626
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0131	0.3213	0.3542
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0279	0.8428	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0279	0.8428	1
Plasmodium falciparum	alpha tubulin 1	0.0193	0.5408	0.6231
Trypanosoma brucei	epsilon tubulin	0.0144	0.3669	0.4061
Leishmania major	alpha tubulin	0.0193	0.5408	0.6231
Echinococcus multilocularis	Tubulin beta 2C chain	0.0279	0.8428	0.836
Leishmania major	alpha tubulin	0.0193	0.5408	0.6231
Leishmania major	beta tubulin	0.0279	0.8428	1
Plasmodium vivax	tubulin beta chain, putative	0.0279	0.8428	1
Toxoplasma gondii	alpha tubulin TUBA1	0.0193	0.5408	0.6231
Trichomonas vaginalis	tubulin beta-1 chain, putative	0.0062	0.0809	0.0959
Plasmodium vivax	delta tubulin, putative	0.0062	0.0809	0.0492
Trypanosoma brucei	alpha tubulin	0.0193	0.5408	0.6231
Echinococcus granulosus	tubulin alpha 3 chain	0.0193	0.5408	0.5218
Trichomonas vaginalis	conserved hypothetical protein	0.0158	0.4163	0.4939
Trypanosoma cruzi	epsilon tubulin, putative	0.0144	0.3669	0.4061
Trichomonas vaginalis	conserved hypothetical protein	0.0158	0.4163	0.4939
Giardia lamblia	Beta tubulin	0.0279	0.8428	1
Toxoplasma gondii	beta tubulin	0.0279	0.8428	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0144	0.3669	0.4354
Brugia malayi	Tubulin beta chain	0.0081	0.1474	0.1322
Brugia malayi	Cell division protein ftsZ	0.0062	0.0809	0.0492
Echinococcus granulosus	tubulin delta chain	0.0062	0.0809	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0193	0.5408	0.626
Trichomonas vaginalis	conserved hypothetical protein	0.0158	0.4163	0.4939
Leishmania major	alpha tubulin	0.0193	0.5408	0.6231
Echinococcus granulosus	tubulin alpha 1C chain	0.0193	0.5408	0.5218
Trypanosoma brucei	alpha tubulin	0.0193	0.5408	0.6231
Loa Loa (eye worm)	tubulin gamma chain	0.0144	0.3669	0.4108
Echinococcus granulosus	tubulin gamma 1 chain	0.0144	0.3669	0.3402
Trypanosoma brucei	beta tubulin	0.0279	0.8428	1
Echinococcus multilocularis	tubulin beta 1 chain	0.0279	0.8428	0.836
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0117	0.2722	0.8067
Loa Loa (eye worm)	tubulin beta-2A chain	0.0279	0.8428	1
Plasmodium vivax	tubulin alpha chain, putative	0.0193	0.5408	0.6231
Loa Loa (eye worm)	alpha-tubulin	0.0193	0.5408	0.626
Plasmodium falciparum	alpha tubulin 2	0.0193	0.5408	0.6231
Brugia malayi	alpha-tubulin	0.0193	0.5408	0.6231
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0081	0.1474	0.1749
Trichomonas vaginalis	tubulin beta chain, putative	0.0081	0.1474	0.1749
Echinococcus granulosus	tubulin alpha chain	0.0193	0.5408	0.5218
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.008	0.1439	0.1278
Trypanosoma cruzi	zeta tubulin, putative	0.0062	0.0809	0.0492
Trichomonas vaginalis	conserved hypothetical protein	0.0158	0.4163	0.4939
Leishmania major	gamma-tubulin	0.0144	0.3669	0.4061
Entamoeba histolytica	tubulin alpha-1 chain	0.0193	0.5408	0.6416
Trichomonas vaginalis	tubulin beta chain, putative	0.0193	0.5408	0.6416
Giardia lamblia	Alpha-tubulin	0.0193	0.5408	0.6036
Trypanosoma cruzi	alpha tubulin, putative	0.0193	0.5408	0.6231
Echinococcus multilocularis	tubulin alpha chain	0.0193	0.5408	0.5209
Echinococcus granulosus	tubulin subunit TubB	0.0193	0.5408	0.5218
Trypanosoma brucei	beta tubulin	0.0279	0.8428	1
Leishmania major	beta tubulin	0.0279	0.8428	1
Echinococcus multilocularis	tubulin alpha 1C chain	0.0193	0.5408	0.5209
Trypanosoma cruzi	tubulin delta chain	0.0062	0.0809	0.0492
Brugia malayi	Tubulin beta chain	0.0062	0.0809	0.0492
Echinococcus granulosus	sodium channel protein	0.008	0.1439	0.107
Trypanosoma brucei	tubulin delta chain	0.0062	0.0809	0.0492
Echinococcus granulosus	tubulin beta 4A class IVa	0.0279	0.8428	0.8375
Leishmania major	beta tubulin	0.0279	0.8428	1
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0112	0.2547	0.2718
Loa Loa (eye worm)	tubulin alpha 2	0.0131	0.3213	0.3542
Leishmania major	beta tubulin	0.0279	0.8428	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0279	0.8428	0.8375
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.013	0.3181	1
Giardia lamblia	Beta tubulin	0.0279	0.8428	1
Schistosoma mansoni	tubulin subunit alpha	0.0193	0.5408	0.5237
Loa Loa (eye worm)	alpha-tubulin	0.0193	0.5408	0.626
Schistosoma mansoni	transient receptor potential cation channel subfamily A member	0.0312	0.9591	1
Echinococcus granulosus	peroxisome assembly protein 26	0.0193	0.5408	0.5218
Trichomonas vaginalis	conserved hypothetical protein	0.0118	0.2776	0.3294
Leishmania major	beta tubulin	0.0279	0.8428	1
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0809	0.0959
Echinococcus granulosus	ankyrin repeat protein	0.0312	0.9591	0.9591
Loa Loa (eye worm)	beta-tubulin	0.0279	0.8428	1
Loa Loa (eye worm)	tubulin beta-4 chain	0.0279	0.8428	1
Trypanosoma brucei	alpha tubulin	0.0193	0.5408	0.6231
Giardia lamblia	NADPH oxidoreductase, putative	0.0158	0.4163	0.4402
Leishmania major	beta tubulin	0.0279	0.8428	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0131	0.3213	0.3812
Giardia lamblia	NADPH oxidoreductase, putative	0.0158	0.4163	0.4402
Trichomonas vaginalis	tubulin beta chain, putative	0.0193	0.5408	0.6416
Toxoplasma gondii	alpha-tubulin I, putative	0.0193	0.5408	0.6231
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0158	0.4163	0.4939
Brugia malayi	Tubulin gamma chain	0.0144	0.3669	0.4061
Trichomonas vaginalis	conserved hypothetical protein	0.0158	0.4163	0.4939
Echinococcus multilocularis	peroxisome assembly protein 26	0.0193	0.5408	0.5209
Trypanosoma brucei	tubulin gamma chain	0.0144	0.3669	0.4061
Trichomonas vaginalis	tubulin gamma chain, putative	0.0144	0.3669	0.4354
Trichomonas vaginalis	conserved hypothetical protein	0.0158	0.4163	0.4939
Echinococcus multilocularis	tubulin alpha 1C chain	0.0193	0.5408	0.5209
Trichomonas vaginalis	tubulin, putative	0.0062	0.0809	0.0959
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0062	0.0809	0.0959
Echinococcus granulosus	tubulin subunit beta	0.0279	0.8428	0.8375
Toxoplasma gondii	beta-tubulin, putative	0.0279	0.8428	1
Plasmodium falciparum	tubulin delta chain, putative	0.0062	0.0809	0.0492
Giardia lamblia	Alpha-tubulin	0.0193	0.5408	0.6036
Trichomonas vaginalis	tubulin alpha chain, putative	0.0081	0.1474	0.1749
Loa Loa (eye worm)	tubulin alpha 2	0.0131	0.3213	0.3542
Echinococcus multilocularis	tubulin alpha 3 chain	0.0193	0.5408	0.5209
Trichomonas vaginalis	tubulin, putative	0.0081	0.1474	0.1749
Leishmania major	zeta tubulin, putative	0.0062	0.0809	0.0492
Trypanosoma cruzi	tubulin delta chain	0.0062	0.0809	0.0492
Echinococcus granulosus	Tubulin beta 2C chain	0.0279	0.8428	0.8375
Loa Loa (eye worm)	tubulin alpha chain	0.0193	0.5408	0.626
Trypanosoma brucei	beta tubulin	0.0144	0.3669	0.4061
Echinococcus multilocularis	hypothetical protein	0.0193	0.5408	0.5209
Schistosoma mansoni	tubulin subunit alpha	0.0193	0.5408	0.5237
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0193	0.5408	0.5209
Leishmania major	alpha tubulin	0.0193	0.5408	0.6231
Leishmania major	alpha tubulin	0.0193	0.5408	0.6231
Onchocerca volvulus		0.0257	0.7654	1
Leishmania major	delta tubulin, putative	0.0062	0.0809	0.0492
Loa Loa (eye worm)	BEN-1 protein	0.0279	0.8428	1
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0809	0.0959
Trichomonas vaginalis	conserved hypothetical protein	0.0158	0.4163	0.4939
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0225	0.6542	0.7664
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0062	0.0809	0.5
Leishmania major	beta tubulin	0.0279	0.8428	1
Echinococcus granulosus	transient receptor potential cation channel	0.0323	0.9983	1
Trypanosoma brucei	alpha tubulin, putative	0.0081	0.1474	0.1322
Plasmodium vivax	tubulin alpha chain, putative	0.0193	0.5408	0.6231
Echinococcus granulosus	tubulin alpha chain	0.0193	0.5408	0.5218
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0144	0.3669	0.4061
Leishmania major	beta tubulin	0.0279	0.8428	1

Activities

Activity type	Activity value	Assay description	Source	Reference
deltaTm (binding)	= 7.1 hr	Binding affinity to calf thymus DNA at pH 7.0 at 20 uM by thermal denaturation assay	ChEMBL.	18325766
deltaTm (binding)	= 9 hr	Binding affinity to calf thymus DNA at pH 7.0 at 20 uM after 18 hrs by thermal denaturation assay	ChEMBL.	18325766

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 518406