TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 391.46 | Formula: C24H25NO4
H donors: 2 H acceptors: 3 LogP: 5.7 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C1=C(O)C(OC1=O)Cc1ccccc1)Nc1ccc(cc1)C1CCCCC1
InChi: 1S/C24H25NO4/c26-22-20(15-16-7-3-1-4-8-16)29-24(28)21(22)23(27)25-19-13-11-18(12-14-19)17-9-5-2-6-10-17/h1,3-4,7-8,11-14,17,20,26H,2,5-6,9-10,15H2,(H,25,27)
InChiKey: STINOZQIDCIKJT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	Undecaprenyl pyrophosphate synthase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium tuberculosis	Long (C50) chain Z-isoprenyl diphosphate synthase (Z-decaprenyl diphosphate synthase)	Get druggable targets OG5_126777	All targets in OG5_126777
Schistosoma japonicum	ko:K00810 dehydrodolichyl diphosphate synthase [EC:2.5.1.-], putative	Get druggable targets OG5_126777	All targets in OG5_126777
Candida albicans	cis-prenyltransferase-like orf	Get druggable targets OG5_126777	All targets in OG5_126777
Leishmania infantum	cis-prenyltransferase-like protein	Get druggable targets OG5_126777	All targets in OG5_126777
Leishmania donovani	cis-prenyltransferase-like protein	Get druggable targets OG5_126777	All targets in OG5_126777
Chlamydia trachomatis	isoprenyl transferase	Get druggable targets OG5_126777	All targets in OG5_126777
Trypanosoma congolense	cis-prenyltransferase-like protein, putative	Get druggable targets OG5_126777	All targets in OG5_126777
Onchocerca volvulus	Dehydrodolichyl diphosphate synthase homolog	Get druggable targets OG5_126777	All targets in OG5_126777
Schistosoma mansoni	dehydrodolichyl diphosphate synthase (dedol-pp synthase)	Get druggable targets OG5_126777	All targets in OG5_126777
Mycobacterium ulcerans	short (C15) chain Z-isoprenyl diphosphate synthase, UppS	Get druggable targets OG5_126777	All targets in OG5_126777
Schistosoma mansoni	dehydrodolichyl diphosphate synthase (dedol-pp synthase)	Get druggable targets OG5_126777	All targets in OG5_126777
Plasmodium berghei	dehydrodolichyl diphosphate synthetase, putative	Get druggable targets OG5_126777	All targets in OG5_126777
Trypanosoma brucei	cis-prenyltransferase-like protein	Get druggable targets OG5_126777	All targets in OG5_126777
Theileria parva	undecaprenyl diphosphate synthase, putative	Get druggable targets OG5_126777	All targets in OG5_126777
Candida albicans	Cis-prenyltransferase	Get druggable targets OG5_126777	All targets in OG5_126777
Candida albicans	Cis-prenyltransferase	Get druggable targets OG5_126777	All targets in OG5_126777
Leishmania mexicana	cis-prenyltransferase-like protein	Get druggable targets OG5_126777	All targets in OG5_126777
Candida albicans	cis-prenyltransferase-like orf	Get druggable targets OG5_126777	All targets in OG5_126777
Brugia malayi	Undecaprenyl diphosphate synthase family protein	Get druggable targets OG5_126777	All targets in OG5_126777
Mycobacterium ulcerans	undecaprenyl pyrophosphate synthase	Get druggable targets OG5_126777	All targets in OG5_126777
Schistosoma mansoni	dehydrodolichyl diphosphate synthase (dedol-pp synthase)	Get druggable targets OG5_126777	All targets in OG5_126777
Leishmania braziliensis	cis-prenyltransferase-like protein	Get druggable targets OG5_126777	All targets in OG5_126777
Echinococcus multilocularis	dehydrodolichyl diphosphate synthase	Get druggable targets OG5_126777	All targets in OG5_126777
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_126777	All targets in OG5_126777
Babesia bovis	undecaprenyl pyrophosphate synthetase, putative	Get druggable targets OG5_126777	All targets in OG5_126777
Plasmodium knowlesi	dehydrodolichyl diphosphate synthetase, putative	Get druggable targets OG5_126777	All targets in OG5_126777
Treponema pallidum	undecaprenyl pyrophosphate synthase	Get druggable targets OG5_126777	All targets in OG5_126777
Plasmodium falciparum	dehydrodolichyl diphosphate synthetase, putative	Get druggable targets OG5_126777	All targets in OG5_126777
Mycobacterium tuberculosis	Short (C15) chain Z-isoprenyl diphosphate synthase (Z-FPP synthase) (Z-farnesyl diphosphate synthase) (Z-FPP synthetase) (Z-farn	Get druggable targets OG5_126777	All targets in OG5_126777
Toxoplasma gondii	undecaprenyl diphosphate synthase	Get druggable targets OG5_126777	All targets in OG5_126777
Trichomonas vaginalis	undecaprenyl diphosphate synthase, putative	Get druggable targets OG5_126777	All targets in OG5_126777
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126777	All targets in OG5_126777
Trypanosoma brucei gambiense	cis-prenyltransferase-like protein, putative	Get druggable targets OG5_126777	All targets in OG5_126777
Leishmania major	cis-prenyltransferase-like protein	Get druggable targets OG5_126777	All targets in OG5_126777
Neospora caninum	GF20994, related	Get druggable targets OG5_126777	All targets in OG5_126777
Plasmodium yoelii	undecaprenyl pyrophosphate synthetase-like-related	Get druggable targets OG5_126777	All targets in OG5_126777
Giardia lamblia	Undecaprenyl pyrophosphate synthase	Get druggable targets OG5_126777	All targets in OG5_126777
Mycobacterium ulcerans	Z-decaprenyl diphosphate synthase	Get druggable targets OG5_126777	All targets in OG5_126777
Trypanosoma cruzi	cis-prenyltransferase, putative	Get druggable targets OG5_126777	All targets in OG5_126777
Mycobacterium leprae	Probable Long (C50) chain Z-isoprenyl diphosphate synthase (Z-DECAPRENYL DIPHOSPHATE SYNTHASE)	Get druggable targets OG5_126777	All targets in OG5_126777
Echinococcus granulosus	dehydrodolichyl diphosphate synthase	Get druggable targets OG5_126777	All targets in OG5_126777
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126777	All targets in OG5_126777
Mycobacterium leprae	SHORT (C15) CHAIN Z-ISOPRENYL DIPHOSPHATE SYNTHASE (Z-FPP SYNTHASE) (Z-FARNESYL DIPHOSPHATE SYNTHASE) (Z-FPP SYNTHETASE) (Z-FARN	Get druggable targets OG5_126777	All targets in OG5_126777
Wolbachia endosymbiont of Brugia malayi	undecaprenyl pyrophosphate synthase	Get druggable targets OG5_126777	All targets in OG5_126777
Plasmodium vivax	dehydrodolichyl diphosphate synthetase, putative	Get druggable targets OG5_126777	All targets in OG5_126777

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus	still life protein homolog	Undecaprenyl pyrophosphate synthase	252 aa	233 aa	37.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	integrin alpha ps	0.0409	0.0992	0.1829
Echinococcus multilocularis	oligomeric golgi complex subunit 3	0.0184	0.0404	0.0936
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0118	0.0231	0.2505
Giardia lamblia	Furin precursor putative serine protease	0.0424	0.1032	0.4896
Trichomonas vaginalis	cyclins, putative	0.009	0.0158	0.0401
Loa Loa (eye worm)	glutamate receptor 1	0.0066	0.0095	0.0171
Echinococcus multilocularis	Niemann Pick C1 protein	0.0109	0.0207	0.048
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.0078	0.0078
Brugia malayi	Angiotensin-converting enzyme family protein	0.0651	0.1626	0.2993
Trichomonas vaginalis	cyclin B, putative	0.0118	0.0231	0.0622
Echinococcus granulosus	dna polymerase kappa	0.004	0.0027	0.005
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0094	0.0168	0.043
Schistosoma mansoni	patched 1	0.0109	0.0207	0.0207
Brugia malayi	CHE-14 protein	0.0109	0.0207	0.0379
Trichomonas vaginalis	cyclin H, putative	0.0145	0.0302	0.0841
Trypanosoma cruzi	trypanothione synthetase	0.0069	0.0102	0.0905
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0118	0.0231	0.0421
Trichomonas vaginalis	cyclin D, putative	0.009	0.0158	0.0401
Schistosoma mansoni	integrin beta subunit	0.019	0.0419	0.0419
Trichomonas vaginalis	CMGC family protein kinase	0.01	0.0185	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0264	0.0614	0.1128
Trypanosoma brucei	trypanothione synthetase	0.0069	0.0102	0.1642
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.2105	0.5426	0.5426
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0094	0.0168	0.043
Brugia malayi	N-myristoyltransferase 2	0.0174	0.0377	0.0692
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4)	0.0094	0.0168	0.5
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0102	0.0189	0.0437
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0066	0.0095	0.0174
Trichomonas vaginalis	CMGC family protein kinase	0.01	0.0185	0.0483
Toxoplasma gondii	subtilisin SUB6	0.0094	0.0168	0.8367
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0109	0.0207	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0207	0.0379
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0027	0.0415
Brugia malayi	Cyclin, N-terminal domain containing protein	0.057	0.1412	0.26
Trypanosoma cruzi	cyclin, putative	0.0118	0.0231	0.2448
Echinococcus multilocularis	cyclins	0.009	0.0158	0.0367
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.129	0.3295	0.6073
Mycobacterium ulcerans	proline rich membrane-anchored mycosin MycP5	0.0094	0.0168	0.2394
Chlamydia trachomatis	outer membrane protein PmpF	0.0073	0.0112	0.5
Brugia malayi	cell division control protein 2 homolog	0.01	0.0185	0.0338
Echinococcus multilocularis	cyclins	0.009	0.0158	0.0367
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0094	0.0168	0.043
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0051	0.009
Trichomonas vaginalis	conserved hypothetical protein	0.0094	0.0168	0.043
Plasmodium falciparum	plasmepsin IV	0.0102	0.0189	0.1377
Trichomonas vaginalis	N-myristoyl transferase, putative	0.0114	0.0222	0.0594
Echinococcus multilocularis	cyclins	0.009	0.0158	0.0367
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0102	0.0189	0.0348
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0066	0.0095	0.0219
Leishmania major	subtilisin-like serine peptidase	0.0094	0.0168	0.1278
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0264	0.0614	0.7066
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0109	0.0207	0.0207
Brugia malayi	cyclin-dependent kinase 7 homolog	0.0178	0.0388	0.0712
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0094	0.0168	0.043
Chlamydia trachomatis	outer membrane protein PmpE	0.0073	0.0112	0.5
Echinococcus multilocularis	cyclin dependent kinase 1	0.01	0.0185	0.0429
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0094	0.0168	0.043
Echinococcus multilocularis	protein dispatched 1	0.0109	0.0207	0.048
Trichomonas vaginalis	CMGC family protein kinase	0.01	0.0185	0.0483
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0094	0.0168	0.043
Echinococcus granulosus	cyclins	0.009	0.0158	0.0292
Plasmodium falciparum	glycylpeptide N-tetradecanoyltransferase	0.0174	0.0377	1
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0124	0.0247	0.0672
Echinococcus granulosus	cyclins	0.009	0.0158	0.0292
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0518	0.1276	0.1276
Echinococcus granulosus	cyclin	0.0184	0.0404	0.0745
Schistosoma mansoni	hydroxymethylglutaryl-CoA reductase (NADPH)	0.0264	0.0614	0.0614
Echinococcus multilocularis	cyclin b3	0.009	0.0158	0.0367
Toxoplasma gondii	subtilisin SUB5	0.0094	0.0168	0.8367
Trypanosoma brucei	N-myristoyl transferase, putative	0.0174	0.0377	0.6135
Leishmania major	3-hydroxy-3-methylglutaryl-CoA reductase	0.0264	0.0614	1
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.0701	0.1755	0.1755
Entamoeba histolytica	hypothetical protein	0.0145	0.0302	0.6564
Mycobacterium tuberculosis	Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like)	0.0094	0.0168	0.5
Echinococcus granulosus	Furin 1	0.0518	0.1276	0.2352
Echinococcus granulosus	neuroendocrine convertase 2	0.1333	0.3407	0.628
Trichomonas vaginalis	conserved hypothetical protein	0.0424	0.1032	0.3073
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0066	0.0095	0.0174
Plasmodium falciparum	subtilisin-like protease 3	0.0094	0.0168	0.0426
Giardia lamblia	CDC72	0.0174	0.0377	0.1228
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0066	0.0095	0.0174
Brugia malayi	Hydroxymethylglutaryl-coenzyme A reductase family protein	0.0264	0.0614	0.1128
Echinococcus granulosus	hydroxymethylglutaryl coenzyme A reductase	0.0264	0.0614	0.1131
Trypanosoma cruzi	N-myristoyl transferase, putative	0.0174	0.0377	0.4217
Trichomonas vaginalis	cyclin B, putative	0.009	0.0158	0.0401
Mycobacterium leprae	PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5)	0.0094	0.0168	0.5
Echinococcus multilocularis	cyclins	0.009	0.0158	0.0367
Trichomonas vaginalis	conserved hypothetical protein	0.0424	0.1032	0.3073
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0094	0.0168	0.0168
Echinococcus multilocularis	cyclin B	0.0118	0.0231	0.0534
Echinococcus multilocularis	integrin beta 2	0.0239	0.0547	0.1267
Plasmodium vivax	plasmepsin IV, putative	0.0102	0.0189	0.0993
Echinococcus multilocularis	cyclins	0.009	0.0158	0.0367
Echinococcus granulosus	integrin beta 2	0.0239	0.0547	0.1008
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0424	0.1032	0.3073
Echinococcus multilocularis	hydroxymethylglutaryl coenzyme A reductase	0.0264	0.0614	0.1422
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0094	0.0168	0.043
Toxoplasma gondii	subtilisin SUB12	0.0094	0.0168	0.8367
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0094	0.0168	0.043
Leishmania major	N-myristoyl transferase, putative	0.0174	0.0377	0.5376
Brugia malayi	Protein kinase domain containing protein	0.01	0.0185	0.0338
Trichomonas vaginalis	cyclins, putative	0.0057	0.0071	0.0134
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.009	0.0158	0.0292
Mycobacterium leprae	Possible secreted protease	0.0094	0.0168	0.5
Trichomonas vaginalis	cyclin A, putative	0.0118	0.0231	0.0622
Trichomonas vaginalis	conserved hypothetical protein	0.0424	0.1032	0.3073
Echinococcus multilocularis	glutamate receptor 2	0.0041	0.0031	0.0072
Trichomonas vaginalis	conserved hypothetical protein	0.0424	0.1032	0.3073
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0094	0.0168	0.0168
Trichomonas vaginalis	conserved hypothetical protein	0.0424	0.1032	0.3073
Echinococcus granulosus	cyclins	0.009	0.0158	0.0292
Loa Loa (eye worm)	cyclin domain-containing protein	0.057	0.1412	0.26
Leishmania major	cyclin	0.0118	0.0231	0.2505
Echinococcus granulosus	cyclin dependent kinase 1	0.01	0.0185	0.0341
Trypanosoma brucei	DNA polymerase IV, putative	0.004	0.0027	0.0415
Echinococcus multilocularis	protein patched	0.0109	0.0207	0.048
Trichomonas vaginalis	cyclin B, putative	0.0118	0.0231	0.0622
Echinococcus granulosus	integrin alpha ps	0.0196	0.0435	0.0802
Trichomonas vaginalis	conserved hypothetical protein	0.0094	0.0168	0.043
Trypanosoma brucei	mitotic cyclin 6	0.0118	0.0231	0.3736
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0094	0.0168	0.043
Echinococcus multilocularis	cyclin dependent kinase 5	0.01	0.0185	0.0429
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.01	0.0185	0.1619
Loa Loa (eye worm)	DEAH box polypeptide 35	0.0072	0.0111	0.02
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0329	0.0783	0.1441
Schistosoma mansoni	ATP-binding cassette transporter	0.0066	0.0095	0.0095
Echinococcus granulosus	membrane bound transcription factor site 1	0.0094	0.0168	0.0309
Trichomonas vaginalis	cyclins, putative	0.0118	0.0231	0.0622
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.129	0.3295	1
Trypanosoma cruzi	cdc2-related kinase 3	0.01	0.0185	0.1902
Loa Loa (eye worm)	subtilase	0.0094	0.0168	0.0306
Mycobacterium ulcerans	hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase	0.0264	0.0614	1
Trichomonas vaginalis	cyclins, putative	0.0118	0.0231	0.0622
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0231	0.0421
Echinococcus multilocularis	dnaJ subfamily B	0.0398	0.0962	0.2229
Brugia malayi	Integrin alpha cytoplasmic region family protein	0.069	0.1727	0.318
Toxoplasma gondii	subtilisin SUB4	0.0094	0.0168	0.8367
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0094	0.0168	0.043
Loa Loa (eye worm)	integrin beta-2	0.0322	0.0765	0.1408
Mycobacterium ulcerans	membrane-anchored mycosin MycP3	0.0094	0.0168	0.2394
Plasmodium falciparum	subtilisin-like protease 1	0.0094	0.0168	0.0426
Loa Loa (eye worm)	hypothetical protein	0.069	0.1727	0.318
Echinococcus granulosus	cyclin dependent kinase	0.01	0.0185	0.0341
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0118	0.0231	0.2448
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0102	0.0189	0.0344
Echinococcus granulosus	integrin alpha 3	0.07	0.1751	0.3228
Trypanosoma cruzi	glutathionylspermidine synthase, putative	0.0358	0.0857	1
Echinococcus multilocularis	cyclin dependent kinase 7	0.0178	0.0388	0.0899
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0094	0.0168	0.043
Echinococcus granulosus	cyclin dependent kinase 7	0.0178	0.0388	0.0715
Loa Loa (eye worm)	hypothetical protein	0.0716	0.1796	0.3307
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.01	0.0185	0.1619
Echinococcus multilocularis	cyclin	0.0184	0.0404	0.0936
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0094	0.0168	0.043
Schistosoma mansoni	furin-1 (S08 family)	0.0909	0.2299	0.2299
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0027	0.0415
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0168	0.0306
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0066	0.0095	0.0219
Trichomonas vaginalis	conserved hypothetical protein	0.0424	0.1032	0.3073
Echinococcus granulosus	cyclins	0.009	0.0158	0.0292
Schistosoma mansoni	glutamate receptor kainate	0.0066	0.0095	0.0095
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0518	0.1276	0.3822
Echinococcus granulosus	cyclins	0.009	0.0158	0.0292
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0066	0.0095	0.0174
Schistosoma mansoni	cyclin B3	0.009	0.0158	0.0158
Trypanosoma brucei	DNA polymerase IV, putative	0.0034	0.0011	0.0141
Trichomonas vaginalis	cyclins, putative	0.0118	0.0231	0.0622
Plasmodium falciparum	plasmepsin VI	0.0102	0.0189	0.1377
Trypanosoma brucei	serine peptidase, clan SB, family S8-like protein	0.0094	0.0168	0.271
Schistosoma mansoni	glutamate receptor kainate	0.0066	0.0095	0.0095
Schistosoma mansoni	glutamate receptor kainate	0.0066	0.0095	0.0095
Loa Loa (eye worm)	endoprotease bli-4	0.2105	0.5426	1
Toxoplasma gondii	subtilisin SUB8	0.0094	0.0168	0.8367
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0094	0.0168	0.043
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0066	0.0095	0.0174
Echinococcus multilocularis	cyclins	0.009	0.0158	0.0367
Echinococcus multilocularis		0.1681	0.4317	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0027	0.0415
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0124	0.0247	0.0672
Brugia malayi	proprotein convertase 2	0.1333	0.3407	0.6278
Echinococcus granulosus	glutamate receptor 2	0.0066	0.0095	0.0174
Trypanosoma cruzi	cyclin, putative	0.0118	0.0231	0.2448
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0066	0.0095	0.0219
Trichomonas vaginalis	cyclin B, putative	0.0118	0.0231	0.0622
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0094	0.0168	0.0168
Schistosoma mansoni	hypothetical protein	0.0424	0.1032	0.1032
Schistosoma mansoni	N-myristoyltransferase	0.0174	0.0377	0.0377
Chlamydia trachomatis	outer membrane protein PmpB	0.0073	0.0112	0.5
Brugia malayi	Glutamate receptor 1 precursor	0.0066	0.0095	0.0171
Echinococcus multilocularis	Furin 1	0.0518	0.1276	0.2957
Giardia lamblia	Kinase, CMGC CDK	0.01	0.0185	0.015
Echinococcus granulosus	dnaJ subfamily B	0.0398	0.0962	0.1774
Loa Loa (eye worm)	proprotein convertase 2	0.0518	0.1276	0.235
Brugia malayi	neuroendocrine convertase 1 precursor	0.1333	0.3407	0.6278
Chlamydia trachomatis	outer membrane protein PmpD	0.0073	0.0112	0.5
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0111	0.02
Trichomonas vaginalis	conserved hypothetical protein	0.0424	0.1032	0.3073
Schistosoma mansoni	cyclin B	0.0118	0.0231	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0196	0.0435	0.0799
Echinococcus multilocularis	glycylpeptide N tetradecanoyltransferase	0.0174	0.0377	0.0874
Schistosoma mansoni	hypothetical protein	0.0196	0.0435	0.0435
Trichomonas vaginalis	N-myristoyl transferase, putative	0.0174	0.0377	0.1071
Schistosoma mansoni	hypothetical protein	0.0398	0.0962	0.0962
Brugia malayi	Probable ATP-dependent helicase DHX35	0.0072	0.0111	0.02
Trypanosoma brucei	unspecified product	0.0034	0.0011	0.0141
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0027	0.0415
Echinococcus multilocularis	cyclin dependent kinase 1	0.01	0.0185	0.0429
Schistosoma mansoni	tyrosine kinase	0.019	0.042	0.042
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0027	0.0415
Echinococcus multilocularis	glutamate receptor 2	0.0066	0.0095	0.0219
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0178	0.0325
Giardia lamblia	Kinase, CMGC CDK	0.01	0.0185	0.015
Trichomonas vaginalis	cyclin B3, putative	0.009	0.0158	0.0401
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0094	0.0168	0.1692
Echinococcus multilocularis	integrin alpha ps	0.0196	0.0435	0.1009
Toxoplasma gondii	subtilisin SUB2	0.0094	0.0168	0.8367
Echinococcus granulosus	epidermal growth factor receptor	0.019	0.042	0.0774
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0094	0.0168	0.043
Echinococcus multilocularis	glutamate receptor 2	0.0066	0.0095	0.0219
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0066	0.0095	0.0219
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0518	0.1276	0.3822
Brugia malayi	endoprotease bli-4 precursor	0.2105	0.5426	1
Trypanosoma cruzi	cdc2-related kinase 1	0.01	0.0185	0.1902
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0094	0.0168	0.043
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0094	0.0168	0.043
Echinococcus multilocularis	integrin alpha ps	0.0409	0.0992	0.2298
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0027	0.0415
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.0094	0.0168	0.0309
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0424	0.1032	0.3073
Echinococcus multilocularis	dna polymerase kappa	0.004	0.0027	0.0063
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0094	0.0168	0.043
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0518	0.1276	0.3822
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0094	0.0168	0.1692
Echinococcus multilocularis	cyclins	0.009	0.0158	0.0367
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.129	0.3295	0.7632
Brugia malayi	Cyclin, N-terminal domain containing protein	0.009	0.0158	0.0289
Trypanosoma cruzi	cyclin 6, putative	0.0118	0.0231	0.2448
Loa Loa (eye worm)	cyclin C	0.0184	0.0404	0.0741
Mycobacterium tuberculosis	Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5)	0.0094	0.0168	0.5
Trichomonas vaginalis	hypothetical protein	0.0424	0.1032	0.3073
Loa Loa (eye worm)	N-myristoyltransferase 2	0.0174	0.0377	0.0692
Loa Loa (eye worm)	CMGC/CDK/CDK7 protein kinase	0.0178	0.0388	0.0712
Schistosoma mansoni	integrin alpha	0.0913	0.2308	0.2308
Trypanosoma brucei	subtilisin peptidase	0.0094	0.0168	0.271
Brugia malayi	hypothetical protein	0.0049	0.0051	0.009
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.01	0.0185	0.0338
Trichomonas vaginalis	conserved hypothetical protein	0.0424	0.1032	0.3073
Trichomonas vaginalis	conserved hypothetical protein	0.0424	0.1032	0.3073
Trichomonas vaginalis	conserved hypothetical protein	0.009	0.0158	0.0401
Trichomonas vaginalis	conserved hypothetical protein	0.0109	0.0207	0.0551
Trichomonas vaginalis	conserved hypothetical protein	0.0094	0.0168	0.043
Echinococcus multilocularis	integrin alpha ps	0.0409	0.0992	0.2298
Schistosoma mansoni	glutamate receptor NMDA	0.0066	0.0095	0.0095
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.0049	0.0051	0.009
Giardia lamblia	G2/mitotic-specific cyclin B	0.0118	0.0231	0.0404
Trypanosoma brucei	N-myristoyltransferase	0.0174	0.0377	0.6135
Echinococcus granulosus	oligomeric golgi complex subunit 3	0.0184	0.0404	0.0745
Schistosoma mansoni	cathepsin D (A01 family)	0.03	0.0706	0.0706
Echinococcus multilocularis	cyclin dependent kinase	0.01	0.0185	0.0429
Trypanosoma brucei	cdc2-related kinase 3	0.01	0.0185	0.2995
Trichomonas vaginalis	conserved hypothetical protein	0.0424	0.1032	0.3073
Brugia malayi	Kelch motif family protein	0.0049	0.0051	0.009
Loa Loa (eye worm)	hypothetical protein	0.2105	0.5426	1
Onchocerca volvulus		0.0094	0.0168	0.6369
Toxoplasma gondii	subtilisin SUB11	0.0094	0.0168	0.8367
Brugia malayi	Integrin beta pat-3 precursor	0.0322	0.0765	0.1408
Trichomonas vaginalis	conserved hypothetical protein	0.0094	0.0168	0.043
Echinococcus multilocularis	cyclin B3 1	0.009	0.0158	0.0367
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0094	0.0168	0.043
Plasmodium vivax	aspartyl proteinase, putative	0.0102	0.0189	0.0993
Trypanosoma cruzi	subtilisin peptidase	0.0094	0.0168	0.1692
Toxoplasma gondii	aspartyl protease ASP1	0.0102	0.0189	1
Brugia malayi	Glutamate receptor 2 precursor	0.0066	0.0095	0.0171
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.129	0.3295	1
Toxoplasma gondii	subtilisin SUB9	0.0094	0.0168	0.8367
Brugia malayi	celfurPC protein	0.1681	0.4317	0.7956
Schistosoma mansoni	glutamate receptor AMPA	0.0066	0.0095	0.0095
Schistosoma mansoni	cyclins	0.009	0.0158	0.0158
Toxoplasma gondii	subtilisin SUB1	0.0094	0.0168	0.8367
Echinococcus multilocularis	epidermal growth factor receptor	0.019	0.042	0.0972
Echinococcus granulosus	sterol regulatory element binding protein	0.0109	0.0207	0.0382
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase	0.0264	0.0614	0.7066
Brugia malayi	Furin-like cysteine rich region family protein	0.019	0.042	0.077
Echinococcus multilocularis	neuroendocrine convertase 2	0.1333	0.3407	0.7892
Brugia malayi	Integrin alpha pat-2 precursor	0.0913	0.2308	0.4252
Loa Loa (eye worm)	hypothetical protein	0.0213	0.048	0.0881
Trypanosoma brucei	cdc2-related kinase 1	0.01	0.0185	0.2995
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0189	0.0344
Schistosoma mansoni	g1/s-specific cyclin C	0.0184	0.0404	0.0404
Trypanosoma cruzi	trypanothione synthetase	0.0069	0.0102	0.0905
Schistosoma mansoni	serine/threonine protein kinase	0.0178	0.0388	0.0388
Loa Loa (eye worm)	hypothetical protein	0.0815	0.2054	0.3783
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0518	0.1276	0.3822
Trichomonas vaginalis	cyclin B, putative	0.0118	0.0231	0.0622
Echinococcus granulosus	glutamate receptor 2	0.0041	0.0031	0.0057
Trypanosoma brucei	DNA polymerase IV, putative	0.004	0.0027	0.0415
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0027	0.0415
Brugia malayi	Hypothetical subtilase-type proteinase F21H12.6 in chromosome II	0.0094	0.0168	0.0306
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0518	0.1276	0.3822
Echinococcus granulosus	cyclin dependent kinase 5	0.01	0.0185	0.0341
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.0094	0.0168	0.0168
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0094	0.0168	0.043
Plasmodium falciparum	plasmepsin I	0.0102	0.0189	0.1377
Chlamydia trachomatis	outer membrane protein PmpC	0.0073	0.0112	0.5
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0102	0.0189	1
Plasmodium vivax	glycylpeptide N-tetradecanoyltransferase, putative	0.0174	0.0377	1
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.01	0.0185	0.0338
Toxoplasma gondii	subtilisin SUB10	0.0094	0.0168	0.8367
Entamoeba histolytica	glycylpeptide N-tetradecanoyltransferase, putative	0.0174	0.0377	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0102	0.0189	0.0189
Loa Loa (eye worm)	glutamate receptor 2	0.0066	0.0095	0.0171
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0102	0.0189	0.0493
Echinococcus multilocularis	sterol regulatory element binding protein	0.0109	0.0207	0.048
Brugia malayi	Subtilase family protein	0.0094	0.0168	0.0306
Echinococcus granulosus	Niemann Pick C1 protein	0.0109	0.0207	0.0382
Schistosoma mansoni	integrin alpha-ps	0.0409	0.0992	0.0992
Giardia lamblia	High cysteine membrane protein Group 2	0.0772	0.1942	1
Toxoplasma gondii	hypothetical protein	0.0061	0.0082	0.1649
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.01	0.0185	0.9736
Trypanosoma cruzi	serine peptidase, clan SB, family S8-like protein	0.0094	0.0168	0.1692
Entamoeba histolytica	cell division protein kinase 2, putative	0.01	0.0185	0.1223
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0094	0.0168	0.043
Mycobacterium leprae	PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3)	0.0094	0.0168	0.5
Trypanosoma brucei	trypanothione synthetase, putative	0.0069	0.0102	0.1642
Trypanosoma cruzi	cdc2-related kinase 1	0.01	0.0185	0.1902
Loa Loa (eye worm)	TK/EGFR protein kinase	0.019	0.042	0.077
Loa Loa (eye worm)	cyclin domain-containing protein	0.009	0.0158	0.0289
Trichomonas vaginalis	cyclins, putative	0.0118	0.0231	0.0622
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0094	0.0168	0.043
Schistosoma mansoni	cathepsin D (A01 family)	0.03	0.0706	0.0706
Loa Loa (eye worm)	cyclin domain-containing protein	0.0329	0.0783	0.1441
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0518	0.1276	0.3822
Entamoeba histolytica	cyclin, putative	0.0118	0.0231	0.3293
Trypanosoma cruzi	cdc2-related kinase 3	0.01	0.0185	0.1902
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.0094	0.0168	0.0389
Schistosoma mansoni	serine/threonine protein kinase	0.0178	0.0388	0.0388
Echinococcus multilocularis	membrane bound transcription factor site 1	0.0094	0.0168	0.0389
Plasmodium vivax	protein kinase Crk2	0.01	0.0185	0.0832
Mycobacterium ulcerans	membrane-anchored serine protease (mycosin), MycP4	0.0094	0.0168	0.2394
Echinococcus granulosus	cyclin B3 1	0.009	0.0158	0.0292
Schistosoma mansoni	serine/threonine protein kinase	0.01	0.0185	0.0185
Schistosoma mansoni	glutamate receptor NMDA	0.0066	0.0095	0.0095
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0124	0.0247	0.0672
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.0651	0.1626	0.2993
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.009	0.0158	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0231	0.0421
Trichomonas vaginalis	cyclin D, putative	0.009	0.0158	0.0401
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3)	0.0094	0.0168	0.5
Plasmodium falciparum	subtilisin-like protease 2	0.0094	0.0168	0.0426
Loa Loa (eye worm)	integrin alpha pat-2	0.1407	0.36	0.6633
Loa Loa (eye worm)	hypothetical protein	0.0503	0.1239	0.228
Schistosoma mansoni	glutamate receptor AMPA	0.0066	0.0095	0.0095
Schistosoma mansoni	serine/threonine protein kinase	0.01	0.0185	0.0185
Schistosoma mansoni	integrin alpha-ps	0.0213	0.048	0.048
Plasmodium falciparum	protein kinase 5	0.01	0.0185	0.1223
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0424	0.1032	0.3073
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0066	0.0095	0.0219
Trypanosoma brucei	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0264	0.0614	1
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.01	0.0185	0.0338
Plasmodium falciparum	plasmepsin II	0.0102	0.0189	0.1377
Echinococcus granulosus	glycylpeptide N tetradecanoyltransferase	0.0174	0.0377	0.0696
Giardia lamblia	3-hydroxy-3-methylglutaryl-coenzyme A reductase	0.0124	0.0247	0.0497
Trichomonas vaginalis	conserved hypothetical protein	0.0424	0.1032	0.3073
Entamoeba histolytica	cell division protein kinase 2, putative	0.01	0.0185	0.1223
Echinococcus granulosus	Protein patched homolog 1	0.0109	0.0207	0.0382
Echinococcus granulosus	furin	0.2105	0.5426	1
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.01	0.0185	0.0341
Echinococcus granulosus	cyclin b3	0.009	0.0158	0.0292
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0027	0.0415
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0094	0.0168	0.043
Onchocerca volvulus		0.0118	0.0231	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0027	0.0415
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0118	0.0231	0.0421
Brugia malayi	Membrane-bound transcription factor site-1 protease precursor	0.0094	0.0168	0.0306
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0094	0.0168	0.043
Brugia malayi	Cyclin C	0.0184	0.0404	0.0741
Echinococcus granulosus	cyclin B	0.0118	0.0231	0.0425
Echinococcus multilocularis	integrin alpha 3	0.07	0.1751	0.4056
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0094	0.0168	0.043
Toxoplasma gondii	subtilisin SUB7	0.0094	0.0168	0.8367
Trypanosoma cruzi	N-myristoyl transferase, putative	0.0174	0.0377	0.4217
Trichomonas vaginalis	conserved hypothetical protein	0.0094	0.0168	0.043

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.5 uM	Inhibition of Streptococcus pneumoniae UPPS	ChEMBL.	18295483
IC50 (binding)	= 0.5 uM	Inhibition of Streptococcus pneumoniae UPPS	ChEMBL.	18295483
IC50 (binding)	> 50 uM	Inhibition of human FPPS	ChEMBL.	18295483
IC50 (binding)	> 50 uM	Inhibition of human FPPS	ChEMBL.	18295483
MIC (functional)	= 1 ug ml-1	Antibacterial activity against Streptococcus pneumoniae by microdilution broth method	ChEMBL.	18295483
MIC (functional)	= 32 ug ml-1	Antibacterial activity against Enterococcus faecalis by microdilution broth method	ChEMBL.	18295483
MIC (functional)	= 64 ug ml-1	Antibacterial activity against Staphylococcus aureus by microdilution broth method	ChEMBL.	18295483

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL255828

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 518524