Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Homo sapiens | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0076 | 0.2468 | 0.4828 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0076 | 0.2468 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0076 | 0.2468 | 0.5 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0076 | 0.2468 | 0.2468 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0076 | 0.2468 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 0 | 0.5 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0076 | 0.2468 | 0.4441 |
Schistosoma mansoni | thyroid hormone receptor | 0.0156 | 0.5558 | 1 |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0076 | 0.2468 | 0.4441 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0145 | 0.5112 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 0 | 0.5 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0044 | 0.1241 | 0.2232 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0044 | 0.1241 | 0.2427 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0156 | 0.5558 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 0 | 0.5 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0076 | 0.2468 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0145 | 0.5112 | 0.9197 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0145 | 0.5112 | 0.9197 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0076 | 0.2468 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0156 | 0.5558 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0272 | 1 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0076 | 0.2468 | 0.2468 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 92 % | Displacement of radioligand from human CB1 receptor expressed in HEK293 cells at 10 uM | ChEMBL. | 18083560 |
Inhibition (binding) | = 92 % | Displacement of radioligand from human CB1 receptor expressed in HEK293 cells at 10 uM | ChEMBL. | 18083560 |
Ki (binding) | = 198 nM | Displacement of radioligand from human CB1 receptor expressed in HEK293 cells | ChEMBL. | 18083560 |
Ki (binding) | = 198 nM | Displacement of radioligand from human CB1 receptor expressed in HEK293 cells | ChEMBL. | 18083560 |
Ki (binding) | = 6000 nM | Displacement of radioligand from human CB2 receptor expressed in HEK293 cells | ChEMBL. | 18083560 |
Ki (binding) | = 6000 nM | Displacement of radioligand from human CB2 receptor expressed in HEK293 cells | ChEMBL. | 18083560 |
Ratio Ki (binding) | = 30 | Selectivity ratio, Ki for human CB2 receptor to Ki for human CB1 receptor | ChEMBL. | 18083560 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.