Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0218 | 1 | 1 |
Onchocerca volvulus | 0.0063 | 0.1298 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1298 | 0.1298 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.1298 | 0.127 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.1298 | 0.127 |
Echinococcus multilocularis | peroxidasin | 0.0063 | 0.1298 | 0.127 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1298 | 0.1298 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0218 | 1 | 0.5 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0218 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0063 | 0.1298 | 0.127 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0218 | 1 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0218 | 1 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0218 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1298 | 0.1298 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0218 | 1 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0218 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1298 | 0.1298 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0218 | 1 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0063 | 0.1298 | 0.5 |
Leishmania major | fk506-binding protein 1-like protein | 0.0218 | 1 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0218 | 1 | 1 |
Schistosoma mansoni | immunophilin | 0.0218 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1298 | 0.1298 |
Brugia malayi | Blistered cuticle protein 3 | 0.0063 | 0.1298 | 0.127 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0218 | 1 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0218 | 1 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0218 | 1 | 1 |
Schistosoma mansoni | immunophilin | 0.0188 | 0.831 | 0.8305 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0218 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0063 | 0.1298 | 0.5 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0218 | 1 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0063 | 0.1298 | 0.127 |
Brugia malayi | Peroxidasin | 0.0063 | 0.1298 | 0.127 |
Schistosoma mansoni | immunophilin | 0.0218 | 1 | 1 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0218 | 1 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0063 | 0.1298 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1298 | 0.1298 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1298 | 0.1298 |
Onchocerca volvulus | 0.0063 | 0.1298 | 0.5 | |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0218 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.1298 | 0.127 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.1298 | 0.1298 |
Onchocerca volvulus | Peroxidasin homolog | 0.0063 | 0.1298 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0063 | 0.1298 | 0.1298 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0218 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1298 | 0.1298 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.1298 | 0.1298 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.831 | 0.831 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0218 | 1 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0188 | 0.831 | 0.8305 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.1298 | 0.1298 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1298 | 0.1298 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1298 | 0.1298 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0218 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0063 | 0.1298 | 0.127 |
Toxoplasma gondii | protein phosphatase 2B catalytic subunit, calcineurin family phosphatse superfamily protein | 0.0041 | 0.0033 | 0.5 |
Echinococcus multilocularis | fk506 binding protein | 0.0218 | 1 | 1 |
Loa Loa (eye worm) | FKBP5 protein | 0.0218 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.1298 | 0.127 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0033 | 0.0033 |
Trichomonas vaginalis | immunophilin, putative | 0.0218 | 1 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0188 | 0.831 | 0.8305 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.1298 | 0.127 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1298 | 0.1298 |
Onchocerca volvulus | Peroxidase homolog | 0.0063 | 0.1298 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0063 | 0.1298 | 0.127 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1298 | 0.1298 |
Onchocerca volvulus | Peroxidase homolog | 0.0063 | 0.1298 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.1298 | 0.1298 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0218 | 1 | 0.5 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0218 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1298 | 0.1298 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0218 | 1 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0218 | 1 | 1 |
Onchocerca volvulus | 0.0063 | 0.1298 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1298 | 0.1298 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.02 uM | Inhibition of human purified Prostaglandin G/H synthase 2 | ChEMBL. | 11906292 |
IC50 (binding) | = 0.02 uM | Inhibition of human purified Prostaglandin G/H synthase 2 | ChEMBL. | 11906292 |
IC50 (binding) | = 0.024 uM | In vitro inhibitory activity of the compound towards human recombinant Prostaglandin G/H synthase 2 enzyme | ChEMBL. | 11738574 |
IC50 (binding) | = 0.024 uM | In vitro inhibitory activity of the compound towards human recombinant Prostaglandin G/H synthase 2 enzyme | ChEMBL. | 11738574 |
IC50 (binding) | = 4.7 uM | In vitro inhibitory activity of the compound towards human platelet recombinant Prostaglandin G/H synthase 1 | ChEMBL. | 11738574 |
IC50 (binding) | = 4.7 uM | In vitro inhibitory activity of the compound towards human platelet recombinant Prostaglandin G/H synthase 1 | ChEMBL. | 11738574 |
IC50 (binding) | = 5 uM | Inhibition of human purified Prostaglandin G/H synthase 1 | ChEMBL. | 11906292 |
IC50 (binding) | = 5 uM | Inhibition of human purified Prostaglandin G/H synthase 1 | ChEMBL. | 11906292 |
Ratio (binding) | = 250 | Selectivity ratio for COX-1 over COX-2 | ChEMBL. | 11906292 |
Ratio (binding) | = 250 | Selectivity ratio for COX-1 over COX-2 | ChEMBL. | 11906292 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.