Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Dihydrofolate reductase | 0.1478 | 1 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0107 | 0.0511 | 0.0108 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0158 | 0.0862 | 0.1258 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0107 | 0.0511 | 0.0108 |
Leishmania major | pteridine reductase 1 | 0.0192 | 0.1102 | 0.1608 |
Schistosoma mansoni | dihydrofolate reductase | 0.1478 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1024 | 0.6857 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1478 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1024 | 0.6857 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0332 | 0.2066 | 0.173 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0107 | 0.0511 | 0.5921 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0332 | 0.2066 | 0.1317 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1478 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.0332 | 0.2066 | 0.1639 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0107 | 0.0511 | 0.0108 |
Trypanosoma brucei | pteridine reductase 1 | 0.019 | 0.1085 | 0.1582 |
Loa Loa (eye worm) | thymidylate synthase | 0.0332 | 0.2066 | 0.1639 |
Onchocerca volvulus | 0.0332 | 0.2066 | 0.5 | |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1478 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1024 | 0.6857 | 1 |
Brugia malayi | hypothetical protein | 0.0158 | 0.0862 | 0.0371 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1478 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0107 | 0.0511 | 0.0108 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0332 | 0.2066 | 0.1639 |
Echinococcus granulosus | dihydrofolate reductase | 0.1478 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1478 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0107 | 0.0511 | 0.0108 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1024 | 0.6857 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0332 | 0.2066 | 0.173 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1024 | 0.6857 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1478 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0158 | 0.0862 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1024 | 0.6857 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0107 | 0.0511 | 0.0108 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0107 | 0.0511 | 0.0108 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0107 | 0.0511 | 0.0108 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MED (functional) | = 1 mg kg-1 | Antiamnesic activity in sc dosed mouse after 30 mins by passive avoidance test | ChEMBL. | 17981042 |
MED (functional) | = 1 mg kg-1 | Antiamnesic activity in sc dosed mouse after 30 mins by passive avoidance test | ChEMBL. | 17981042 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.