Detailed information for compound 518979

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 512.917 | Formula: C25H22ClFN4O5
  • H donors: 2 H acceptors: 4 LogP: 4.09 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 2
  • SMILES: Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)c1c(F)cc2c3c1OCC(n3cc(c2=O)C(=O)O)C
  • InChi: 1S/C25H22ClFN4O5/c1-12-11-36-23-20-15(22(32)16(24(33)34)10-30(12)20)9-17(27)21(23)29-6-4-14(5-7-29)31-19-3-2-13(26)8-18(19)28-25(31)35/h2-3,8-10,12,14H,4-7,11H2,1H3,(H,28,35)(H,33,34)
  • InChiKey: RJAQXJBKKRQRDS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0119 0.0119
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0258 0.0258
Plasmodium falciparum ferrodoxin reductase-like protein 0.0012 0.0017 0.0027
Trichomonas vaginalis apoptosis inducing factor, putative 0.0012 0.0017 0.0014
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0306 0.3635 0.3624
Loa Loa (eye worm) CYP4Cod1 0.0013 0.0025 0.0025
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0119 0.019
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0201 0.0648
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.01 0.01
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0647 0.5053
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0012 0.0017 0.0027
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0052 0.0052
Mycobacterium ulcerans 6-phosphofructokinase 0.0113 0.1262 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.01 0.0083
Brugia malayi hypothetical protein 0.0149 0.1698 0.1698
Echinococcus multilocularis thyroid hormone receptor alpha 0.0152 0.1735 0.1735
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.01 0.0083
Trypanosoma brucei trypanothione reductase 0.0133 0.1502 0.1487
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0046 0.0433 0.0417
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0012 0.0017 0.0017
Schistosoma mansoni lamin 0.0028 0.0213 0.0213
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0025 0.0025
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0306 0.3635 0.3627
Echinococcus multilocularis lamin 0.0028 0.0213 0.0213
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0119 0.0119
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0025 0.0025
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0244 0.0231
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0012 0.0017 0.0004
Toxoplasma gondii selenide, water dikinase 0.0012 0.0017 0.0004
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0058 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0119 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0368 0.1223
Onchocerca volvulus 0.0028 0.0213 0.0361
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0012 0.0017 0.0014
Echinococcus granulosus chromobox protein 1 0.0073 0.0761 0.0761
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.01 0.0083
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0244 0.0795
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0201 0.0188
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0244 0.0231
Schistosoma mansoni sulfide quinone reductase 0.0012 0.0017 0.0017
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0034 0.0034
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0046 0.0433 0.2822
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0028 0.0207 0.0207
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0119 0.0119
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0303 0.3596 0.8958
Brugia malayi glutathione reductase 0.0133 0.1502 0.1502
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.1262 0.4304
Schistosoma mansoni coup transcription factor 0.002 0.0119 0.0119
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0213 0.0213
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0012 0.0017 0.0014
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.01 0.0664
Brugia malayi hypothetical protein 0.0012 0.0015 0.0015
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0052 0.0052
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0119 0.0119
Brugia malayi Cytochrome P450 family protein 0.0013 0.0025 0.0025
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.01 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0119 0.0119
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0647 0.0634
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.1262 0.1262
Plasmodium falciparum flap endonuclease 1 0.0027 0.0201 0.1263
Echinococcus granulosus death domain containing protein 0.0015 0.0052 0.0052
Echinococcus multilocularis thioredoxin glutathione reductase 0.0133 0.1508 0.1508
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.1262 0.4304
Echinococcus granulosus 6 phosphofructokinase 0.0113 0.1262 0.1262
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0822 1 1
Echinococcus multilocularis Ankyrin 0.0015 0.0053 0.0053
Loa Loa (eye worm) phosphofructokinase 0.0113 0.1262 0.1262
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0119 0.0119
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.01 0.0207
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0433 0.0417
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0647 0.5053
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0647 0.0647
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0119 0.0119
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0119 0.0119
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0058 0.0058
Echinococcus granulosus nuclear factor of activated T cells 5 0.0077 0.0812 0.0812
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0058 0.0041
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0244 0.5447
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0012 0.0017 0.0017
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0046 0.0433 0.0417
Brugia malayi nuclear hormone receptor 0.002 0.0119 0.0119
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.4805 0.4805
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.01 0.0083
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0058 0.0058
Brugia malayi SET domain containing protein 0.0014 0.0035 0.0035
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0034 0.0034
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.01 0.0083
Schistosoma mansoni cpg binding protein 0.003 0.0233 0.0233
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0368 0.1223
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0119 0.0119
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0058 0.0303
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0244 0.5447
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0058 0.0045
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0647 0.063
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0012 0.0017 0.0032
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0419 0.0419
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0034 0.0283 0.0283
Trypanosoma brucei unspecified product 0.0013 0.0028 0.001
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0647 0.0647
Trichomonas vaginalis mercuric reductase, putative 0.0046 0.0433 0.1447
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0053 0.0053
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0647 0.5053
Loa Loa (eye worm) runx1 0.0058 0.058 0.058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0119 0.0119
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.01 0.0083
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0244 0.155
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0822 1 1
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0012 0.0017 0.0017
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0012 0.0017 0.0014
Brugia malayi hypothetical protein 0.0461 0.5553 0.5553
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.1262 0.1247
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0119
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0433 0.0417
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Echinococcus multilocularis musashi 0.0028 0.0213 0.0213
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0486 0.0486
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0058 0.0058
Onchocerca volvulus 0.005 0.0486 0.0853
Echinococcus granulosus dna polymerase eta 0.0019 0.01 0.01
Echinococcus granulosus lamin 0.0028 0.0213 0.0213
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.01 0.0207
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0056 0.0145
Loa Loa (eye worm) helicase 0.0012 0.0013 0.0013
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.01 0.0083
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0336 0.4012 1
Echinococcus multilocularis dna polymerase eta 0.0019 0.01 0.01
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0406 0.1354
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0222 0.0719
Onchocerca volvulus 0.0028 0.0213 0.0361
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.01 0.01
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0133 0.1502 0.3716
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0046 0.0433 0.0417
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0258 0.0258
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0046 0.0433 0.0433
Onchocerca volvulus 0.0247 0.2917 0.5241
Leishmania major ATP-dependent phosphofructokinase 0.0113 0.1262 0.1247
Schistosoma mansoni glutamate synthase 0.0012 0.0017 0.0017
Brugia malayi CHD4 protein 0.0013 0.0033 0.0033
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0058 0.0041
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0119 0.0119
Schistosoma mansoni hypothetical protein 0.0012 0.0017 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0028 0.001
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0092 0.0271
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0131 0.1483 0.1483
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0119 0.0119
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.1262 0.1262
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0025 0.0008
Brugia malayi ecdysteroid receptor 0.002 0.0119 0.0119
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0303 0.3596 0.8958
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0201 0.1505
Schistosoma mansoni chromobox protein 0.0073 0.0761 0.0761
Treponema pallidum NADH oxidase 0.0046 0.0433 0.3342
Echinococcus granulosus lamin dm0 0.0028 0.0213 0.0213
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0119 0.0119
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0058 0.0041
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0052 0.0069
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0034 0.0283 0.0283
Brugia malayi Protein cec-1. 0.0012 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0119
Echinococcus granulosus neuropeptide s receptor 0.0483 0.5824 0.5824
Echinococcus multilocularis Protein lozenge 0.0058 0.058 0.058
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0046 0.0433 0.2822
Plasmodium falciparum thioredoxin reductase 0.0046 0.0433 0.2822
Schistosoma mansoni survival motor neuron protein 0.005 0.0486 0.0486
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0119 0.0119
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0419 0.0419
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0046 0.0433 0.0417
Loa Loa (eye worm) hypothetical protein 0.0032 0.0258 0.0258
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0046 0.0433 0.0433
Schistosoma mansoni sulfide quinone reductase 0.0012 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0028
Echinococcus multilocularis chromobox protein 1 0.0073 0.0761 0.0761
Echinococcus granulosus flap endonuclease 1 0.0027 0.0201 0.0201
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0244 0.2871 0.2871
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0201 0.0184
Onchocerca volvulus 0.0012 0.0017 0.0007
Schistosoma mansoni flap endonuclease-1 0.0025 0.0169 0.0169
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0433 0.0417
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0028
Echinococcus granulosus cpg binding protein 0.003 0.0233 0.0233
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0822 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.01 0.0083
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0761 0.2578
Echinococcus granulosus intermediate filament protein 0.0028 0.0213 0.0213
Trypanosoma cruzi trypanothione reductase, putative 0.0133 0.1502 0.1487
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0046 0.0433 0.1042
Leishmania major 0.0822 1 1
Schistosoma mansoni hypothetical protein 0.0131 0.1483 0.1483
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0058 0.0058
Brugia malayi follicle stimulating hormone receptor 0.0244 0.2871 0.2871
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0433 0.0417
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0012 0.0017 0.0017
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0058 0.0058
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0046 0.0433 0.2822
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.01 0.01
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.01 0.0083
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.1262 1
Plasmodium vivax SET domain protein, putative 0.0032 0.0258 0.1642
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0419 0.0419
Schistosoma mansoni hypothetical protein 0.005 0.0486 0.0486
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.1262 0.1262
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0058 0.0058
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0761 0.2578
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0113 0.1262 1
Echinococcus granulosus chromobox protein 2 0.0012 0.0013 0.0013
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0012 0.0017 0.0014
Onchocerca volvulus 0.002 0.0119 0.019
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0015 0.0053 0.0053
Echinococcus multilocularis cpg binding protein 0.003 0.0233 0.0233
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0013 0.0013
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0119 0.0119
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0046 0.0433 0.0433
Loa Loa (eye worm) hypothetical protein 0.0015 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0051 0.0494 0.0494
Echinococcus granulosus FTZ F1 alpha 0.002 0.0119 0.0119
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0119 0.0119
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0077 0.0812 0.0812
Brugia malayi intermediate filament protein 0.0028 0.0213 0.0213
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0214 0.0214
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0119 0.0119
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0033 0.0033
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0012 0.0017 0.0017
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0046 0.0433 1
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0058 0.0045
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0046 0.0433 0.0421
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0119 0.0119
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0119 0.0119
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0433 0.0417
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0201 0.0201
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0119 0.019
Trypanosoma brucei unspecified product 0.0013 0.0028 0.001
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.0761 0.0761
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0246 0.2903 0.2903
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0025 0.0008
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0046 0.0433 0.2822
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0119 0.0119
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0012 0.0017 0.0014
Schistosoma mansoni chromobox protein 0.0012 0.0013 0.0013
Brugia malayi Protein kinase domain containing protein 0.0015 0.0052 0.0052
Brugia malayi Pre-SET motif family protein 0.0217 0.2547 0.2547
Toxoplasma gondii NADPH-glutathione reductase 0.0046 0.0433 0.0421
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.01 0.0298
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0052 0.0052
Trichomonas vaginalis glutamate synthase, putative 0.0012 0.0017 0.0014
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0012 0.0017 0.0004
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0012 0.0017 0.0032
Plasmodium falciparum thioredoxin reductase 0.0133 0.1502 1
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0244 0.0795
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0052 0.0052
Echinococcus granulosus dnaJ subfamily B 0.0401 0.4805 0.4805
Loa Loa (eye worm) thioredoxin reductase 0.0133 0.1502 0.1502
Schistosoma mansoni hypothetical protein 0.0015 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.026
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.2547 0.2547
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0303 0.3596 0.8958
Schistosoma mansoni lamin 0.0028 0.0213 0.0213
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0092 0.0271
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.1262 0.4304
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0092 0.0271
Echinococcus granulosus Chromo domain 0.0012 0.0013 0.0013
Loa Loa (eye worm) programmed cell death 8 0.0012 0.0017 0.0017
Brugia malayi glutamate synthase 0.0012 0.0017 0.0017
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.01 0.0298
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0258 0.0258
Plasmodium vivax ferrodoxin reductase, putative 0.0012 0.0017 0.0027
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0617 0.0617
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0046 0.0433 0.3342
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0244 0.0231
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0013 0.0025 0.0061
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0822 1 1
Brugia malayi Pre-SET motif family protein 0.0032 0.0258 0.0258
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0244 0.0795
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0119
Trichomonas vaginalis glutamate synthase, putative 0.0012 0.0017 0.0014
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0822 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0401 0.4805 0.4805
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0058 0.0041
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0419 0.0419
Brugia malayi Heterochromatin protein 1 0.0073 0.0761 0.0761
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0012 0.0017 0.0014
Loa Loa (eye worm) hypothetical protein 0.0149 0.1698 0.1698
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0013 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.01 0.0083
Brugia malayi Thioredoxin reductase 0.0133 0.1502 0.1502
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.01 0.0083
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.01 0.0083
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.1262 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0046 0.0433 0.3342
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0119
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0012 0.0017 0.0017
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0306 0.3635 0.3624
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0119 0.0119
Trichomonas vaginalis glutathione reductase, putative 0.0046 0.0433 0.1447
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0303 0.3596 0.8958
Leishmania major DNA polymerase kappa, putative 0.0019 0.01 0.0083
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0012 0.0017 0.0027
Toxoplasma gondii fructose-bisphospatase II 0.0822 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.1262 0.4304
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0336 0.4012 1
Echinococcus granulosus neuropeptide receptor A26 0.0483 0.5824 0.5824
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0012 0.0017 0.0017
Schistosoma mansoni glutamate synthase 0.0012 0.0017 0.0017
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0119 0.0119
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0019 0.01 0.01
Echinococcus granulosus glutamate synthase 0.0012 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Echinococcus multilocularis glutamate synthase 0.0012 0.0017 0.0017
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0013 0.0013
Echinococcus multilocularis survival motor neuron protein 1 0.0246 0.2903 0.2903
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0046 0.0433 0.0417
Onchocerca volvulus 0.0461 0.5553 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.005 0.0125
Onchocerca volvulus 0.0032 0.026 0.0445
Onchocerca volvulus 0.0012 0.0013 0.000000048293
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0046 0.0433 0.0433
Schistosoma mansoni chromobox protein 0.0073 0.0761 0.0761
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0822 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0028 0.001
Brugia malayi Flap endonuclease-1 0.0027 0.0201 0.0201
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0119 0.0119
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0046 0.0433 0.0417
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0052 0.0052
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.01 0.0083
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0012 0.0017 0.0017
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0013 0.0013
Echinococcus multilocularis dna polymerase kappa 0.0019 0.01 0.01
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0058 0.0303
Leishmania major DNA polymerase eta, putative 0.0019 0.01 0.0083
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Echinococcus multilocularis 6 phosphofructokinase 0.0113 0.1262 0.1262
Brugia malayi nuclear receptor NHR-88 0.002 0.0119 0.0119
Entamoeba histolytica thioredoxin reductase, putative 0.0012 0.0017 0.0032
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0419 0.0419
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0012 0.0017 0.0027
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0119 0.0119
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0012 0.0017 0.0014
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0013 0.0013
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0013 0.0013
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0244 0.0795
Loa Loa (eye worm) hypothetical protein 0.0461 0.5553 0.5553
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0244 0.1846
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0056 0.0145
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0119 0.0119
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0306 0.3635 0.3624
Brugia malayi steroid hormone receptor 0.002 0.0119 0.0119
Brugia malayi 6-phosphofructokinase 0.0113 0.1262 0.1262
Mycobacterium tuberculosis Probable oxidoreductase 0.0336 0.4012 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0119 0.0119
Echinococcus multilocularis lamin dm0 0.0028 0.0213 0.0213
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0046 0.0433 0.0417
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0201 0.0184
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0013 0.0013
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0244 0.0795
Leishmania major trypanothione reductase 0.0133 0.1502 0.1487
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0647 0.1575
Schistosoma mansoni hypothetical protein 0.0012 0.0013 0.0013
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0012 0.0017 0.0017
Brugia malayi Uncoordinated protein 44 0.0015 0.0052 0.0052
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0119 0.0119
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.01 0.01
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0119 0.0119
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0012 0.0017 0.0017
Brugia malayi phosphofructokinase 0.0113 0.1262 0.1262
Echinococcus multilocularis neuropeptide s receptor 0.0483 0.5824 0.5824
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0012 0.0017 0.0027
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0244 0.155
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0244 0.155
Giardia lamblia DINP protein human, muc B family 0.0019 0.01 0.1986
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0092 0.0271
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0119 0.0119
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0028 0.001
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0113 0.1262 0.3117
Echinococcus granulosus thioredoxin glutathione reductase 0.0133 0.1508 0.1508
Brugia malayi 6-phosphofructokinase 0.0113 0.1262 0.1262
Echinococcus multilocularis neuropeptide receptor A26 0.0483 0.5824 0.5824
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0119 0.0119
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0336 0.4012 1
Onchocerca volvulus 0.0044 0.0404 0.0705
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0058 0.0058
Echinococcus granulosus survival motor neuron protein 1 0.0246 0.2903 0.2903
Loa Loa (eye worm) glutathione reductase 0.0133 0.1502 0.1502
Schistosoma mansoni lozenge 0.0058 0.058 0.058
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0222 0.0719
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0092 0.0271
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0213 0.0213
Schistosoma mansoni disulfide oxidoreductase 0.0012 0.0017 0.0017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0119 0.0119
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0244 0.5447
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0012 0.0017 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0119 0.0119
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.1262 1
Schistosoma mansoni chromobox protein 0.0012 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0119 0.0119
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0406 0.1354
Toxoplasma gondii thioredoxin reductase 0.0133 0.1502 0.149
Echinococcus multilocularis chromobox protein 2 0.0012 0.0013 0.0013
Onchocerca volvulus 0.0028 0.0214 0.0362
Trypanosoma brucei unspecified product 0.0019 0.01 0.0083
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0012 0.0017 0.0004
Brugia malayi Cytochrome P450 family protein 0.0013 0.0025 0.0025
Echinococcus granulosus Ankyrin 0.0015 0.0053 0.0053
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0119 0.0119
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0822 1 1
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0119
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0012 0.0017 0.0017
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0033 0.0033
Schistosoma mansoni netrin receptor unc5 0.0015 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0041 0.0368 0.0368
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0244 0.0795
Schistosoma mansoni thyroid hormone receptor 0.0152 0.1735 0.1735
Brugia malayi Death domain containing protein 0.0015 0.0052 0.0052
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0119 0.019
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0119 0.0119
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0046 0.0433 1
Schistosoma mansoni cpg binding protein 0.0028 0.0214 0.0214
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0236 0.0236
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0012 0.0017 0.0032
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0012 0.0017 0.0014
Loa Loa (eye worm) hypothetical protein 0.0028 0.0213 0.0213
Schistosoma mansoni nuclear hormone receptor 0.002 0.0119 0.0119
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0012 0.0017 0.0004
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0647 0.0647
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0119 0.0119
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.01 0.0664
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0119 0.0119
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0046 0.0433 0.0417
Schistosoma mansoni glutamate synthase 0.0012 0.0017 0.0017
Leishmania major cytochrome p450-like protein 0.0013 0.0025 0.0008
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0119
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0419 0.0419
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0244 0.0795
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0033 0.0033
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0012 0.0017 0.0017
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.01 0.0693
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.01 0.0083
Echinococcus granulosus Chromobox protein 3 0.0012 0.0013 0.0013
Mycobacterium tuberculosis Probable reductase 0.0303 0.3596 0.8958
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0012 0.0017 0.0032
Echinococcus multilocularis Chromo domain 0.0012 0.0013 0.0013
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0052 0.0052
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0012 0.0017 0.0017
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0131 0.1483 0.1483
Echinococcus granulosus dna polymerase kappa 0.0019 0.01 0.01
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0201 0.0184
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0012 0.0017 0.0017
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.01 0.01
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0012 0.0017 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.01 0.0083
Schistosoma mansoni cpg binding protein 0.003 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0034
Trichomonas vaginalis set domain proteins, putative 0.0247 0.2916 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0406 0.071
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0258 0.0258
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0119 0.0119
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0419 0.0419
Echinococcus multilocularis chromobox protein 1 0.0073 0.0761 0.0761
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0404 0.0404
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0012 0.0017 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0119 0.0119
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0046 0.0433 0.0417
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0052 0.0052
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0017
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0119 0.0119
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0012 0.0017 0.0032
Giardia lamblia NADH oxidase lateral transfer candidate 0.0046 0.0433 1
Schistosoma mansoni thyroid hormone receptor 0.0152 0.1735 0.1735
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0058 0.0058
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0119 0.0119
Plasmodium falciparum glutathione reductase 0.0133 0.1502 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.01 0.01
Brugia malayi hypothetical protein 0.0246 0.2903 0.2903
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.1262 0.1262
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0213 0.0213
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0119 0.0119
Mycobacterium tuberculosis Probable dehydrogenase 0.0303 0.3596 0.8958
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0461 0.5553 0.5553
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0119 0.0119
Onchocerca volvulus 0.0149 0.1698 0.304
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0012 0.0017 0.0004
Echinococcus granulosus chromobox protein 1 0.0073 0.0761 0.0761
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0258 0.0258
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0258 0.0245
Trypanosoma brucei cytochrome P450, putative 0.0013 0.0025 0.0008
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.1262 0.1247
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0046 0.0433 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0012 0.0017 0.0017
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0303 0.3596 0.8958
Plasmodium vivax glutathione reductase, putative 0.0133 0.1502 1
Schistosoma mansoni intermediate filament proteins 0.0028 0.0213 0.0213
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0033 0.0033
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0052 0.0052
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0201 0.4421
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0092 0.0271
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0119 0.0119
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0046 0.0433 0.0417
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0368 0.0641
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0244 0.155
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0092 0.0271
Brugia malayi chromobox protein homolog 3 0.0041 0.0368 0.0368
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0013 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0258 0.0258
Brugia malayi CXXC zinc finger family protein 0.0028 0.0214 0.0214
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0113 0.1262 0.3117
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0419 0.0419
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0058 0.0041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0419 0.0419
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0046 0.0433 0.3342
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0119 0.0119
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0433 0.0417
Entamoeba histolytica disulphide oxidoreductase, putative 0.0012 0.0017 0.0032
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0058 0.0103
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.01 0.0083
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0244 0.182
Schistosoma mansoni DNA polymerase eta 0.0019 0.01 0.01
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0092 0.0271
Plasmodium vivax thioredoxin reductase, putative 0.0133 0.1502 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0647 0.0647
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0201 0.1263
Plasmodium falciparum glutathione reductase 0.0046 0.0433 0.2822
Brugia malayi isocitrate dehydrogenase 0.0016 0.0058 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.01 0.0083
Toxoplasma gondii fructose-bisphospatase I 0.0306 0.3635 0.3627
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0119
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0433 0.0417
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0538 0.0525
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.01 0.0083
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.01 0.0083

Activities

Activity type Activity value Assay description Source Reference
IC50 (ADMET) > 121.85 uM Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay ChEMBL. 18068979
MIC99 (functional) = 0.76 uM Antimycobacterial activity against multidrug resistant Mycobacterium tuberculosis by agar dilution method ChEMBL. 18068979
MIC99 (functional) = 0.76 uM Antimycobacterial activity against multidrug resistant Mycobacterium tuberculosis by agar dilution method ChEMBL. 18068979
MIC99 (functional) = 1.52 uM Antimycobacterial activity against Mycobacterium tuberculosis H37Rv by agar dilution method ChEMBL. 18068979
MIC99 (functional) = 1.52 uM Antimycobacterial activity against Mycobacterium tuberculosis H37Rv by agar dilution method ChEMBL. 18068979
MIC99 (functional) = 48.74 uM Antimycobacterial activity against Mycobacterium smegmatis ATCC 14468 by agar dilution method ChEMBL. 18068979

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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