Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | References |
Homo sapiens | histamine receptor H1 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | dopamine receptor D3 | 400 aa | 392 aa | 19.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | adenosine deaminase | 0.0264 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1172 | 0.1172 |
Schistosoma mansoni | adenosine deaminase-related | 0.0264 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.1403 | 0.1403 |
Trypanosoma cruzi | AMP deaminase 2, putative | 0.0086 | 0.3024 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0086 | 0.3024 | 0.5 |
Mycobacterium ulcerans | adenosine deaminase | 0.0264 | 1 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.0264 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.663 | 0.663 |
Schistosoma mansoni | adenosine deaminase | 0.0264 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.3024 | 0.3024 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.1564 | 0.1564 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0086 | 0.3024 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.663 | 0.663 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.1403 | 0.1403 |
Loa Loa (eye worm) | AMP deaminase | 0.0086 | 0.3024 | 0.3024 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0161 | 0.0161 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0264 | 1 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.1403 | 0.1403 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0264 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.0264 | 1 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.1288 | 0.1288 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0013 | 0.0161 | 0.0161 |
Echinococcus granulosus | voltage gated potassium channel | 0.0013 | 0.0161 | 0.0161 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.0086 | 0.3024 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0161 | 0.0161 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0264 | 1 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0264 | 1 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.0264 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.0086 | 0.3024 | 0.5 |
Leishmania major | adenine aminohydrolase | 0.0264 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.1288 | 0.1288 |
Brugia malayi | adenosine monophosphate deaminase | 0.0086 | 0.3024 | 0.3024 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.663 | 0.663 |
Schistosoma mansoni | AMP deaminase | 0.0086 | 0.3024 | 0.3024 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0013 | 0.0161 | 0.0161 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0264 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0264 | 1 | 1 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.0086 | 0.3024 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0013 | 0.0161 | 0.0161 |
Plasmodium falciparum | adenosine deaminase | 0.0264 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.0086 | 0.3024 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0161 | 0.0161 |
Echinococcus granulosus | AMP deaminase 2 | 0.0086 | 0.3024 | 0.3024 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.663 | 0.663 |
Echinococcus multilocularis | AMP deaminase 2 | 0.0086 | 0.3024 | 0.3024 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.1564 | 0.1564 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0264 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0086 | 0.3024 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.0086 | 0.3024 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0264 | 1 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0264 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0086 | 0.3024 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0086 | 0.3024 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.0086 | 0.3024 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.1403 | 0.1403 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0013 | 0.0161 | 0.0161 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = -6.8 | Inhibition of human ERG | ChEMBL. | 18178090 |
Ki (functional) | = -8.7 | Antagonist activity at dopamine D3 receptor (unknown origin) by GTPgammaS binding assay | ChEMBL. | 18178090 |
Ki (functional) | < -6.5 | Antagonist activity at dopamine D2 receptor (unknown origin) by GTPgammaS binding assay | ChEMBL. | 18178090 |
Ki (functional) | = -6.4 | Antagonist activity at histamine H1 receptor (unknown origin) by FLIPR assay | ChEMBL. | 18178090 |
Log IC50 (binding) | = 6.8 | Inhibition of human ERG | ChEMBL. | 18178090 |
Log Ki (functional) | = 6.4 | Antagonist activity at histamine H1 receptor (unknown origin) by FLIPR assay | ChEMBL. | 18178090 |
Log Ki (functional) | < 6.5 | Antagonist activity at dopamine D2 receptor (unknown origin) by GTPgammaS binding assay | ChEMBL. | 18178090 |
Log Ki (functional) | = 8.7 | Antagonist activity at dopamine D3 receptor (unknown origin) by GTPgammaS binding assay | ChEMBL. | 18178090 |
Selectivity ratio (binding) | = 100 | Selectivity for dopamine D3 receptor (unknown origin) over dopamine D2 receptor (unknown origin) | ChEMBL. | 18178090 |
Selectivity ratio (binding) | = 100 | Selectivity for dopamine D3 receptor (unknown origin) over histamine H1 receptor (unknown origin) | ChEMBL. | 18178090 |
Selectivity ratio (binding) | = 100 | Selectivity for dopamine D3 receptor (unknown origin) over human ERG (unknown origin) | ChEMBL. | 18178090 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.