Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Adenosine deaminase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Dictyostelium discoideum | adenosine deaminase-related growth factor | Adenosine deaminase | 363 aa | 299 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | adenosine deaminase, putative | 0.0104 | 1 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.0034 | 0.2188 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.0104 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.0034 | 0.2188 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0104 | 1 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0034 | 0.2188 | 0.5 |
Loa Loa (eye worm) | AMP deaminase | 0.0034 | 0.2188 | 0.2188 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0104 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase 2, putative | 0.0034 | 0.2188 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 1 | 1 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.0034 | 0.2188 | 0.5 |
Echinococcus multilocularis | adenosine deaminase | 0.0104 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0104 | 1 | 1 |
Echinococcus granulosus | adenosine deaminase | 0.0104 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.0104 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase-related | 0.0104 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0034 | 0.2188 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0104 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0104 | 1 | 1 |
Onchocerca volvulus | 0.0034 | 0.2188 | 0.2188 | |
Schistosoma mansoni | adenosine deaminase | 0.0104 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.6225 | 0.6225 |
Echinococcus granulosus | AMP deaminase 2 | 0.0034 | 0.2188 | 0.2188 |
Entamoeba histolytica | AMP deaminase, putative | 0.0034 | 0.2188 | 0.2188 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.6225 | 0.6225 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0034 | 0.2188 | 0.5 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.0034 | 0.2188 | 0.2188 |
Brugia malayi | adenosine monophosphate deaminase | 0.0034 | 0.2188 | 0.2188 |
Mycobacterium ulcerans | adenosine deaminase | 0.0104 | 1 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.0034 | 0.2188 | 0.5 |
Schistosoma mansoni | AMP deaminase | 0.0034 | 0.2188 | 0.2188 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0104 | 1 | 0.5 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0104 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.0034 | 0.2188 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.6225 | 0.6225 |
Echinococcus multilocularis | AMP deaminase 2 | 0.0034 | 0.2188 | 0.2188 |
Entamoeba histolytica | AMP deaminase, putative | 0.0034 | 0.2188 | 0.2188 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0034 | 0.2188 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.0034 | 0.2188 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.6225 | 0.6225 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0034 | 0.2188 | 0.5 |
Plasmodium falciparum | adenosine deaminase | 0.0104 | 1 | 1 |
Leishmania major | adenine aminohydrolase | 0.0104 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.2188 | 0.2188 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0104 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | > 7.5 uM | Inhibitory activity against calf intestinal Adenosine deaminase (ADA) | ChEMBL. | 10780907 |
Ki (binding) | > 7.5 uM | Inhibitory activity against calf intestinal Adenosine deaminase (ADA) | ChEMBL. | 10780907 |
Ki (binding) | = 18 uM | Inhibitory activity against porcine heart Adenylate deaminase (AMPDA) | ChEMBL. | 10780907 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.