Detailed information for compound 519067

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 466.599 | Formula: C24H30N6O2S
  • H donors: 0 H acceptors: 4 LogP: 4.17 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(c1nc2c(o1)cc1c(c2)CCN(CC1)CCCSc1nnc(n1C)c1ocnc1C)C
  • InChi: 1S/C24H30N6O2S/c1-15(2)23-26-19-12-17-6-9-30(10-7-18(17)13-20(19)32-23)8-5-11-33-24-28-27-22(29(24)4)21-16(3)25-14-31-21/h12-15H,5-11H2,1-4H3
  • InChiKey: GKDLNLYIGUXYSK-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histamine receptor H1 Starlite/ChEMBL References
Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 2 Starlite/ChEMBL References
Homo sapiens dopamine receptor D3 Starlite/ChEMBL References
Homo sapiens dopamine receptor D2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum Potassium voltage-gated channel subfamily H member 2, putative Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus multilocularis potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128858 All targets in OG5_128858
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog Get druggable targets OG5_128858 All targets in OG5_128858
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) voltage and ligand gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein dopamine receptor D3 400 aa 392 aa 19.9 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.016 0.577 1
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0013 0.0306 0.0306
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.016 0.577 0.577
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Trichomonas vaginalis D-aminoacylase, putative 0.0007 0.01 0.0086
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0022 0.064 0.1984
Loa Loa (eye worm) oxidoreductase 0.016 0.577 1
Brugia malayi GnHR receptor homolog 0.0012 0.0287 0.0424
Schistosoma mansoni steroid dehydrogenase 0.016 0.577 1
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.016 0.577 0.577
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0013 0.0302 0.0302
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0006 0.0051 0.0089
Echinococcus multilocularis glycine receptor subunit beta 0.0013 0.0306 0.0306
Leishmania major hypothetical protein, conserved 0.016 0.577 1
Echinococcus granulosus neuropeptide receptor A26 0.0012 0.0287 0.0287
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0187 0.0289
Schistosoma mansoni short chain dehydrogenase 0.016 0.577 1
Schistosoma mansoni short chain dehydrogenase 0.016 0.577 1
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.016 0.577 1
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Echinococcus granulosus histone lysine methyltransferase setb 0.0009 0.0181 0.0181
Loa Loa (eye worm) mbt repeat family protein 0.001 0.0187 0.0289
Schistosoma mansoni myosin xvIII 0.0012 0.0287 0.0497
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0006 0.0051 0.0089
Echinococcus multilocularis conserved hypothetical protein 0.016 0.577 0.577
Trypanosoma brucei short-chain dehydrogenase, putative 0.016 0.577 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0013 0.0306 0.0306
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.016 0.577 1
Leishmania major hypothetical protein, conserved 0.016 0.577 1
Echinococcus multilocularis neuropeptide s receptor 0.0012 0.0287 0.0287
Mycobacterium tuberculosis Probable lipase LipE 0.0007 0.01 0.0085
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.016 0.577 1
Trypanosoma cruzi trypanothione reductase, putative 0.0008 0.0113 0.0109
Brugia malayi Dehydrogenases, short chain protein 30 0.016 0.577 1
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Mycobacterium ulcerans beta-lactamase 0.0007 0.01 0.0085
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.016 0.577 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0009 0.0181 0.0313
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Trypanosoma cruzi hypothetical protein, conserved 0.016 0.577 1
Onchocerca volvulus 0.016 0.577 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.016 0.577 1
Leishmania major quinonoid dihydropteridine reductase 0.016 0.577 1
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.016 0.577 1
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0013 0.0306 0.0458
Plasmodium vivax metacaspase 1, putative 0.001 0.0212 0.0282
Loa Loa (eye worm) ACC-1 protein 0.0013 0.0306 0.0497
Brugia malayi beta-lactamase family protein 0.0007 0.01 0.0098
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0009 0.016 0.016
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0006 0.0051 0.0089
Onchocerca volvulus 0.0012 0.0287 0.0411
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0009 0.016 0.016
Brugia malayi Retinol dehydrogenase 12 0.016 0.577 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0015 0.0376 0.0376
Treponema pallidum exodeoxyribonuclease (exoA) 0.0015 0.0376 0.1094
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.016 0.577 1
Leishmania major metacaspase, putative 0.001 0.0212 0.0281
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.016 0.577 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0012 0.0287 0.0411
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0287 0.0497
Echinococcus multilocularis g-protein coupled receptor 0.0012 0.0287 0.0287
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0012 0.0287 0.0463
Treponema pallidum catabolite gene activator 0.0006 0.0051 0.0002
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0.0287 0.0287
Echinococcus multilocularis transient receptor potential cation channel 0.016 0.577 0.577
Echinococcus granulosus serotonin receptor 0.0012 0.0287 0.0287
Loa Loa (eye worm) dehydrogenase 0.016 0.577 1
Echinococcus multilocularis caspase 8 0.001 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Echinococcus granulosus glycine receptor subunit alpha 1 0.0013 0.0306 0.0306
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.001 0.0212 0.0212
Leishmania major quinonoid dihydropteridine reductase 0.016 0.577 1
Schistosoma mansoni nAChR subunit 0.0013 0.0306 0.0531
Echinococcus granulosus steroid dehydrogenase 0.016 0.577 0.577
Loa Loa (eye worm) hypothetical protein 0.016 0.577 1
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0006 0.0051 0.0051
Echinococcus multilocularis caspase 2 0.0034 0.1096 0.1096
Brugia malayi hypothetical protein 0.0012 0.0287 0.0424
Echinococcus granulosus 7tm_1 domain containing protein 0.0012 0.0287 0.0287
Toxoplasma gondii oxidoreductase, putative 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0287 0.0463
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0019 0.0545 0.0863
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0015 0.0376 0.0567
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0046 0.154 0.2604
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.016 0.577 1
Plasmodium falciparum steroid dehydrogenase, putative 0.016 0.577 1
Echinococcus multilocularis steroid dehydrogenase 0.016 0.577 0.577
Schistosoma mansoni short chain dehydrogenase 0.016 0.577 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.0376 0.0567
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0021 0.0606 0.1017
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0013 0.0306 0.0306
Echinococcus granulosus histone acetyltransferase KAT2B 0.0009 0.0167 0.0167
Echinococcus granulosus carbonyl reductase 1 0.016 0.577 0.577
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.016 0.577 1
Loa Loa (eye worm) TYRA-2 protein 0.0012 0.0287 0.0463
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0086 0.302 0.519
Brugia malayi hypothetical protein 0.0012 0.0287 0.0424
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Schistosoma mansoni short chain dehydrogenase 0.016 0.577 1
Schistosoma mansoni bromodomain containing protein 0.0013 0.0329 0.057
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0007 0.01 0.0173
Mycobacterium tuberculosis Probable oxidoreductase 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0029 0.0926 0.1605
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0009 0.016 0.0192
Echinococcus granulosus polycomb protein SCMH1 0.001 0.0187 0.0187
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.016 0.577 1
Schistosoma mansoni nAChR subunit 0.0013 0.0306 0.0531
Onchocerca volvulus 0.0012 0.0287 0.0411
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.016 0.577 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0287 0.0287
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0012 0.0287 0.0424
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0013 0.0312 0.0469
Echinococcus granulosus cGMP dependent protein kinase 1 0.0006 0.0059 0.0059
Loa Loa (eye worm) oxidoreductase 0.016 0.577 1
Mycobacterium ulcerans hypothetical protein 0.0007 0.01 0.0085
Leishmania major short chain dehydrogenase/reductase, putative 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Brugia malayi Dopamine receptor protein 2 0.0012 0.0287 0.0424
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0376 0.0568
Onchocerca volvulus 0.0007 0.01 0.0085
Schistosoma mansoni steroid dehydrogenase 0.016 0.577 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Onchocerca volvulus 0.016 0.577 1
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0013 0.0306 0.0497
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0021 0.0606 0.0606
Schistosoma mansoni adenoreceptor 0.0012 0.0287 0.0497
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Brugia malayi N-terminal motif family protein 0.0006 0.0051 0.0013
Echinococcus granulosus g protein coupled receptor 0.0012 0.0287 0.0287
Toxoplasma gondii exonuclease III APE 0.0015 0.0376 0.0568
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0009 0.016 0.0192
Schistosoma mansoni hypothetical protein 0.0024 0.0716 0.1241
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0306 0.0458
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0306 0.0458
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0006 0.0051 0.0089
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Echinococcus granulosus caspase 2 0.0034 0.1096 0.1096
Schistosoma mansoni amine GPCR 0.0012 0.0287 0.0497
Trypanosoma brucei cytochrome P450, putative 0.0007 0.0096 0.0079
Onchocerca volvulus 0.0007 0.01 0.0085
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0006 0.0051 0.0051
Loa Loa (eye worm) oxidoreductase 0.016 0.577 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0012 0.0287 0.0287
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.001 0.0212 0.0282
Trichomonas vaginalis short-chain dehydrogenase, putative 0.016 0.577 1
Echinococcus granulosus cGMP dependent protein kinase 1 0.0006 0.0059 0.0059
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0006 0.0051 0.0001
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0287 0.0287
Schistosoma mansoni sex comb on midleg homolog 0.001 0.0187 0.0324
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0287 0.0463
Echinococcus granulosus hypothetical protein 0.016 0.577 0.577
Loa Loa (eye worm) hypothetical protein 0.0007 0.01 0.0138
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.1489 0.1489
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.001 0.0187 0.0324
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Echinococcus granulosus oxidoreductase 0.016 0.577 0.577
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0012 0.0287 0.0463
Mycobacterium tuberculosis Probable oxidoreductase 0.016 0.577 1
Leishmania major short chain dehydrogenase-like protein 0.016 0.577 1
Leishmania major short chain dehydrogenase, putative 0.016 0.577 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0015 0.0376 0.0567
Brugia malayi Bromodomain containing protein 0.0008 0.0143 0.0174
Schistosoma mansoni nAChR subunit 0.0013 0.0306 0.0531
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0358 0.0586
Brugia malayi Dopamine receptor protein 1 0.0012 0.0287 0.0424
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0019 0.0545 0.0863
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.016 0.577 1
Echinococcus multilocularis carbonyl reductase 1 0.016 0.577 0.577
Mycobacterium ulcerans short-chain dehydrogenase 0.016 0.577 1
Leishmania major ATP-dependent phosphofructokinase 0.0022 0.064 0.1029
Onchocerca volvulus 0.0012 0.0287 0.0411
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.016 0.577 1
Trypanosoma cruzi short chain dehydrogenase, putative 0.016 0.577 1
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0287 0.0463
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0011 0.0236 0.0236
Leishmania major hypothetical protein, conserved 0.0007 0.01 0.0085
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0287 0.0497
Echinococcus multilocularis expressed conserved protein 0.0006 0.0059 0.0059
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0086 0.302 1
Echinococcus granulosus caspase 8 0.001 0.0212 0.0212
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.016 0.577 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.016 0.577 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0012 0.0287 0.0411
Brugia malayi neuropeptide F receptor 0.0012 0.0287 0.0424
Echinococcus granulosus sex peptide receptor 0.0012 0.0287 0.0287
Onchocerca volvulus 0.001 0.0187 0.0237
Mycobacterium ulcerans oxidoreductase 0.016 0.577 1
Plasmodium vivax hypothetical protein, conserved 0.016 0.577 1
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0013 0.0306 0.0458
Trypanosoma cruzi hypothetical protein, conserved 0.016 0.577 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Echinococcus multilocularis voltage gated potassium channel 0.0013 0.0312 0.0312
Trypanosoma brucei short-chain dehydrogenase, putative 0.016 0.577 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0013 0.0306 0.0306
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.016 0.577 1
Loa Loa (eye worm) oxidoreductase 0.016 0.577 1
Echinococcus granulosus zinc finger protein 0.0005 0.0004 0.0004
Plasmodium vivax hypothetical protein, conserved 0.0007 0.01 0.0086
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.016 0.577 0.577
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0212 0.0282
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.138 0.2324
Echinococcus granulosus nAChR subunit 0.0013 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Brugia malayi beta-lactamase family protein 0.0007 0.01 0.0098
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.001 0.0212 0.0282
Schistosoma mansoni hypothetical protein 0.0012 0.0287 0.0497
Schistosoma mansoni 6-phosphofructokinase 0.0022 0.064 0.1109
Schistosoma mansoni opsin-like receptor 0.0012 0.0287 0.0497
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0013 0.0306 0.0306
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Onchocerca volvulus 0.016 0.577 1
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.016 0.577 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0009 0.0167 0.0203
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0006 0.0051 0.0089
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0287 0.0287
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0287 0.0463
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.016 0.577 1
Echinococcus granulosus carbonyl reductase 1 0.016 0.577 0.577
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0012 0.0287 0.0497
Trypanosoma brucei metacaspase 0.001 0.0212 0.0281
Chlamydia trachomatis UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0086 0.302 0.5938
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0306 0.0458
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0021 0.0606 0.0606
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.016 0.577 1
Brugia malayi G protein-coupled receptor 0.0012 0.0287 0.0424
Onchocerca volvulus 0.0012 0.0287 0.0411
Plasmodium vivax steroid dehydrogenase, putative 0.016 0.577 1
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.016 0.577 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0012 0.0287 0.0287
Trypanosoma cruzi hypothetical protein, conserved 0.016 0.577 1
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.016 0.577 1
Brugia malayi beta-lactamase 0.0007 0.01 0.0098
Giardia lamblia Reductase, putative 0.016 0.577 1
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.016 0.577 1
Echinococcus granulosus carbonyl reductase 1 0.016 0.577 0.577
Trichomonas vaginalis D-aminoacylase, putative 0.0007 0.01 0.0086
Echinococcus multilocularis G protein coupled receptor 139 0.0012 0.0287 0.0287
Loa Loa (eye worm) oxidoreductase 0.016 0.577 1
Trichomonas vaginalis AGC family protein kinase 0.0021 0.0606 0.097
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0006 0.0054 0.0006
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0287 0.0287
Schistosoma mansoni ap endonuclease 0.0015 0.0376 0.0651
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.016 0.0278
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.001 0.0212 0.0212
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.016 0.577 1
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.016 0.577 1
Leishmania major short chain dehydrogenase/reductase, putative 0.016 0.577 1
Onchocerca volvulus 0.0012 0.0287 0.0411
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.016 0.577 1
Schistosoma mansoni serine/threonine protein kinase 0.0006 0.0059 0.0102
Brugia malayi oxidoreductase 0.016 0.577 1
Echinococcus granulosus G protein coupled receptor 139 0.0012 0.0287 0.0287
Trichomonas vaginalis steroid dehydrogenase, putative 0.016 0.577 1
Leishmania major quinonoid dihydropteridine reductase 0.016 0.577 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.016 0.577 1
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0287 0.0287
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0013 0.0306 0.0306
Onchocerca volvulus 0.0012 0.0287 0.0411
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0006 0.0051 0.0089
Trichomonas vaginalis penicillin-binding protein, putative 0.0007 0.01 0.0086
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0287 0.0287
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0006 0.0059 0.0059
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0287 0.0287
Leishmania major protein kinase, putative 0.0006 0.0059 0.0013
Schistosoma mansoni neuropeptide receptor 0.0012 0.0287 0.0497
Onchocerca volvulus 0.0012 0.0287 0.0411
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Schistosoma mansoni hypothetical protein 0.0006 0.0051 0.0089
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Onchocerca volvulus 0.0012 0.0287 0.0411
Schistosoma mansoni steroid dehydrogenase 0.016 0.577 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.016 0.577 1
Mycobacterium tuberculosis Probable oxidoreductase 0.016 0.577 1
Echinococcus multilocularis steroid dehydrogenase 0.016 0.577 0.577
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0012 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0009 0.016 0.0243
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0009 0.0181 0.0181
Echinococcus granulosus caspase 0.001 0.0212 0.0212
Schistosoma mansoni neuropeptide receptor 0.0012 0.0287 0.0497
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.016 0.577 0.577
Leishmania major quinonoid dihydropteridine reductase 0.016 0.577 1
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.016 0.577 1
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.016 0.577 1
Onchocerca volvulus 0.0013 0.0306 0.0446
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.016 0.577 1
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0022 0.064 0.1029
Loa Loa (eye worm) MBCTL1 0.0011 0.0236 0.0374
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.016 0.577 1
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0006 0.0051 0.0001
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0006 0.0051 0.0051
Mycobacterium ulcerans 6-phosphofructokinase 0.0022 0.064 0.1029
Trypanosoma cruzi cytochrome P450, putative 0.0007 0.0096 0.0079
Loa Loa (eye worm) hypothetical protein 0.0007 0.01 0.0138
Brugia malayi 6-phosphofructokinase 0.0022 0.064 0.104
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.016 0.577 1
Onchocerca volvulus 0.0012 0.0287 0.0411
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Onchocerca volvulus 0.016 0.577 1
Schistosoma mansoni serine/threonine protein kinase 0.0006 0.0059 0.0102
Plasmodium falciparum cGMP-dependent protein kinase 0.0006 0.0059 0.0014
Leishmania major 3-keto-dihydrosphingosine reductase 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0006 0.0051 0.0051
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.016 0.577 1
Mycobacterium ulcerans lipase LipD 0.0007 0.01 0.0085
Echinococcus granulosus glycine receptor subunit beta 0.0013 0.0306 0.0306
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0013 0.0306 0.0531
Brugia malayi Pre-SET motif family protein 0.0042 0.1378 0.233
Schistosoma mansoni short chain dehydrogenase 0.016 0.577 1
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.016 0.577 0.577
Brugia malayi Pre-SET motif family protein 0.0006 0.0054 0.0018
Schistosoma mansoni steroid dehydrogenase 0.016 0.577 1
Treponema pallidum cyclic nucleotide binding protein 0.0006 0.0051 0.0002
Loa Loa (eye worm) 6-phosphofructokinase 0.0022 0.064 0.1077
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0287 0.0287
Echinococcus granulosus 6 phosphofructokinase 0.0022 0.064 0.064
Onchocerca volvulus 0.016 0.577 1
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.1641 0.2844
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0012 0.0287 0.0497
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0007 0.0099 0.0099
Mycobacterium tuberculosis Possible ketoacyl reductase 0.016 0.577 1
Echinococcus multilocularis carbonyl reductase 1 0.016 0.577 0.577
Trypanosoma cruzi metacaspase, putative 0.001 0.0212 0.0281
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.016 0.577 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0012 0.0287 0.0424
Leishmania major quinonoid dihydropteridine reductase 0.016 0.577 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.004 0.1338 0.1338
Brugia malayi Cation transporter family protein 0.0013 0.0306 0.0458
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0011 0.0236 0.0236
Brugia malayi Serotonin receptor 0.0012 0.0287 0.0424
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0007 0.0096 0.0079
Brugia malayi Serotonin receptor 0.0012 0.0287 0.0424
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0118 0.0169
Loa Loa (eye worm) hypothetical protein 0.0006 0.0051 0.0054
Plasmodium vivax SET domain protein, putative 0.0006 0.0054 0.0006
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0012 0.0287 0.0287
Brugia malayi Protein kinase domain containing protein 0.0021 0.0606 0.0981
Schistosoma mansoni neuropeptide f receptor 76f 0.0012 0.0287 0.0497
Brugia malayi G protein-coupled receptor F59B2.13 0.0012 0.0287 0.0424
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0017 0.0473 0.0738
Echinococcus multilocularis polycomb protein SCMH1 0.001 0.0187 0.0187
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0006 0.0051 0.0001
Echinococcus multilocularis retinol dehydrogenase 11 0.016 0.577 0.577
Echinococcus multilocularis carbonyl reductase 1 0.016 0.577 0.577
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0013 0.0312 0.0312
Onchocerca volvulus 0.016 0.577 1
Mycobacterium tuberculosis Probable hydrolase 0.0007 0.01 0.0085
Brugia malayi phosphofructokinase 0.0022 0.064 0.104
Onchocerca volvulus Sepiapterin reductase homolog 0.016 0.577 1
Echinococcus granulosus nAChR subunit 0.0013 0.0306 0.0306
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0012 0.0287 0.0463
Mycobacterium ulcerans ketoacyl reductase 0.016 0.577 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0006 0.0054 0.0094
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.016 0.577 1
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0006 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.016 0.577 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.001 0.0212 0.0282
Echinococcus granulosus hypothetical protein 0.016 0.577 0.577
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Echinococcus granulosus peptide allatostatin:somatostatin 0.0012 0.0287 0.0287
Loa Loa (eye worm) oxidoreductase 0.016 0.577 1
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0006 0.0051 0.0001
Schistosoma mansoni histamine h1 receptor 0.0012 0.0287 0.0497
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0007 0.01 0.0138
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0013 0.0306 0.0306
Trichomonas vaginalis short-chain dehydrogenase, putative 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0287 0.0497
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0006 0.0054 0.0054
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0013 0.0306 0.0306
Echinococcus granulosus neuropeptide receptor 0.0012 0.0287 0.0287
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.1489 0.1489
Brugia malayi G-protein coupled receptor 0.0012 0.0287 0.0424
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0287 0.0497
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0013 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0007 0.01 0.0138
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0306 0.0458
Echinococcus granulosus beta LACTamase domain containing family member 0.0007 0.01 0.01
Onchocerca volvulus 0.0047 0.1591 0.2693
Echinococcus multilocularis retinol dehydrogenase 11 0.016 0.577 0.577
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0011 0.0236 0.0335
Brugia malayi excitatory GABA receptor EXP-1A 0.0013 0.0306 0.0458
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0287 0.0287
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0006 0.0054 0.0094
Echinococcus granulosus g protein coupled receptor 0.0012 0.0287 0.0287
Mycobacterium leprae 3-dehydroquinate synthase AroB 0.0055 0.1864 0.3169
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0212 0.0282
Brugia malayi hypothetical protein 0.0012 0.0287 0.0424
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0042 0.1378 0.2361
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.016 0.577 1
Schistosoma mansoni zinc finger protein 0.0005 0.0004 0.0008
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0287 0.0497
Schistosoma mansoni myelin transcription factor 1 myt1 0.0011 0.0236 0.0409
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.0376 0.0568
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Loa Loa (eye worm) glutathione reductase 0.0008 0.0113 0.0162
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Entamoeba histolytica short chain dehydrogenase family protein 0.016 0.577 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0006 0.0051 0.0001
Echinococcus granulosus fmrfamide receptor 0.0012 0.0287 0.0287
Trichomonas vaginalis phosphofructokinase, putative 0.0022 0.064 0.103
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.001 0.0212 0.0282
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0287 0.0287
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0012 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0007 0.01 0.0138
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0007 0.01 0.0085
Giardia lamblia Short-chain dehydrogenase, putative 0.016 0.577 1
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.0006 0.0051 0.0001
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0017 0.0473 0.0738
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0287 0.0287
Brugia malayi hypothetical protein 0.0012 0.0287 0.0424
Echinococcus granulosus hyperpolarization activated cyclic 0.0009 0.016 0.016
Schistosoma mansoni short chain dehydrogenase 0.016 0.577 1
Echinococcus granulosus glycine receptor subunit beta 0.0013 0.0306 0.0306
Loa Loa (eye worm) melatonin receptor type 1A 0.0012 0.0287 0.0463
Trichomonas vaginalis phosphofructokinase, putative 0.0022 0.064 0.103
Onchocerca volvulus 0.0013 0.0306 0.0446
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0006 0.0059 0.0059
Leishmania major hypothetical protein, conserved 0.016 0.577 1
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.016 0.577 0.577
Trypanosoma brucei short-chain dehydrogenase, putative 0.016 0.577 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.016 0.577 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.016 0.577 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0013 0.0306 0.0531
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.016 0.577 1
Echinococcus multilocularis zinc finger protein 0.0005 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Echinococcus multilocularis caspase 0.001 0.0212 0.0212
Onchocerca volvulus 0.016 0.577 1
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.016 0.577 1
Trypanosoma cruzi oxidoreductase-like protein, putative 0.016 0.577 1
Entamoeba histolytica hypothetical protein 0.016 0.577 1
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0013 0.0306 0.0531
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0287 0.0287
Echinococcus granulosus glycine receptor subunit alpha 1 0.0013 0.0306 0.0306
Trypanosoma cruzi oxidoreductase-like protein, putative 0.016 0.577 1
Echinococcus granulosus hypothetical protein 0.0012 0.0287 0.0287
Schistosoma mansoni opsin-like receptor 0.0012 0.0287 0.0497
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0013 0.0306 0.0497
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0.0287 0.0497
Mycobacterium ulcerans short-chain dehydrogenase 0.016 0.577 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0009 0.016 0.016
Schistosoma mansoni biogenic amine receptor 0.0012 0.0287 0.0497
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0013 0.0306 0.0458
Trypanosoma cruzi hypothetical protein, conserved 0.016 0.577 1
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0006 0.0051 0.0001
Brugia malayi mbt repeat family protein 0.001 0.0187 0.0249
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0013 0.0306 0.0458
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0015 0.0376 0.0567
Onchocerca volvulus 0.0012 0.0287 0.0411
Schistosoma mansoni neurotransmitter gated ion channel 0.0013 0.0306 0.0531
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0009 0.016 0.016
Onchocerca volvulus Putative nachr subunit 0.0013 0.0306 0.0446
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0287 0.0287
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.016 0.577 1
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0013 0.0306 0.0306
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.0306 0.0458
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.016 0.577 1
Plasmodium falciparum metacaspase 1 0.001 0.0212 0.0282
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0287 0.0287
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0012 0.0287 0.0424
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0009 0.0167 0.0203
Entamoeba histolytica phosphofructokinase, putative 0.0022 0.064 0.103
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0287 0.0287
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0013 0.0306 0.0531
Mycobacterium tuberculosis Probable oxidoreductase 0.016 0.577 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0013 0.0306 0.0306
Echinococcus granulosus tachykinin peptides receptor 99D 0.0012 0.0287 0.0287
Onchocerca volvulus 0.0012 0.0287 0.0411
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0212 0.0282
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0013 0.0306 0.0458
Loa Loa (eye worm) hypothetical protein 0.016 0.577 1
Loa Loa (eye worm) oxidoreductase 0.016 0.577 1
Schistosoma mansoni short chain dehydrogenase 0.016 0.577 1
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0013 0.0306 0.0306
Schistosoma mansoni caspase-3 (C14 family) 0.001 0.0212 0.0368
Loa Loa (eye worm) oxidoreductase 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0212 0.0282
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0006 0.0051 0.0051
Schistosoma mansoni hypothetical protein 0.0012 0.0287 0.0497
Brugia malayi ORL1-like opioid receptor 0.0012 0.0287 0.0424
Loa Loa (eye worm) hypothetical protein 0.016 0.577 1
Mycobacterium tuberculosis Possible oxidoreductase 0.016 0.577 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0006 0.0051 0.0089
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0287 0.0287
Schistosoma mansoni steroid dehydrogenase 0.016 0.577 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0287 0.0287
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0017 0.0473 0.0738
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.016 0.577 1
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.0376 0.0568
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Loa Loa (eye worm) hypothetical protein 0.0013 0.0312 0.0508
Brugia malayi AKH receptor 0.0012 0.0287 0.0424
Trichomonas vaginalis phosphofructokinase, putative 0.0022 0.064 0.103
Echinococcus multilocularis 6 phosphofructokinase 0.0022 0.064 0.064
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0287 0.0287
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.001 0.0212 0.0282
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0009 0.016 0.0243
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0006 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Plasmodium falciparum glutathione reductase 0.0008 0.0113 0.011
Onchocerca volvulus Cell death protein 3 homolog 0.0034 0.1096 0.1826
Loa Loa (eye worm) hypothetical protein 0.016 0.577 1
Echinococcus multilocularis somatostatin receptor 0.0012 0.0287 0.0287
Mycobacterium ulcerans esterase/lipase LipP 0.0007 0.01 0.0085
Brugia malayi 6-phosphofructokinase 0.0022 0.064 0.104
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0008 0.0113 0.0109
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Echinococcus multilocularis beta LACTamase domain containing family member 0.0007 0.01 0.01
Echinococcus multilocularis glycine receptor subunit beta 0.0013 0.0306 0.0306
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.004 0.1338 0.1338
Echinococcus granulosus histone acetyltransferase MYST2 0.0011 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0009 0.0176 0.027
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.016 0.577 1
Brugia malayi hypothetical protein 0.0012 0.0287 0.0424
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0287 0.0287
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.016 0.0278
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0013 0.0306 0.0531
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0009 0.016 0.016
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0006 0.0051 0.0001
Trypanosoma cruzi metacaspase, putative 0.001 0.0212 0.0281
Onchocerca volvulus 0.0013 0.0306 0.0446
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Toxoplasma gondii ABC1 family protein 0.0007 0.01 0.0086
Echinococcus multilocularis serotonin receptor 0.0012 0.0287 0.0287
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0013 0.0306 0.0458
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0012 0.0287 0.0497
Brugia malayi putative neuropeptide receptor 0.0012 0.0287 0.0424
Trypanosoma cruzi hypothetical protein, conserved 0.016 0.577 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.001 0.0212 0.0282
Schistosoma mansoni hypothetical protein 0.0061 0.2095 0.3631
Schistosoma mansoni nAChR subunit 0.0013 0.0306 0.0531
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.016 0.577 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.016 0.577 1
Echinococcus multilocularis allatostatin A receptor 0.0012 0.0287 0.0287
Schistosoma mansoni voltage-gated potassium channel 0.0007 0.0094 0.0162
Echinococcus multilocularis nAChR subunit 0.0013 0.0306 0.0306
Trypanosoma cruzi metacaspase 5, putative 0.001 0.0212 0.0281
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Onchocerca volvulus 0.0012 0.0287 0.0411
Trypanosoma brucei metacaspase 5, putative 0.001 0.0212 0.0281
Brugia malayi putative neuropeptide receptor NPR1 0.0012 0.0287 0.0424
Mycobacterium tuberculosis Probable dehydrogenase 0.0017 0.0473 0.0738
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0287 0.0497
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0015 0.0376 0.0568
Leishmania major short chain dehydrogenase, putative 0.016 0.577 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0287 0.0287
Trichomonas vaginalis short-chain dehydrogenase, putative 0.016 0.577 1
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0287 0.0287
Loa Loa (eye worm) 6-phosphofructokinase 0.0022 0.064 0.1077
Trypanosoma cruzi metacaspase, putative 0.001 0.0212 0.0281
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0013 0.0306 0.0306
Trypanosoma brucei oxidoreductase-like protein 0.016 0.577 1
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0006 0.0051 0.0001
Echinococcus multilocularis hyperpolarization activated cyclic 0.0009 0.016 0.016
Trichomonas vaginalis phosphofructokinase, putative 0.0022 0.064 0.103
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Schistosoma mansoni hypothetical protein 0.0012 0.0287 0.0497
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0287 0.0287
Schistosoma mansoni steroid dehydrogenase 0.016 0.577 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0287 0.0287
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0009 0.0167 0.0203
Treponema pallidum catabolite gene activator (Crp) 0.0006 0.0051 0.0002
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Mycobacterium tuberculosis Probable dehydrogenase 0.016 0.577 1
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.016 0.577 1
Echinococcus granulosus g protein coupled receptor 0.0012 0.0287 0.0287
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.001 0.0212 0.0282
Schistosoma mansoni short chain dehydrogenase 0.016 0.577 1
Trypanosoma cruzi short chain dehydrogenase, putative 0.016 0.577 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.016 0.577 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.016 0.577 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0306 0.0458
Echinococcus multilocularis retinol dehydrogenase 13 0.016 0.577 0.577
Loa Loa (eye worm) hypothetical protein 0.0024 0.0716 0.121
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.016 0.577 1
Toxoplasma gondii thioredoxin reductase 0.0008 0.0113 0.011
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0013 0.0306 0.0497
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0287 0.0287
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0015 0.0376 0.0567
Echinococcus granulosus allatostatin A receptor 0.0012 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Brugia malayi Melatonin receptor type 1A 0.0012 0.0287 0.0424
Leishmania major protein kinase, putative 0.0006 0.0059 0.0013
Trichomonas vaginalis bromodomain-containing protein, putative 0.0009 0.0167 0.0203
Schistosoma mansoni amine GPCR 0.0012 0.0287 0.0497
Echinococcus granulosus histone acetyltransferase KAT2B 0.0028 0.0879 0.0879
Echinococcus multilocularis neuropeptide receptor A26 0.0012 0.0287 0.0287
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.016 0.577 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0287 0.0497
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Leishmania major trypanothione reductase 0.0008 0.0113 0.0109
Brugia malayi hypothetical protein 0.0024 0.0716 0.1174
Schistosoma mansoni caspase-7 (C14 family) 0.0034 0.1096 0.1899
Brugia malayi mbt repeat family protein 0.001 0.0187 0.0249
Brugia malayi G-protein coupled receptor 0.0012 0.0287 0.0424
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0009 0.016 0.016
Onchocerca volvulus 0.016 0.577 1
Schistosoma mansoni 3-dehydroquinate synthase 0.0055 0.1864 0.323
Echinococcus granulosus WW domain containing oxidoreductase 0.016 0.577 0.577
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.016 0.577 1
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0006 0.0051 0.0013
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0606 0.1049
Mycobacterium ulcerans oxidoreductase 0.016 0.577 1
Brugia malayi hypothetical protein 0.0012 0.0287 0.0424
Echinococcus granulosus neuropeptide FF receptor 2 0.0012 0.0287 0.0287
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.016 0.0278
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.016 0.577 0.577
Schistosoma mansoni short chain dehydrogenase 0.016 0.577 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0015 0.0376 0.0567
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0012 0.0287 0.0424
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0287 0.0287
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0012 0.0287 0.0287
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.001 0.0187 0.0237
Brugia malayi acetyltransferase, GNAT family protein 0.0029 0.0926 0.1541
Giardia lamblia Hypothetical protein 0.016 0.577 1
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0009 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0007 0.01 0.0138
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0013 0.0306 0.0458
Onchocerca volvulus 0.0006 0.0054 0.0005
Mycobacterium tuberculosis Possible oxidoreductase 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Loa Loa (eye worm) hypothetical protein 0.0039 0.127 0.2174
Onchocerca volvulus 0.0012 0.0287 0.0411
Schistosoma mansoni sex comb on midleg homolog 0.001 0.0187 0.0324
Loa Loa (eye worm) hypothetical protein 0.0007 0.01 0.0138
Onchocerca volvulus 0.0024 0.0716 0.1163
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0.0287 0.0497
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Schistosoma mansoni carbonyl reductase 0.016 0.577 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0006 0.0046 0.0046
Schistosoma mansoni serine/threonine protein kinase 0.0006 0.0059 0.0102
Mycobacterium ulcerans short-chain dehydrogenase 0.016 0.577 1
Mycobacterium ulcerans short-chain dehydrogenase 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Brugia malayi Cyclic-nucleotide gated cation channel 0.0009 0.016 0.0203
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0012 0.0287 0.0497
Trichomonas vaginalis short-chain dehydrogenase, putative 0.016 0.577 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0012 0.0287 0.0287
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0273 1 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0022 0.064 0.1029
Mycobacterium tuberculosis Probable reductase 0.0017 0.0473 0.0738
Leishmania major cytochrome p450-like protein 0.0007 0.0096 0.0079
Onchocerca volvulus 0.0012 0.0287 0.0411
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0012 0.0287 0.0497
Loa Loa (eye worm) hypothetical protein 0.016 0.577 1
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.016 0.577 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0012 0.0287 0.0424
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0013 0.0306 0.0458
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.016 0.577 1
Echinococcus granulosus carbonyl reductase 1 0.016 0.577 0.577
Echinococcus granulosus alpha 1A adrenergic receptor 0.0012 0.0287 0.0287
Chlamydia trachomatis dehyroquinate synthase 0.0055 0.1864 0.3626
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0006 0.0051 0.0089
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.016 0.577 0.577
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.016 0.577 1
Schistosoma mansoni steroid dehydrogenase 0.016 0.577 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0022 0.064 0.1029
Schistosoma mansoni nAChR subunit 0.0013 0.0306 0.0531
Trichomonas vaginalis esterase, putative 0.0007 0.01 0.0086
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Schistosoma mansoni 60S ribosomal protein L21 0.0007 0.0094 0.0162
Echinococcus multilocularis carbonyl reductase 1 0.016 0.577 0.577
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.01 0.0085
Trypanosoma brucei short-chain dehydrogenase, putative 0.016 0.577 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.016 0.577 0.577
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Echinococcus multilocularis nAChR subunit 0.0013 0.0306 0.0306
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0012 0.0287 0.0497
Schistosoma mansoni ap endonuclease 0.0015 0.0376 0.0651
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Brugia malayi sulfakinin receptor protein 0.0012 0.0287 0.0424
Toxoplasma gondii oxidoreductase, putative 0.016 0.577 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.0306 0.0458
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0009 0.016 0.016
Schistosoma mansoni growth hormone secretagogue receptor 0.0012 0.0287 0.0497
Loa Loa (eye worm) hypothetical protein 0.0006 0.0051 0.0054
Trypanosoma brucei hypothetical protein, conserved 0.0007 0.01 0.0085
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.014 0.5051 0.8742
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0007 0.01 0.0098
Onchocerca volvulus 0.0013 0.0306 0.0446
Mycobacterium leprae conserved hypothetical protein 0.0007 0.01 0.0085
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0021 0.0606 0.1017
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.016 0.0278
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0376 0.0568
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0012 0.0287 0.0287
Echinococcus multilocularis hyperpolarization activated cyclic 0.0009 0.016 0.016
Schistosoma mansoni amine GPCR 0.0012 0.0287 0.0497
Mycobacterium tuberculosis Conserved protein 0.0007 0.01 0.0085
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.1489 0.2554
Leishmania major dehydrogenase-like protein 0.016 0.577 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0012 0.0287 0.0497
Plasmodium vivax hypothetical protein, conserved 0.001 0.0212 0.0282
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.016 0.577 1
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.014 0.5051 1
Onchocerca volvulus 0.0013 0.0306 0.0446
Trichomonas vaginalis set domain proteins, putative 0.0047 0.1591 0.2694
Onchocerca volvulus 0.016 0.577 1
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0013 0.0306 0.0497
Loa Loa (eye worm) hypothetical protein 0.0009 0.0161 0.0245
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0287 0.0287
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.138 0.2324
Schistosoma mansoni steroid dehydrogenase 0.016 0.577 1
Schistosoma mansoni steroid dehydrogenase 0.016 0.577 1
Echinococcus granulosus neuropeptide receptor 0.0012 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Mycobacterium ulcerans dehydrogenase/reductase 0.016 0.577 1
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0013 0.0306 0.0306
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0029 0.0926 0.0926
Loa Loa (eye worm) hypothetical protein 0.001 0.0212 0.0333
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0015 0.0376 0.0376
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0013 0.0306 0.0531
Brugia malayi hypothetical protein 0.0012 0.0287 0.0424
Brugia malayi Cation transporter family protein 0.0013 0.0306 0.0458
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.016 0.577 1
Leishmania major hypothetical protein, conserved 0.016 0.577 1
Trypanosoma cruzi short-chain dehydrogenase, putative 0.016 0.577 1
Echinococcus granulosus cGMP dependent protein kinase 0.0006 0.0059 0.0059
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0013 0.0306 0.0306
Echinococcus granulosus orexin receptor type 2 0.0012 0.0287 0.0287
Plasmodium vivax glutathione reductase, putative 0.0008 0.0113 0.011
Echinococcus granulosus dro:myosuppressin receptor 0.0012 0.0287 0.0287
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0287 0.0497
Plasmodium falciparum thioredoxin reductase 0.0008 0.0113 0.011
Treponema pallidum cyclic nucleotide binding protein 0.0006 0.0051 0.0002
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0007 0.0099 0.0099
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0006 0.0051 0.0001
Leishmania major pteridine reductase 1 0.016 0.577 1
Brugia malayi Cytochrome P450 family protein 0.0007 0.0096 0.0092
Echinococcus granulosus retinol dehydrogenase 11 0.016 0.577 0.577
Trypanosoma cruzi metacaspase, putative 0.001 0.0212 0.0281
Brugia malayi Cytochrome P450 family protein 0.0007 0.0096 0.0092
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0017 0.0473 0.0738
Trichomonas vaginalis D-aminoacylase, putative 0.0007 0.01 0.0086
Plasmodium falciparum histone acetyltransferase GCN5 0.0008 0.0123 0.0126
Loa Loa (eye worm) cytochrome P450 family protein 0.0007 0.0096 0.0132
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0287 0.0287
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0013 0.0306 0.0458
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Schistosoma mansoni amine GPCR 0.0012 0.0287 0.0497
Schistosoma mansoni short chain dehydrogenase 0.016 0.577 1
Loa Loa (eye worm) AGC/PKG protein kinase 0.0006 0.0059 0.0066
Echinococcus multilocularis apoptotic protease activating factor 1 0.0024 0.0716 0.0716
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.0306 0.0458
Loa Loa (eye worm) GABA receptor subunit 0.0013 0.0306 0.0497
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0287 0.0287
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.001 0.0212 0.0282
Brugia malayi hypothetical protein 0.016 0.577 1
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0287 0.0287
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0006 0.0051 0.0001
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.016 0.577 1
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.1641 0.2844
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0006 0.0051 0.0001
Leishmania major quinonoid dihydropteridine reductase 0.016 0.577 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0212 0.0282
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Schistosoma mansoni short chain dehydrogenase 0.016 0.577 1
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Echinococcus granulosus somatostatin receptor 0.0012 0.0287 0.0287
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0006 0.0051 0.0051
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0287 0.0287
Trypanosoma brucei trypanothione reductase 0.0008 0.0113 0.0109
Brugia malayi Bromodomain containing protein 0.0016 0.0416 0.0649
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0006 0.0051 0.0051
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.016 0.577 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.1489 0.2523
Entamoeba histolytica protein kinase, putative 0.0021 0.0606 0.097
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Schistosoma mansoni short chain dehydrogenase 0.016 0.577 1
Leishmania major quinonoid dihydropteridine reductase 0.016 0.577 1
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0287 0.0497
Trypanosoma cruzi metacaspase 5, putative 0.001 0.0212 0.0281
Mycobacterium tuberculosis 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) 0.0055 0.1864 0.3169
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Loa Loa (eye worm) hypothetical protein 0.016 0.577 1
Entamoeba histolytica hypothetical protein, conserved 0.016 0.577 1
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0006 0.0051 0.0089
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0006 0.0051 0.0089
Schistosoma mansoni short chain dehydrogenase 0.016 0.577 1
Schistosoma mansoni neuropeptide receptor 0.0012 0.0287 0.0497
Schistosoma mansoni biogenic amine receptor 0.0012 0.0287 0.0497
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Echinococcus multilocularis thioredoxin glutathione reductase 0.0008 0.0117 0.0117
Toxoplasma gondii carbonyl reductase 1, putative 0.016 0.577 1
Mycobacterium ulcerans carveol-like dehydrogenase 0.016 0.577 1
Brugia malayi follicle stimulating hormone receptor 0.0012 0.0287 0.0424
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0312 0.0542
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.001 0.0212 0.0368
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0022 0.064 0.1029
Trichomonas vaginalis AGC family protein kinase 0.0021 0.0606 0.097
Onchocerca volvulus 0.0012 0.0287 0.0411
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0013 0.0306 0.0531
Echinococcus multilocularis sex peptide receptor 0.0012 0.0287 0.0287
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.001 0.0212 0.0282
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0287 0.0287
Mycobacterium tuberculosis Conserved protein 0.0007 0.01 0.0085
Echinococcus multilocularis dro:myosuppressin receptor 0.0012 0.0287 0.0287
Loa Loa (eye worm) LGC-31 protein 0.0013 0.0306 0.0497
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.016 0.577 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0287 0.0287
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0019 0.0545 0.0863
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0012 0.0287 0.0287
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0006 0.0051 0.0001
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0006 0.0051 0.0089
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Echinococcus multilocularis oxidoreductase 0.016 0.577 0.577
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.016 0.577 1
Mycobacterium ulcerans 3-dehydroquinate synthase 0.0055 0.1864 0.3169
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Onchocerca volvulus 0.0012 0.0287 0.0411
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.01 0.0085
Loa Loa (eye worm) dehydrogenase 0.016 0.577 1
Onchocerca volvulus 0.016 0.577 1
Brugia malayi Egg laying defective protein 4 0.0006 0.0059 0.0026
Echinococcus multilocularis orexin receptor type 2 0.0012 0.0287 0.0287
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0006 0.0051 0.0013
Brugia malayi exodeoxyribonuclease III family protein 0.0015 0.0376 0.0579
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.014 0.5051 0.8742
Loa Loa (eye worm) oxidoreductase 0.016 0.577 1
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0006 0.0051 0.0089
Schistosoma mansoni hypothetical protein 0.0012 0.0287 0.0497
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Mycobacterium ulcerans short-chain type oxidoreductase 0.016 0.577 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.016 0.0278
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Brugia malayi Cell death protein 3 precursor 0.0034 0.1096 0.1837
Brugia malayi Cation transporter family protein 0.0013 0.0306 0.0458
Loa Loa (eye worm) CYP4Cod1 0.0007 0.0096 0.0132
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0007 0.01 0.0085
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0015 0.0376 0.0568
Entamoeba histolytica phosphofructokinase, putative 0.0022 0.064 0.103
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0009 0.016 0.0243
Brugia malayi Thioredoxin reductase 0.0008 0.0113 0.0121
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0009 0.0181 0.0313
Loa Loa (eye worm) ACC-1 protein 0.0013 0.0306 0.0497
Mycobacterium leprae Probable lipase LipE 0.0007 0.01 0.0085
Schistosoma mansoni short chain dehydrogenase 0.016 0.577 1
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.016 0.577 1
Echinococcus granulosus neuropeptide s receptor 0.0012 0.0287 0.0287
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0012 0.0287 0.0497
Schistosoma mansoni retinal dehydrogenase 0.016 0.577 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.001 0.0212 0.0282
Leishmania major hypothetical protein, conserved 0.016 0.577 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0012 0.0287 0.0463
Trypanosoma cruzi cytochrome P450, putative 0.0007 0.0096 0.0079
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Loa Loa (eye worm) hypothetical protein 0.016 0.577 1
Trypanosoma cruzi hypothetical protein, conserved 0.016 0.577 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0015 0.0376 0.0618
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0013 0.0312 0.0312
Mycobacterium tuberculosis Probable lipase LipD 0.0007 0.01 0.0085
Mycobacterium ulcerans dehydrogenase 0.016 0.577 1
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.016 0.577 1
Leishmania major oxidoreductase-like protein 0.016 0.577 1
Brugia malayi larval opioid receptor 0.0012 0.0287 0.0424
Brugia malayi hypothetical protein 0.0012 0.0287 0.0424
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0086 0.302 0.4901
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.016 0.577 1
Schistosoma mansoni nAChR subunit 0.0013 0.0306 0.0531
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.016 0.577 1
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.001 0.0212 0.0294
Mycobacterium tuberculosis Probable oxidoreductase 0.016 0.577 1
Trypanosoma brucei Metacaspase-4 0.001 0.0212 0.0281
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Mycobacterium leprae Probable oxidoreductase 0.016 0.577 1
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0312 0.0542
Mycobacterium ulcerans ketoacyl reductase 0.016 0.577 1
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.016 0.577 1
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0013 0.0306 0.0306
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.001 0.0212 0.0282
Echinococcus granulosus apoptotic protease activating factor 1 0.0024 0.0716 0.0716
Onchocerca volvulus 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.0306 0.0458
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0012 0.0287 0.0287
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.016 0.577 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0012 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.016 0.0278
Echinococcus granulosus voltage gated potassium channel 0.0013 0.0312 0.0312
Echinococcus granulosus g-protein coupled receptor 0.0012 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.016 0.577 1
Schistosoma mansoni short chain dehydrogenase 0.016 0.577 1
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0013 0.0306 0.0497
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.016 0.577 1
Brugia malayi dehydrogenases, short chain protein 9 0.016 0.577 1
Schistosoma mansoni biogenic amine receptor 0.0012 0.0287 0.0497
Giardia lamblia Histone acetyltransferase GCN5 0.0008 0.0123 0.0126
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0236 0.0374
Brugia malayi Dehydrogenases, short chain protein 2 0.016 0.577 1
Brugia malayi Dopamine receptor 0.0012 0.0287 0.0424
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.014 0.5051 0.8742
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0013 0.0306 0.0531
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0006 0.0051 0.0054
Brugia malayi dehydrogenases, short chain protein 2 0.016 0.577 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0012 0.0287 0.0287
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0006 0.0051 0.0001
Mycobacterium tuberculosis 3-dehydroquinate synthase AroB 0.0055 0.1864 0.3169
Entamoeba histolytica phosphofructokinase, putative 0.0022 0.064 0.103
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.016 0.577 1
Echinococcus granulosus patatin phospholipase domain containing protein 0.0006 0.0051 0.0051
Schistosoma mansoni carbonyl reductase 0.016 0.577 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0008 0.0123 0.0126
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0287 0.0287
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0013 0.0306 0.0497
Brugia malayi hypothetical protein 0.0012 0.0287 0.0424
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Schistosoma mansoni neuropeptide receptor 0.0012 0.0287 0.0497
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0287 0.0497
Echinococcus multilocularis serotonin receptor 0.0012 0.0287 0.0287
Loa Loa (eye worm) cytochrome P450 family protein 0.0007 0.0096 0.0132
Mycobacterium ulcerans ketoacyl reductase 0.016 0.577 1
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.016 0.577 1
Loa Loa (eye worm) phosphofructokinase 0.0022 0.064 0.1077
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0006 0.0059 0.0014
Loa Loa (eye worm) hypothetical protein 0.016 0.577 1
Entamoeba histolytica short chain dehydrogenase family protein 0.016 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0007 0.01 0.0085
Schistosoma mansoni short-chain dehydrogenase/reductase 0.016 0.577 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0011 0.0236 0.0236
Mycobacterium ulcerans short chain dehydrogenase 0.016 0.577 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0007 0.01 0.0086
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0287 0.0287
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0007 0.01 0.0085
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0287 0.0497
Loa Loa (eye worm) hypothetical protein 0.016 0.577 1
Brugia malayi phosphoinositide-dependent protein kinase I 0.0021 0.0606 0.0981
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Mycobacterium tuberculosis Conserved protein 0.0007 0.01 0.0085
Trichomonas vaginalis AGC family protein kinase 0.0021 0.0606 0.097
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.0306 0.0458
Brugia malayi RE15519p 0.0012 0.0287 0.0424
Onchocerca volvulus 0.0013 0.0306 0.0446
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.016 0.577 1
Onchocerca volvulus 0.016 0.577 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.016 0.577 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.016 0.577 1
Schistosoma mansoni amine GPCR 0.0012 0.0287 0.0497
Onchocerca volvulus 0.0013 0.0306 0.0446
Loa Loa (eye worm) hypothetical protein 0.0009 0.0181 0.0279
Schistosoma mansoni opsin-like receptor 0.0012 0.0287 0.0497
Loa Loa (eye worm) beta-lactamase 0.0007 0.01 0.0138
Echinococcus granulosus SAM and MBT domain containing protein 0.001 0.0187 0.0187
Echinococcus granulosus 7TM GPCR rhodopsin 0.0012 0.0287 0.0287
Brugia malayi glutathione reductase 0.0008 0.0113 0.0121
Schistosoma mansoni alpha-1 adrenergic receptor 0.0012 0.0287 0.0497
Plasmodium falciparum metacaspase-like protein 0.001 0.0212 0.0282
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.016 0.577 1
Loa Loa (eye worm) acetyltransferase 0.0029 0.0926 0.1575
Plasmodium vivax thioredoxin reductase, putative 0.0008 0.0113 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0287 0.0497
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0012 0.0287 0.0463
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0009 0.0167 0.0203
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Schistosoma mansoni carbonyl reductase 0.016 0.577 1
Trypanosoma brucei metacaspase MCA2 0.001 0.0212 0.0281
Echinococcus multilocularis SAM and MBT domain containing protein 0.001 0.0187 0.0187
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0006 0.0051 0.0013
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0017 0.0473 0.0738
Onchocerca volvulus 0.0007 0.01 0.0085
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0287 0.0497
Echinococcus granulosus glycine receptor subunit alpha 1 0.0013 0.0306 0.0306
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0287 0.0287
Mycobacterium tuberculosis Probable oxidoreductase 0.0019 0.0545 0.0863
Onchocerca volvulus 0.0012 0.0287 0.0411
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0306 0.0458
Schistosoma mansoni caspase-7 (C14 family) 0.001 0.0212 0.0368
Schistosoma mansoni 6-phosphofructokinase 0.0022 0.064 0.1109
Trichomonas vaginalis short-chain dehydrogenase, putative 0.016 0.577 1
Mycobacterium tuberculosis Probable oxidoreductase 0.016 0.577 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0013 0.0302 0.0302
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0012 0.0287 0.0424
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.016 0.577 1
Brugia malayi hypothetical protein 0.0012 0.0287 0.0424
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0012 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0012 0.0287 0.0463
Onchocerca volvulus 0.0013 0.0306 0.0446
Echinococcus granulosus thioredoxin glutathione reductase 0.0008 0.0117 0.0117
Brugia malayi neuropeptide F receptor 0.0012 0.0287 0.0424
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0007 0.01 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0212 0.0282
Trypanosoma cruzi short-chain dehydrogenase, putative 0.016 0.577 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0051 0.0001
Schistosoma mansoni nAChR subunit 0.0013 0.0306 0.0531
Entamoeba histolytica hypothetical protein, conserved 0.016 0.577 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0013 0.0306 0.0306
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0006 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0013 0.0306 0.0497
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0287 0.0287
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.016 0.577 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0287 0.0497
Trypanosoma brucei metacaspase MCA3 0.001 0.0212 0.0281
Entamoeba histolytica hypothetical protein 0.0013 0.0306 0.0447
Mycobacterium tuberculosis Probable esterase LipL 0.0007 0.01 0.0085
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0013 0.0306 0.0306
Loa Loa (eye worm) thioredoxin reductase 0.0008 0.0113 0.0162
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.001 0.0212 0.0282
Echinococcus granulosus retinol dehydrogenase 11 0.016 0.577 0.577
Onchocerca volvulus 0.016 0.577 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0287 0.0497
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0287 0.0497
Loa Loa (eye worm) hypothetical protein 0.0034 0.1096 0.187
Schistosoma mansoni steroid dehydrogenase 0.016 0.577 1

Activities

Activity type Activity value Assay description Source Reference
CL (ADMET) = 152 ml/min.kg Blood clearance in rat ChEMBL. 18248991
IC50 (binding) = 5.4 Displacement of [3H]Dofetilide from human ERG ChEMBL. 18248991
Ki (functional) > 5.5 Antagonist activity at histamine H1 receptor (unknown origin) by FLIPR assay ChEMBL. 18248991
Ki (functional) > 6.1 Antagonist activity at dopamine D2 receptor (unknown origin) by GTPgammaS binding assay ChEMBL. 18248991
Ki (functional) = 8 Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay ChEMBL. 18248991
Log IC50 (binding) = 5.4 Displacement of [3H]Dofetilide from human ERG ChEMBL. 18248991
Log Ki (functional) < 5.5 Antagonist activity at histamine H1 receptor (unknown origin) by FLIPR assay ChEMBL. 18248991
Log Ki (functional) < 6.1 Antagonist activity at dopamine D2 receptor (unknown origin) by GTPgammaS binding assay ChEMBL. 18248991
Log Ki (functional) = 8 Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assay ChEMBL. 18248991
Ratio (binding) = 100 Selectivity for human dopamine D3 receptor over human ERG ChEMBL. 18248991

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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