Detailed information for compound 519108

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 459.497 | Formula: C25H25N5O4
  • H donors: 0 H acceptors: 3 LogP: 1.62 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N(Cc2ccccc2)Cc2c1n(CCN1CCOCC1)c1n(c2=O)nc(c1)c1ccco1
  • InChi: 1S/C25H25N5O4/c31-24-19-17-28(16-18-5-2-1-3-6-18)25(32)23(19)29(9-8-27-10-13-33-14-11-27)22-15-20(26-30(22)24)21-7-4-12-34-21/h1-7,12,15H,8-11,13-14,16-17H2
  • InChiKey: YZHDURKAVVDNFF-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0035 0.1149 0.2537
Loa Loa (eye worm) hypothetical protein 0.0008 0.0167 0.0186
Entamoeba histolytica fatty acid elongase, putative 0.0037 0.1198 0.2652
Brugia malayi exodeoxyribonuclease III family protein 0.0008 0.0184 0.021
Schistosoma mansoni hypothetical protein 0.0025 0.0788 0.0873
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0008 0.0184 0.0204
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0378 0.2114
Echinococcus granulosus lipoxygenase domain containing protein 0.0032 0.1029 0.114
Trypanosoma cruzi RNA polymerase I second largest subunit, putative 0.0004 0.0026 0.0066
Echinococcus multilocularis DNA directed RNA polymerase II subunit RPB2 0.0006 0.0082 0.009
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0378 0.225
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0284 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.1173 0.6989
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0378 0.0727
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0462 0.0576
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0152 0.0152
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0014 0.0369 0.0798
Loa Loa (eye worm) galectin 0.0217 0.7636 1
Brugia malayi small heat shock protein 0.0215 0.7548 0.9885
Giardia lamblia Kinase, PLK 0.0036 0.1173 0.2666
Trypanosoma brucei polo-like protein kinase 0.0036 0.1173 0.6726
Entamoeba histolytica fatty acid elongase, putative 0.0037 0.1198 0.2652
Plasmodium vivax histone acetyltransferase GCN5, putative 0.002 0.0594 0.057
Brugia malayi galectin 0.0217 0.7636 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0008 0.0184 0.0204
Trichomonas vaginalis sucrase-isomaltase, putative 0.0014 0.0378 0.225
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0378 0.225
Entamoeba histolytica acyl-CoA synthetase, putative 0.0011 0.0263 0.0457
Schistosoma mansoni DNA-directed rna polymerase II subunit 0.0006 0.0082 0.009
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0378 0.0727
Entamoeba histolytica fatty acid elongase, putative 0.0037 0.1198 0.2652
Brugia malayi intermediate filament protein 0.003 0.0963 0.1234
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0008 0.0184 0.0158
Schistosoma mansoni rab6-interacting 0.0032 0.1029 0.114
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0052 0.1731 1
Toxoplasma gondii exonuclease III APE 0.0008 0.0184 0.2016
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0052 0.1731 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0004 0.0026 0.0029
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0014 0.0378 0.0462
Onchocerca volvulus 0.0011 0.0263 0.0257
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0008 0.0184 0.0184
Schistosoma mansoni jun-related protein 0.0025 0.0788 0.0873
Loa Loa (eye worm) CXXC zinc finger family protein 0.0013 0.0342 0.0415
Brugia malayi Galactoside-binding lectin family protein 0.0217 0.7636 1
Schistosoma mansoni lamin 0.003 0.0963 0.1067
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.1173 0.13
Echinococcus multilocularis dnaJ subfamily B 0.0183 0.6399 0.709
Schistosoma mansoni intermediate filament proteins 0.003 0.0963 0.1067
Onchocerca volvulus 0.0024 0.0758 0.0911
Loa Loa (eye worm) hypothetical protein 0.003 0.0966 0.1236
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0963 0.1232
Onchocerca volvulus 0.003 0.0963 0.1183
Trichomonas vaginalis ap endonuclease, putative 0.0008 0.0184 0.1095
Trichomonas vaginalis phosphofructokinase, putative 0.005 0.1679 1
Giardia lamblia DNA-directed RNA polymerase subunit B 0.0006 0.0082 0.0129
Echinococcus granulosus lamin dm0 0.003 0.0963 0.1067
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0284 1 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0036 0.1173 0.151
Echinococcus multilocularis musashi 0.003 0.0963 0.1067
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0052 0.1731 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0005 0.0068 0.0058
Loa Loa (eye worm) hypothetical protein 0.003 0.0963 0.1232
Entamoeba histolytica fatty acid elongase, putative 0.0037 0.1198 0.2652
Plasmodium vivax 6-phosphofructokinase, putative 0.0014 0.0369 0.0344
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0014 0.0369 0.2199
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0125 0.4329 1
Echinococcus granulosus dnaJ subfamily B 0.0183 0.6399 0.709
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.1173 0.6989
Brugia malayi AMP-binding enzyme family protein 0.0011 0.0263 0.0314
Echinococcus multilocularis DNA directed RNA polymerase III subunit RPC2 0.0006 0.0082 0.009
Plasmodium falciparum DNA-directed RNA polymerase II subunit RPB2, putative 0.0006 0.0082 0.0056
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0052 0.1731 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0052 0.1731 1
Schistosoma mansoni alpha-glucosidase 0.0054 0.1798 0.1992
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0011 0.0263 0.0263
Leishmania major ATP-dependent phosphofructokinase 0.005 0.1679 0.969
Brugia malayi AMP-binding enzyme family protein 0.0011 0.0263 0.0314
Onchocerca volvulus Serine\/threonine kinase homolog 0.0036 0.1173 0.146
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0036 0.1173 0.13
Trypanosoma cruzi polo-like protein kinase, putative 0.0036 0.1173 0.6748
Echinococcus granulosus DNA directed RNA polymerase III subunit RPC2 0.0006 0.0082 0.009
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0008 0.0167 0.0167
Echinococcus multilocularis Galectin, carbohydrate recognition domain 0.0217 0.7636 0.8461
Entamoeba histolytica DNA-directed RNA polymerase subunit, putative 0.0006 0.0082 0.0032
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.005 0.1679 0.4527
Entamoeba histolytica fatty acid elongase, putative 0.0037 0.1198 0.2652
Loa Loa (eye worm) 6-phosphofructokinase 0.005 0.1679 0.2172
Brugia malayi Cytochrome P450 family protein 0.001 0.0245 0.029
Brugia malayi bZIP transcription factor family protein 0.0031 0.0997 0.1278
Echinococcus multilocularis lipoxygenase domain containing protein 0.0032 0.1029 0.114
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0011 0.0263 0.0263
Brugia malayi Galactoside-binding lectin family protein 0.0217 0.7636 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0014 0.0369 0.0205
Echinococcus multilocularis jun protein 0.0031 0.0997 0.1104
Brugia malayi Galactoside-binding lectin family protein 0.0217 0.7636 1
Loa Loa (eye worm) galactoside-binding lectin family protein 0.0217 0.7636 1
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0031 0.0997 0.1104
Trichomonas vaginalis CAMK family protein kinase 0.0018 0.0522 0.3112
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0052 0.1731 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.002 0.0594 0.0658
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0008 0.0167 0.0167
Schistosoma mansoni ap endonuclease 0.0008 0.0184 0.0204
Brugia malayi galectin 0.0217 0.7636 1
Echinococcus granulosus geminin 0.0065 0.2196 0.2434
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0462 0.0573
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0052 0.1731 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0385 0.0472
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0284 1 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.002 0.0594 0.3539
Schistosoma mansoni hypothetical protein 0.0032 0.1029 0.114
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0004 0.0026 0.0029
Echinococcus granulosus neutral alpha glucosidase AB 0.0014 0.0378 0.0418
Plasmodium falciparum LCCL domain-containing protein 0.0032 0.1029 0.1005
Wolbachia endosymbiont of Brugia malayi DNA-directed RNA polymerase subunit beta/beta' 0.0107 0.3708 0.3708
Giardia lamblia DNA repair protein RAD52 0.0125 0.4329 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0014 0.0369 0.0344
Mycobacterium ulcerans 6-phosphofructokinase 0.005 0.1679 0.1679
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0008 0.0184 0.0184
Trypanosoma brucei DNA-directed RNA polymerase II subunit 2, putative 0.0006 0.0082 0.0326
Entamoeba histolytica phosphofructokinase, putative 0.005 0.1679 0.378
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.005 0.1679 0.1679
Loa Loa (eye worm) doublecortin family protein 0.0032 0.1029 0.1318
Plasmodium falciparum histone acetyltransferase GCN5 0.0018 0.0535 0.0511
Trypanosoma brucei glucosidase, putative 0.0014 0.0378 0.2062
Schistosoma mansoni lamin 0.003 0.0963 0.1067
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0052 0.1731 1
Echinococcus granulosus RUN 0.0032 0.1029 0.114
Schistosoma mansoni cpg binding protein 0.0013 0.0342 0.0379
Echinococcus granulosus intermediate filament protein 0.003 0.0963 0.1067
Mycobacterium ulcerans hypothetical protein 0.0011 0.0263 0.0263
Echinococcus granulosus lamin 0.003 0.0963 0.1067
Brugia malayi DNA-directed RNA polymerase III subunit 127.6 kDa polypeptide 0.0006 0.0082 0.0075
Schistosoma mansoni alpha-glucosidase 0.0054 0.1798 0.1992
Trypanosoma cruzi polo-like protein kinase, putative 0.0036 0.1173 0.6748
Loa Loa (eye worm) hypothetical protein 0.0215 0.7548 0.9885
Loa Loa (eye worm) RNA polymerase III 128kD subunit-PA 0.0006 0.0082 0.0073
Leishmania major glycosyl hydrolase-like protein 0.0005 0.0068 0.0247
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0152 0.0152
Loa Loa (eye worm) acetyltransferase 0.0067 0.2283 0.2966
Entamoeba histolytica acyl-coA synthetase, putative 0.0011 0.0263 0.0457
Brugia malayi CXXC zinc finger family protein 0.0013 0.0342 0.0417
Loa Loa (eye worm) hypothetical protein 0.0011 0.0263 0.0311
Loa Loa (eye worm) 6-phosphofructokinase 0.005 0.1679 0.2172
Mycobacterium leprae DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) 0.0107 0.3708 1
Trypanosoma brucei calpain-like protein, putative 0.0052 0.1731 1
Brugia malayi phosphofructokinase 0.005 0.1679 0.2173
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0011 0.0263 0.0263
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0014 0.0369 0.0706
Loa Loa (eye worm) phosphofructokinase 0.005 0.1679 0.2172
Plasmodium vivax acyl-CoA synthetase, putative 0.0008 0.0167 0.0142
Loa Loa (eye worm) hypothetical protein 0.0014 0.0385 0.0472
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0284 1 1
Plasmodium vivax DNA-directed RNA polymerase II subunit RPB2, putative 0.0006 0.0082 0.0056
Echinococcus multilocularis cpg binding protein 0.0014 0.0368 0.0408
Schistosoma mansoni 6-phosphofructokinase 0.005 0.1679 0.186
Brugia malayi Doublecortin family protein 0.0032 0.1029 0.132
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0014 0.0369 0.4379
Brugia malayi Glycosyl hydrolases family 31 protein 0.0062 0.2107 0.2737
Trypanosoma brucei hypothetical protein 0.0052 0.1731 1
Echinococcus multilocularis microtubule associated protein 2 0.0256 0.9025 1
Mycobacterium tuberculosis DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) 0.0026 0.0819 0.0819
Echinococcus multilocularis lamin dm0 0.003 0.0963 0.1067
Loa Loa (eye worm) DNA-directed RNA polymerase II second largest subunit 0.0006 0.0082 0.0073
Echinococcus granulosus Galectin carbohydrate recognition domain 0.0217 0.7636 0.8461
Mycobacterium ulcerans acyl-CoA synthetase 0.0011 0.0263 0.0263
Echinococcus granulosus DNA directed RNA polymerase II subunit RPB2 0.0006 0.0082 0.009
Trichomonas vaginalis maltase-glucoamylase, putative 0.0005 0.0068 0.0405
Echinococcus granulosus histone acetyltransferase KAT2B 0.0065 0.221 0.2448
Trichomonas vaginalis phosphofructokinase, putative 0.0014 0.0369 0.2199
Loa Loa (eye worm) hypothetical protein 0.0015 0.0405 0.0498
Plasmodium vivax DNA-directed RNA polymerase III subunit, putative 0.0006 0.0082 0.0056
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0011 0.0263 0.0708
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.1173 0.6989
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0104 0.3611 0.4711
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0378 0.225
Loa Loa (eye worm) hypothetical protein 0.0032 0.1029 0.1318
Schistosoma mansoni DNA-directed RNA polymerase I subunit 0.0004 0.0026 0.0029
Onchocerca volvulus 0.0032 0.1029 0.1269
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0027 0.0855 0.0947
Brugia malayi 6-phosphofructokinase 0.005 0.1679 0.2173
Loa Loa (eye worm) galectin 0.0217 0.7636 1
Echinococcus granulosus cpg binding protein 0.0014 0.0368 0.0408
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0963 0.1234
Echinococcus granulosus 6 phosphofructokinase 0.005 0.1679 0.186
Loa Loa (eye worm) hypothetical protein 0.0011 0.0263 0.0311
Schistosoma mansoni hypothetical protein 0.0065 0.2196 0.2434
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0011 0.0263 0.0263
Brugia malayi Galactoside-binding lectin family protein 0.0217 0.7636 1
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0284 1 1
Loa Loa (eye worm) runx1 0.0015 0.0433 0.0535
Entamoeba histolytica DNA-directed RNA polymerase subunit, putative 0.0006 0.0082 0.0032
Onchocerca volvulus 0.003 0.0963 0.1183
Loa Loa (eye worm) cytochrome P450 family protein 0.001 0.0245 0.0287
Brugia malayi acetyltransferase, GNAT family protein 0.0067 0.2283 0.2967
Plasmodium vivax multidomain scavenger receptor, putative 0.0032 0.1029 0.1005
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.1173 0.6989
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0067 0.2283 0.2529
Toxoplasma gondii 6-phosphofructokinase 0.0014 0.0369 0.4379
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.1173 0.6989
Schistosoma mansoni DNA-directed RNA polymerase III subunit 0.0006 0.0082 0.009
Loa Loa (eye worm) hypothetical protein 0.0008 0.0167 0.0186
Entamoeba histolytica serine/threonine protein kinase, putative 0.0036 0.1173 0.2594
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0112 0.389 0.431
Schistosoma mansoni cpg binding protein 0.0014 0.0368 0.0408
Trypanosoma brucei glycosyl hydrolase-like protein 0.0005 0.0068 0.0247
Trypanosoma cruzi DNA-directed RNA polymerase III, putative 0.0006 0.0082 0.039
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0031 0.0997 0.1104
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0112 0.389 0.431
Plasmodium falciparum DNA-directed RNA polymerase subunit beta, putative 0.0029 0.0923 0.09
Schistosoma mansoni alpha glucosidase 0.0014 0.0378 0.0418
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0008 0.0167 0.0186
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0011 0.0263 0.0263
Loa Loa (eye worm) DNA-directed RNA polymerase 0.0005 0.0046 0.0027
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0378 0.225
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0152 0.0152
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.1173 0.6989
Schistosoma mansoni rab6-interacting 0.0032 0.1029 0.114
Trichomonas vaginalis CAMK family protein kinase 0.0018 0.0522 0.3112
Echinococcus granulosus lipoxygenase domain containing protein 0.0032 0.1029 0.114
Trichomonas vaginalis phosphofructokinase, putative 0.0014 0.0369 0.2199
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0035 0.1149 0.2537
Schistosoma mansoni lipoxygenase 0.0055 0.1831 0.2028
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0378 0.225
Trypanosoma brucei calpain, putative 0.0052 0.1731 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0167 0.0186
Echinococcus multilocularis 6 phosphofructokinase 0.005 0.1679 0.186
Toxoplasma gondii DNA-directed RNA polymerase III RPC2 0.0006 0.0082 0.071
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0008 0.0184 0.0367
Trichomonas vaginalis phosphofructokinase, putative 0.005 0.1679 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0378 0.225
Plasmodium falciparum DNA-directed RNA polymerase III subunit RPC2, putative 0.0006 0.0082 0.0056
Trichomonas vaginalis DNA-directed RNA polymerase III subunit, putative 0.0006 0.0082 0.0486
Trichomonas vaginalis ap endonuclease, putative 0.0008 0.0184 0.1095
Mycobacterium ulcerans DNA-directed RNA polymerase subunit beta 0.0107 0.3708 0.3708
Loa Loa (eye worm) galactoside-binding lectin family protein 0.0217 0.7636 1
Echinococcus multilocularis lamin 0.003 0.0963 0.1067
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0011 0.0263 0.0708
Leishmania major 4-coumarate:coa ligase-like protein 0.0011 0.0263 0.1389
Entamoeba histolytica phosphofructokinase, putative 0.005 0.1679 0.378
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0005 0.0068 0.0405
Echinococcus granulosus lysosomal alpha glucosidase 0.0062 0.2107 0.2335
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0052 0.1731 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.1029 0.1318
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0008 0.0184 0.0926
Leishmania major alpha glucosidase II subunit, putative 0.0014 0.0378 0.2062
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0405 0.0449
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0284 1 1
Schistosoma mansoni galectin 0.0217 0.7636 0.8461
Loa Loa (eye worm) hypothetical protein 0.0217 0.7636 1
Schistosoma mansoni kinase 0.0018 0.0539 0.0598
Echinococcus granulosus jun protein 0.0031 0.0997 0.1104
Chlamydia trachomatis DNA-directed RNA polymerase subunit beta 0.0107 0.3708 0.3601
Trichomonas vaginalis phosphofructokinase, putative 0.0014 0.0369 0.2199
Loa Loa (eye worm) hypothetical protein 0.0008 0.0167 0.0186
Echinococcus multilocularis DNA directed RNA polymerase I subunit RPA2 0.0006 0.0082 0.009
Loa Loa (eye worm) hypothetical protein 0.0011 0.0263 0.0311
Echinococcus multilocularis lysosomal alpha glucosidase 0.0062 0.2107 0.2335
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0036 0.1173 0.6726
Schistosoma mansoni loxhd1 0.0032 0.1029 0.114
Echinococcus multilocularis neutral alpha glucosidase AB 0.0014 0.0378 0.0418
Trichomonas vaginalis DNA-directed RNA polymerase I subunit, putative 0.0006 0.0082 0.0486
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0011 0.0263 0.0263
Leishmania major 4-coumarate:coa ligase-like protein 0.0011 0.0263 0.1389
Loa Loa (eye worm) intermediate filament protein 0.003 0.0963 0.1232
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.002 0.0594 0.3539
Trichomonas vaginalis alpha-glucosidase, putative 0.0005 0.0068 0.0405
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.002 0.0594 0.725
Schistosoma mansoni hypothetical protein 0.0183 0.6399 0.709
Giardia lamblia Histone acetyltransferase GCN5 0.0018 0.0535 0.1184
Onchocerca volvulus Galectin homolog 0.0217 0.7636 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0068 0.0055
Brugia malayi 6-phosphofructokinase 0.005 0.1679 0.2173
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0014 0.0369 0.0344
Brugia malayi DNA-directed RNA polymerase II second largest subunit, putative 0.0006 0.0082 0.0075
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0008 0.0184 0.0272
Trichomonas vaginalis DNA-directed RNA polymerase I subunit, putative 0.0006 0.0082 0.0486
Echinococcus multilocularis Polycystic kidney disease protein 0.0032 0.1029 0.114
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0378 0.225
Schistosoma mansoni hypothetical protein 0.0065 0.2196 0.2434
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0014 0.0369 0.0344
Trichomonas vaginalis alpha-glucosidase, putative 0.0005 0.0068 0.0405
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.005 0.1679 0.969
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0052 0.1731 1
Schistosoma mansoni ap endonuclease 0.0008 0.0184 0.0204
Onchocerca volvulus 0.0036 0.117 0.1456
Echinococcus multilocularis lysosomal alpha glucosidase 0.0062 0.2107 0.2335
Loa Loa (eye worm) hypothetical protein 0.003 0.0943 0.1206
Echinococcus multilocularis geminin 0.0065 0.2196 0.2434
Trichomonas vaginalis phosphofructokinase, putative 0.0014 0.0369 0.2199
Schistosoma mansoni 6-phosphofructokinase 0.005 0.1679 0.186
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0036 0.1173 0.1508
Trypanosoma brucei DNA-directed RNA polymerase III, putative 0.0006 0.0082 0.0326
Entamoeba histolytica phosphofructokinase, putative 0.005 0.1679 0.378
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0378 0.225
Schistosoma mansoni polycystin 1-related 0.0032 0.1029 0.114
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0378 0.0464
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.1173 0.6989
Trichomonas vaginalis phosphofructokinase, putative 0.005 0.1679 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0005 0.0068 0.0405
Leishmania major 4-coumarate:coa ligase-like protein 0.0011 0.0263 0.1389
Echinococcus multilocularis lipoxygenase domain containing protein 0.0032 0.1029 0.114
Brugia malayi hypothetical protein 0.0032 0.1029 0.132
Entamoeba histolytica DNA-directed RNA polymerase III subunit 127.6 kDa polypeptide, putative 0.0006 0.0082 0.0032
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.005 0.1679 0.9692
Schistosoma mansoni microtubule-associated protein tau 0.0256 0.9025 1
Echinococcus granulosus DNA directed RNA polymerase I subunit RPA2 0.0006 0.0082 0.009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0008 0.0184 0.0986
Echinococcus multilocularis Protein lozenge 0.0015 0.0433 0.048
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0008 0.0184 0.0926
Toxoplasma gondii histone lysine methyltransferase SET1 0.0026 0.081 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0008 0.0184 0.0158
Onchocerca volvulus 0.0032 0.1029 0.1269
Entamoeba histolytica acyl-CoA synthetase, putative 0.0011 0.0263 0.0457
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.002 0.0594 0.725
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0052 0.1731 1
Treponema pallidum DNA-directed RNA polymerase subunit beta 0.0107 0.3708 1
Toxoplasma gondii phosphofructokinase PFKII 0.0014 0.0369 0.4379
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0005 0.0068 0.0405
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0005 0.0068 0.0311
Trichomonas vaginalis phosphofructokinase, putative 0.005 0.1679 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0052 0.1731 1
Schistosoma mansoni cpg binding protein 0.0014 0.0368 0.0408
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0378 0.2114
Mycobacterium ulcerans acyl-CoA synthetase 0.0011 0.0263 0.0263
Mycobacterium ulcerans acyl-CoA synthetase 0.0011 0.0263 0.0263
Echinococcus granulosus microtubule associated protein 2 0.0256 0.9025 1
Brugia malayi follicle stimulating hormone receptor 0.0104 0.3611 0.4713
Schistosoma mansoni hypothetical protein 0.0039 0.1288 0.1427
Onchocerca volvulus Galectin homolog 0.0217 0.7636 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0008 0.0184 0.0986
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0036 0.1173 0.13
Loa Loa (eye worm) hypothetical protein 0.0217 0.7636 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0018 0.0535 0.1097
Echinococcus multilocularis RUN 0.0032 0.1029 0.114
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0052 0.1731 1
Giardia lamblia DNA-directed RNA polymerase RPB2 0.0006 0.0082 0.0129
Schistosoma mansoni lipoxygenase 0.0112 0.389 0.431
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0008 0.0184 0.0184
Treponema pallidum exodeoxyribonuclease (exoA) 0.0008 0.0184 0.0496
Toxoplasma gondii DNA-directed RNA polymerase II RPB2 0.0006 0.0082 0.071
Loa Loa (eye worm) hypothetical protein 0.0217 0.7636 1
Leishmania major DNA-directed RNA polymerase polypeptide, putative 0.0006 0.0082 0.0326
Trichomonas vaginalis phosphofructokinase, putative 0.0014 0.0369 0.2199
Onchocerca volvulus 0.0013 0.0342 0.0362
Brugia malayi hypothetical protein 0.0032 0.1029 0.132
Brugia malayi AMP-binding enzyme family protein 0.0011 0.0263 0.0314
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0014 0.0369 0.0205
Schistosoma mansoni DNA-directed RNA polymerase III subunit 0.0006 0.0082 0.009
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0008 0.0184 0.0208
Trichomonas vaginalis phosphofructokinase, putative 0.0014 0.0369 0.2199
Brugia malayi hypothetical protein 0.0024 0.0758 0.0964
Echinococcus granulosus Polycystic kidney disease protein 0.0032 0.1029 0.114
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0405 0.0449
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0067 0.2283 0.2529
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0052 0.1731 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0005 0.0068 0.0405
Loa Loa (eye worm) galactoside-binding lectin family protein 0.0217 0.7636 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0014 0.0369 0.0995
Brugia malayi DNA-directed RNA polymerase, beta subunit family protein 0.0006 0.0082 0.0075
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0052 0.1731 1
Plasmodium falciparum acyl-CoA synthetase 0.0008 0.0167 0.0142
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0005 0.0068 0.0311
Trichomonas vaginalis alpha-glucosidase, putative 0.0005 0.0068 0.0405
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0014 0.0378 0.4488
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0284 1 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0062 0.2107 0.2735
Schistosoma mansoni lozenge 0.0015 0.0433 0.048
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.005 0.1679 0.4527

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 0 % Inhibition of Aurora A kinase (unknown origin) at 10 uM ChEMBL. 18243698
Inhibition (binding) = 0 % Inhibition of Aurora A kinase (unknown origin) at 10 uM ChEMBL. 18243698
Inhibition (binding) = 1.1 % Inhibition of Aurora A kinase (unknown origin) at 50 uM ChEMBL. 18243698
Inhibition (binding) = 1.1 % Inhibition of Aurora A kinase (unknown origin) at 50 uM ChEMBL. 18243698

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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