Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0082 | 0.0517 | 0.1014 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0694 | 0.1361 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0607 | 0.51 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0056 | 0.0284 | 0.0274 |
Echinococcus granulosus | acetylcholinesterase | 0.0607 | 0.51 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0607 | 0.51 | 1 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0082 | 0.0517 | 0.0557 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0517 | 0.1014 |
Brugia malayi | Carboxylesterase family protein | 0.0607 | 0.51 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0789 | 0.6687 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0051 | 0.0247 | 0.0976 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0142 | 0.1038 | 0.4294 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0097 | 0.0648 | 0.1088 |
Brugia malayi | amidase | 0.0098 | 0.0659 | 0.1291 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.099 | 0.1773 |
Schistosoma mansoni | acetylcholinesterase | 0.0103 | 0.0694 | 0.1181 |
Loa Loa (eye worm) | hypothetical protein | 0.0607 | 0.51 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0082 | 0.0517 | 0.2097 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0694 | 0.1361 |
Onchocerca volvulus | 0.0103 | 0.0694 | 1 | |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0103 | 0.0694 | 0.0896 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0103 | 0.0694 | 0.0748 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0173 | 0.0139 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0103 | 0.0694 | 0.1181 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0103 | 0.0694 | 0.1181 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0082 | 0.0517 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0056 | 0.0284 | 0.0361 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0103 | 0.0694 | 0.0694 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0043 | 0.0173 | 0.0105 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.0167 | 0.0641 |
Onchocerca volvulus | 0.0092 | 0.0599 | 0.8628 | |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0013 | 0.0025 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0043 | 0.0173 | 0.0139 |
Giardia lamblia | PHD finger protein 15 | 0.0035 | 0.0108 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0607 | 0.51 | 1 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0035 | 0.0108 | 0.0006 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0106 | 0.0387 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0161 | 0.0315 |
Onchocerca volvulus | 0.0103 | 0.0694 | 1 | |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0142 | 0.1038 | 0.4264 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0098 | 0.0659 | 0.0842 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.03 | 0.2417 | 1 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0082 | 0.0517 | 1 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0145 | 0.0081 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0103 | 0.0694 | 0.1181 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0103 | 0.0694 | 1 |
Onchocerca volvulus | 0.0103 | 0.0694 | 1 | |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0098 | 0.0659 | 0.0842 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0145 | 0.0081 |
Brugia malayi | Carboxylesterase family protein | 0.0103 | 0.0694 | 0.1361 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0103 | 0.0694 | 0.0896 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0108 | 0.0212 |
Echinococcus multilocularis | protein dispatched 1 | 0.0047 | 0.0208 | 0.0158 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0041 | 0.0158 | 0.0309 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0158 | 0.1178 | 0.1269 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0103 | 0.0694 | 0.1181 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0096 | 0.0635 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0043 | 0.0173 | 0.034 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0098 | 0.0659 | 0.111 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0161 | 0.0315 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0517 | 0.1014 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0694 | 0.1361 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0694 | 0.1361 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0108 | 0.0008 |
Brugia malayi | Carboxylesterase family protein | 0.0607 | 0.51 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0035 | 0.0108 | 0.0212 |
Brugia malayi | hypothetical protein | 0.0103 | 0.0694 | 0.1361 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0056 | 0.0284 | 0.0361 |
Echinococcus granulosus | expressed conserved protein | 0.009 | 0.0584 | 0.0961 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0082 | 0.0517 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0103 | 0.0694 | 0.1361 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0145 | 0.0081 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0082 | 0.0517 | 0.0627 |
Echinococcus multilocularis | 0.0082 | 0.0517 | 0.0627 | |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0082 | 0.0517 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.03 | 0.2417 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0104 | 0.1641 |
Loa Loa (eye worm) | hypothetical protein | 0.0607 | 0.51 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0607 | 0.51 | 0.7589 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0607 | 0.51 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0607 | 0.51 | 0.7589 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0035 | 0.0108 | 0.1895 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0104 | 0.1641 |
Echinococcus multilocularis | protein patched | 0.0041 | 0.0158 | 0.0081 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0694 | 0.1361 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0104 | 0.1641 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0013 | 0.0025 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0142 | 0.1038 | 0.4264 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0158 | 0.1183 | 0.2159 |
Echinococcus granulosus | peregrin | 0.0035 | 0.0108 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.033 | 0.0646 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0042 | 0.0167 | 0.0641 |
Onchocerca volvulus | Alhambra homolog | 0.0035 | 0.0108 | 0.156 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0035 | 0.0108 | 0.0212 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0098 | 0.0659 | 0.111 |
Plasmodium vivax | hypothetical protein, conserved | 0.0082 | 0.0517 | 1 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0049 | 0.023 | 0.019 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0035 | 0.0108 | 0.0008 |
Mycobacterium ulcerans | hypothetical protein | 0.0158 | 0.1178 | 0.1178 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0061 | 0.0328 | 0.0643 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0238 | 0.0467 |
Loa Loa (eye worm) | carboxylesterase | 0.0103 | 0.0694 | 0.1361 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0082 | 0.0517 | 0.0627 |
Leishmania major | UDP-galactopyranose mutase | 0.0082 | 0.0517 | 0.2139 |
Onchocerca volvulus | 0.0082 | 0.0517 | 0.7446 | |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0103 | 0.0694 | 0.1181 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 0.1183 | 0.1638 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0035 | 0.0106 | 0.1665 |
Schistosoma mansoni | amidase | 0.0098 | 0.0659 | 0.111 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0158 | 0.088 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 0.1183 | 0.1638 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0082 | 0.0517 | 0.0826 |
Brugia malayi | Carboxylesterase family protein | 0.0103 | 0.0694 | 0.1361 |
Mycobacterium ulcerans | oxidoreductase | 0.0082 | 0.0517 | 0.0517 |
Schistosoma mansoni | gliotactin | 0.0103 | 0.0694 | 0.1181 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0517 | 0.1014 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0103 | 0.0694 | 0.1181 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0659 | 0.1291 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0694 | 0.1361 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0035 | 0.0106 | 0.0002 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0035 | 0.0108 | 0.1895 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0082 | 0.0517 | 1 |
Brugia malayi | CHE-14 protein | 0.0041 | 0.0158 | 0.0309 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0145 | 0.0081 |
Brugia malayi | PHD-finger family protein | 0.0035 | 0.0108 | 0.0212 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0082 | 0.0517 | 0.5 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.1086 | 0.9282 | 1 |
Plasmodium falciparum | phd finger protein, putative | 0.0035 | 0.0108 | 0.1895 |
Loa Loa (eye worm) | carboxylesterase | 0.0103 | 0.0694 | 0.1361 |
Schistosoma mansoni | alpha glucosidase | 0.0035 | 0.0106 | 0.0003 |
Onchocerca volvulus | 0.0103 | 0.0694 | 1 | |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0082 | 0.0517 | 0.0517 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0517 | 0.1014 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0041 | 0.0158 | 0.0107 |
Echinococcus granulosus | neuroligin | 0.0103 | 0.0694 | 0.1181 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0056 | 0.0284 | 0.0361 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0137 | 0.0994 | 0.1351 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.099 | 0.1773 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0104 | 0.0204 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0056 | 0.0284 | 0.0558 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0043 | 0.0173 | 0.034 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0082 | 0.0517 | 0.0826 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0056 | 0.0284 | 0.0274 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0158 | 0.1183 | 0.2319 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0103 | 0.0694 | 0.1181 |
Onchocerca volvulus | 0.0103 | 0.0694 | 1 | |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0116 | 0.0813 | 0.1419 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0158 | 0.1183 | 0.2319 |
Mycobacterium ulcerans | monoamine oxidase | 0.0082 | 0.0517 | 0.0517 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0082 | 0.0517 | 0.2097 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0035 | 0.0106 | 0.1665 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0035 | 0.0106 | 0.0207 |
Echinococcus granulosus | acetylcholinesterase | 0.0607 | 0.51 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0108 | 0.1895 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0173 | 0.0139 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0073 | 0.0438 | 0.0859 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0082 | 0.0517 | 0.0557 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0635 | 0.1245 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0035 | 0.0106 | 0.1844 |
Schistosoma mansoni | amine oxidase | 0.0082 | 0.0517 | 0.0826 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0061 | 0.0328 | 0.0643 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0103 | 0.0694 | 0.1181 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0328 | 0.0643 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0158 | 0.0309 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0082 | 0.0517 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0137 | 0.0994 | 0.1781 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0082 | 0.0517 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0096 | 0.0635 | 0.1062 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0061 | 0.0328 | 0.0643 |
Echinococcus multilocularis | peregrin | 0.0035 | 0.0108 | 0.0006 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0104 | 0.1641 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0096 | 0.0635 | 0.0806 |
Plasmodium vivax | hypothetical protein, conserved | 0.0082 | 0.0517 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0103 | 0.0694 | 0.0748 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0103 | 0.0694 | 0.0748 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0056 | 0.0284 | 0.0361 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0035 | 0.0106 | 0.0207 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0035 | 0.0106 | 0.0437 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0116 | 0.0813 | 0.1077 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0035 | 0.0106 | 0.0003 |
Echinococcus granulosus | jumonji domain containing protein | 0.0049 | 0.023 | 0.0251 |
Schistosoma mansoni | patched 1 | 0.0041 | 0.0158 | 0.0107 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0035 | 0.0108 | 0.0008 |
Trypanosoma brucei | glucosidase, putative | 0.0035 | 0.0106 | 0.0387 |
Schistosoma mansoni | amine oxidase | 0.0082 | 0.0517 | 0.0826 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0607 | 0.51 | 0.7589 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.0167 | 0.0641 |
Brugia malayi | SWIRM domain containing protein | 0.0082 | 0.0517 | 0.1014 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0041 | 0.0158 | 0.0107 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0103 | 0.0694 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0082 | 0.0517 | 0.0826 |
Toxoplasma gondii | hypothetical protein | 0.0048 | 0.0221 | 0.4129 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0013 | 0.0053 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0056 | 0.0284 | 0.0361 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0041 | 0.0158 | 0.0081 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0517 | 0.1014 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0517 | 0.1014 |
Brugia malayi | hypothetical protein | 0.0082 | 0.0517 | 0.1014 |
Echinococcus multilocularis | expressed conserved protein | 0.009 | 0.0584 | 0.0729 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0096 | 0.0635 | 0.1245 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0082 | 0.0517 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0092 | 0.0604 | 0.1001 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0103 | 0.0694 | 0.0896 |
Leishmania major | mitochondrial DNA polymerase beta | 0.03 | 0.2417 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0042 | 0.0167 | 0.0641 |
Brugia malayi | Carboxylesterase family protein | 0.0103 | 0.0694 | 0.1361 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.03 | 0.2417 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0161 | 0.0113 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0098 | 0.0659 | 0.111 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0082 | 0.0517 | 0.0826 |
Echinococcus multilocularis | neuroligin | 0.0103 | 0.0694 | 0.0896 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0106 | 0.0387 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.1168 | 1 | 1 |
Mycobacterium ulcerans | dehydrogenase | 0.0082 | 0.0517 | 0.0517 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0694 | 0.1361 |
Brugia malayi | jmjC domain containing protein | 0.0116 | 0.0813 | 0.1594 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0056 | 0.0284 | 0.0558 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.