Detailed information for compound 51926

Basic information

Technical information
  • TDR Targets ID: 51926
  • Name: 2-Butyloxycarbonyloxy-1,1,10-trimethyl-6,9-ep idioxydecalin
  • MW: 326.428 | Formula: C18H30O5
  • H donors: 0 H acceptors: 1 LogP: 4.64 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCOC(=O)OC1CCC2(C3(C1(C)C)CCC(C2)OO3)C
  • InChi: 1S/C18H30O5/c1-5-6-11-20-15(19)21-14-8-9-17(4)12-13-7-10-18(17,23-22-13)16(14,2)3/h13-14H,5-12H2,1-4H3
  • InChiKey: PGXROGJUTKCNEB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-Butyloxycarbonyl-1,1,10-trimethyl-6,9-epidioxy decalin
  • AIDS-146911
  • AIDS146911
  • NSC675726

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0075 0.0113
Brugia malayi RNase H family protein 0.0022 0.003 0.0308
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0013 0.0136
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0012
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0074 0.0287 0.3918
Schistosoma mansoni hypothetical protein 0.0169 0.0745 0.1122
Entamoeba histolytica hypothetical protein 0.0078 0.0304 0.0811
Entamoeba histolytica hypothetical protein 0.0078 0.0304 0.0811
Echinococcus granulosus concentrative Na nucleoside cotransporter 0.0342 0.1589 0.239
Schistosoma mansoni glycogen phosphorylase 0.0048 0.016 0.024
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0022 0.0012
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0009 0.0014
Brugia malayi Cathepsin L-like precursor 0.0017 0.0009 0.0098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0013 0.0136
Brugia malayi hypothetical protein 0.0078 0.0302 0.311
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0142 0.0214
Echinococcus multilocularis thymidine kinase 0.1382 0.6646 1
Brugia malayi RNase H family protein 0.0022 0.003 0.0308
Toxoplasma gondii ribonuclease HI protein 0.0022 0.003 0.0288
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0013 0.002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0136
Trichomonas vaginalis ribonuclease H1, putative 0.0022 0.003 0.0056
Echinococcus granulosus solute carrier family 28 0.0342 0.1589 0.239
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0012
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0287 0.0764
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0161 0.1661
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0304 0.0811
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0018 0.0023
Echinococcus multilocularis ribonuclease H1 0.0022 0.003 0.0045
Echinococcus granulosus dna polymerase kappa 0.002 0.0022 0.0034
Schistosoma mansoni inositol monophosphatase 0.0074 0.0287 0.0432
Loa Loa (eye worm) deoxynucleoside kinase 0.0078 0.0304 0.3129
Trypanosoma cruzi cytidine deaminase-like protein 0.0053 0.0185 0.0483
Echinococcus multilocularis thymidylate synthase 0.0163 0.0718 0.108
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0022 0.023
Trypanosoma brucei ingi protein (ORF1) 0.0026 0.0054 0.0098
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0018 0.0119
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.0177 0.0462
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.023
Brugia malayi Cathepsin L-like precursor 0.0017 0.0009 0.0098
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.0972 1
Toxoplasma gondii cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein 0.0053 0.0185 0.2479
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0287 0.0764
Giardia lamblia CDC8 0.0146 0.0634 0.0617
Loa Loa (eye worm) fibroinase 0.0017 0.0009 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0013 0.0136
Echinococcus multilocularis thyroid hormone receptor alpha 0.0146 0.0633 0.0953
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0012
Treponema pallidum ribonuclease H (rnhA) 0.0022 0.003 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0304 0.0811
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0018 0.0119
Mycobacterium ulcerans cytidine deaminase 0.0053 0.0185 0.2388
Trichomonas vaginalis glycogen phosphorylase, putative 0.0111 0.0467 0.1261
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.0146 0.0634 0.8427
Echinococcus multilocularis dna polymerase kappa 0.002 0.0022 0.0034
Trichomonas vaginalis glycogen phosphorylase, putative 0.0111 0.0467 0.1261
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0022 0.0012
Loa Loa (eye worm) inositol-1 0.0074 0.0287 0.2953
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0078 0.0304 0.0458
Echinococcus multilocularis inositol monophosphatase 1 0.0074 0.0287 0.0432
Schistosoma mansoni hypothetical protein 0.0169 0.0745 0.1122
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0018 0.0023
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0013 0.0136
Trypanosoma cruzi ribonuclease H1, putative 0.0022 0.003 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0302 0.0806
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.007 0.0105
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0078 0.0304 0.0811
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0163 0.0718 0.195
Mycobacterium ulcerans thymidylate synthase 0.0163 0.0718 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0013 0.0136
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0022 0.0035
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0013 0.002
Entamoeba histolytica glycogen phosphorylase, putative 0.0111 0.0467 0.1261
Echinococcus granulosus glycogen phosphorylase 0.0111 0.0467 0.0703
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0009 0.0014
Echinococcus multilocularis transfer RNA-Ile 0.1382 0.6646 1
Entamoeba histolytica cytidine deaminase, putative 0.0053 0.0185 0.0483
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0074 0.0287 0.4367
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0013 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0013 0.0136
Onchocerca volvulus 0.0053 0.0185 0.1586
Toxoplasma gondii thymidylate kinase 0.0146 0.0634 0.8817
Leishmania major cytidine deaminase-like protein 0.0053 0.0185 0.0483
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0161 0.1661
Trichomonas vaginalis cytidine deaminase, putative 0.0053 0.0185 0.0483
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0009 0.0014
Echinococcus granulosus cytidine deaminase 0.0053 0.0185 0.0278
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0022 0.0012
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0218 0.0575
Loa Loa (eye worm) cysteine protease 0.0017 0.0009 0.0098
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0018 0.0023
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0161 0.1661
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0013 0.0136
Leishmania major thymidine kinase, putative 0.0764 0.3641 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0142 0.0214
Trichomonas vaginalis thymidylate kinase, putative 0.0146 0.0634 0.1719
Echinococcus granulosus inositol monophosphatase 1 0.0074 0.0287 0.0432
Entamoeba histolytica glycogen phosphorylase, putative 0.0048 0.016 0.0414
Echinococcus multilocularis thymidine kinase 0.1382 0.6646 1
Plasmodium falciparum thymidylate kinase 0.0146 0.0634 0.8817
Trypanosoma brucei unspecified product 0.0026 0.0054 0.0098
Echinococcus multilocularis cysteine protease 0.0017 0.0009 0.0014
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0045 0.0507
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0246 0.063
Onchocerca volvulus 0.0245 0.1116 1
Trichomonas vaginalis thymidine kinase, putative 0.0764 0.3641 1
Brugia malayi Pre-SET motif family protein 0.0215 0.0972 1
Schistosoma mansoni thymidylate kinase 0.0146 0.0634 0.0954
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0048 0.016 0.2026
Leishmania major cathepsin L-like protease 0.0066 0.0246 0.0651
Leishmania major DNA polymerase eta, putative 0.002 0.0022 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0246 0.063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0246 0.063
Onchocerca volvulus Protein ultraspiracle homolog 0.0018 0.0013 0.0034
Echinococcus granulosus Glycosyl transferase family 35 0.0111 0.0467 0.0703
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0078 0.0302 0.0806
Giardia lamblia Hypothetical protein 0.0078 0.0304 0.0287
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0022 0.0012
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0022 0.0034
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0246 0.0651
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0022 0.0034
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0136
Echinococcus multilocularis cytidine deaminase 0.0053 0.0185 0.0278
Echinococcus granulosus thymidylate kinase 0.0146 0.0634 0.0954
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0013 0.002
Trypanosoma cruzi cytidine deaminase-like protein, putative 0.0053 0.0185 0.0483
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0128 0.0545 0.0821
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0013 0.0136
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0067 0.0249 0.3303
Schistosoma mansoni glycogen phosphorylase 0.0111 0.0467 0.0703
Entamoeba histolytica hypothetical protein 0.0078 0.0304 0.0811
Onchocerca volvulus 0.0018 0.0013 0.0034
Leishmania major cathepsin L-like protease 0.0066 0.0246 0.0651
Echinococcus granulosus ribonuclease H1 0.0022 0.003 0.0045
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0142 0.0214
Brugia malayi nuclear receptor NHR-88 0.0018 0.0013 0.0136
Brugia malayi thymidylate synthase 0.0163 0.0718 0.7386
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0022 0.003 0.0194
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0287 0.0764
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0026 0.0054 0.0098
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0163 0.0718 0.195
Echinococcus granulosus glycogen phosphorylase 0.0111 0.0467 0.0703
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0022 0.0034
Toxoplasma gondii exonuclease III APE 0.0019 0.0018 0.0119
Echinococcus multilocularis glycogen phosphorylase 0.0111 0.0467 0.0703
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0013 0.0136
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0045 0.0507
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.1382 0.6646 1
Brugia malayi Pre-SET motif family protein 0.0031 0.0075 0.0776
Giardia lamblia Glycogen phosphorylase 0.0111 0.0467 0.045
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0022 0.0035
Schistosoma mansoni thyroid hormone receptor 0.0146 0.0633 0.0953
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0163 0.0718 1
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0013 0.0136
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0022 0.0035
Schistosoma mansoni hypothetical protein 0.0106 0.044 0.0662
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0022 0.0063
Echinococcus granulosus geminin 0.0169 0.0745 0.1122
Mycobacterium tuberculosis Hypothetical protein 0.0078 0.0302 0.4063
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0009 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0013 0.0136
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0013 0.002
Trypanosoma cruzi thymidylate kinase, putative 0.0146 0.0634 0.1719
Brugia malayi ecdysteroid receptor 0.0018 0.0013 0.0136
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0022 0.0063
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0009 0.0098
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0013 0.002
Onchocerca volvulus Putative thymidylate kinase 0.0146 0.0634 0.5641
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0075 0.0113
Loa Loa (eye worm) hypothetical protein 0.0031 0.0075 0.0776
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0078 0.0304 0.0811
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0163 0.0718 1
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0022 0.0063
Brugia malayi steroid hormone receptor 0.0018 0.0013 0.0136
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0057 0.0203 0.0534
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0013 0.0136
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0013 0.002
Trypanosoma brucei RNA helicase, putative 0.0215 0.0971 0.2631
Trypanosoma brucei unspecified product 0.002 0.0022 0.0012
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0075 0.0931
Schistosoma mansoni thyroid hormone receptor 0.0146 0.0633 0.0953
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0009 0.0014
Trypanosoma cruzi thymidine kinase, putative 0.0764 0.3641 1
Trypanosoma brucei thymidylate kinase, putative 0.0146 0.0634 0.17
Giardia lamblia Cytidine deaminase 0.0053 0.0185 0.0167
Schistosoma mansoni phosphoglucomutase 0.0022 0.003 0.0045
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0013 0.002
Loa Loa (eye worm) glycogen phosphorylase 0.0111 0.0467 0.481
Leishmania major cathepsin L-like protease 0.0066 0.0246 0.0651
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0009 0.0014
Schistosoma mansoni hypothetical protein 0.0033 0.0087 0.013
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0013 0.002
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0022 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0246 0.063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0246 0.063
Trichomonas vaginalis thymidylate kinase, putative 0.0146 0.0634 0.1719
Trypanosoma brucei thymidylate kinase, putative 0.0146 0.0634 0.17
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0022 0.0035
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0009 0.0098
Schistosoma mansoni thymidine kinase 0.1382 0.6646 1
Echinococcus multilocularis concentrative Na+ nucleoside cotransporter 0.0342 0.1589 0.239
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0075 0.0113
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0057 0.0203 0.0534
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0098
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0022 0.023
Echinococcus multilocularis glycogen phosphorylase 0.0111 0.0467 0.0703
Giardia lamblia Ribonuclease H 0.0022 0.003 0.0012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0246 0.063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0013 0.0136
Schistosoma mansoni inositol monophosphatase 0.0074 0.0287 0.0432
Entamoeba histolytica thymidine kinase, putative 0.0764 0.3641 1
Trichomonas vaginalis cytidine deaminase, putative 0.0053 0.0185 0.0483
Brugia malayi Deoxynucleoside kinase family protein 0.0078 0.0304 0.3129
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0013 0.0136
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0022 0.0035
Trypanosoma brucei cytidine deaminase 0.0053 0.0185 0.0461
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0163 0.0718 1
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.0246 0.0651
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0136
Loa Loa (eye worm) hypothetical protein 0.0025 0.0045 0.0467
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0018 0.0023
Entamoeba histolytica hypothetical protein 0.0078 0.0304 0.0811
Onchocerca volvulus 0.0163 0.0718 0.6398
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0013 0.002
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0013 0.002
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0045 0.0076
Echinococcus granulosus NADH ubiquinone oxidoreductase 42 kDa subunit 0.0078 0.0304 0.0458
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0045 0.0507
Mycobacterium ulcerans thymidylate kinase 0.0146 0.0634 0.8802
Echinococcus granulosus cathepsin l1 0.0017 0.0009 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0304 0.0811
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0013 0.0136
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0013 0.002
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0013 0.002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0018 0.0023
Onchocerca volvulus Glycogen phosphorylase homolog 0.0111 0.0467 0.4138
Schistosoma mansoni thymidylate kinase 0.0146 0.0634 0.0954
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0018 0.0027
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0013 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0012
Brugia malayi hypothetical protein 0.0025 0.0045 0.0467
Giardia lamblia Hypothetical protein 0.0078 0.0304 0.0287
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0074 0.0287 0.3844
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0013 0.0136
Schistosoma mansoni phosphoglucomutase 0.0022 0.003 0.0045
Brugia malayi Inositol-1 0.0074 0.0287 0.2953
Schistosoma mansoni hypothetical protein 0.0146 0.0634 0.0954
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0075 0.0113
Leishmania major hypothetical protein, conserved 0.0025 0.0045 0.0099
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0136
Schistosoma mansoni coup transcription factor 0.0018 0.0013 0.002
Onchocerca volvulus Bile acid receptor homolog 0.0018 0.0013 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0246 0.063
Entamoeba histolytica hypothetical protein 0.0078 0.0304 0.0811
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0142 0.0214
Loa Loa (eye worm) thymidylate kinase 0.0146 0.0634 0.6523
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0012
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0067 0.0249 0.1202
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0287 0.0764
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0087 0.0892
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0163 0.0718 1
Trichomonas vaginalis thymidine kinase, putative 0.0764 0.3641 1
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0246 0.0651
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0142 0.1461
Echinococcus granulosus thymidine kinase 0.1382 0.6646 1
Echinococcus multilocularis solute carrier family 28 0.0342 0.1589 0.239
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0075 0.0113
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0009 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0013 0.0136
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0018 0.0023
Chlamydia trachomatis thymidylate kinase 0.0146 0.0634 1
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0013 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0304 0.0811
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0146 0.0634 1
Schistosoma mansoni phosphoglucomutase 0.0022 0.003 0.0045
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0022 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0246 0.063
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0163 0.0718 0.108
Brugia malayi Cathepsin L-like precursor 0.0017 0.0009 0.0098
Echinococcus granulosus dna polymerase eta 0.002 0.0022 0.0034
Onchocerca volvulus 0.0053 0.0185 0.1586
Trypanosoma brucei thymidine kinase 0.0764 0.3641 1
Giardia lamblia DINP protein human, muc B family 0.002 0.0022 0.0004
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0018 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0246 0.063
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0013 0.002
Brugia malayi thymidylate kinase 0.0146 0.0634 0.6523
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0075 0.0113
Brugia malayi carbohydrate phosphorylase 0.0111 0.0467 0.481
Brugia malayi Cathepsin L-like precursor 0.0017 0.0009 0.0098
Onchocerca volvulus Ribonuclease H1 homolog 0.0022 0.003 0.0184
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0013 0.002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0142 0.0214
Schistosoma mansoni hypothetical protein 0.0215 0.0971 0.1461
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0013 0.002
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0013 0.002
Brugia malayi RNase H family protein 0.0022 0.003 0.0308
Echinococcus multilocularis NADH ubiquinone oxidoreductase 42 kDa subunit 0.0078 0.0304 0.0458
Entamoeba histolytica glycogenphosphorylase, putative 0.0048 0.016 0.0414
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0048 0.016 0.2026
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0013 0.002
Echinococcus multilocularis geminin 0.0169 0.0745 0.1122
Leishmania major DNA polymerase kappa, putative 0.002 0.0022 0.0035
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0013 0.0136
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0022 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0012
Leishmania major hypothetical protein, conserved 0.0057 0.0203 0.0534
Trypanosoma cruzi ribonuclease H1, putative 0.0022 0.003 0.0056
Entamoeba histolytica hypothetical protein 0.0078 0.0304 0.0811
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0013 0.002
Schistosoma mansoni glycogen phosphorylase 0.0111 0.0467 0.0703
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0022 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0136
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0078 0.0304 0.0811
Onchocerca volvulus 0.0031 0.0075 0.0595
Entamoeba histolytica hypothetical protein 0.0078 0.0304 0.0811
Giardia lamblia Deoxyguanosine kinase/deoxyadenosine kinase subunit, putative 0.0078 0.0304 0.0287
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0075 0.0113
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0018 0.0013 0.0034
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0287 0.0764
Mycobacterium tuberculosis Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) 0.0053 0.0185 0.2388
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0146 0.0634 0.8802
Echinococcus multilocularis thymidylate kinase 0.0146 0.0634 0.0954
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0012
Schistosoma mansoni hypothetical protein 0.0128 0.0545 0.0821
Entamoeba histolytica hypothetical protein 0.0078 0.0304 0.0811
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0022 0.0035
Echinococcus multilocularis dna polymerase eta 0.002 0.0022 0.0034
Brugia malayi hypothetical protein 0.0016 0.0003 0.0029
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0163 0.0718 1
Trichomonas vaginalis thymidine kinase, putative 0.0764 0.3641 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0013 0.002
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0013 0.0136
Echinococcus granulosus thymidylate synthase 0.0163 0.0718 0.108
Leishmania major thymidylate kinase-like protein 0.0146 0.0634 0.1719
Trypanosoma brucei ingi protein (ORF1) 0.0026 0.0054 0.0098
Trypanosoma cruzi thymidylate kinase, putative 0.0146 0.0634 0.1719
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0078 0.0304 0.0811
Loa Loa (eye worm) ctsf protein 0.0017 0.0009 0.0098
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0045 0.0099
Leishmania major ribonuclease H1, putative 0.0022 0.003 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0012
Brugia malayi cytidine deaminase, identical 0.0053 0.0185 0.1904
Schistosoma mansoni ap endonuclease 0.0019 0.0018 0.0027
Entamoeba histolytica glycogen phosphorylase, putative 0.0048 0.016 0.0414
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0022 0.0063
Trichomonas vaginalis inositol monophosphatase, putative 0.0074 0.0287 0.0764
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0246 0.063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0246 0.063
Trypanosoma cruzi thymidine kinase, putative 0.0764 0.3641 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0013 0.0136
Entamoeba histolytica glycogen phosphorylase, putative 0.0111 0.0467 0.1261
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0013 0.002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0142 0.0214
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0009 0.0014
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0013 0.002
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0045 0.0507
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0012
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0022 0.023
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0246 0.0651
Brugia malayi Cathepsin L-like precursor 0.0017 0.0009 0.0098
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0018 0.0185
Plasmodium vivax SET domain protein, putative 0.0031 0.0075 0.0931
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0013 0.0136
Echinococcus multilocularis sodium:nucleoside cotransporter 2 0.0223 0.101 0.152
Echinococcus multilocularis cysteine protease 0.0017 0.0009 0.0014
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0045 0.0099
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0013 0.002
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0013 0.002
Treponema pallidum thymidylate kinase (tmk) 0.0146 0.0634 1
Loa Loa (eye worm) thymidylate synthase 0.0163 0.0718 0.7386
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0018 0.0185
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0304 0.0811
Entamoeba histolytica hypothetical protein 0.0078 0.0304 0.0811
Schistosoma mansoni DNA polymerase eta 0.002 0.0022 0.0034
Trichomonas vaginalis set domain proteins, putative 0.0245 0.1116 0.3048
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0074 0.0287 0.0764
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0142 0.1461
Giardia lamblia Thymidine kinase 0.0764 0.3641 0.363
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0054 0.0098
Entamoeba histolytica Thymidylate kinase, putative 0.0146 0.0634 0.1719
Echinococcus granulosus thymidine kinase 0.1382 0.6646 1
Echinococcus multilocularis Glycosyl transferase, family 35 0.0111 0.0467 0.0703
Loa Loa (eye worm) hypothetical protein 0.0033 0.0087 0.0892
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0009 0.0098
Brugia malayi nuclear hormone receptor 0.0018 0.0013 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0013 0.0136
Echinococcus granulosus Na+ dependent nucleoside transporter 0.0342 0.1589 0.239
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0013 0.0136
Trypanosoma brucei ribonuclease H1 0.0022 0.003 0.0033
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0128 0.0545 0.0821
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0013 0.002
Schistosoma mansoni ap endonuclease 0.0019 0.0018 0.0027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0142 0.0214
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0287 0.0742
Loa Loa (eye worm) hypothetical protein 0.0049 0.0161 0.1661
Plasmodium vivax thymidylate kinase, putative 0.0146 0.0634 0.8817
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0013 0.0136
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0163 0.0718 0.1931
Brugia malayi Cathepsin L-like precursor 0.0017 0.0009 0.0098

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) ng ml-1 Blood schizonticidal activity against Plasmodium berghei in mice at the dose of 160 mg/kg; Inactive ChEMBL. 3302259
IC50 (functional) ng ml-1 Blood schizonticidal activity against Plasmodium berghei in mice at the dose of 40 mg/kg; Inactive ChEMBL. 3302259
IC50 (functional) ng ml-1 Blood schizonticidal activity against Plasmodium berghei in mice at the dose of 640 mg/kg; Inactive ChEMBL. 3302259
IC50 (functional) 0 ng ml-1 Blood schizonticidal activity against Plasmodium berghei in mice at the dose of 40 mg/kg; Inactive ChEMBL. 3302259
IC50 (functional) 0 ng ml-1 Blood schizonticidal activity against Plasmodium berghei in mice at the dose of 160 mg/kg; Inactive ChEMBL. 3302259
IC50 (functional) 0 ng ml-1 Blood schizonticidal activity against Plasmodium berghei in mice at the dose of 640 mg/kg; Inactive ChEMBL. 3302259

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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