Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0046 | 0.0102 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0282 | 0.03 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0282 | 0.03 |
Schistosoma mansoni | stromal cell-derived factor 2 precursor-like protein | 0.0168 | 0.0725 | 0.0654 |
Plasmodium falciparum | glutathione reductase | 0.0063 | 0.0186 | 0.043 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0063 | 0.0186 | 0.5 |
Brugia malayi | Cytohesin 3 | 0.009 | 0.0326 | 0.0326 |
Loa Loa (eye worm) | fructose-bisphosphate aldolase 2 | 0.0543 | 0.2635 | 0.372 |
Loa Loa (eye worm) | hypothetical protein | 0.023 | 0.1039 | 0.1399 |
Brugia malayi | Variant SH3 domain containing protein | 0.0046 | 0.0102 | 0.0102 |
Trypanosoma brucei | fructose-bisphosphate aldolase, glycosomal, putative | 0.0543 | 0.2635 | 0.5786 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.1218 | 0.6078 | 0.7141 |
Entamoeba histolytica | MIR domain protein | 0.0168 | 0.0725 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0769 | 0.3788 | 0.5394 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0543 | 0.2635 | 0.6801 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0907 | 0.4491 | 1 |
Brugia malayi | Phosphatidylinositol-specific phospholipase C, X domain containing protein | 0.0041 | 0.0076 | 0.0076 |
Echinococcus multilocularis | stromal cell derived factor 2 | 0.0168 | 0.0725 | 0.1498 |
Trypanosoma cruzi | inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative | 0.0082 | 0.0282 | 0.044 |
Schistosoma mansoni | guanyl-nucleotide exchange factor | 0.009 | 0.0326 | 0.017 |
Echinococcus multilocularis | cytohesin 1 | 0.009 | 0.0326 | 0.039 |
Plasmodium falciparum | fructose-bisphosphate aldolase | 0.0543 | 0.2635 | 1 |
Echinococcus granulosus | fructose bisphosphate aldolase class I | 0.0543 | 0.2635 | 0.6801 |
Plasmodium vivax | fructose 1,6-bisphosphate aldolase, putative | 0.0543 | 0.2635 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0063 | 0.0186 | 0.0221 |
Brugia malayi | Thioredoxin reductase | 0.0063 | 0.0186 | 0.0186 |
Echinococcus granulosus | cytohesin 1 | 0.009 | 0.0326 | 0.039 |
Plasmodium falciparum | thioredoxin reductase | 0.0063 | 0.0186 | 0.043 |
Loa Loa (eye worm) | MIR domain-containing protein | 0.0168 | 0.0725 | 0.0944 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0543 | 0.2635 | 0.5786 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0543 | 0.2635 | 0.5786 |
Loa Loa (eye worm) | glutathione reductase | 0.0063 | 0.0186 | 0.016 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.168 | 0.8438 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0368 | 0.0425 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0543 | 0.2635 | 0.5786 |
Toxoplasma gondii | fructose-bisphosphate aldolase, putative | 0.0543 | 0.2635 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0537 | 0.067 |
Echinococcus multilocularis | 1 phosphatidylinositol 4,5 bisphosphate | 0.0098 | 0.0368 | 0.0505 |
Echinococcus multilocularis | fructose bisphosphate aldolase class I | 0.0543 | 0.2635 | 0.6801 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0543 | 0.2635 | 0.6801 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0769 | 0.3788 | 1 |
Loa Loa (eye worm) | fructose-bisphosphate aldolase 1 | 0.0543 | 0.2635 | 0.372 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0063 | 0.0186 | 0.016 |
Brugia malayi | Ryanodine Receptor TM 4-6 family protein | 0.1075 | 0.535 | 0.535 |
Schistosoma mansoni | fructose 16-bisphosphate aldolase | 0.0543 | 0.2635 | 0.2968 |
Loa Loa (eye worm) | hypothetical protein | 0.139 | 0.6957 | 1 |
Schistosoma mansoni | phospholipase C beta | 0.0096 | 0.0355 | 0.0205 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0597 | 0.2909 | 0.7561 |
Onchocerca volvulus | 0.0131 | 0.0537 | 0.4725 | |
Brugia malayi | MIR domain containing protein | 0.0168 | 0.0725 | 0.0725 |
Schistosoma mansoni | ryanodine receptor related | 0.1075 | 0.535 | 0.6258 |
Leishmania major | trypanothione reductase | 0.0063 | 0.0186 | 0.0375 |
Onchocerca volvulus | 0.0168 | 0.0725 | 1 | |
Brugia malayi | Phosphatidylinositol-specific phospholipase C, X domain containing protein | 0.0044 | 0.0088 | 0.0088 |
Schistosoma mansoni | phospholipase C-like protein 2 plc-L2 | 0.0072 | 0.0234 | 0.0058 |
Leishmania major | phospholipase c-like protein | 0.0044 | 0.0088 | 0.0043 |
Trypanosoma brucei | inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative | 0.0085 | 0.0301 | 0.0484 |
Echinococcus granulosus | stromal cell derived factor 2 | 0.0168 | 0.0725 | 0.1498 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0597 | 0.2909 | 0.7561 |
Schistosoma mansoni | fructose 16-bisphosphate aldolase | 0.0543 | 0.2635 | 0.2968 |
Brugia malayi | fructose-bisphosphate aldolase 1 | 0.0543 | 0.2635 | 0.2635 |
Brugia malayi | glutathione reductase | 0.0063 | 0.0186 | 0.0186 |
Loa Loa (eye worm) | phosphatidylinositol-specific phospholipase C | 0.0044 | 0.0088 | 0.0018 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0769 | 0.3788 | 1 |
Schistosoma mansoni | ryanodine receptor 1 skeletal muscle | 0.029 | 0.1347 | 0.1407 |
Brugia malayi | fructose-bisphosphate aldolase 2 | 0.0543 | 0.2635 | 0.2635 |
Toxoplasma gondii | fructose-1,6-bisphosphate aldolase | 0.0543 | 0.2635 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1218 | 0.6078 | 0.8723 |
Leishmania major | fructose-1,6-bisphosphate aldolase | 0.0543 | 0.2635 | 0.8723 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0543 | 0.2635 | 0.6801 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0063 | 0.0186 | 0.043 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0543 | 0.2635 | 0.6801 |
Toxoplasma gondii | thioredoxin reductase | 0.0063 | 0.0186 | 0.0383 |
Plasmodium vivax | glutathione reductase, putative | 0.0063 | 0.0186 | 0.043 |
Loa Loa (eye worm) | cytohesin 3 | 0.009 | 0.0326 | 0.0364 |
Loa Loa (eye worm) | Plcb4 protein | 0.0096 | 0.0355 | 0.0406 |
Schistosoma mansoni | phospholipase C-like protein 2 plc-L2 | 0.0158 | 0.0671 | 0.0588 |
Trichomonas vaginalis | mannosyltransferase 1, putative | 0.0168 | 0.0725 | 0.5 |
Toxoplasma gondii | fructose-1,6-bisphosphate aldolase | 0.0543 | 0.2635 | 1 |
Loa Loa (eye worm) | ryanodine receptor | 0.029 | 0.1347 | 0.1847 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0063 | 0.0186 | 0.0221 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0543 | 0.2635 | 0.6801 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0543 | 0.2635 | 0.6801 |
Leishmania major | hypothetical protein, conserved | 0.0616 | 0.301 | 1 |
Echinococcus granulosus | 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 | 0.0098 | 0.0368 | 0.0505 |
Trypanosoma cruzi | inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative | 0.0082 | 0.0282 | 0.044 |
Brugia malayi | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 | 0.0096 | 0.0355 | 0.0355 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0543 | 0.2635 | 0.5786 |
Loa Loa (eye worm) | hypothetical protein | 0.137 | 0.6856 | 0.9853 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0907 | 0.4491 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0282 | 0.03 |
Brugia malayi | phospholipase C homolog | 0.0072 | 0.0234 | 0.0234 |
Leishmania major | inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative | 0.0082 | 0.0282 | 0.0703 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.