Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hypocretin (orexin) receptor 2 | Starlite/ChEMBL | References |
Homo sapiens | hypocretin (orexin) receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Schistosoma mansoni | neuropeptide receptor | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Echinococcus multilocularis | neuropeptide receptor | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Echinococcus granulosus | neuropeptide receptor | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Echinococcus multilocularis | G protein coupled receptor 139 | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | sex peptide receptor | hypocretin (orexin) receptor 1 | 425 aa | 350 aa | 23.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | neuropeptide receptor | 0.0128 | 0.0863 | 1 |
Echinococcus multilocularis | neuropeptide receptor | 0.0128 | 0.0863 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0174 | 1 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0174 | 1 | 0.5 |
Onchocerca volvulus | 0.0124 | 0 | 0.5 | |
Schistosoma mansoni | neuropeptide receptor | 0.0128 | 0.0863 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0124 | 0 | 0.5 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0128 | 0.0863 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0174 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0174 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0174 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0124 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0124 | 0 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0124 | 0 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0124 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 4050 nM | Antagonist activity at human OX2R expressed in CHOK1 cells assessed as effect on calcium mobilization | ChEMBL. | 18207395 |
Activity (functional) | = 4050 nM | Antagonist activity at human OX2R expressed in CHOK1 cells assessed as effect on calcium mobilization | ChEMBL. | 18207395 |
Activity (functional) | = 20000 nM | Antagonist activity at human OX1R expressed in CHOK1 cells assessed as effect on calcium mobilization | ChEMBL. | 18207395 |
Activity (functional) | = 20000 nM | Antagonist activity at human OX1R expressed in CHOK1 cells assessed as effect on calcium mobilization | ChEMBL. | 18207395 |
Ki (binding) | = 560 nM | Displacement of [3H](S)-N-(2-(1H-pyrrol-1-yl)phenyl)-1-(2-(1-methyl-1H-benzo[d]imidazol-2-ylthio)acetyl)pyrrolidine-2-carboxamide from human OX2R expressed in CHO cells | ChEMBL. | 18207395 |
Ki (binding) | = 560 nM | Displacement of [3H](S)-N-(2-(1H-pyrrol-1-yl)phenyl)-1-(2-(1-methyl-1H-benzo[d]imidazol-2-ylthio)acetyl)pyrrolidine-2-carboxamide from human OX2R expressed in CHO cells | ChEMBL. | 18207395 |
Ki (binding) | = 1400 nM | Displacement of [3H](S)-1-[2-(1-methyl-1H-benzoimidazol-2-ylsulfanyl)-acetyl]-pyrrolidine-2-carboxylic acid biphenyl-2-ylamide from human OX1R expressed in CHO cells | ChEMBL. | 18207395 |
Ki (binding) | = 1400 nM | Displacement of [3H](S)-1-[2-(1-methyl-1H-benzoimidazol-2-ylsulfanyl)-acetyl]-pyrrolidine-2-carboxylic acid biphenyl-2-ylamide from human OX1R expressed in CHO cells | ChEMBL. | 18207395 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.