Detailed information for compound 519609

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 354.469 | Formula: C19H22N4OS
  • H donors: 1 H acceptors: 4 LogP: 4.07 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(c(c1)c1nc(ncc1Sc1nccn1C)C(C)(C)C)O
  • InChi: 1S/C19H22N4OS/c1-12-6-7-14(24)13(10-12)16-15(25-18-20-8-9-23(18)5)11-21-17(22-16)19(2,3)4/h6-11,24H,1-5H3
  • InChiKey: XVCZIYSTPMTWMA-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0124 0.0344 0.044
Loa Loa (eye worm) hypothetical protein 0.0061 0.0124 0.0318
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0028 0.0056
Onchocerca volvulus 0.0054 0.0103 0.0348
Schistosoma mansoni biogenic amine (5HT) receptor 0.0124 0.0344 0.044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0124 0.0344 0.044
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0061 0.0126 0.016
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0027 0.001 0.0011
Echinococcus multilocularis neuropeptides capa receptor 0.0124 0.0344 0.044
Trichomonas vaginalis glucosylceramidase, putative 0.0298 0.0944 0.332
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.0942 0.0941
Schistosoma mansoni hypothetical protein 0.0107 0.0286 0.0365
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0147 0.0514
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0027 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.1005 0.3383 0.9145
Brugia malayi cytoplasmic intermediate filament protein 0.0033 0.0029 0.006
Brugia malayi putative neuropeptide receptor 0.0124 0.0344 0.0908
Brugia malayi hypothetical protein 0.0055 0.0103 0.026
Brugia malayi Carboxylesterase family protein 0.0374 0.1204 0.3225
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0063 0.0133 0.0169
Echinococcus multilocularis g protein coupled receptor 0.0124 0.0344 0.044
Echinococcus multilocularis lysine specific demethylase 5A 0.01 0.0259 0.0331
Brugia malayi G-protein coupled receptor 0.0124 0.0344 0.0908
Loa Loa (eye worm) hypothetical protein 0.0033 0.003 0.0062
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.059 0.2071
Loa Loa (eye worm) hypothetical protein 0.0043 0.0064 0.0155
Entamoeba histolytica hypothetical protein 0.0041 0.0056 0.0803
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0225 0.069 0.2432
Trichomonas vaginalis glucosylceramidase, putative 0.0298 0.0944 0.332
Brugia malayi Augmenter of liver regeneration 0.0039 0.005 0.0115
Schistosoma mansoni sodium/chloride dependent transporter 0.0056 0.0107 0.0136
Loa Loa (eye worm) hypothetical protein 0.0063 0.0133 0.0341
Echinococcus multilocularis dro:myosuppressin receptor 0.0124 0.0344 0.044
Echinococcus multilocularis rhodopsin orphan GPCR 0.0124 0.0344 0.044
Loa Loa (eye worm) hypothetical protein 0.0702 0.2337 0.6312
Schistosoma mansoni neuropeptide F-like receptor 0.0124 0.0344 0.044
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0846 0.2835 0.7665
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0121 0.0331 0.0979
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0028 0.0034
Mycobacterium ulcerans monoxygenase 0.0225 0.069 0.2432
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0225 0.069 0.0689
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1084 0.3653 0.9877
Brugia malayi Heterochromatin protein 1 0.0077 0.0181 0.0468
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0225 0.069 0.1864
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.0942 0.0941
Trichomonas vaginalis glucosylceramidase, putative 0.0298 0.0944 0.332
Loa Loa (eye worm) hypothetical protein 0.1005 0.3383 0.9145
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0049 0.0083 0.0064
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0374 0.1204 0.1542
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0846 0.2835 0.3632
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.059 0.2071
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0055 0.0103 0.0261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.016 0.0554
Toxoplasma gondii cytochrome p450 superfamily protein 0.0049 0.0083 0.0221
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0062 0.0128 0.0329
Trypanosoma cruzi trypanothione reductase, putative 0.1096 0.3698 0.3698
Brugia malayi G-protein coupled receptor 0.0124 0.0344 0.0908
Schistosoma mansoni biogenic amine (5HT) receptor 0.0383 0.1238 0.1585
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.016 0.0554
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0124 0.0344 0.044
Echinococcus granulosus microtubule associated protein 2 0.2286 0.7803 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0124 0.0344 0.044
Trichomonas vaginalis glucosylceramidase, putative 0.0298 0.0944 0.332
Schistosoma mansoni jumonji/arid domain-containing protein 0.01 0.0259 0.0331
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0505 0.1657 0.2123
Trypanosoma cruzi trypanothione reductase, putative 0.0846 0.2835 0.2834
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0124 0.0344 0.044
Mycobacterium tuberculosis Probable oxidoreductase 0.1084 0.3653 0.9877
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0049 0.0083 0.0288
Brugia malayi Doublecortin family protein 0.0131 0.0368 0.0971
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0248 0.0317
Echinococcus multilocularis G protein coupled receptor 139 0.0124 0.0344 0.044
Trypanosoma cruzi cytochrome P450, putative 0.0067 0.0145 0.0144
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0284 0.0895 0.1146
Loa Loa (eye worm) phosphatidylinositol 3 0.0096 0.0245 0.0645
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0225 0.069 0.2434
Plasmodium falciparum JmjC domain-containing protein, putative 0.0027 0.0007 0.0016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0124 0.0344 0.044
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0055 0.0103 0.0131
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0042 0.0059 0.0058
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0846 0.2835 0.7665
Loa Loa (eye worm) cytochrome P450 family protein 0.0088 0.0218 0.0572
Echinococcus granulosus BC026374 protein S09 family 0.0063 0.0133 0.0169
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0049 0.0083 0.0288
Echinococcus multilocularis neuropeptide Y receptor 0.0124 0.0344 0.044
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0462 0.1509 0.3983
Echinococcus multilocularis chromobox protein 1 0.0077 0.0181 0.0231
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.016 0.0554
Echinococcus granulosus lamin 0.0062 0.0128 0.0163
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0114 0.0307 0.0306
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.0163 0.2357
Entamoeba histolytica hypothetical protein 0.0041 0.0056 0.0803
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0225 0.069 0.1864
Treponema pallidum sodium- and chloride- dependent transporter 0.0321 0.1024 0.3551
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0177 0.0614
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0114 0.0307 0.0306
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0846 0.2835 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0225 0.069 0.2425
Echinococcus multilocularis neuropeptide Y receptor 0.0124 0.0344 0.044
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0114 0.0307 0.0306
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0124 0.0344 0.044
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0027 0.0071
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0114 0.0307 0.0306
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0248 0.0317
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0014 0.0017
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0055 0.0103 0.0277
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Schistosoma mansoni inositol monophosphatase 0.0121 0.0331 0.0423
Echinococcus granulosus tachykinin peptides receptor 99D 0.0124 0.0344 0.044
Echinococcus multilocularis chromobox protein 1 0.0077 0.0181 0.0231
Brugia malayi Uncoordinated protein 44 0.0033 0.0029 0.0059
Schistosoma mansoni netrin receptor unc5 0.0033 0.0029 0.0036
Loa Loa (eye worm) jmjC domain-containing protein 0.01 0.0259 0.0684
Loa Loa (eye worm) hypothetical protein 0.0029 0.0014 0.002
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0049 0.0083 0.0288
Loa Loa (eye worm) hypothetical protein 0.0321 0.1024 0.2756
Echinococcus multilocularis hyperpolarization activated cyclic 0.0027 0.001 0.0011
Toxoplasma gondii hypothetical protein 0.0055 0.0103 0.0277
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0191 0.0575 0.0575
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0093 0.0316
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0147 0.0187
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0032 0.0026 0.0032
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.0163 0.0208
Schistosoma mansoni hypothetical protein 0.0377 0.1215 0.1556
Loa Loa (eye worm) neuropeptide F receptor 0.0124 0.0344 0.0913
Echinococcus multilocularis somatostatin receptor 0.0124 0.0344 0.044
Schistosoma mansoni opsin-like receptor 0.0124 0.0344 0.044
Loa Loa (eye worm) hypothetical protein 0.0383 0.1238 0.3335
Echinococcus granulosus peregrin 0.0029 0.0014 0.0017
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0225 0.069 0.2432
Trypanosoma brucei protein kinase, putative 0.0114 0.0307 0.0306
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0096 0.0245 0.0244
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0846 0.2835 0.2834
Echinococcus granulosus neuropeptide receptor 0.0124 0.0344 0.044
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0055 0.0103 0.026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.011 0.0377
Mycobacterium ulcerans ferredoxin reductase 0.0225 0.069 0.2432
Echinococcus granulosus mitogen activated protein kinase 3 0.0114 0.0307 0.0392
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0298 0.0942 0.0941
Loa Loa (eye worm) hypothetical protein 0.0063 0.0133 0.0341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0093 0.0316
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0055 0.0103 0.0131
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0124 0.0344 0.044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0124 0.0344 0.044
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0147 0.0187
Treponema pallidum NADH oxidase 0.0846 0.2835 1
Brugia malayi hypothetical protein 0.0051 0.009 0.0223
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0042 0.0059 0.0058
Echinococcus granulosus Polycystic kidney disease protein 0.0131 0.0368 0.047
Onchocerca volvulus 0.0124 0.0344 0.1297
Loa Loa (eye worm) hypothetical protein 0.0783 0.2617 0.7072
Loa Loa (eye worm) hypothetical protein 0.003 0.0018 0.003
Loa Loa (eye worm) hypothetical protein 0.0096 0.0248 0.0653
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0054 0.0103 0.035
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0298 0.0944 0.2538
Brugia malayi RE15519p 0.0124 0.0344 0.0908
Mycobacterium ulcerans hypothetical protein 0.0157 0.0456 0.1605
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0026 0.0078
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0027 0.0083
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0067 0.0145 0.0507
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Onchocerca volvulus 0.0048 0.0081 0.0263
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.059 0.2071
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0027 0.0007 0.0016
Onchocerca volvulus Neuropeptide F receptor homolog 0.0124 0.0344 0.1297
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0042 0.0059 0.0206
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0055 0.0103 0.0277
Onchocerca volvulus 0.0107 0.0286 0.1068
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0673 0.2236 0.604
Loa Loa (eye worm) heterochromatin protein 1 0.0077 0.0181 0.0471
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0191 0.0575 0.2027
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0159 0.0464 0.0593
Echinococcus granulosus tumor protein p63 0.0329 0.1049 0.1344
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0042 0.0059 0.0142
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.0163 0.0421
Trichomonas vaginalis PIKK family atypical protein kinase 0.0096 0.0245 0.0852
Loa Loa (eye worm) thioredoxin reductase 0.1096 0.3698 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0225 0.069 0.1864
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0054 0.0103 0.0102
Echinococcus multilocularis conserved hypothetical protein 0.1468 0.498 0.6381
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0505 0.1657 0.2123
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0093 0.0236 0.0301
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.012 0.033 0.1078
Schistosoma mansoni sodium-dependent amino acid transporter 0.0055 0.0103 0.0131
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0225 0.069 0.0689
Echinococcus multilocularis g protein coupled receptor 0.0124 0.0344 0.044
Brugia malayi Thioredoxin reductase 0.1096 0.3698 0.994
Echinococcus granulosus para nitrobenzyl esterase 0.0063 0.0133 0.0169
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0049 0.0083 0.0288
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.0163 0.0424
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0124 0.0344 0.044
Echinococcus granulosus tm gpcr rhodopsin 0.0124 0.0344 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0026 0.0078
Leishmania major hypothetical protein, conserved 0.0039 0.005 0.0049
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0163 0.0162
Schistosoma mansoni aryl hydrocarbon receptor 0.0209 0.0637 0.0815
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0846 0.2835 0.7627
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.0147 0.0394
Trypanosoma brucei hypothetical protein, conserved 0.0225 0.069 0.0689
Plasmodium falciparum glutathione reductase 0.1096 0.3698 1
Trypanosoma cruzi NADH dehydrogenase, putative 0.0225 0.069 0.0689
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0061 0.0126 0.016
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0059 0.0158
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0055 0.0106 0.0105
Brugia malayi hypothetical protein 0.0124 0.0344 0.0908
Brugia malayi hypothetical protein 0.0124 0.0344 0.0908
Brugia malayi GnHR receptor homolog 0.0124 0.0344 0.0908
Schistosoma mansoni hypothetical protein 0.0124 0.0344 0.044
Loa Loa (eye worm) hypothetical protein 0.0659 0.219 0.5914
Schistosoma mansoni amine GPCR 0.1181 0.399 0.5114
Echinococcus granulosus 7TM GPCR rhodopsin 0.0124 0.0344 0.044
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0055 0.0103 0.0131
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0049 0.0083 0.0288
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0055 0.0103 0.026
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0055 0.0103 0.0277
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0032 0.0026 0.0025
Onchocerca volvulus 0.0124 0.0344 0.1297
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Echinococcus multilocularis 0.0049 0.0083 0.0105
Loa Loa (eye worm) hypothetical protein 0.0055 0.0103 0.0261
Echinococcus granulosus acetylcholinesterase 0.0374 0.1204 0.1542
Onchocerca volvulus 0.0124 0.0344 0.1297
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Loa Loa (eye worm) 6-phosphofructokinase 0.012 0.033 0.0874
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0225 0.069 1
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0014 0.0036
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0846 0.2835 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0225 0.069 0.2425
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0846 0.2835 0.7665
Loa Loa (eye worm) neuropeptide F receptor 0.0124 0.0344 0.0913
Entamoeba histolytica thioredoxin reductase, putative 0.0225 0.069 1
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0225 0.069 0.1701
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0103 0.035
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0114 0.0307 0.0827
Echinococcus granulosus rhodopsin orphan GPCR 0.0124 0.0344 0.044
Echinococcus granulosus aryl hydrocarbon receptor 0.0054 0.0103 0.013
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0096 0.0245 0.0244
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0401 0.04
Trypanosoma brucei cytochrome P450, putative 0.0067 0.0145 0.0144
Echinococcus multilocularis neuropeptide receptor 0.0124 0.0344 0.044
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0028 0.0057
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0059 0.0074
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0049 0.0083 0.0288
Loa Loa (eye worm) inositol-1 0.0121 0.0331 0.0878
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0462 0.1509 0.3983
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0032 0.0026 0.0032
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0271 0.0712
Echinococcus multilocularis voltage gated potassium channel 0.0031 0.0023 0.0028
Echinococcus granulosus thioredoxin glutathione reductase 0.1096 0.3698 0.4739
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0049 0.0083 0.0288
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0027 0.001 0.0008
Echinococcus multilocularis lipoxygenase domain containing protein 0.0131 0.0368 0.047
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0124 0.0344 0.044
Echinococcus multilocularis phd:f box containing protein 0.0027 0.0007 0.0008
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0055 0.0103 0.0131
Echinococcus multilocularis mitogen activated protein kinase 0.0114 0.0307 0.0392
Echinococcus granulosus lipoxygenase domain containing protein 0.0131 0.0368 0.047
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0031 0.0023 0.0028
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1886 0.6421 0.8229
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0027 0.0071
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0147 0.0514
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0039 0.005 0.0132
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0096 0.0245 0.354
Loa Loa (eye worm) hypothetical protein 0.0055 0.0103 0.0261
Toxoplasma gondii target of rapamycin (TOR), putative 0.0071 0.016 0.0431
Schistosoma mansoni jumonji domain containing protein 0.0027 0.0007 0.0008
Brugia malayi Protein kinase domain containing protein 0.0034 0.0032 0.0068
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0096 0.0245 0.0313
Schistosoma mansoni hypothetical protein 0.0124 0.0344 0.044
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0846 0.2835 0.2834
Brugia malayi larval opioid receptor 0.0124 0.0344 0.0908
Onchocerca volvulus 0.0124 0.0344 0.1297
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0129 0.0444
Giardia lamblia PHD finger protein 15 0.0029 0.0014 0.005
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0846 0.2835 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0076 0.0178 0.0177
Brugia malayi neuropeptide F receptor 0.0124 0.0344 0.0908
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0059 0.0058
Trypanosoma brucei C-8 sterol isomerase, putative 0.0783 0.2617 0.2617
Onchocerca volvulus 0.0131 0.0368 0.1389
Echinococcus granulosus mitogen activated protein kinase 0.0114 0.0307 0.0392
Echinococcus granulosus nuclear factor of activated T cells 5 0.0169 0.0497 0.0636
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0055 0.0103 0.0131
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0124 0.0344 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.011 0.0377
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0027 0.0083
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0039 0.005 0.0049
Loa Loa (eye worm) hypothetical protein 0.0056 0.0107 0.0271
Echinococcus granulosus neuropeptide receptor A26 0.0124 0.0344 0.044
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0121 0.0331 0.033
Brugia malayi Carboxylesterase family protein 0.0063 0.0133 0.0339
Brugia malayi sulfakinin receptor protein 0.0124 0.0344 0.0908
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.016 0.0554
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0049 0.0083 0.0288
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0059 0.0197
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0027 0.001 0.0011
Echinococcus granulosus acetylcholinesterase 0.0374 0.1204 0.1542
Loa Loa (eye worm) hypothetical protein 0.0071 0.0159 0.0411
Loa Loa (eye worm) doublecortin family protein 0.0131 0.0368 0.0977
Echinococcus granulosus tm gpcr rhodopsin 0.1886 0.6421 0.8229
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0225 0.069 0.1851
Trypanosoma brucei PAB1-binding protein , putative 0.0078 0.0186 0.0185
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Loa Loa (eye worm) hypothetical protein 0.0131 0.0368 0.0977
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.0026 0.0051
Echinococcus multilocularis aryl hydrocarbon receptor 0.0054 0.0103 0.013
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0054 0.0103 0.035
Chlamydia trachomatis thioredoxin reductase 0.0225 0.069 0.2361
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0124 0.0344 0.044
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0049 0.0083 0.0064
Schistosoma mansoni protein phosphatase 2C 0.0027 0.0007 0.0008
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0225 0.069 0.0883
Loa Loa (eye worm) hypothetical protein 0.0054 0.0103 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0064 0.0214
Onchocerca volvulus 0.0063 0.0133 0.0467
Loa Loa (eye worm) G-protein coupled receptor 0.0124 0.0344 0.0913
Echinococcus multilocularis rhodopsin orphan GPCR 0.0124 0.0344 0.044
Onchocerca volvulus 0.0055 0.0103 0.0351
Brugia malayi Pre-SET motif family protein 0.0096 0.0248 0.0649
Entamoeba histolytica phosphofructokinase, putative 0.012 0.033 0.477
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0159 0.0464 0.0593
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0164 0.0209
Onchocerca volvulus 0.0124 0.0344 0.1297
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0121 0.0331 0.033
Schistosoma mansoni 60S ribosomal protein L21 0.0026 0.0004 0.0004
Trichomonas vaginalis apoptosis inducing factor, putative 0.0225 0.069 0.2425
Brugia malayi AKH receptor 0.0124 0.0344 0.0908
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0114 0.0307 0.0306
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0321 0.1024 0.1311
Loa Loa (eye worm) hypothetical protein 0.0078 0.0186 0.0485
Schistosoma mansoni lipoxygenase 0.0269 0.0843 0.1079
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0096 0.0248 0.0317
Echinococcus multilocularis peregrin 0.0029 0.0014 0.0017
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0124 0.0344 0.044
Onchocerca volvulus 0.0055 0.0103 0.0351
Onchocerca volvulus 0.0124 0.0344 0.1297
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.0163 0.0162
Schistosoma mansoni biogenic amine receptor 0.0124 0.0344 0.044
Echinococcus multilocularis musashi 0.0062 0.0128 0.0163
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0124 0.0344 0.0908
Brugia malayi jmjC domain containing protein 0.0159 0.0464 0.1231
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.0147 0.0146
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0049 0.0083 0.0064
Echinococcus multilocularis neuropeptide s receptor 0.0124 0.0344 0.044
Toxoplasma gondii LsmAD domain-containing protein 0.0078 0.0186 0.05
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0027 0.0071
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0163 0.0162
Plasmodium falciparum transporter, putative 0.0055 0.0103 0.0277
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0055 0.0106 0.0105
Echinococcus multilocularis lipoxygenase domain containing protein 0.0131 0.0368 0.047
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.1096 0.3698 1
Leishmania major cytochrome p450-like protein 0.0067 0.0145 0.0144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0096 0.0245 0.0852
Schistosoma mansoni hypothetical protein 0.0124 0.0344 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0026 0.0078
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0201 0.0607 0.0777
Echinococcus multilocularis neuropeptide receptor A26 0.0124 0.0344 0.044
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0225 0.069 0.0689
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.0307 0.1071
Echinococcus multilocularis acetylcholinesterase 0.0374 0.1204 0.1542
Echinococcus granulosus tar DNA binding protein 0.0072 0.0164 0.0209
Mycobacterium tuberculosis Probable dehydrogenase 0.0462 0.1509 0.3983
Brugia malayi hypothetical protein 0.0124 0.0344 0.0908
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0124 0.0344 0.044
Trichomonas vaginalis glutamate synthase, putative 0.0225 0.069 0.2425
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.2923 1 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0124 0.0344 0.044
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0225 0.069 0.1864
Loa Loa (eye worm) hepatopoietin HPO2 0.0039 0.005 0.0116
Echinococcus granulosus serotonin receptor 0.0124 0.0344 0.044
Brugia malayi hypothetical protein 0.0063 0.0133 0.0339
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0049 0.0083 0.0288
Toxoplasma gondii hypothetical protein 0.0048 0.0081 0.0216
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0225 0.069 0.0883
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0225 0.069 0.1733
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0225 0.069 0.2425
Schistosoma mansoni BC026374 protein (S09 family) 0.0063 0.0133 0.0169
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0049 0.0083 0.0082
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0401 0.04
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0124 0.0344 0.044
Trichomonas vaginalis chromobox protein, putative 0.0077 0.0181 0.0626
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0124 0.0344 0.044
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0225 0.069 0.0883
Echinococcus granulosus inositol monophosphatase 1 0.0121 0.0331 0.0423
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0027 0.001 0.0008
Echinococcus granulosus sex peptide receptor 0.0124 0.0344 0.044
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Echinococcus granulosus alpha 1A adrenergic receptor 0.0124 0.0344 0.044
Brugia malayi hypothetical protein 0.0124 0.0344 0.0908
Brugia malayi Dopamine receptor protein 1 0.0124 0.0344 0.0908
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0039 0.005 0.0062
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0075 0.0254
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0027 0.0071
Brugia malayi chromobox protein homolog 3 0.0043 0.0064 0.0154
Echinococcus granulosus hyperpolarization activated cyclic 0.0027 0.001 0.0011
Echinococcus granulosus neuroligin 0.0063 0.0133 0.0169
Echinococcus granulosus serotonin transporter 0.0321 0.1024 0.1311
Loa Loa (eye worm) programmed cell death 8 0.0225 0.069 0.1851
Brugia malayi follicle stimulating hormone receptor 0.0348 0.1116 0.2987
Plasmodium falciparum amino acid transporter, putative 0.0055 0.0103 0.0277
Echinococcus multilocularis jumonji domain containing 1A 0.0027 0.0007 0.0008
Echinococcus multilocularis tumor protein p63 0.0329 0.1049 0.1344
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Loa Loa (eye worm) hypothetical protein 0.0029 0.0014 0.002
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0027 0.0083
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0059 0.0058
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.0103 0.0271 0.0716
Leishmania major hypothetical protein, conserved 0.0027 0.0007 0.0006
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0186 0.05
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0055 0.0103 0.0272
Echinococcus granulosus hyperpolarization activated cyclic 0.0027 0.001 0.0011
Onchocerca volvulus 0.0124 0.0344 0.1297
Echinococcus multilocularis serotonin receptor 0.0383 0.1238 0.1585
Loa Loa (eye worm) hypothetical protein 0.0063 0.0133 0.0341
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0049 0.0083 0.0288
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.2923 1 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0201 0.0607 0.0777
Loa Loa (eye worm) 6-phosphofructokinase 0.012 0.033 0.0874
Echinococcus multilocularis rhodopsin orphan GPCR 0.0124 0.0344 0.044
Echinococcus multilocularis Ankyrin 0.0033 0.003 0.0037
Loa Loa (eye worm) TAR-binding protein 0.0072 0.0164 0.0425
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0096 0.0245 0.0313
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0401 0.04
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0225 0.069 0.2432
Plasmodium falciparum LCCL domain-containing protein 0.0131 0.0368 0.0991
Brugia malayi intermediate filament protein 0.0062 0.0128 0.0327
Loa Loa (eye worm) hypothetical protein 0.0276 0.0868 0.2333
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0225 0.069 0.2273
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0055 0.0103 0.0131
Echinococcus multilocularis glutamate synthase 0.0225 0.069 0.0883
Brugia malayi G protein-coupled receptor F59B2.13 0.0124 0.0344 0.0908
Schistosoma mansoni neuropeptide receptor 0.0124 0.0344 0.044
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Leishmania major protein kinase, putative 0.0061 0.0125 0.0124
Echinococcus granulosus peptide allatostatin:somatostatin 0.0124 0.0344 0.044
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0056 0.0071
Brugia malayi neuropeptide F receptor 0.0124 0.0344 0.0908
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0121 0.0331 0.1157
Loa Loa (eye worm) hypothetical protein 0.0055 0.0103 0.0261
Brugia malayi hypothetical protein 0.0078 0.0186 0.0482
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0049 0.0083 0.0288
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0225 0.069 0.0689
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0056 0.0071
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0225 0.069 0.2432
Echinococcus multilocularis rhodopsin orphan GPCR 0.0124 0.0344 0.044
Mycobacterium ulcerans 6-phosphofructokinase 0.012 0.033 0.116
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0096 0.0248 0.0668
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0225 0.069 0.2432
Trichomonas vaginalis chromobox protein, putative 0.0077 0.0181 0.0626
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.016 0.0554
Onchocerca volvulus 0.0766 0.2558 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0032 0.0026 0.0051
Loa Loa (eye worm) hypothetical protein 0.0034 0.0032 0.0068
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0225 0.069 0.1864
Brugia malayi Dopamine receptor 0.0124 0.0344 0.0908
Leishmania major hypothetical protein, conserved 0.0225 0.069 0.0689
Schistosoma mansoni cytochrome P450 0.0049 0.0083 0.0105
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0225 0.069 0.0883
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.2466 0.8424 0.8424
Onchocerca volvulus 0.0124 0.0344 0.1297
Brugia malayi Inositol-1 0.0121 0.0331 0.0873
Schistosoma mansoni hypothetical protein 0.0029 0.0014 0.0017
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0055 0.0103 0.026
Loa Loa (eye worm) melatonin receptor type 1A 0.0124 0.0344 0.0913
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0026 0.0078
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0061 0.0126 0.0321
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0093 0.0315
Schistosoma mansoni neuropeptide F-like receptor 0.0124 0.0344 0.044
Leishmania major NADH dehydrogenase, putative 0.0225 0.069 0.0689
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0027 0.0071
Mycobacterium ulcerans hypothetical protein 0.0225 0.069 0.2432
Leishmania major phosphatidylinositol 3-kinase, putative 0.0032 0.0026 0.0025
Echinococcus granulosus sodium and chloride dependent glycine 0.0055 0.0103 0.0131
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0107 0.0286 0.0751
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0124 0.0344 0.044
Schistosoma mansoni intermediate filament proteins 0.0062 0.0128 0.0163
Entamoeba histolytica hypothetical protein 0.0041 0.0056 0.0803
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0027 0.0007 0.0008
Echinococcus granulosus neuropeptides capa receptor 0.0124 0.0344 0.044
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0201 0.0607 0.0606
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0124 0.0344 0.044
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0027 0.001 0.0011
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0096 0.0245 0.0641
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0191 0.0575 0.0575
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0049 0.0083 0.0064
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0225 0.069 0.1733
Echinococcus granulosus survival motor neuron protein 1 0.0527 0.1733 0.222
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0186 0.0185
Echinococcus multilocularis jun protein 0.0284 0.0895 0.1146
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0124 0.0344 0.0913
Echinococcus granulosus allatostatin A receptor 0.0124 0.0344 0.044
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0225 0.069 0.0883
Brugia malayi 6-phosphofructokinase 0.012 0.0331 0.0872
Trichomonas vaginalis guanylate cyclase, putative 0.0054 0.0103 0.035
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.012 0.033 0.0743
Onchocerca volvulus 0.0124 0.0344 0.1297
Plasmodium vivax ataxin-2 like protein, putative 0.0078 0.0186 0.05
Mycobacterium ulcerans glutamate synthase subunit beta 0.0225 0.069 0.2432
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0846 0.2835 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0067 0.0145 0.0374
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0049 0.0083 0.0288
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0124 0.0344 0.0913
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0159 0.0408
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0846 0.2835 0.7665
Echinococcus granulosus hypothetical protein 0.1592 0.5408 0.6931
Echinococcus multilocularis 6 phosphofructokinase 0.012 0.033 0.0421
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0846 0.2835 0.2834
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0027 0.0007 0.0016
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0225 0.069 0.0689
Entamoeba histolytica disulphide oxidoreductase, putative 0.0225 0.069 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Echinococcus granulosus sodium and chloride dependent glycine 0.0055 0.0103 0.0131
Echinococcus granulosus lysine specific demethylase 5A 0.01 0.0259 0.0331
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.003 0.0018 0.0022
Schistosoma mansoni neuropeptide f receptor 76f 0.0124 0.0344 0.044
Entamoeba histolytica hypothetical protein 0.0041 0.0056 0.0803
Leishmania major mitochondrial DNA polymerase beta 0.0298 0.0942 0.0941
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0027 0.0083
Echinococcus multilocularis lamin dm0 0.0062 0.0128 0.0163
Trichomonas vaginalis glucosylceramidase, putative 0.0206 0.0626 0.2199
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0225 0.069 0.1733
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.2466 0.8424 0.8424
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0054 0.0103 0.035
Trypanosoma cruzi cytochrome P450, putative 0.0067 0.0145 0.0144
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0063 0.0133 0.0202
Leishmania major hypothetical protein, conserved 0.0078 0.0186 0.0185
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0027 0.0083
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.012 0.033 0.0329
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Schistosoma mansoni opsin-like receptor 0.0124 0.0344 0.044
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Loa Loa (eye worm) hypothetical protein 0.0131 0.0368 0.0977
Echinococcus granulosus cytochrome P450 2K1 0.0049 0.0083 0.0105
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0004 0.0004
Echinococcus granulosus rhodopsin orphan GPCR 0.0124 0.0344 0.044
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0028 0.0034
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0225 0.069 0.0883
Echinococcus multilocularis serotonin transporter 0.0321 0.1024 0.1311
Echinococcus granulosus neuropeptide s receptor 0.0124 0.0344 0.044
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0121 0.0331 0.1165
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0201 0.0607 0.1617
Onchocerca volvulus 0.0063 0.0133 0.0467
Loa Loa (eye worm) carboxylesterase 0.0063 0.0133 0.0341
Mycobacterium ulcerans dehydrogenase 0.0225 0.069 0.2432
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0032 0.0026 0.0025
Onchocerca volvulus 0.0124 0.0344 0.1297
Brugia malayi G protein-coupled receptor 0.0124 0.0344 0.0908
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0103 0.035
Loa Loa (eye worm) G-protein coupled receptor 0.0124 0.0344 0.0913
Brugia malayi Immunoglobulin I-set domain containing protein 0.0033 0.0029 0.0059
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0225 0.069 0.1701
Schistosoma mansoni microtubule-associated protein tau 0.2286 0.7803 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0027 0.001 0.0011
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0055 0.0103 0.0131
Echinococcus granulosus lysine specific demethylase 6a 0.0027 0.0007 0.0008
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0045 0.0071 0.007
Brugia malayi Intermediate filament tail domain containing protein 0.0062 0.0128 0.0327
Loa Loa (eye worm) glutathione reductase 0.1096 0.3698 1
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0191 0.0575 0.0575
Toxoplasma gondii Erv1 / Alr family protein 0.0039 0.005 0.0132
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0055 0.0103 0.0131
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.216 0.7369 0.7369
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0055 0.0103 0.0131
Trichomonas vaginalis inositol monophosphatase, putative 0.0121 0.0331 0.1157
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Echinococcus granulosus jun protein 0.0284 0.0895 0.1146
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0462 0.1509 0.3994
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0225 0.069 0.2432
Plasmodium falciparum phd finger protein, putative 0.0029 0.0014 0.0036
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Leishmania major acetoin dehydrogenase e3 component-like protein 0.216 0.7369 0.7369
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0049 0.0083 0.0288
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0014 0.0017
Schistosoma mansoni amine GPCR 0.0124 0.0344 0.044
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.059 0.2071
Schistosoma mansoni loxhd1 0.0131 0.0368 0.047
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Brugia malayi Carboxylesterase family protein 0.0063 0.0133 0.0339
Echinococcus multilocularis JmjC domain containing protein 4 0.0027 0.0007 0.0008
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0027 0.001 0.0011
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0049 0.0083 0.0064
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0033 0.0029 0.0036
Echinococcus granulosus biogenic amine 5HT receptor 0.0383 0.1238 0.1585
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0096 0.0248 0.0317
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0033 0.0029 0.0036
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0027 0.0007 0.0006
Brugia malayi hypothetical protein 0.0124 0.0344 0.0908
Schistosoma mansoni neuroligin 3 (S09 family) 0.0063 0.0133 0.0169
Brugia malayi hypoxia-induced factor 1 0.0648 0.2149 0.5769
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.0307 0.1071
Echinococcus multilocularis survival motor neuron protein 1 0.0527 0.1733 0.222
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0049 0.0083 0.0288
Giardia lamblia GTOR 0.0096 0.0245 0.0864
Echinococcus granulosus intermediate filament protein 0.0062 0.0128 0.0163
Trichomonas vaginalis PIKK family atypical protein kinase 0.0096 0.0245 0.0852
Onchocerca volvulus 0.0062 0.0128 0.0449
Echinococcus multilocularis geminin 0.0377 0.1215 0.1556
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.0307 0.1071
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0124 0.0344 0.044
Echinococcus multilocularis neuropeptides capa receptor 0.0124 0.0344 0.044
Echinococcus multilocularis microtubule associated protein 2 0.2286 0.7803 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0075 0.0241
Plasmodium vivax multidomain scavenger receptor, putative 0.0131 0.0368 0.0991
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0027 0.0083
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0059 0.0074
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0124 0.0344 0.0908
Brugia malayi Melatonin receptor type 1A 0.0124 0.0344 0.0908
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0169 0.0497 0.0636
Brugia malayi glutathione reductase 0.1096 0.3698 0.994
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0063 0.0133 0.0202
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.0023 0.0028
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0307 0.0392
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0076 0.0178 0.0177
Schistosoma mansoni single-minded 0.0209 0.0637 0.0815
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0124 0.0344 0.044
Echinococcus multilocularis sodium and chloride dependent glycine 0.0055 0.0103 0.0131
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Onchocerca volvulus 0.0109 0.0292 0.109
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0096 0.0245 0.0244
Echinococcus granulosus rhodopsin orphan GPCR 0.0124 0.0344 0.044
Brugia malayi Cytochrome P450 family protein 0.0067 0.0145 0.0371
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0186 0.05
Echinococcus granulosus 6 phosphofructokinase 0.012 0.033 0.0421
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0124 0.0344 0.044
Echinococcus granulosus jumonji domain containing protein 0.004 0.0053 0.0067
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0124 0.0344 0.0908
Echinococcus multilocularis rhodopsin orphan GPCR 0.0124 0.0344 0.044
Toxoplasma gondii hypothetical protein 0.0055 0.0103 0.0277
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0049 0.0083 0.0064
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0027 0.001 0.0011
Brugia malayi Pre-SET motif family protein 0.0673 0.2236 0.6004
Schistosoma mansoni gliotactin 0.0063 0.0133 0.0169
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.033 0.1152
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0039 0.005 0.0132
Echinococcus multilocularis neuropeptide receptor 0.0124 0.0344 0.044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0124 0.0344 0.044
Schistosoma mansoni hypothetical protein 0.0049 0.0083 0.0105
Giardia lamblia NADH oxidase lateral transfer candidate 0.0846 0.2835 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0063 0.0133 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.0197 0.0682
Trichomonas vaginalis glutathione reductase, putative 0.0846 0.2835 1
Trichomonas vaginalis glucosylceramidase, putative 0.0298 0.0944 0.332
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Echinococcus granulosus g protein coupled receptor 0.0124 0.0344 0.044
Echinococcus granulosus voltage gated potassium channel 0.0031 0.0023 0.0028
Schistosoma mansoni disulfide oxidoreductase 0.0225 0.069 0.0883
Echinococcus multilocularis fmrfamide receptor 0.0124 0.0344 0.044
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0124 0.0344 0.044
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0225 0.069 0.0883
Schistosoma mansoni 6-phosphofructokinase 0.012 0.033 0.0421
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0055 0.0103 0.0261
Echinococcus multilocularis carboxylesterase 5A 0.0374 0.1204 0.1542
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0124 0.0344 0.044
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0037 0.0046
Loa Loa (eye worm) RNA binding protein 0.0072 0.0164 0.0425
Schistosoma mansoni rab6-interacting 0.0131 0.0368 0.047
Brugia malayi Tachykinin-like peptides receptor 99D 0.0124 0.0344 0.0908
Echinococcus multilocularis netrin receptor unc 5 0.0033 0.0029 0.0036
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0124 0.0344 0.044
Echinococcus multilocularis sex peptide receptor 0.0124 0.0344 0.044
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0124 0.0344 0.044
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0124 0.0344 0.044
Echinococcus multilocularis sodium and chloride dependent glycine 0.0055 0.0103 0.0131
Echinococcus granulosus g-protein coupled receptor 0.0124 0.0344 0.044
Leishmania major cytochrome p450-like protein 0.0049 0.0083 0.0082
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0191 0.0575 0.1418
Echinococcus multilocularis allatostatin A receptor 0.0124 0.0344 0.044
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.012 0.033 0.0329
Loa Loa (eye worm) TYRA-2 protein 0.0124 0.0344 0.0913
Brugia malayi hypothetical protein 0.0124 0.0344 0.0908
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0177 0.0614
Loa Loa (eye worm) serotonin transporter b 0.0321 0.1024 0.2756
Loa Loa (eye worm) solute carrier family 6 member 4 0.0321 0.1024 0.2756
Echinococcus multilocularis rhodopsin orphan GPCR 0.0124 0.0344 0.044
Onchocerca volvulus 0.0062 0.0128 0.0449
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0271 0.0712
Mycobacterium tuberculosis Probable reductase 0.0462 0.1509 0.3983
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0124 0.0344 0.0908
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0846 0.2835 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0055 0.0103 0.0131
Brugia malayi PHD-finger family protein 0.0029 0.0014 0.002
Echinococcus granulosus neuropeptide receptor 0.0124 0.0344 0.044
Loa Loa (eye worm) intermediate filament protein 0.0062 0.0128 0.0329
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0049 0.0083 0.0064
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0121 0.0331 0.033
Loa Loa (eye worm) hypothetical protein 0.0225 0.069 0.1851
Brugia malayi hypothetical protein 0.0527 0.1733 0.4647
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0846 0.2835 0.3632
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0124 0.0344 0.044
Trypanosoma cruzi hypothetical protein, conserved 0.0225 0.069 0.0689
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0059 0.0158
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0622 0.206 0.5528
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0121 0.0331 0.0893
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.012 0.033 0.0692
Brugia malayi hypothetical protein 0.0124 0.0344 0.0908
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0783 0.2617 0.703
Echinococcus granulosus Ankyrin 0.0033 0.003 0.0037
Onchocerca volvulus 0.0034 0.0032 0.007
Treponema pallidum oxidoreductase 0.0225 0.069 0.2361
Leishmania major hypothetical protein, conserved 0.0225 0.069 0.0689
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0055 0.0103 0.0131
Onchocerca volvulus 0.0124 0.0344 0.1297
Loa Loa (eye worm) cytochrome P450 family protein 0.0067 0.0145 0.0374
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0124 0.0344 0.044
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0225 0.069 0.0883
Loa Loa (eye worm) hypothetical protein 0.0527 0.1733 0.4675
Schistosoma mansoni amine GPCR 0.0124 0.0344 0.044
Schistosoma mansoni biogenic amine receptor 0.0124 0.0344 0.044
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0225 0.069 0.1701
Treponema pallidum thioredoxin reductase (trxB) 0.0225 0.069 0.2361
Loa Loa (eye worm) hypothetical protein 0.0062 0.0128 0.0329
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0028 0.0034
Schistosoma mansoni amine GPCR 0.0124 0.0344 0.044
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.0164 0.0422
Onchocerca volvulus 0.0063 0.0133 0.0467
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0225 0.069 1
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0225 0.069 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0124 0.0344 0.044
Brugia malayi Death domain containing protein 0.0033 0.0029 0.0059
Echinococcus granulosus chromobox protein 1 0.0077 0.0181 0.0231
Echinococcus multilocularis inositol monophosphatase 1 0.0121 0.0331 0.0423
Schistosoma mansoni hypothetical protein 0.0071 0.0159 0.0202
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0246 0.0763 0.0762
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0846 0.2835 1
Echinococcus granulosus RUN 0.0131 0.0368 0.047
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0298 0.0944 0.2523
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0225 0.069 0.0689
Brugia malayi hypothetical protein 0.0223 0.0685 0.1825
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0049 0.0083 0.0064
Onchocerca volvulus 0.0063 0.0133 0.0467
Brugia malayi hypothetical protein 0.0124 0.0344 0.0908
Echinococcus granulosus fmrfamide receptor 0.0124 0.0344 0.044
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0846 0.2835 0.7665
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0056 0.0071
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0124 0.0344 0.0908
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0049 0.0083 0.0064
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0114 0.0307 0.0306
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.005 0.0165
Onchocerca volvulus 0.0124 0.0344 0.1297
Brugia malayi ORL1-like opioid receptor 0.0124 0.0344 0.0908
Echinococcus multilocularis transfer RNA-Lys 0.0155 0.0449 0.0575
Onchocerca volvulus 0.0155 0.0449 0.1711
Schistosoma mansoni chromobox protein 0.0077 0.0181 0.0231
Echinococcus multilocularis g-protein coupled receptor 0.0124 0.0344 0.044
Echinococcus multilocularis hyperpolarization activated cyclic 0.0027 0.001 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0109 0.0292 0.0372
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0121 0.0331 0.1157
Schistosoma mansoni glutamate synthase 0.0225 0.069 0.0883
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0225 0.069 0.2425
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0028 0.0056
Echinococcus granulosus neuropeptides capa receptor 0.0124 0.0344 0.044
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0147 0.0514
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0063 0.0133 0.0169
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0284 0.0895 0.1146
Echinococcus granulosus somatostatin receptor 0.0124 0.0344 0.044
Brugia malayi hypothetical protein 0.0041 0.0056 0.0133
Echinococcus multilocularis neuropeptide FF receptor 2 0.0124 0.0344 0.044
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0039 0.005 0.0049
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0055 0.0106 0.0105
Brugia malayi Carboxylesterase family protein 0.0063 0.0133 0.0339
Trichomonas vaginalis spcc417.12 protein, putative 0.0063 0.0133 0.0457
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0027 0.001 0.0022
Schistosoma mansoni chromobox protein 0.0077 0.0181 0.0231
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0124 0.0344 0.044
Brugia malayi Carboxylesterase family protein 0.0374 0.1204 0.3225
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0032 0.0026 0.0025
Schistosoma mansoni sulfide quinone reductase 0.0225 0.069 0.0883
Brugia malayi jmjC domain containing protein 0.01 0.0259 0.068
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0103 0.035
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0059 0.0197
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0033 0.0029 0.0061
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0622 0.206 0.5528
Trichomonas vaginalis set domain proteins, putative 0.0766 0.2557 0.9019
Loa Loa (eye worm) hypothetical protein 0.04 0.1296 0.3493
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Schistosoma mansoni hypothetical protein 0.0377 0.1215 0.1556
Schistosoma mansoni hypothetical protein 0.0231 0.0711 0.0911
Trypanosoma cruzi NADH dehydrogenase, putative 0.0225 0.069 0.0689
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0846 0.2835 0.2834
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0225 0.069 0.2432
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0014 0.002
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0225 0.069 0.2425
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0846 0.2835 0.7616
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0114 0.0307 0.0306
Schistosoma mansoni ap endonuclease 0.0042 0.0059 0.0075
Schistosoma mansoni growth hormone secretagogue receptor 0.0124 0.0344 0.044
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0032 0.0026 0.0025
Echinococcus granulosus sodium channel protein 0.0246 0.0763 0.0977
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.0164 0.0425
Mycobacterium ulcerans NADH dehydrogenase 0.0225 0.069 0.2432
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0049 0.0083 0.0064
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0027 0.0083
Plasmodium falciparum thioredoxin reductase 0.0846 0.2835 0.7665
Echinococcus multilocularis thioredoxin glutathione reductase 0.1096 0.3698 0.4739
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0225 0.069 0.1733
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0225 0.069 0.2273
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0027 0.001 0.0011
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0055 0.0103 0.0131
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0124 0.0344 0.1297
Trichomonas vaginalis adenylate cyclase, putative 0.0054 0.0103 0.035
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.033 0.1152
Loa Loa (eye worm) hypothetical protein 0.0374 0.1204 0.3244
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0246 0.0763 0.0977
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0225 0.069 0.2425
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0064 0.0214
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0091 0.009
Toxoplasma gondii selenide, water dikinase 0.0225 0.069 0.1864
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0225 0.069 1
Plasmodium vivax glutathione reductase, putative 0.1096 0.3698 1
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0054 0.0103 0.026
Entamoeba histolytica phosphofructokinase, putative 0.012 0.033 0.477
Echinococcus granulosus carboxylesterase 5A 0.0374 0.1204 0.1542
Echinococcus multilocularis lamin 0.0062 0.0128 0.0163
Echinococcus granulosus neuropeptide FF receptor 2 0.0124 0.0344 0.044
Onchocerca volvulus 0.0225 0.069 0.2657
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0014 0.0017
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0225 0.069 0.0883
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0054 0.0103 0.0269
Schistosoma mansoni hypothetical protein 0.0033 0.0028 0.0034
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0201 0.0607 0.214
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0225 0.069 0.0689
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.0023 0.0028
Schistosoma mansoni survival motor neuron protein 0.0107 0.0286 0.0365
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0049 0.0083 0.0288
Brugia malayi PAS domain containing protein 0.0209 0.0637 0.1697
Loa Loa (eye worm) hypothetical protein 0.0033 0.0029 0.0059
Plasmodium vivax amine transporter, putative 0.0055 0.0103 0.0277
Schistosoma mansoni hypothetical protein 0.0035 0.0037 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0112 0.0384
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0027 0.0007 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.0124 0.0344 0.044
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.012 0.0306
Echinococcus granulosus tm gpcr rhodopsin 0.0124 0.0344 0.044
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0075 0.0254
Brugia malayi Carboxylesterase family protein 0.0063 0.0133 0.0339
Plasmodium vivax ferrodoxin reductase, putative 0.0225 0.069 0.1864
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0021 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0021 0.006
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0121 0.0331 0.033
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0321 0.1024 0.2739
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0049 0.0083 0.0064
Schistosoma mansoni ap endonuclease 0.0042 0.0059 0.0075
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0096 0.0245 0.0244
Schistosoma mansoni phd/f-box containing protein 0.0027 0.0007 0.0008
Leishmania major protein kinase, putative 0.0055 0.0106 0.0105
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0054 0.0103 0.035
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.0147 0.0187
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.0307 0.1071
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0124 0.0344 0.0913
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0031 0.0023 0.0044
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0027 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0033 0.0028 0.0057
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0225 0.069 0.2425
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0093 0.0315
Loa Loa (eye worm) hypothetical protein 0.0321 0.1024 0.2756
Schistosoma mansoni opsin-like receptor 0.0124 0.0344 0.044
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0039 0.005 0.0062
Leishmania major C-8 sterol isomerase-like protein 0.0783 0.2617 0.2617
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0049 0.0083 0.0288
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0026 0.0078
Brugia malayi Cyclic-nucleotide gated cation channel 0.0027 0.001 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0164 0.0209
Brugia malayi phosphofructokinase 0.012 0.033 0.0869
Schistosoma mansoni lamin 0.0062 0.0128 0.0163
Brugia malayi Serotonin receptor 0.0124 0.0344 0.0908
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.2923 1 1
Brugia malayi Dopamine receptor protein 2 0.0124 0.0344 0.0908
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0049 0.0083 0.0064
Brugia malayi MAP kinase sur-1 0.0114 0.0307 0.0807
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0271 0.0716
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0063 0.0133 0.0457
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.059 0.2071
Echinococcus multilocularis orexin receptor type 2 0.0124 0.0344 0.044
Schistosoma mansoni 6-phosphofructokinase 0.012 0.033 0.0421
Plasmodium falciparum ferrodoxin reductase-like protein 0.0225 0.069 0.1864
Schistosoma mansoni hypothetical protein 0.0164 0.0481 0.0616
Schistosoma mansoni jumonji domain containing protein 0.014 0.0397 0.0508
Plasmodium vivax hypothetical protein, conserved 0.0055 0.0103 0.0277
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0049 0.0083 0.0288
Echinococcus granulosus lamin dm0 0.0062 0.0128 0.0163
Schistosoma mansoni alpha-1 adrenergic receptor 0.0124 0.0344 0.044
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0063 0.0133 0.0169
Echinococcus granulosus G protein coupled receptor 139 0.0124 0.0344 0.044
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.0147 0.0187
Loa Loa (eye worm) hypothetical protein 0.0048 0.0081 0.0201
Echinococcus granulosus 7tm_1 domain containing protein 0.0124 0.0344 0.044
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0225 0.069 0.0883
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0081 0.0103
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0783 0.2617 0.2617
Echinococcus multilocularis fmrfamide receptor 0.0124 0.0344 0.044
Schistosoma mansoni glutamate synthase 0.0225 0.069 0.0883
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0049 0.0083 0.0064
Echinococcus granulosus geminin 0.0377 0.1215 0.1556
Echinococcus granulosus jumonji domain containing 1A 0.0027 0.0007 0.0008
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0055 0.0103 0.0131
Echinococcus multilocularis sodium channel protein 0.0246 0.0763 0.0977
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0124 0.0344 0.044
Schistosoma mansoni adenoreceptor 0.0124 0.0344 0.044
Echinococcus multilocularis para nitrobenzyl esterase 0.0063 0.0133 0.0169
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0124 0.0344 0.044
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0225 0.069 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.0456 0.109
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0225 0.069 0.0689
Giardia lamblia Kinase, CMGC MAPK 0.0114 0.0307 0.1082
Plasmodium vivax thioredoxin reductase, putative 0.1096 0.3698 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0124 0.0344 0.044
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0121 0.0331 0.4791
Plasmodium falciparum thioredoxin reductase 0.1096 0.3698 1
Trichomonas vaginalis glucosylceramidase, putative 0.0206 0.0626 0.2199
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0124 0.0344 0.0913
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0124 0.0344 0.044
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0042 0.0059 0.0075
Onchocerca volvulus 0.0124 0.0344 0.1297
Toxoplasma gondii NADPH-glutathione reductase 0.0846 0.2835 0.7665
Echinococcus granulosus chromobox protein 1 0.0077 0.0181 0.0231
Schistosoma mansoni sodium/chloride dependent transporter 0.0321 0.1024 0.1311
Brugia malayi exodeoxyribonuclease III family protein 0.0042 0.0059 0.0141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0177 0.0614
Schistosoma mansoni jun-related protein 0.0231 0.0711 0.0911
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0027 0.0096
Echinococcus multilocularis serotonin receptor 0.0383 0.1238 0.1585
Onchocerca volvulus 0.0124 0.0344 0.1297
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0248 0.0317
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0348 0.1116 0.3005
Schistosoma mansoni sulfide quinone reductase 0.0225 0.069 0.0883
Echinococcus multilocularis GPCR, family 2 0.0033 0.0028 0.0034
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0164 0.0209
Brugia malayi hypothetical protein 0.0131 0.0368 0.0971
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1084 0.3653 0.9877
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Echinococcus multilocularis acetylcholinesterase 0.0374 0.1204 0.1542
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0059 0.0058
Plasmodium falciparum glutathione reductase 0.0846 0.2835 0.7665
Schistosoma mansoni myosin xvIII 0.0124 0.0344 0.044
Loa Loa (eye worm) hypothetical protein 0.0055 0.0103 0.0261
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.0163 0.0208
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0037 0.0046
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0163 0.0162
Mycobacterium ulcerans putative regulatory protein 0.0155 0.0449 0.1582
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0027 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0112 0.0384
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.216 0.7369 0.7369
Brugia malayi hypothetical protein 0.0253 0.0788 0.2103
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0225 0.069 0.2425
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0042 0.0059 0.0075
Loa Loa (eye worm) hypothetical protein 0.0321 0.1024 0.2756
Loa Loa (eye worm) hypothetical protein 0.0063 0.0133 0.0341
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.059 0.2071
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.001 0.0011
Brugia malayi hypothetical protein 0.0124 0.0344 0.0908
Schistosoma mansoni glutamate synthase 0.0225 0.069 0.0883
Toxoplasma gondii exonuclease III APE 0.0042 0.0059 0.0158
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0049 0.0083 0.0288
Onchocerca volvulus Glucosylceramidase homolog 0.0196 0.059 0.2263
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.0147 0.024
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.004 0.0052 0.0051
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0225 0.069 0.1864
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0225 0.069 0.0883
Echinococcus granulosus rhodopsin orphan GPCR 0.0124 0.0344 0.044
Loa Loa (eye worm) hypoxia-induced factor 1 0.0648 0.2149 0.5804
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0031 0.0023 0.0028
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0225 0.069 0.184
Schistosoma mansoni amine GPCR 0.0124 0.0344 0.044
Mycobacterium ulcerans carboxylesterase, LipT 0.0063 0.0133 0.0466
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0049 0.0083 0.0064
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0225 0.069 0.1864
Loa Loa (eye worm) phosphofructokinase 0.012 0.033 0.0874
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0027 0.0007 0.0008
Echinococcus granulosus cytoplasmic intermediate filament protein 0.003 0.0018 0.0022
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0042 0.0059 0.0209
Brugia malayi Cytochrome P450 family protein 0.0088 0.0218 0.0569
Echinococcus multilocularis RUN 0.0131 0.0368 0.047
Brugia malayi Cytochrome P450 family protein 0.0067 0.0145 0.0371
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0049 0.0083 0.0064
Echinococcus granulosus neuropeptide Y receptor 0.0124 0.0344 0.044
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0055 0.0103 0.026
Echinococcus multilocularis lysine specific demethylase 6a 0.0027 0.0007 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0298 0.0944 0.332
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1084 0.3653 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0124 0.0344 0.044
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0225 0.069 0.1733
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0124 0.0344 0.044
Loa Loa (eye worm) hypothetical protein 0.0055 0.0103 0.0261
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0049 0.0083 0.0064
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0201 0.0607 0.1506
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0225 0.069 0.2425
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0032 0.0026 0.0025
Loa Loa (eye worm) hypothetical protein 0.0029 0.0014 0.002
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0027 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0027 0.0379
Echinococcus granulosus rhodopsin orphan GPCR 0.0124 0.0344 0.044
Toxoplasma gondii thioredoxin reductase 0.1096 0.3698 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0133 0.0341
Brugia malayi putative neuropeptide receptor NPR1 0.0124 0.0344 0.0908
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.016 0.0554
Giardia lamblia Thioredoxin reductase 0.0225 0.069 0.2434
Mycobacterium tuberculosis Carboxylesterase LipT 0.0063 0.0133 0.0202
Onchocerca volvulus 0.0124 0.0344 0.1297
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.2466 0.8424 0.8424
Echinococcus granulosus biogenic amine 5HT receptor 0.0124 0.0344 0.044
Schistosoma mansoni hypothetical protein 0.0124 0.0344 0.044
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0225 0.069 0.1864
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0462 0.1509 0.3983
Loa Loa (eye worm) CYP4Cod1 0.0067 0.0145 0.0374
Schistosoma mansoni rab6-interacting 0.0131 0.0368 0.047
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0179 0.0534 0.1427
Brugia malayi hypothetical protein 0.0702 0.2337 0.6275
Schistosoma mansoni histamine h1 receptor 0.0124 0.0344 0.044
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0108 0.0288 0.0574
Schistosoma mansoni hypothetical protein 0.0033 0.0028 0.0034
Brugia malayi cytochrome P450 0.0049 0.0083 0.0204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0177 0.0614
Plasmodium vivax SET domain protein, putative 0.0096 0.0248 0.0668
Schistosoma mansoni hypothetical protein 0.0033 0.0028 0.0034
Loa Loa (eye worm) carboxylesterase 0.0063 0.0133 0.0341
Leishmania major ATP-dependent phosphofructokinase 0.012 0.033 0.0329
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0049 0.0083 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0177 0.0614
Brugia malayi Cytochrome P450 family protein 0.0049 0.0083 0.0204
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0054 0.0103 0.013
Trichomonas vaginalis mercuric reductase, putative 0.0846 0.2835 1
Schistosoma mansoni ankyrin 23/unc44 0.0033 0.0029 0.0036
Echinococcus granulosus g protein coupled receptor 0.0124 0.0344 0.044
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0124 0.0344 0.044
Schistosoma mansoni biogenic amine receptor 0.0124 0.0344 0.044
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0049 0.0083 0.0064
Loa Loa (eye worm) carboxylesterase 0.0374 0.1204 0.3244
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.033 0.1152
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0054 0.0103 0.0102
Echinococcus granulosus dro:myosuppressin receptor 0.0124 0.0344 0.044
Onchocerca volvulus 0.0131 0.0368 0.1389
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0054 0.0103 0.0102
Echinococcus granulosus GPCR family 2 0.0033 0.0028 0.0034
Echinococcus multilocularis neuroligin 0.0063 0.0133 0.0169
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0027 0.0071
Onchocerca volvulus 0.0223 0.0685 0.2635
Loa Loa (eye worm) hypothetical protein 0.0055 0.0103 0.0261
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0014 0.0036
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0027 0.0071
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Schistosoma mansoni lipoxygenase 0.0505 0.1657 0.2123
Loa Loa (eye worm) hypothetical protein 0.0063 0.0133 0.0341
Echinococcus granulosus glutamate synthase 0.0225 0.069 0.0883
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0093 0.0316
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.033 0.1152
Brugia malayi bZIP transcription factor family protein 0.0284 0.0895 0.2392
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0042 0.0059 0.0058
Schistosoma mansoni inositol monophosphatase 0.0121 0.0331 0.0423
Onchocerca volvulus 0.0124 0.0344 0.1297
Echinococcus granulosus orexin receptor type 2 0.0124 0.0344 0.044
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0055 0.0103 0.0131
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0225 0.069 0.184
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0055 0.0103 0.0131
Loa Loa (eye worm) norepinephrine transporter 0.0321 0.1024 0.2756
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.0163 0.0208
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0201 0.0607 0.0777
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.005 0.0165
Brugia malayi hypothetical protein 0.0124 0.0344 0.0908
Echinococcus multilocularis BC026374 protein (S09 family) 0.0063 0.0133 0.0169
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0225 0.069 0.2273
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0032 0.0026 0.0032
Schistosoma mansoni acetylcholinesterase 0.0063 0.0133 0.0169
Echinococcus granulosus lipoxygenase domain containing protein 0.0131 0.0368 0.047
Loa Loa (eye worm) hypothetical protein 0.0027 0.001 0.0008
Brugia malayi RNA binding protein 0.0072 0.0164 0.0422
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0225 0.069 0.0689
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0225 0.069 0.1864
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0027 0.001 0.0011
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0064 0.0196
Plasmodium vivax JmjC domain containing protein 0.0027 0.0007 0.0016
Schistosoma mansoni hypothetical protein 0.0033 0.0028 0.0034
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0108 0.0288 0.0627
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0124 0.0344 0.044
Schistosoma mansoni hypothetical protein 0.0033 0.0029 0.0036
Schistosoma mansoni sodium/chloride dependent transporter 0.0055 0.0103 0.0131
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0225 0.069 0.0883
Echinococcus granulosus netrin receptor unc 5 0.0033 0.0029 0.0036
Echinococcus granulosus death domain containing protein 0.0033 0.0029 0.0036
Echinococcus granulosus g protein coupled receptor 0.0124 0.0344 0.044
Echinococcus multilocularis Polycystic kidney disease protein 0.0131 0.0368 0.047
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.216 0.7369 0.7369
Trypanosoma brucei NADH dehydrogenase 0.0225 0.069 0.0689
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0191 0.0575 0.0575
Brugia malayi Serotonin receptor 0.1103 0.372 1
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0033 0.003 0.0037
Onchocerca volvulus 0.0055 0.0103 0.0351
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0112 0.0384
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0055 0.0106 0.0105
Schistosoma mansoni neuropeptide receptor 0.0124 0.0344 0.044
Giardia lamblia Glutamate synthase 0.0225 0.069 0.2434
Trichomonas vaginalis guanylate cyclase, putative 0.0054 0.0103 0.035
Onchocerca volvulus 0.0063 0.0133 0.0467
Loa Loa (eye worm) hypothetical protein 0.0055 0.0103 0.0261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0136 0.0469
Echinococcus granulosus JmjC domain containing protein 4 0.0027 0.0007 0.0008
Trichomonas vaginalis glutamate synthase, putative 0.0225 0.069 0.2425
Loa Loa (eye worm) acetylcholinesterase 1 0.0374 0.1204 0.3244
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0124 0.0344 0.044
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0053 0.0067
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0027 0.001 0.0022
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0096 0.0245 0.0244
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0076 0.0178 0.0177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.016 0.0554
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0027 0.001 0.0011
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0164 0.0209
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0061 0.0126 0.0323
Onchocerca volvulus Netrin receptor homolog 0.0033 0.0029 0.0057
Schistosoma mansoni voltage-gated potassium channel 0.0065 0.0139 0.0177
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0049 0.0083 0.0288
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0096 0.0245 0.0244
Schistosoma mansoni lamin 0.0062 0.0128 0.0163
Echinococcus granulosus phd:f box containing protein 0.0027 0.0007 0.0008
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0042 0.0059 0.0058
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0054 0.0103 0.013
Mycobacterium leprae Possible regulatory protein 0.0054 0.0103 0.0056
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0846 0.2835 0.3632
Schistosoma mansoni hypothetical protein 0.0041 0.0056 0.0071
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0039 0.005 0.0049
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0225 0.069 0.1733
Echinococcus granulosus single minded 2 0.0159 0.0463 0.0592
Echinococcus multilocularis tar DNA binding protein 0.0072 0.0164 0.0209
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0039 0.005 0.0049
Echinococcus granulosus neuropeptide Y receptor 0.0124 0.0344 0.044
Trypanosoma brucei trypanothione reductase 0.1096 0.3698 0.3698
Echinococcus granulosus histone lysine methyltransferase setb 0.0096 0.0248 0.0317
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0225 0.069 0.0689
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0186 0.0185
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0124 0.0344 0.044
Schistosoma mansoni phosphatidylserine receptor 0.0027 0.0007 0.0008
Schistosoma mansoni hypothetical protein 0.0131 0.0368 0.047
Loa Loa (eye worm) hypothetical protein 0.0374 0.1204 0.3244
Brugia malayi Bromodomain containing protein 0.0029 0.0014 0.002
Leishmania major cytochrome p450-like protein 0.0049 0.0083 0.0082
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0042 0.0059 0.0847
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0096 0.0245 0.354
Entamoeba histolytica phosphofructokinase, putative 0.012 0.033 0.477
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0164 0.0209
Schistosoma mansoni neuropeptide receptor 0.0124 0.0344 0.044
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0462 0.1509 0.3983
Loa Loa (eye worm) hypothetical protein 0.0067 0.0145 0.0374
Echinococcus multilocularis g protein coupled receptor 0.0124 0.0344 0.044
Brugia malayi glutamate synthase 0.0225 0.069 0.184
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0201 0.0607 0.214
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0096 0.0245 0.0313
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0093 0.0316
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0225 0.069 0.184
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0225 0.069 0.0689
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0028 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0093 0.0315
Onchocerca volvulus 0.0124 0.0344 0.1297
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0027 0.001 0.0011
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0114 0.0307 0.0812
Loa Loa (eye worm) hypothetical protein 0.0383 0.1238 0.3335
Loa Loa (eye worm) hypothetical protein 0.0031 0.0023 0.0044
Brugia malayi bHLH-PAS transcription factor 0.0155 0.0449 0.1192
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0049 0.0083 0.0064
Loa Loa (eye worm) hypothetical protein 0.0063 0.0133 0.0341
Schistosoma mansoni hypothetical protein 0.0225 0.069 0.0883
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.059 0.2071
Trypanosoma cruzi hypothetical protein, conserved 0.0225 0.069 0.0689
Toxoplasma gondii Erv1 / Alr family protein 0.0039 0.005 0.0132
Schistosoma mansoni neuropeptide receptor 0.0124 0.0344 0.044
Schistosoma mansoni voltage-gated potassium channel 0.0065 0.0139 0.0177
Brugia malayi TAR-binding protein 0.0072 0.0164 0.0422
Loa Loa (eye worm) cytochrome P450 0.0049 0.0083 0.0205
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0225 0.069 0.2425
Brugia malayi 6-phosphofructokinase 0.012 0.033 0.0869
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0063 0.0133 0.0169
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.2466 0.8424 0.8424
Schistosoma mansoni polycystin 1-related 0.0131 0.0368 0.047
Brugia malayi hypothetical protein 0.0131 0.0368 0.0971
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0225 0.069 0.1701
Echinococcus multilocularis mitogen activated protein kinase 3 0.0114 0.0307 0.0392
Leishmania major hypothetical protein, conserved 0.0225 0.069 0.0689
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Onchocerca volvulus 0.0321 0.1024 0.397
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0014 0.0036
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0033 0.0029 0.0059
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0054 0.0103 0.035
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0124 0.0344 0.044
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.0913
Treponema pallidum exodeoxyribonuclease (exoA) 0.0042 0.0059 0.0115
Leishmania major trypanothione reductase 0.1096 0.3698 0.3698
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0124 0.0344 0.044
Schistosoma mansoni jumonji/arid domain-containing protein 0.01 0.0259 0.0331

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 115.56 mg/ml Cytotoxicity against dog MDCK cells ChEMBL. 18160286

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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