TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 388.545 | Formula: C26H32N2O
H donors: 0 H acceptors: 0 LogP: 3.84 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O1CCN(CC1)CCc1ccc(cc1)C1=CCC2C1CN(C2)Cc1ccccc1
InChi: 1S/C26H32N2O/c1-2-4-22(5-3-1)18-28-19-24-10-11-25(26(24)20-28)23-8-6-21(7-9-23)12-13-27-14-16-29-17-15-27/h1-9,11,24,26H,10,12-20H2
InChiKey: UNRGMCLRRBQICS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Histamine H3 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	hypothetical protein	Histamine H3 receptor	445 aa	384 aa	22.4 %
Echinococcus granulosus	biogenic amine 5HT receptor	Histamine H3 receptor	445 aa	405 aa	25.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0159	0.1511	0.1511
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0033	0.016	0.016
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.0092	0.0092
Loa Loa (eye worm)	raf kinase	0.0032	0.015	0.015
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.0092	0.0092
Trichomonas vaginalis	AGC family protein kinase	0.0046	0.0294	0.0646
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0036	0.0189	0.0189
Brugia malayi	Ras association domain family 1 isoform A	0.0032	0.015	0.015
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.0476	0.1045
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0081	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0081	0.0081
Brugia malayi	ShTK domain containing protein	0.0099	0.0863	0.0863
Leishmania major	phosphopantetheinyl transferase-like protein	0.0023	0.0048	0.0106
Giardia lamblia	Cgi67 serine protease precursor-like protein	0.0026	0.0081	1
Brugia malayi	hypothetical protein	0.0027	0.0092	0.0092
Echinococcus multilocularis	g protein coupled receptor	0.0027	0.0092	0.0092
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0039	0.0219	0.0219
Schistosoma mansoni	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0114	0.1031	0.1031
Schistosoma mansoni	myosin xvIII	0.0027	0.0092	0.0092
Echinococcus granulosus	abhydrolase domain containing 3	0.0026	0.0081	0.0081
Echinococcus multilocularis	neuropeptides capa receptor	0.0027	0.0092	0.0092
Echinococcus multilocularis	regulator of G protein signaling 3	0.0039	0.0219	0.0219
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0114	0.1031	0.1031
Trypanosoma brucei	monoglyceride lipase, putative	0.0442	0.456	1
Plasmodium vivax	lysophospholipase, putative	0.0026	0.0081	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0032	0.015	0.015
Echinococcus granulosus	G protein coupled receptor 139	0.0027	0.0092	0.0092
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0476	0.1045
Echinococcus granulosus	protein kinase c epsilon type	0.0149	0.1407	0.1407
Echinococcus multilocularis	dro:myosuppressin receptor	0.0027	0.0092	0.0092
Plasmodium falciparum	prodrug activation and resistance esterase	0.0026	0.0081	0.0178
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0027	0.0092	0.0092
Echinococcus granulosus	g protein coupled receptor	0.0027	0.0092	0.0092
Schistosoma mansoni	amine GPCR	0.0027	0.0092	0.0092
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0027	0.0092	0.0092
Brugia malayi	Serotonin receptor	0.0027	0.0092	0.0092
Echinococcus granulosus	fmrfamide receptor	0.0027	0.0092	0.0092
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0027	0.0092	0.0092
Trypanosoma brucei	Alpha/beta hydrolase family, putative	0.0026	0.0081	0.0178
Echinococcus granulosus	rhodopsin orphan GPCR	0.0027	0.0092	0.0092
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.0092	0.0092
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.015	0.015
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0033	0.016	0.016
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0219	0.0481
Schistosoma mansoni	opsin-like receptor	0.0027	0.0092	0.0092
Brugia malayi	hypothetical protein	0.0027	0.0092	0.0092
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0046	0.0294	0.0294
Echinococcus multilocularis	regulator of G protein signaling 7	0.0039	0.0219	0.0219
Plasmodium falciparum	esterase, putative	0.0026	0.0081	0.0178
Trypanosoma cruzi	amidase, putative	0.0114	0.1031	0.2261
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0099	0.0863	0.0863
Schistosoma mansoni	tyrosinase precursor	0.0099	0.0863	0.0863
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0476	0.1045
Echinococcus multilocularis	G protein coupled receptor 139	0.0027	0.0092	0.0092
Onchocerca volvulus		0.0099	0.0863	0.2961
Echinococcus multilocularis	fmrfamide receptor	0.0027	0.0092	0.0092
Leishmania major	cathepsin L-like protease	0.0063	0.0476	0.1045
Echinococcus multilocularis	serotonin receptor	0.0027	0.0092	0.0092
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0046	0.0294	0.0294
Echinococcus granulosus	hypothetical protein	0.0027	0.0092	0.0092
Schistosoma mansoni	regulator of G protein signaling	0.0039	0.0219	0.0219
Schistosoma mansoni	axis inhibition protein axin	0.0039	0.0219	0.0219
Loa Loa (eye worm)	hypothetical protein	0.0032	0.015	0.015
Brugia malayi	Protein C20orf22	0.0026	0.0081	0.0081
Schistosoma mansoni	tyrosinase precursor	0.0099	0.0863	0.0863
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0026	0.0081	0.0178
Echinococcus granulosus	raf serine:threonine protein kinase	0.0032	0.015	0.015
Toxoplasma gondii	diacylglycerol kinase, putative	0.0032	0.015	0.5089
Entamoeba histolytica	hypothetical protein	0.0026	0.0081	0.0178
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.0092	0.0092
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0027	0.0092	0.0092
Leishmania major	cathepsin L-like protease	0.0063	0.0476	0.1045
Trypanosoma cruzi	major cysteine proteinase, putative	0.0049	0.0332	0.0728
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0032	0.015	0.015
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0081	0.0081
Brugia malayi	neuropeptide F receptor	0.0027	0.0092	0.0092
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0027	0.0092	0.0092
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0027	0.0092	0.0092
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0023	0.0048	0.047
Schistosoma mansoni	amine GPCR	0.0027	0.0092	0.0092
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0046	0.0294	0.0646
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.016	0.016
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0033	0.016	0.016
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0027	0.0092	0.0092
Schistosoma mansoni	serine/threonine protein kinase	0.0149	0.1407	0.1407
Schistosoma mansoni	unc-13 (munc13)	0.0036	0.0189	0.0189
Loa Loa (eye worm)	ShTK domain-containing protein	0.0099	0.0863	0.0863
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0046	0.0294	0.0294
Schistosoma mansoni	serine/threonine protein kinase	0.0046	0.0294	0.0294
Plasmodium falciparum	lysophospholipase, putative	0.0026	0.0081	0.0178
Brugia malayi	RhoGAP domain containing protein	0.0032	0.015	0.015
Echinococcus granulosus	regulator of G protein signaling 7	0.0039	0.0219	0.0219
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0081	0.0081
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0081	0.0178
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0149	0.1407	0.1407
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.0476	0.1045
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0027	0.0092	0.0092
Mycobacterium tuberculosis	Probable amidase AmiB2 (aminohydrolase)	0.0114	0.1031	0.2261
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0027	0.0092	0.0092
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0027	0.0092	0.0092
Echinococcus granulosus	Phospholipase carboxylesterase	0.0026	0.0081	0.0081
Plasmodium vivax	PST-A protein	0.0026	0.0081	0.0178
Toxoplasma gondii	hydrolase, alpha/beta fold family protein	0.0026	0.0081	0.2764
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0027	0.0092	0.0092
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0026	0.0081	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Trichomonas vaginalis	AGC family protein kinase	0.0046	0.0294	0.0646
Brugia malayi	hypothetical protein	0.0027	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0219	0.0219
Brugia malayi	G protein-coupled receptor F59B2.13	0.0027	0.0092	0.0092
Trichomonas vaginalis	AGC family protein kinase	0.0046	0.0294	0.0646
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0046	0.0294	0.0294
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0946	1	1
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0082	0.0681	0.0681
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0219	0.0481
Loa Loa (eye worm)	amidase	0.0114	0.1031	0.1031
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0027	0.0092	0.0092
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0023	0.0048	0.0106
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0946	1	1
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0026	0.0081	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0269	0.2699	0.2699
Echinococcus granulosus	unc 13 munc13	0.0036	0.0189	0.0189
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0081	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Brugia malayi	diacylglycerol kinase	0.0032	0.015	0.015
Schistosoma mansoni	fatty-acid amide hydrolase	0.0114	0.1031	0.1031
Mycobacterium tuberculosis	Probable amidase AmiA2 (aminohydrolase)	0.0114	0.1031	0.2261
Onchocerca volvulus		0.0032	0.015	0.0224
Loa Loa (eye worm)	tyrosinase 1	0.0099	0.0863	0.0863
Brugia malayi	hypothetical protein	0.0027	0.0092	0.0092
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0027	0.0092	0.0092
Schistosoma mansoni	adenoreceptor	0.0027	0.0092	0.0092
Trypanosoma cruzi	amidase, putative	0.0114	0.1031	0.2261
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0027	0.0092	0.0092
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0027	0.0092	0.0092
Entamoeba histolytica	diacylglycerol kinase, putative	0.0032	0.015	0.0329
Echinococcus multilocularis	myotubularin protein 13	0.0032	0.015	0.015
Mycobacterium ulcerans	lysophospholipase	0.0442	0.456	1
Echinococcus multilocularis	beta adrenergic receptor kinase	0.004	0.023	0.023
Schistosoma mansoni	opsin-like receptor	0.0027	0.0092	0.0092
Trichomonas vaginalis	AGC family protein kinase	0.0046	0.0294	0.0646
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0476	0.1045
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0476	0.1045
Echinococcus granulosus	NDR protein kinase	0.0046	0.0294	0.0294
Trichomonas vaginalis	AGC family protein kinase	0.0046	0.0294	0.0646
Brugia malayi	ORL1-like opioid receptor	0.0027	0.0092	0.0092
Loa Loa (eye worm)	neuropeptide F receptor	0.0027	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0032	0.015	0.015
Schistosoma mansoni	regulator of G protein signaling	0.0039	0.0219	0.0219
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0027	0.0092	0.0092
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0476	0.1045
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0476	0.1045
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0027	0.0092	0.0092
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0442	0.456	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0027	0.0092	0.0092
Brugia malayi	regulator of G-protein signaling egl-10	0.0039	0.0219	0.0219
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0946	1	1
Echinococcus granulosus	N chimaerin	0.0032	0.015	0.015
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0027	0.0092	0.0092
Plasmodium falciparum	epoxide hydrolase 2	0.0026	0.0081	0.0178
Brugia malayi	PXA domain containing protein	0.0039	0.0219	0.0219
Schistosoma mansoni	peptidase	0.0026	0.0081	0.0081
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0027	0.0092	0.0092
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0032	0.015	0.015
Onchocerca volvulus		0.0099	0.0863	0.2961
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0057	0.0418	0.0916
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0046	0.0294	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0219	0.0219
Echinococcus multilocularis	neuropeptide receptor	0.0027	0.0092	0.0092
Leishmania major	hypothetical protein, conserved	0.0114	0.1031	0.2261
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0046	0.0294	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0219	0.0219
Loa Loa (eye worm)	hypothetical protein	0.0269	0.2699	0.2699
Plasmodium vivax	PST-A protein	0.0026	0.0081	0.0178
Trichomonas vaginalis	AGC family protein kinase	0.0046	0.0294	0.0646
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.004	0.023	0.023
Trypanosoma brucei	Alpha/beta hydrolase family, putative	0.0026	0.0081	0.0178
Echinococcus multilocularis	fmrfamide receptor	0.0027	0.0092	0.0092
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0219	0.0481
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0027	0.0092	0.0092
Plasmodium falciparum	esterase, putative	0.0442	0.456	1
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0026	0.0081	0.0178
Brugia malayi	hypothetical protein	0.0027	0.0092	0.0092
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0027	0.0092	0.0092
Plasmodium falciparum	lysophospholipase, putative	0.0442	0.456	1
Echinococcus multilocularis	N chimaerin	0.0032	0.015	0.015
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.0092	0.0092
Trypanosoma cruzi	cruzipain precursor, putative	0.0063	0.0476	0.1045
Schistosoma mansoni	neuropeptide receptor	0.0027	0.0092	0.0092
Echinococcus granulosus	regulator of G protein signaling 3	0.0039	0.0219	0.0219
Toxoplasma gondii	protein c14orf29, putative	0.0026	0.0081	0.2764
Loa Loa (eye worm)	TYRA-2 protein	0.0027	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0027	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Toxoplasma gondii	phospholipase/carboxylesterase	0.0026	0.0081	0.2764
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0023	0.0048	0.1646
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0032	0.015	0.015
Onchocerca volvulus		0.0082	0.0681	0.2262
Echinococcus multilocularis	allatostatin A receptor	0.0027	0.0092	0.0092
Loa Loa (eye worm)	ShTK domain-containing protein	0.0099	0.0863	0.0863
Brugia malayi	hypothetical protein	0.0027	0.0092	0.0092
Schistosoma mansoni	hypothetical protein	0.0032	0.015	0.015
Schistosoma mansoni	serine/threonine protein kinase	0.004	0.023	0.023
Toxoplasma gondii	hypothetical protein	0.0026	0.0081	0.2764
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0046	0.0294	0.0294
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0027	0.0092	0.0092
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0081	0.0178
Echinococcus multilocularis	g protein coupled receptor	0.0027	0.0092	0.0092
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0077	0.0629	0.0629
Echinococcus granulosus	serine:threonine protein kinase N2	0.0068	0.0536	0.0536
Echinococcus multilocularis	somatostatin receptor	0.0027	0.0092	0.0092
Schistosoma mansoni	serine/threonine protein kinase	0.0046	0.0294	0.0294
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0081	0.0679	0.0679
Brugia malayi	RE15519p	0.0027	0.0092	0.0092
Echinococcus granulosus	L aminoadipate semialdehyde	0.0082	0.0681	0.0681
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0219	0.0481
Plasmodium falciparum	alpha/beta-hydrolase, putative	0.0026	0.0081	0.0178
Plasmodium vivax	alpha/beta hydrolase, putative	0.0026	0.0081	0.0178
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0032	0.015	0.015
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0045	0.0284	0.0622
Echinococcus granulosus	regulator of G protein signaling 7	0.0039	0.0219	0.0219
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0027	0.0092	0.0092
Schistosoma mansoni	histamine h1 receptor	0.0027	0.0092	0.0092
Brugia malayi	hypothetical protein	0.0027	0.0092	0.0092
Echinococcus multilocularis	neuropeptide Y receptor	0.0027	0.0092	0.0092
Brugia malayi	hypothetical protein	0.0039	0.0219	0.0219
Schistosoma mansoni	growth hormone secretagogue receptor	0.0027	0.0092	0.0092
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0032	0.015	0.015
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0027	0.0092	0.0092
Schistosoma mansoni	family S9 unassigned peptidase (S09 family)	0.0026	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0032	0.015	0.015
Chlamydia trachomatis	acyltransferase family protein	0.0026	0.0081	0.0335
Echinococcus granulosus	axis inhibition protein axin	0.0039	0.0219	0.0219
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0027	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Brugia malayi	A-kinase anchor protein 10, precursor	0.0039	0.0219	0.0219
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0189	0.0189
Brugia malayi	PXA domain containing protein	0.0039	0.0219	0.0219
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0032	0.015	0.015
Trypanosoma cruzi	monoglyceride lipase, putative	0.0442	0.456	1
Wolbachia endosymbiont of Brugia malayi	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0114	0.1031	1
Echinococcus multilocularis	glutamyl tRNA(Gln) amidotransferase subunit A	0.0114	0.1031	0.1031
Echinococcus granulosus	7TM GPCR rhodopsin	0.0027	0.0092	0.0092
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0027	0.0092	0.0092
Trichomonas vaginalis	AGC family protein kinase	0.0046	0.0294	0.0646
Plasmodium vivax	glutamyl-tRNA(Gln) amidotransferase subunit A, putative	0.0114	0.1031	0.2261
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0027	0.0092	0.0092
Schistosoma mansoni	fatty-acid amide hydrolase	0.0946	1	1
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0099	0.0863	0.0863
Brugia malayi	Common central domain of tyrosinase family protein	0.0099	0.0863	0.0863
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0026	0.0081	0.0178
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0082	0.0681	0.0681
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0046	0.0294	0.0294
Brugia malayi	AKH receptor	0.0027	0.0092	0.0092
Schistosoma mansoni	protein kinase C mu	0.0033	0.016	0.016
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Schistosoma mansoni	protein kinase C	0.0036	0.0189	0.0189
Onchocerca volvulus		0.0099	0.0863	0.2961
Schistosoma mansoni	protein kinase C mu	0.0032	0.015	0.015
Echinococcus multilocularis	protein kinase c iota type	0.0078	0.0643	0.0643
Plasmodium falciparum	BEM46-like protein, putative	0.0026	0.0081	0.0178
Schistosoma mansoni	hypothetical protein	0.0027	0.0092	0.0092
Brugia malayi	G-protein coupled receptor	0.0027	0.0092	0.0092
Mycobacterium ulcerans	amidase	0.0114	0.1031	0.2261
Echinococcus multilocularis	protein kinase c epsilon type	0.0149	0.1407	0.1407
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Brugia malayi	Protein kinase c protein 2	0.0114	0.1028	0.1028
Mycobacterium ulcerans	amidase	0.0114	0.1031	0.2261
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Trypanosoma brucei	fatty-acid amide hydrolase, putative	0.0114	0.1031	0.2261
Echinococcus granulosus	tm gpcr rhodopsin	0.0027	0.0092	0.0092
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0219	0.0481
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.0476	0.1045
Echinococcus granulosus	abhydrolase domain containing protein 13	0.0026	0.0081	0.0081
Schistosoma mansoni	opsin-like receptor	0.0027	0.0092	0.0092
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0032	0.015	0.015
Echinococcus granulosus	tm gpcr rhodopsin	0.0027	0.0092	0.0092
Schistosoma mansoni	regulator of G protein signaling	0.0039	0.0219	0.0219
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0027	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Echinococcus multilocularis	RNA directed DNA polymerase	0.0077	0.0629	0.0629
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0033	0.016	0.016
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0023	0.0048	0.0106
Onchocerca volvulus		0.0036	0.0189	0.0375
Brugia malayi	larval opioid receptor	0.0027	0.0092	0.0092
Trypanosoma brucei	hypothetical protein, conserved	0.0023	0.0048	0.0106
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.0442	0.456	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Brugia malayi	G-protein coupled receptor	0.0027	0.0092	0.0092
Plasmodium falciparum	exported lipase 1	0.0026	0.0081	0.0178
Echinococcus granulosus	neuropeptides capa receptor	0.0027	0.0092	0.0092
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0027	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0863	0.0863
Mycobacterium ulcerans	hydrolase	0.0026	0.0081	0.0178
Schistosoma mansoni	amine GPCR	0.0027	0.0092	0.0092
Brugia malayi	RhoGEF domain containing protein	0.0032	0.015	0.015
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0219	0.0219
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0046	0.0294	0.0294
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0039	0.0219	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0032	0.015	0.015
Loa Loa (eye worm)	G-protein coupled receptor	0.0027	0.0092	0.0092
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0442	0.456	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0027	0.0092	0.0092
Schistosoma mansoni	regulator of G protein signaling	0.0039	0.0219	0.0219
Brugia malayi	Amidase family protein	0.0114	0.1031	0.1031
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0081	0.0178
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.004	0.023	0.023
Plasmodium falciparum	alpha/beta hydrolase fold domain containing protein, putative	0.0026	0.0081	0.0178
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0039	0.0219	0.0219
Brugia malayi	hypothetical protein	0.0027	0.0092	0.0092
Brugia malayi	p70 ribosomal S6 kinase beta	0.0046	0.0294	0.0294
Schistosoma mansoni	serine/threonine protein kinase	0.0046	0.0294	0.0294
Echinococcus multilocularis	neuropeptide receptor A26	0.0027	0.0092	0.0092
Schistosoma mansoni	diacylglycerol kinase theta	0.0032	0.015	0.015
Echinococcus granulosus	neuropeptide FF receptor 2	0.0027	0.0092	0.0092
Plasmodium vivax	hypothetical protein, conserved	0.0026	0.0081	0.0178
Echinococcus granulosus	beta-adrenergic receptor kinase	0.004	0.023	0.023
Brugia malayi	Dopamine receptor protein 1	0.0027	0.0092	0.0092
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0026	0.0081	0.0178
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0039	0.0219	0.0219
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0294	0.0294
Entamoeba histolytica	protein kinase, putative	0.0046	0.0294	0.0646
Loa Loa (eye worm)	RGS-3 protein	0.0039	0.0219	0.0219
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0027	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Mycobacterium ulcerans	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0114	0.1031	0.2261
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0629	0.0629
Brugia malayi	Melatonin receptor type 1A	0.0027	0.0092	0.0092
Plasmodium falciparum	esterase, putative	0.0026	0.0081	0.0178
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0476	0.1045
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0476	0.1045
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Mycobacterium ulcerans	hypothetical protein	0.0442	0.456	1
Trypanosoma cruzi	hydrolase, alpha/beta fold family, putative	0.0026	0.0081	0.0178
Entamoeba histolytica	hypothetical protein	0.0032	0.015	0.0329
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0027	0.0092	0.0092
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0027	0.0092	0.0092
Entamoeba histolytica	protein kinase, putative	0.0046	0.0294	0.0646
Plasmodium vivax	lysophospholipase, putative	0.0026	0.0081	0.0178
Schistosoma mansoni	diacylglycerol kinase theta	0.0032	0.015	0.015
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0476	0.1045
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0294	0.0294
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0023	0.0048	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Echinococcus granulosus	Regulator of G protein signaling 20	0.0039	0.0219	0.0219
Brugia malayi	hypothetical protein	0.0027	0.0092	0.0092
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0027	0.0092	0.0092
Echinococcus multilocularis	serine threonine protein kinase	0.0126	0.1162	0.1162
Loa Loa (eye worm)	hypothetical protein	0.0032	0.015	0.015
Echinococcus granulosus	glutamyl tRNAGln amidotransferase subunit A	0.0114	0.1031	0.1031
Echinococcus granulosus	serotonin receptor	0.0027	0.0092	0.0092
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0476	0.1045
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0027	0.0092	0.0092
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0033	0.016	0.016
Loa Loa (eye worm)	hypothetical protein	0.0301	0.3048	0.3048
Echinococcus multilocularis	unc 13 (munc13)	0.0036	0.0189	0.0189
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0032	0.015	0.015
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0442	0.456	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Entamoeba histolytica	hypothetical protein	0.0039	0.0219	0.0481
Mycobacterium tuberculosis	Probable amidase AmiD (acylamidase) (acylase)	0.0114	0.1031	0.2261
Schistosoma mansoni	serine/threonine protein kinase	0.0159	0.1511	0.1511
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0026	0.0081	0.0178
Toxoplasma gondii	hydrolase, alpha/beta fold family protein	0.0026	0.0081	0.2764
Entamoeba histolytica	diacylglycerol kinase, putative	0.0032	0.015	0.0329
Loa Loa (eye worm)	G-protein coupled receptor	0.0027	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Schistosoma mansoni	serine/threonine protein kinase	0.0046	0.0294	0.0294
Echinococcus granulosus	monoacylglycerol lipase abhd12	0.0026	0.0081	0.0081
Plasmodium vivax	PST-A protein	0.0026	0.0081	0.0178
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0039	0.0219	0.0219
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0027	0.0092	0.0092
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0027	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Schistosoma mansoni	serine/threonine protein kinase	0.004	0.023	0.023
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0863	0.0863
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0039	0.0219	0.0219
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Treponema pallidum	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0114	0.1031	1
Schistosoma mansoni	neuropeptide receptor	0.0027	0.0092	0.0092
Mycobacterium ulcerans	amidase	0.0114	0.1031	0.2261
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0219	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0315	0.3192	0.3192
Entamoeba histolytica	protein kinase, putative	0.0046	0.0294	0.0646
Mycobacterium leprae	PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A)	0.0114	0.1031	0.2178
Echinococcus granulosus	neuropeptide receptor	0.0027	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0081	0.0081
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0027	0.0092	0.0092
Schistosoma mansoni	neuropeptide F-like receptor	0.0027	0.0092	0.0092
Onchocerca volvulus		0.0269	0.2699	1
Echinococcus granulosus	orexin receptor type 2	0.0027	0.0092	0.0092
Echinococcus granulosus	g-protein coupled receptor	0.0027	0.0092	0.0092
Echinococcus granulosus	Diacylglycerol kinase theta	0.0032	0.015	0.015
Brugia malayi	follicle stimulating hormone receptor	0.0027	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Plasmodium vivax	PST-A protein	0.0026	0.0081	0.0178
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0027	0.0092	0.0092
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0039	0.0219	0.0219
Echinococcus granulosus	rhodopsin orphan GPCR	0.0027	0.0092	0.0092
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0294	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0269	0.2699	0.2699
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Trichomonas vaginalis	AGC family protein kinase	0.0046	0.0294	0.0646
Loa Loa (eye worm)	PXA domain-containing protein	0.0039	0.0219	0.0219
Entamoeba histolytica	hypothetical protein	0.0026	0.0081	0.0178
Toxoplasma gondii	AGC kinase	0.0046	0.0294	1
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0081	0.0178
Schistosoma mansoni	neuropeptide receptor	0.0027	0.0092	0.0092
Brugia malayi	Hypothetical tyrosinase-like protein F21C3.2 in chromosome I	0.0099	0.0863	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0032	0.015	0.015
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0046	0.0294	0.0294
Schistosoma mansoni	serine/threonine protein kinase	0.004	0.023	0.023
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0081	0.0178
Trypanosoma cruzi	Serine peptidase, Clan SC, Family S09X, putative	0.0026	0.0081	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Echinococcus multilocularis	serotonin receptor	0.0027	0.0092	0.0092
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0027	0.0092	0.0092
Plasmodium falciparum	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0114	0.1031	0.2261
Brugia malayi	Dopamine receptor	0.0027	0.0092	0.0092
Chlamydia trachomatis	hydrolase	0.0026	0.0081	0.0335
Schistosoma mansoni	amine GPCR	0.0027	0.0092	0.0092
Schistosoma mansoni	hypothetical protein	0.0027	0.0092	0.0092
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.016	0.016
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Trichomonas vaginalis	AGC family protein kinase	0.0046	0.0294	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0027	0.0092	0.0092
Echinococcus multilocularis	neuropeptide receptor	0.0027	0.0092	0.0092
Echinococcus granulosus	neuropeptide Y receptor	0.0027	0.0092	0.0092
Echinococcus granulosus	Rac GTPase activating protein 1	0.0032	0.015	0.015
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0946	1	1
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.0026	0.0081	0.0178
Plasmodium vivax	hypothetical protein, conserved	0.0026	0.0081	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0219	0.0219
Echinococcus granulosus	7tm_1 domain containing protein	0.0027	0.0092	0.0092
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0027	0.0092	0.0092
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0046	0.0294	0.0294
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0027	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0032	0.015	0.015
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0039	0.0219	0.0219
Echinococcus granulosus	protein kinase C gamma type	0.0126	0.1162	0.1162
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0027	0.0092	0.0092
Echinococcus multilocularis	neuropeptide s receptor	0.0027	0.0092	0.0092
Schistosoma mansoni	hypothetical protein	0.0027	0.0092	0.0092
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0027	0.0092	0.0092
Brugia malayi	Protein kinase domain containing protein	0.0033	0.016	0.016
Echinococcus granulosus	protein kinase c eta type	0.0032	0.015	0.015
Leishmania major	hypothetical protein, conserved	0.0026	0.0081	0.0178
Schistosoma mansoni	atypical protein kinase C	0.0078	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Plasmodium vivax	alpha/beta hydrolase, putative	0.0026	0.0081	0.0178
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0026	0.0081	0.0178
Echinococcus granulosus	rhodopsin orphan GPCR	0.0027	0.0092	0.0092
Leishmania major	cathepsin L-like protease	0.0063	0.0476	0.1045
Brugia malayi	Variant SH3 domain containing protein	0.0032	0.015	0.015
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Brugia malayi	hypothetical protein	0.0039	0.0219	0.0219
Brugia malayi	Pleckstrin Homology Domain	0.0032	0.015	0.015
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.0092	0.0092
Schistosoma mansoni	neuropeptide F-like receptor	0.0027	0.0092	0.0092
Brugia malayi	regulator of G-protein signaling rgs-7	0.0039	0.0219	0.0219
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0081	0.0178
Brugia malayi	MGC79044 protein	0.0026	0.0081	0.0081
Plasmodium vivax	unspecified product	0.0026	0.0081	0.0178
Mycobacterium tuberculosis	Possible amidase (aminohydrolase)	0.0114	0.1031	0.2261
Echinococcus granulosus	Protein kinase C brain isozyme	0.0159	0.1511	0.1511
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0026	0.0081	0.0178
Toxoplasma gondii	phospholipase	0.0026	0.0081	0.2764
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Toxoplasma gondii	hypothetical protein	0.0026	0.0081	0.2764
Brugia malayi	Hr1 repeat family protein	0.0046	0.0294	0.0294
Brugia malayi	RhoGAP domain containing protein	0.0032	0.015	0.015
Schistosoma mansoni	family S9 unassigned peptidase (S09 family)	0.0026	0.0081	0.0081
Trichomonas vaginalis	conserved hypothetical protein	0.0442	0.456	1
Toxoplasma gondii	peptidase S15, putative	0.0026	0.0081	0.2764
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Plasmodium falciparum	exported lipase 2	0.0026	0.0081	0.0178
Trypanosoma cruzi	serine peptidase, putative	0.0026	0.0081	0.0178
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0068	0.0536	0.1175
Mycobacterium ulcerans	peptide amidase, GatA	0.0114	0.1031	0.2261
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.0026	0.0081	0.0178
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0442	0.456	1
Mycobacterium leprae	PROBABLE AMIDASE AMIC (AMINOHYDROLASE)	0.0114	0.1031	0.2178
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0023	0.0048	0.1646
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0026	0.0081	0.0178
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0032	0.015	0.015
Echinococcus granulosus	tm gpcr rhodopsin	0.0027	0.0092	0.0092
Echinococcus granulosus	rhodopsin orphan GPCR	0.0027	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0219	0.0219
Echinococcus multilocularis	neuropeptide Y receptor	0.0027	0.0092	0.0092
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0046	0.0294	0.0294
Mycobacterium ulcerans	amidase	0.0114	0.1031	0.2261
Echinococcus granulosus	neuropeptide Y receptor	0.0027	0.0092	0.0092
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0032	0.015	0.015
Entamoeba histolytica	hypothetical protein	0.0039	0.0219	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Plasmodium vivax	unspecified product	0.0026	0.0081	0.0178
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0039	0.0219	0.0219
Plasmodium vivax	lysophospholipase, putative	0.0026	0.0081	0.0178
Brugia malayi	putative amidase	0.0114	0.1031	0.1031
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0026	0.0081	0.0178
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0032	0.015	0.015
Echinococcus multilocularis	axis inhibition protein axin	0.0039	0.0219	0.0219
Echinococcus granulosus	neuropeptide s receptor	0.0027	0.0092	0.0092
Schistosoma mansoni	unc-13 (munc13)	0.0036	0.0189	0.0189
Echinococcus granulosus	axis inhibition protein axin	0.0039	0.0219	0.0219
Schistosoma mansoni	serine/threonine kinase	0.0046	0.0294	0.0294
Brugia malayi	MGC83647 protein	0.0026	0.0081	0.0081
Brugia malayi	hypothetical protein	0.0027	0.0092	0.0092
Brugia malayi	Amidase family protein	0.0114	0.1031	0.1031
Echinococcus multilocularis	monoacylglycerol lipase abhd12	0.0026	0.0081	0.0081
Echinococcus multilocularis	regulator of G protein signaling	0.0039	0.0219	0.0219
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0027	0.0092	0.0092
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0039	0.0219	0.0219
Brugia malayi	neuropeptide F receptor	0.0027	0.0092	0.0092
Entamoeba histolytica	hypothetical protein	0.0023	0.0048	0.0106
Echinococcus multilocularis	regulator of G protein signaling 7	0.0039	0.0219	0.0219
Trichomonas vaginalis	conserved hypothetical protein	0.0442	0.456	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0027	0.0092	0.0092
Echinococcus granulosus	g protein coupled receptor	0.0027	0.0092	0.0092
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0027	0.0092	0.0092
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0442	0.456	1
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0114	0.1031	0.1031
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0026	0.0081	0.0178
Plasmodium falciparum	lysophospholipase, putative	0.0442	0.456	1
Brugia malayi	Dopamine receptor protein 2	0.0027	0.0092	0.0092
Brugia malayi	C1-like domain containing protein	0.0033	0.016	0.016
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0081	0.0178
Echinococcus multilocularis	regulator of G protein signaling 3	0.0039	0.0219	0.0219
Loa Loa (eye worm)	melatonin receptor type 1A	0.0027	0.0092	0.0092
Schistosoma mansoni	z-protein (S1r protein)	0.0039	0.0219	0.0219
Schistosoma mansoni	biogenic amine receptor	0.0027	0.0092	0.0092
Mycobacterium tuberculosis	Possible lysophospholipase	0.0442	0.456	1
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0099	0.0863	0.0863
Leishmania major	Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X	0.0026	0.0081	0.0178
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0027	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0032	0.015	0.015
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0027	0.0092	0.0092
Echinococcus granulosus	rhodopsin orphan GPCR	0.0027	0.0092	0.0092
Echinococcus granulosus	protein kinase c iota type	0.0078	0.0643	0.0643
Onchocerca volvulus		0.0099	0.0863	0.2961
Schistosoma mansoni	biogenic amine receptor	0.0027	0.0092	0.0092
Schistosoma mansoni	vav2	0.0032	0.015	0.015
Echinococcus multilocularis	Phospholipase carboxylesterase	0.0026	0.0081	0.0081
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0027	0.0092	0.0092
Brugia malayi	putative neuropeptide receptor	0.0027	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Toxoplasma gondii	esterase/lipase/thioesterase domain-containing protein	0.0026	0.0081	0.2764
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0023	0.0048	0.047
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.0092	0.0092
Echinococcus multilocularis	sex peptide receptor	0.0027	0.0092	0.0092
Echinococcus granulosus	neuropeptide receptor	0.0027	0.0092	0.0092
Echinococcus multilocularis	neuropeptides capa receptor	0.0027	0.0092	0.0092
Schistosoma mansoni	serine/threonine protein kinase	0.0159	0.1511	0.1511
Echinococcus granulosus	neuropeptide receptor A26	0.0027	0.0092	0.0092
Schistosoma mansoni	hypothetical protein	0.0027	0.0092	0.0092
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.0092	0.0092
Echinococcus multilocularis	orexin receptor type 2	0.0027	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0946	1	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0027	0.0092	0.0092
Echinococcus granulosus	serine:threonine protein kinase N2	0.0046	0.0294	0.0294
Plasmodium falciparum	lysophospholipase, putative	0.0442	0.456	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Echinococcus multilocularis	protein kinase c eta type	0.0032	0.015	0.015
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0026	0.0081	0.0178
Echinococcus granulosus	sex peptide receptor	0.0027	0.0092	0.0092
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0442	0.456	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0027	0.0092	0.0092
Trypanosoma brucei	monoglyceride lipase, putative	0.0442	0.456	1
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0113	0.1019	0.1019
Chlamydia trachomatis	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0114	0.1031	1
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.0026	0.0081	0.0178
Schistosoma mansoni	neuropeptide f receptor 76f	0.0027	0.0092	0.0092
Echinococcus multilocularis	abhydrolase domain containing 3	0.0026	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0023	0.0048	0.0106
Loa Loa (eye worm)	neuropeptide F receptor	0.0027	0.0092	0.0092
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0027	0.0092	0.0092
Leishmania major	hypothetical protein, conserved	0.0026	0.0081	0.0178
Plasmodium vivax	hypothetical protein, conserved	0.0026	0.0081	0.0178
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0046	0.0294	0.0294
Echinococcus granulosus	allatostatin A receptor	0.0027	0.0092	0.0092
Echinococcus granulosus	myotubularin protein 13	0.0032	0.015	0.015
Echinococcus granulosus	neuropeptides capa receptor	0.0027	0.0092	0.0092
Schistosoma mansoni	rac gtpase activating protein	0.0032	0.015	0.015
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0046	0.0294	0.0294
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0082	0.0681	0.0681
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0027	0.0092	0.0092
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	0.0442	0.456	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0476	0.1045
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.004	0.023	0.023
Plasmodium falciparum	lysophospholipase, putative	0.0026	0.0081	0.0178
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0027	0.0092	0.0092
Brugia malayi	Serotonin receptor	0.0027	0.0092	0.0092
Schistosoma mansoni	neuropeptide receptor	0.0027	0.0092	0.0092
Schistosoma mansoni	biogenic amine receptor	0.0027	0.0092	0.0092
Onchocerca volvulus		0.0032	0.015	0.0224
Echinococcus multilocularis	g protein coupled receptor	0.0027	0.0092	0.0092
Entamoeba histolytica	protein kinase, putative	0.0046	0.0294	0.0646
Brugia malayi	sulfakinin receptor protein	0.0027	0.0092	0.0092
Echinococcus multilocularis	expressed protein	0.0756	0.7951	0.7951
Echinococcus granulosus	g protein coupled receptor	0.0027	0.0092	0.0092
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0036	0.0189	0.0189
Toxoplasma gondii	hypothetical protein	0.0026	0.0081	0.2764
Trichomonas vaginalis	AGC family protein kinase	0.0046	0.0294	0.0646
Schistosoma mansoni	regulator of G protein signaling	0.0039	0.0219	0.0219
Echinococcus multilocularis	axis inhibition protein axin	0.0039	0.0219	0.0219
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0027	0.0092	0.0092
Echinococcus granulosus	RNA directed DNA polymerase	0.0077	0.0629	0.0629
Schistosoma mansoni	axis inhibition protein axin	0.0039	0.0219	0.0219
Brugia malayi	protein kinase C3,putative	0.0033	0.016	0.016
Echinococcus granulosus	regulator of G protein signaling 3	0.0039	0.0219	0.0219
Plasmodium vivax	PST-A protein	0.0026	0.0081	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Schistosoma mansoni	amidase	0.0946	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0081	0.0178
Trypanosoma cruzi	serine peptidase, putative	0.0026	0.0081	0.0178
Brugia malayi	G protein-coupled receptor	0.0027	0.0092	0.0092
Brugia malayi	GnHR receptor homolog	0.0027	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0978	0.0978
Echinococcus granulosus	dro:myosuppressin receptor	0.0027	0.0092	0.0092
Entamoeba histolytica	hypothetical protein	0.0039	0.0219	0.0481
Brugia malayi	protein kinase C II.	0.0149	0.1407	0.1407
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0026	0.0081	0.0178
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0442	0.456	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0027	0.0092	0.0092
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0081	0.0178
Echinococcus granulosus	somatostatin receptor	0.0027	0.0092	0.0092
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0027	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Entamoeba histolytica	;Alias	0.0026	0.0081	0.0178
Brugia malayi	putative neuropeptide receptor NPR1	0.0027	0.0092	0.0092
Echinococcus multilocularis	g-protein coupled receptor	0.0027	0.0092	0.0092
Mycobacterium ulcerans	amidase	0.0114	0.1031	0.2261
Loa Loa (eye worm)	amidase	0.0114	0.1031	0.1031
Echinococcus granulosus	rhodopsin orphan GPCR	0.0027	0.0092	0.0092
Plasmodium vivax	PST-A protein	0.0442	0.456	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0027	0.0092	0.0092
Brugia malayi	diacylglycerol kinase	0.0032	0.015	0.015
Trichomonas vaginalis	AGC family protein kinase	0.0046	0.0294	0.0646
Mycobacterium tuberculosis	Probable amidase AmiC (aminohydrolase)	0.0114	0.1031	0.2261
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0026	0.0081	0.0178
Echinococcus granulosus	rhodopsin orphan GPCR	0.0027	0.0092	0.0092
Toxoplasma gondii	hypothetical protein	0.0026	0.0081	0.2764
Schistosoma mansoni	amine GPCR	0.0027	0.0092	0.0092
Echinococcus granulosus	expressed protein	0.0756	0.7951	0.7951
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0681	0.0681
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.0092	0.0092
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0046	0.0294	0.0294
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0023	0.0048	0.0106
Trypanosoma brucei	Serine peptidase, Clan SC, Family S09X	0.0026	0.0081	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0092	0.0092
Leishmania major	monoglyceride lipase, putative	0.0442	0.456	1
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0026	0.0081	0.0178

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= -8.77	Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex	ChEMBL.	18194865
Ki (binding)	= 1.7 nM	Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex	ChEMBL.	18194865
Ki (binding)	= 1.7 nM	Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex	ChEMBL.	18194865
Log Ki (binding)	= 8.77	Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex	ChEMBL.	18194865

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 519676