Detailed information for compound 519778

Basic information

Technical information
  • TDR Targets ID: 519778
  • Name: 3-[[(3S)-3-[4-[6-(4-bromophenyl)-5-ethoxycarb onyl-4-methyl-2-oxo-1,6-dihydropyrimidin-3-yl ]butanoylamino]-5-phenylpentanoyl]amino]propa noic acid
  • MW: 671.579 | Formula: C32H39BrN4O7
  • H donors: 4 H acceptors: 6 LogP: 2.98 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOC(=O)C1=C(C)N(CCCC(=O)N[C@H](CC(=O)NCCC(=O)O)CCc2ccccc2)C(=O)NC1c1ccc(cc1)Br
  • InChi: 1S/C32H39BrN4O7/c1-3-44-31(42)29-21(2)37(32(43)36-30(29)23-12-14-24(33)15-13-23)19-7-10-26(38)35-25(16-11-22-8-5-4-6-9-22)20-27(39)34-18-17-28(40)41/h4-6,8-9,12-15,25,30H,3,7,10-11,16-20H2,1-2H3,(H,34,39)(H,35,38)(H,36,43)(H,40,41)/t25-,30?/m0/s1
  • InChiKey: HJADQLXITVFXIY-SUHMBNCMSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[[(3S)-3-[4-[6-(4-bromophenyl)-5-ethoxycarbonyl-4-methyl-2-oxo-1,6-dihydropyrimidin-3-yl]butanoylamino]-5-phenyl-pentanoyl]amino]propanoic acid
  • 3-[[(3S)-3-[[4-[6-(4-bromophenyl)-5-ethoxycarbonyl-4-methyl-2-oxo-1,6-dihydropyrimidin-3-yl]-1-oxobutyl]amino]-1-oxo-5-phenylpentyl]amino]propanoic acid
  • 3-[[(3S)-3-[4-[6-(4-bromophenyl)-5-carbethoxy-2-keto-4-methyl-1,6-dihydropyrimidin-3-yl]butanoylamino]-5-phenyl-pentanoyl]amino]propionic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi beta-lactamase family protein 0.0027 0.0031 0.0055
Toxoplasma gondii aminopeptidase N protein 0.0082 0.0395 0.4895
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0024 0.0011 0.0006
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0082 0.0395 0.4895
Schistosoma mansoni hypothetical protein 0.0051 0.0192 0.0186
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0042 0.013 0.2145
Brugia malayi Latrophilin receptor protein 2 0.0024 0.0011 0.0013
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0028 0.0041 0.5
Echinococcus granulosus GPCR family 2 0.0024 0.0011 0.0011
Schistosoma mansoni sodium/solute symporter 0.012 0.0641 0.0636
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0082 0.0395 0.0466
Loa Loa (eye worm) hypothetical protein 0.0027 0.0031 0.0025
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0144 0.0802 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0392 0.0386
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0082 0.0395 0.0395
Trypanosoma cruzi Aminopeptidase M1, putative 0.0082 0.0395 0.0466
Schistosoma mansoni sodium-bile acid cotransporter 0.0063 0.0271 0.0266
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0082 0.0395 0.0466
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0024 0.0011 0.0011
Loa Loa (eye worm) aminopeptidase N 0.0082 0.0395 0.039
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0082 0.0395 0.0473
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0082 0.0395 0.039
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0144 0.0802 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0027 0.0031 0.0055
Loa Loa (eye worm) leukotriene A4 hydrolase 0.1544 1 1
Echinococcus granulosus sodium:glucose cotransporter 2 0.0469 0.2933 0.2933
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.023 0.1369 0.1364
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0082 0.0395 0.0395
Schistosoma mansoni hypothetical protein 0.0024 0.0011 0.0006
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0028 0.0041 0.0013
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0027 0.0031 0.0018
Loa Loa (eye worm) hypothetical protein 0.0027 0.0031 0.0025
Leishmania major lanosterol synthase, putative 0.12 0.7738 1
Entamoeba histolytica aminopeptidase, putative 0.0082 0.0395 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.023 0.1369 0.1369
Schistosoma mansoni inositol monophosphatase 0.0028 0.0041 0.0035
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0082 0.0395 0.039
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0082 0.0395 0.0473
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0079 0.0372 0.0372
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0169 0.0969 0.1875
Onchocerca volvulus 0.0082 0.0395 0.3767
Schistosoma mansoni biogenic amine (5HT) receptor 0.0081 0.0392 0.0386
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0082 0.0395 0.0466
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0075 0.0347 0.0756
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0028 0.0041 0.0209
Loa Loa (eye worm) hypothetical protein 0.0027 0.0031 0.0025
Brugia malayi Matrixin family protein 0.0036 0.009 0.0186
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0024 0.0011 0.0006
Mycobacterium tuberculosis Probable lipase LipD 0.0027 0.0031 0.0018
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0028 0.0041 0.0103
Echinococcus granulosus inositol monophosphatase 1 0.0028 0.0041 0.0041
Echinococcus multilocularis sodium bile acid cotransporter 0.0106 0.0554 0.0549
Brugia malayi hypothetical protein 0.0082 0.0395 0.0863
Mycobacterium leprae Probable lipase LipE 0.0027 0.0031 0.0177
Loa Loa (eye worm) TATA binding protein associated factor 0.0082 0.0395 0.039
Brugia malayi beta-lactamase 0.0027 0.0031 0.0055
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0082 0.0395 0.0395
Brugia malayi Sodium:solute symporter family protein 0.012 0.0641 0.1409
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0079 0.0372 0.4609
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0082 0.0395 0.0395
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0158 0.0896 0.0891
Schistosoma mansoni hypothetical protein 0.0254 0.1523 0.1518
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0082 0.0395 0.039
Echinococcus granulosus biogenic amine 5HT receptor 0.0081 0.0392 0.0392
Brugia malayi Dihydrofolate reductase 0.0042 0.013 0.0276
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0027 0.0031 0.0025
Schistosoma mansoni sodium-bile acid cotransporter related 0.0106 0.0554 0.0549
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0079 0.0372 0.0436
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0028 0.0041 0.0013
Brugia malayi TATA binding protein associated factor 0.0082 0.0395 0.0863
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0079 0.0372 0.0444
Trichomonas vaginalis inositol monophosphatase, putative 0.0028 0.0041 0.0103
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0075 0.0347 0.0341
Brugia malayi MH2 domain containing protein 0.0088 0.0434 0.0949
Loa Loa (eye worm) hypothetical protein 0.012 0.0641 0.0636
Loa Loa (eye worm) latrophilin receptor protein 2 0.0024 0.0011 0.0006
Brugia malayi hypothetical protein 0.071 0.452 1
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0053 0.0207 0.0202
Loa Loa (eye worm) beta-lactamase 0.0027 0.0031 0.0025
Toxoplasma gondii aminopeptidase N, putative 0.0082 0.0395 0.4895
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0144 0.0802 1
Mycobacterium tuberculosis Probable hydrolase 0.0027 0.0031 0.0018
Trypanosoma brucei aminopeptidase, putative 0.0082 0.0395 0.0466
Loa Loa (eye worm) hypothetical protein 0.0075 0.0347 0.0341
Echinococcus multilocularis GPCR, family 2 0.0024 0.0011 0.0006
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0082 0.0395 0.0473
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.012 0.0641 0.7987
Toxoplasma gondii ABC1 family protein 0.0027 0.0031 0.0314
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0042 0.013 0.2003
Loa Loa (eye worm) MH2 domain-containing protein 0.0088 0.0434 0.0429
Schistosoma mansoni dihydrofolate reductase 0.0042 0.013 0.0125
Trichomonas vaginalis set domain proteins, putative 0.018 0.104 1
Mycobacterium ulcerans aminopeptidase N PepN 0.0082 0.0395 0.7333
Trypanosoma cruzi aminopeptidase, putative 0.0082 0.0395 0.0466
Echinococcus multilocularis sodium bile acid cotransporter 0.0106 0.0554 0.0549
Schistosoma mansoni hypothetical protein 0.0024 0.0011 0.0006
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0082 0.0395 0.3612
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0469 0.2933 0.2929
Loa Loa (eye worm) thymidylate synthase 0.0102 0.0528 0.0523
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0027 0.0031 0.0025
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0027 0.0031 0.0018
Schistosoma mansoni aminopeptidase A (M01 family) 0.0082 0.0395 0.039
Brugia malayi beta-lactamase family protein 0.0027 0.0031 0.0055
Echinococcus multilocularis aminopeptidase N 0.0082 0.0395 0.039
Loa Loa (eye worm) peptidase family M1 containing protein 0.0082 0.0395 0.039
Onchocerca volvulus 0.0082 0.0395 0.3767
Onchocerca volvulus 0.0106 0.0554 0.5304
Trypanosoma brucei Aminopeptidase M1, putative 0.0082 0.0395 0.0466
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0082 0.0395 0.0466
Echinococcus granulosus thymidylate synthase 0.0102 0.0528 0.0528
Trypanosoma cruzi lanosterol synthase, putative 0.1219 0.7864 1
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0144 0.0802 0.0984
Onchocerca volvulus Matrilysin homolog 0.0033 0.007 0.0626
Mycobacterium leprae conserved hypothetical protein 0.0027 0.0031 0.0177
Loa Loa (eye worm) PDE1B protein 0.023 0.1369 0.1364
Onchocerca volvulus 0.0102 0.0528 0.5049
Brugia malayi dihydrofolate reductase family protein 0.0042 0.013 0.0276
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0082 0.0395 0.0395
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0028 0.0041 0.0445
Echinococcus granulosus sodium bile acid cotransporter 0.0106 0.0554 0.0554
Schistosoma mansoni high-affinity choline transporter 0.012 0.0641 0.0636
Schistosoma mansoni inositol transporter 0.0469 0.2933 0.2929
Echinococcus multilocularis beta LACTamase domain containing family member 0.0027 0.0031 0.0025
Brugia malayi GH02984p 0.012 0.0641 0.1409
Trypanosoma brucei Aminopeptidase M1, putative 0.0082 0.0395 0.0466
Mycobacterium tuberculosis Hypothetical protein 0.0049 0.0176 0.0305
Trypanosoma cruzi aminopeptidase, putative 0.0082 0.0395 0.0466
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0082 0.0395 0.0395
Echinococcus granulosus beta LACTamase domain containing family member 0.0027 0.0031 0.0031
Brugia malayi Pre-SET motif family protein 0.0158 0.0896 0.1974
Echinococcus multilocularis sodium bile acid cotransporter 0.0106 0.0554 0.0549
Trypanosoma cruzi lanosterol synthase, putative 0.1219 0.7864 1
Mycobacterium tuberculosis Conserved protein 0.0027 0.0031 0.0018
Brugia malayi Calcitonin receptor-like protein seb-1 0.0075 0.0347 0.0756
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0079 0.0372 0.0436
Loa Loa (eye worm) hypothetical protein 0.0027 0.0031 0.0025
Onchocerca volvulus 0.0027 0.0031 0.0242
Echinococcus multilocularis thymidylate synthase 0.0102 0.0528 0.0523
Mycobacterium tuberculosis Probable esterase LipL 0.0027 0.0031 0.0018
Loa Loa (eye worm) hypothetical protein 0.0082 0.0395 0.039
Mycobacterium ulcerans thymidylate synthase 0.0102 0.0528 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0027 0.0031 0.0018
Onchocerca volvulus 0.0027 0.0031 0.0242
Echinococcus multilocularis serotonin receptor 0.0081 0.0392 0.0386
Brugia malayi hypothetical protein 0.0049 0.0176 0.0377
Echinococcus multilocularis inositol monophosphatase 1 0.0028 0.0041 0.0035
Brugia malayi Sodium Bile acid symporter family protein 0.0106 0.0554 0.1216
Echinococcus multilocularis high affinity choline transporter 1 0.012 0.0641 0.0636
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0597 0.378 0.3777
Echinococcus multilocularis dihydrofolate reductase 0.0042 0.013 0.0125
Echinococcus granulosus sodium bile acid cotransporter 0.0106 0.0554 0.0554
Brugia malayi hypothetical protein 0.0082 0.0395 0.0863
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0469 0.2933 0.2929
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0028 0.0041 0.0013
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0028 0.0041 0.0103
Echinococcus granulosus dihydrofolate reductase 0.0042 0.013 0.013
Loa Loa (eye worm) matrixin family protein 0.0036 0.009 0.0084
Brugia malayi Peptidase family M1 containing protein 0.0082 0.0395 0.0863
Loa Loa (eye worm) hypothetical protein 0.0051 0.0192 0.0186
Onchocerca volvulus 0.018 0.104 1
Schistosoma mansoni hypothetical protein 0.0024 0.0011 0.0006
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0031 0.0314
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0082 0.0395 0.3612
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0082 0.0395 0.039
Echinococcus granulosus sodium:myo inositol cotransporter 0.0469 0.2933 0.2933
Mycobacterium tuberculosis Conserved protein 0.0027 0.0031 0.0018
Schistosoma mansoni hypothetical protein 0.0024 0.0011 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0176 0.1439
Loa Loa (eye worm) hypothetical protein 0.0027 0.0031 0.0025
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0049 0.0176 0.0185
Mycobacterium tuberculosis Conserved protein 0.0027 0.0031 0.0018
Brugia malayi thymidylate synthase 0.0102 0.0528 0.1157
Loa Loa (eye worm) transcription factor SMAD2 0.0088 0.0434 0.0429
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0053 0.0207 0.0207
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0795 0.5078 1
Onchocerca volvulus 0.0082 0.0395 0.3767
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0082 0.0395 0.039
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0082 0.0395 0.4895
Brugia malayi Inositol-1 0.0028 0.0041 0.0078
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0082 0.0395 0.039
Schistosoma mansoni hypothetical protein 0.0254 0.1523 0.1518
Echinococcus multilocularis serotonin receptor 0.0081 0.0392 0.0386
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0079 0.0372 0.4609
Echinococcus granulosus aminopeptidase N 0.0082 0.0395 0.0395
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.023 0.1369 0.1364
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0082 0.0395 0.0466
Loa Loa (eye worm) dihydrofolate reductase 0.0042 0.013 0.0125
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0082 0.0395 0.0466
Mycobacterium ulcerans aminopeptidase N PepN 0.0082 0.0395 0.7333
Onchocerca volvulus 0.012 0.0641 0.6147
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0082 0.0395 0.3612
Loa Loa (eye worm) hypothetical protein 0.012 0.0641 0.0636
Echinococcus granulosus solute carrier family 5 0.0469 0.2933 0.2933
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.012 0.0641 0.0641
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0082 0.0395 0.0473
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0006
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0102 0.0528 0.0523
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0082 0.0395 0.039
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.012 0.0641 0.0636
Brugia malayi Peptidase family M1 containing protein 0.0082 0.0395 0.0863
Echinococcus multilocularis solute carrier family 5 0.0469 0.2933 0.2929
Echinococcus granulosus sodium:glucose cotransporter 0.0469 0.2933 0.2933
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.023 0.1369 0.302
Schistosoma mansoni sodium-bile acid cotransporter related 0.0043 0.0139 0.0134
Echinococcus multilocularis leukotriene A 4 hydrolase 0.1544 1 1
Onchocerca volvulus 0.0027 0.0031 0.0242
Echinococcus multilocularis geminin 0.0254 0.1523 0.1518
Chlamydia trachomatis dihydrofolate reductase 0.0042 0.013 0.5
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0027 0.0031 0.0025
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0144 0.0802 0.1001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0024 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0106 0.0554 0.0549
Echinococcus granulosus histone lysine methyltransferase setb 0.0023 0.0005 0.0005
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0102 0.0528 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0395 0.039
Loa Loa (eye worm) hypothetical protein 0.0081 0.0392 0.0386
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0024 0.0011 0.0013
Mycobacterium tuberculosis Probable lipase LipE 0.0027 0.0031 0.0018
Toxoplasma gondii aminopeptidase n, putative 0.0082 0.0395 0.4895
Schistosoma mansoni inositol transporter 0.0469 0.2933 0.2929
Onchocerca volvulus Matrix metalloproteinase homolog 0.0033 0.007 0.0626
Loa Loa (eye worm) inositol-1 0.0028 0.0041 0.0035
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0042 0.013 0.0215
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0082 0.0395 0.039
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0102 0.0528 0.1001
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0079 0.0372 0.0436
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0028 0.0041 0.0013
Echinococcus granulosus high affinity choline transporter 1 0.012 0.0641 0.0641
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0082 0.0395 0.039
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0079 0.0372 0.4609
Echinococcus granulosus geminin 0.0254 0.1523 0.1523
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0144 0.0802 0.0984
Brugia malayi latrophilin 2 splice variant baaae 0.0051 0.0192 0.0412
Trypanosoma brucei lanosterol synthase 0.1219 0.7864 1
Echinococcus granulosus sodium bile acid cotransporter 0.0106 0.0554 0.0554
Loa Loa (eye worm) hypothetical protein 0.0082 0.0395 0.039
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.1544 1 1
Loa Loa (eye worm) matrixin family protein 0.0033 0.007 0.0065
Loa Loa (eye worm) hypothetical protein 0.0027 0.0031 0.0025
Brugia malayi Peptidase family M1 containing protein 0.0082 0.0395 0.0863
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0079 0.0372 0.0367
Schistosoma mansoni inositol monophosphatase 0.0028 0.0041 0.0035

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) 0 Activation of Escherichia coli DnaK ATPase activity ChEMBL. 18060774
EC50 (binding) = 190 uM Activation of bovine Hsp70 ATPase activity ChEMBL. 18060774

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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