Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0122 | 0.0099 | 0.0093 |
Plasmodium falciparum | amino acid transporter, putative | 0.0122 | 0.0099 | 0.0129 |
Trypanosoma cruzi | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.1352 | 0.1334 | 0.2158 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.0039 | 0.0035 |
Trypanosoma brucei | unspecified product | 0.0075 | 0.0051 | 0.0045 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0161 | 0.0137 | 0.0132 |
Brugia malayi | RNA, U transporter 1 | 0.0086 | 0.0061 | 0.0058 |
Brugia malayi | dihydrolipoamide S-acetyltransferase precursor, putative | 0.0349 | 0.0327 | 0.0333 |
Trypanosoma brucei | RNA helicase, putative | 0.0258 | 0.0235 | 0.0229 |
Toxoplasma gondii | dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase | 0.0349 | 0.0327 | 0.0321 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 | 0.3799 | 0.3794 | 1 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0075 | 0.0051 | 0.0045 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0161 | 0.0137 | 0.0222 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0122 | 0.0099 | 0.0093 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0722 | 0.0701 | 0.0695 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.0099 | 0.0096 |
Loa Loa (eye worm) | serotonin transporter b | 0.0722 | 0.0701 | 0.0721 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 4 AccD4_2 | 0.1352 | 0.1334 | 0.3477 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.3799 | 0.3794 | 0.379 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.0099 | 0.0096 |
Trypanosoma brucei | unspecified product | 0.2498 | 0.2486 | 0.2481 |
Schistosoma mansoni | carbamoyl-phosphate synthetase | 0.0859 | 0.0839 | 0.0833 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0188 | 0.0165 | 0.2285 |
Plasmodium falciparum | dihydrolipoamide acyltransferase component E2 | 0.0349 | 0.0327 | 0.0444 |
Trypanosoma cruzi | dihydrolipoamide acetyltransferase, putative | 0.0349 | 0.0327 | 0.0528 |
Mycobacterium ulcerans | putative regulatory protein | 0.0087 | 0.0063 | 0.0107 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0321 | 0.0298 | 0.0303 |
Echinococcus granulosus | ribonuclease H1 | 0.0069 | 0.0045 | 0.0039 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 5 AccD5 | 0.1352 | 0.1334 | 0.3477 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0122 | 0.0099 | 0.0093 |
Brugia malayi | hypothetical protein | 0.0054 | 0.003 | 0.0025 |
Brugia malayi | Dihydrofolate reductase | 0.0047 | 0.0022 | 0.0017 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase beta chain | 0.1352 | 0.1334 | 0.1329 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.0039 | 0.0033 |
Trypanosoma cruzi | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.1352 | 0.1334 | 0.2158 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0062 | 0.0038 | 0.0032 |
Toxoplasma gondii | hypothetical protein | 0.0122 | 0.0099 | 0.0093 |
Plasmodium vivax | hypothetical protein, conserved | 0.0122 | 0.0099 | 0.0129 |
Mycobacterium ulcerans | thymidylate synthase | 0.0114 | 0.0091 | 0.0181 |
Trichomonas vaginalis | soluble guanylate cyclase gcy, putative | 0.0031 | 0.0006 | 0.138 |
Toxoplasma gondii | hypothetical protein | 0.0122 | 0.0099 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.0099 | 0.0096 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0122 | 0.0099 | 0.0096 |
Leishmania major | dihydrolipoamide acetyltransferase precursor, putative | 0.0349 | 0.0327 | 0.0327 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0054 | 0.003 | 0.0049 |
Leishmania major | 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative | 0.0349 | 0.0327 | 0.0327 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0122 | 0.0099 | 0.0093 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.0039 | 0.0035 |
Brugia malayi | Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor | 0.0349 | 0.0327 | 0.0333 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0038 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.0165 | 0.0165 |
Wolbachia endosymbiont of Brugia malayi | carbamoyl phosphate synthase large subunit | 0.0859 | 0.0839 | 0.2117 |
Chlamydia trachomatis | acetyl-CoA carboxylase biotin carboxyl carrier protein | 0.0349 | 0.0327 | 0.0932 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.3799 | 0.3794 | 0.379 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0038 | 0.0041 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0117 | 0.0094 | 0.0088 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0039 | 0.0033 |
Trypanosoma cruzi | glutamine dependent carbamoyl-phosphate synthase, putative | 0.0859 | 0.0839 | 0.1356 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.0038 | 0.0032 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0031 | 0.0006 | 0.138 |
Schistosoma mansoni | phosphoglucomutase | 0.0069 | 0.0045 | 0.0039 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0722 | 0.0701 | 0.0695 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0122 | 0.0099 | 0.0269 |
Plasmodium falciparum | transporter, putative | 0.0122 | 0.0099 | 0.0129 |
Onchocerca volvulus | 0.0087 | 0.0063 | 0.0817 | |
Leishmania major | acetyl-CoA carboxylase, putative | 0.9975 | 1 | 1 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.9975 | 1 | 1 |
Trypanosoma cruzi | 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative | 0.0349 | 0.0327 | 0.0528 |
Schistosoma mansoni | dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase | 0.0349 | 0.0327 | 0.0321 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0122 | 0.0099 | 0.0093 |
Mycobacterium ulcerans | branched-chain alpha-keto acid dehydrogenase subunit E2 | 0.0349 | 0.0327 | 0.0807 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.0038 | 0.0032 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0062 | 0.0038 | 0.0032 |
Echinococcus granulosus | snurportin 1 | 0.0321 | 0.0298 | 0.0293 |
Trichomonas vaginalis | adenylate cyclase, putative | 0.0031 | 0.0006 | 0.138 |
Schistosoma mansoni | pyruvate carboxylase | 0.3799 | 0.3794 | 0.379 |
Onchocerca volvulus | 0.0114 | 0.0091 | 0.1215 | |
Brugia malayi | bHLH-PAS transcription factor | 0.0087 | 0.0063 | 0.0059 |
Giardia lamblia | Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative | 0.1701 | 0.1685 | 1 |
Echinococcus multilocularis | snurportin 1 | 0.0321 | 0.0298 | 0.0293 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0075 | 0.0051 | 0.0045 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0122 | 0.0099 | 0.0093 |
Leishmania major | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.1352 | 0.1334 | 0.1334 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.0039 | 0.0035 |
Trypanosoma brucei | pyruvate dehydrogenase complex E3 binding protein, putative | 0.0349 | 0.0327 | 0.0321 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E2 | 0.0349 | 0.0327 | 0.0321 |
Mycobacterium tuberculosis | DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase | 0.0349 | 0.0327 | 0.0807 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0122 | 0.0099 | 0.0093 |
Trypanosoma cruzi | dihydrolipoamide acetyltransferase precursor, putative | 0.0349 | 0.0327 | 0.0528 |
Leishmania major | carbamoyl-phosphate synthase, putative | 0.0859 | 0.0839 | 0.0839 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0122 | 0.0099 | 0.0096 |
Mycobacterium ulcerans | pyruvate carboxylase | 0.3799 | 0.3794 | 1 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0122 | 0.0099 | 0.0093 |
Leishmania major | protein kinase, putative | 0.0035 | 0.001 | 0.001 |
Brugia malayi | RNase H family protein | 0.0069 | 0.0045 | 0.004 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0075 | 0.0051 | 0.0045 |
Toxoplasma gondii | 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein | 0.0349 | 0.0327 | 0.0321 |
Leishmania major | carboxylase, putative | 0.3799 | 0.3794 | 0.3794 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0122 | 0.0099 | 0.0093 |
Trypanosoma brucei | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.1352 | 0.1334 | 0.1329 |
Mycobacterium ulcerans | acetyl/propionyl CoA carboxylase subunit beta | 0.1352 | 0.1334 | 0.3477 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0031 | 0.0006 | 0.001 |
Echinococcus multilocularis | dihydrolipoyllysine residue acetyltransferase | 0.0349 | 0.0327 | 0.0321 |
Mycobacterium leprae | Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) | 0.1352 | 0.1334 | 0.3505 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0031 | 0.0006 | 0.138 |
Brugia malayi | RNA binding protein | 0.0063 | 0.0039 | 0.0035 |
Mycobacterium ulcerans | bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 | 0.3799 | 0.3794 | 1 |
Mycobacterium tuberculosis | Biotinylated protein TB7.3 | 0.0349 | 0.0327 | 0.0807 |
Echinococcus granulosus | thymidylate synthase | 0.0114 | 0.0091 | 0.0085 |
Treponema pallidum | pyruvate carboxylase subunit B | 0.0349 | 0.0327 | 0.4298 |
Schistosoma mansoni | aspartate carbamoyltransferase | 0.0859 | 0.0839 | 0.0833 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.0327 | 0.0333 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.0099 | 0.0096 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0075 | 0.0051 | 0.0045 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0054 | 0.003 | 0.0021 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0122 | 0.0099 | 0.0093 |
Onchocerca volvulus | 0.0122 | 0.0099 | 0.1331 | |
Plasmodium vivax | lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative | 0.0349 | 0.0327 | 0.0444 |
Schistosoma mansoni | phosphoglucomutase | 0.0069 | 0.0045 | 0.0039 |
Toxoplasma gondii | biotin-requiring enzyme domain-containing protein | 0.0349 | 0.0327 | 0.0321 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0114 | 0.0091 | 0.0181 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.0098 | 0.0096 |
Echinococcus multilocularis | dihydrolipoyllysine residue succinyltransferase | 0.0349 | 0.0327 | 0.0321 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0114 | 0.0091 | 0.0223 |
Mycobacterium tuberculosis | Probable branched-chain keto acid dehydrogenase E2 component BkdC | 0.0349 | 0.0327 | 0.0807 |
Trypanosoma brucei | dihydrolipoamide branched chain transacylase, putative | 0.0349 | 0.0327 | 0.0321 |
Schistosoma mansoni | propionyl-CoA carboxylase beta chain mitochondrial precursor | 0.1352 | 0.1334 | 0.1329 |
Echinococcus multilocularis | ribonuclease H1 | 0.0069 | 0.0045 | 0.0039 |
Mycobacterium ulcerans | acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 | 0.1352 | 0.1334 | 0.3477 |
Schistosoma mansoni | hypothetical protein | 0.0321 | 0.0298 | 0.0293 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0722 | 0.0701 | 1 |
Trypanosoma cruzi | dihydrolipoamide acetyltransferase precursor, putative | 0.0349 | 0.0327 | 0.0528 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0122 | 0.0099 | 0.0093 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.9975 | 1 | 1 |
Plasmodium falciparum | carbamoyl phosphate synthetase | 0.0859 | 0.0839 | 0.1153 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.0098 | 0.0096 |
Mycobacterium ulcerans | carbamoyl phosphate synthase large subunit | 0.0859 | 0.0839 | 0.2164 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0031 | 0.0006 | 0.138 |
Mycobacterium ulcerans | acetyl-/propionyl-CoA carboxylase subunit beta | 0.1352 | 0.1334 | 0.3477 |
Brugia malayi | RNase H family protein | 0.0069 | 0.0045 | 0.004 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0122 | 0.0099 | 0.0093 |
Mycobacterium ulcerans | hypothetical protein | 0.0349 | 0.0327 | 0.0807 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0031 | 0.0006 | 0.138 |
Brugia malayi | thymidylate synthase | 0.0114 | 0.0091 | 0.0088 |
Chlamydia trachomatis | biotin carboxylase | 0.345 | 0.3443 | 1 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0031 | 0.0006 | 0.138 |
Schistosoma mansoni | dihydrolipoamide S-acetyltransferase | 0.0349 | 0.0327 | 0.0321 |
Echinococcus multilocularis | Biotin lipoyl attachment | 0.0349 | 0.0327 | 0.0321 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0114 | 0.0091 | 0.0085 |
Trypanosoma brucei | dihydrolipoamide acetyltransferase E2 subunit, putative | 0.0349 | 0.0327 | 0.0321 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0122 | 0.0099 | 0.0096 |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.0098 | 0.0096 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0122 | 0.0099 | 0.0093 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0122 | 0.0099 | 0.0096 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0031 | 0.0006 | 0.138 |
Plasmodium vivax | amine transporter, putative | 0.0122 | 0.0099 | 0.0129 |
Brugia malayi | PAS domain containing protein | 0.0117 | 0.0094 | 0.0091 |
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.0031 | 0.0006 | 0.001 |
Brugia malayi | RNase H family protein | 0.0069 | 0.0045 | 0.004 |
Loa Loa (eye worm) | thymidylate synthase | 0.0114 | 0.0091 | 0.0088 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0122 | 0.0099 | 0.0093 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 | 0.3799 | 0.3794 | 1 |
Echinococcus granulosus | serotonin transporter | 0.0722 | 0.0701 | 0.0695 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0161 | 0.0137 | 0.0182 |
Chlamydia trachomatis | acetyl-coenzyme A carboxylase carboxyl transferase subunit beta | 0.1352 | 0.1334 | 0.3864 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0122 | 0.0099 | 0.0093 |
Toxoplasma gondii | ribonuclease HI protein | 0.0069 | 0.0045 | 0.0039 |
Echinococcus granulosus | propionyl coenzyme A carboxylase beta chain | 0.1352 | 0.1334 | 0.1329 |
Schistosoma mansoni | carbamoyl-phosphate synthetase | 0.0859 | 0.0839 | 0.0833 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0031 | 0.0006 | 0.001 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0122 | 0.0099 | 0.0093 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0031 | 0.0006 | 0.138 |
Toxoplasma gondii | acyl-CoA carboxyltransferase beta chain, putative | 0.1352 | 0.1334 | 0.1329 |
Schistosoma mansoni | phosphoglucomutase | 0.0069 | 0.0045 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.0394 | 0.0372 | 0.0379 |
Trypanosoma cruzi | glutamine-dependent carbamoyl-phosphate synthetase, putative | 0.0859 | 0.0839 | 0.1356 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.3799 | 0.3794 | 1 |
Trypanosoma cruzi | dihydrolipoamide branched chain transacylase, putative | 0.0349 | 0.0327 | 0.0528 |
Brugia malayi | hypothetical protein | 0.0394 | 0.0372 | 0.0379 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0069 | 0.0045 | 0.0555 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.7218 | 0.723 | 1 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.9975 | 1 | 1 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.3799 | 0.3794 | 0.379 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0364 | 0.0341 | 0.0348 |
Leishmania major | PAS-domain containing phosphoglycerate kinase, putative | 0.0031 | 0.0006 | 0.0006 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.3799 | 0.3794 | 0.379 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0047 | 0.0022 | 0.0047 |
Leishmania major | methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein | 0.3799 | 0.3794 | 0.3794 |
Plasmodium vivax | carbamoyl phosphate synthetase, putative | 0.0859 | 0.0839 | 0.1153 |
Wolbachia endosymbiont of Brugia malayi | branched-chain alpha-keto acid dehydrogenase subunit E2 | 0.0349 | 0.0327 | 0.0752 |
Toxoplasma gondii | pyruvate carboxylase | 0.3799 | 0.3794 | 0.379 |
Echinococcus granulosus | single minded 2 | 0.0087 | 0.0063 | 0.0057 |
Leishmania major | dihydrolipoamide branched chain transacylase, putative | 0.0349 | 0.0327 | 0.0327 |
Leishmania major | propionyl-coa carboxylase beta chain, putative | 0.1352 | 0.1334 | 0.1334 |
Mycobacterium leprae | ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 | 0.1352 | 0.1334 | 0.3505 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.9975 | 1 | 1 |
Schistosoma mansoni | dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase | 0.0349 | 0.0327 | 0.0321 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0039 | 0.0033 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0161 | 0.0137 | 0.0182 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0122 | 0.0099 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0722 | 0.0701 | 0.0721 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase alpha chain | 0.3799 | 0.3794 | 0.379 |
Toxoplasma gondii | dihydrolipoamide acyltransferase, putative | 0.0349 | 0.0327 | 0.0321 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.0099 | 0.0096 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.3799 | 0.3794 | 1 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0087 | 0.0063 | 0.0057 |
Trypanosoma brucei | glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative | 0.0859 | 0.0839 | 0.0833 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0062 | 0.0038 | 0.0038 |
Wolbachia endosymbiont of Brugia malayi | Acetyl-CoA carboxylase, carboxyltransferase component | 0.1352 | 0.1334 | 0.3439 |
Echinococcus granulosus | propionyl coenzyme A carboxylase alpha chain | 0.3799 | 0.3794 | 0.379 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0069 | 0.0045 | 0.0072 |
Leishmania major | ribonuclease H1, putative | 0.0069 | 0.0045 | 0.0045 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.6175 | 0.6182 | 1 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0122 | 0.0099 | 0.0096 |
Schistosoma mansoni | hypothetical protein | 0.0258 | 0.0235 | 0.0229 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0031 | 0.0006 | 0.001 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.0039 | 0.0035 |
Echinococcus granulosus | dihydrolipoyllysine residue acetyltransferase | 0.0349 | 0.0327 | 0.0321 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0039 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.0722 | 0.0701 | 0.0721 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0722 | 0.0701 | 0.0721 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0039 | 0.0033 |
Plasmodium vivax | dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative | 0.0349 | 0.0327 | 0.0444 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0122 | 0.0099 | 0.0093 |
Brugia malayi | hypothetical protein | 0.0122 | 0.0099 | 0.0096 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.0039 | 0.0035 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.9625 | 0.9649 | 1 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.7218 | 0.723 | 1 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0122 | 0.0099 | 0.0096 |
Trypanosoma brucei | 2-oxoglutarate dehydrogenase E2 component, putative | 0.0349 | 0.0327 | 0.0321 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.3799 | 0.3794 | 1 |
Chlamydia trachomatis | dihydrolipoamide succinyltransferase | 0.0349 | 0.0327 | 0.0932 |
Trypanosoma brucei | ribonuclease H1 | 0.0069 | 0.0045 | 0.0039 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0722 | 0.0701 | 0.0721 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0122 | 0.0099 | 0.0093 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide acyltransferase E2 component | 0.0349 | 0.0327 | 0.0752 |
Plasmodium falciparum | lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex | 0.0349 | 0.0327 | 0.0444 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.3799 | 0.3794 | 1 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0122 | 0.0099 | 0.0093 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0031 | 0.0006 | 0.001 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0161 | 0.0137 | 0.0132 |
Brugia malayi | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta | 0.0349 | 0.0327 | 0.0333 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0039 | 0.0033 |
Leishmania major | dihydrolipoamide acetyltransferase precursorlike protein | 0.0349 | 0.0327 | 0.0327 |
Entamoeba histolytica | acetyl-coA carboxylase, putative | 0.1701 | 0.1685 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0062 | 0.0038 | 0.0032 |
Mycobacterium leprae | Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) | 0.1352 | 0.1334 | 0.3505 |
Echinococcus granulosus | Biotin lipoyl attachment | 0.0349 | 0.0327 | 0.0321 |
Trichomonas vaginalis | adenylate cyclase, type VII, putative | 0.0031 | 0.0006 | 0.138 |
Onchocerca volvulus | 0.0722 | 0.0701 | 1 | |
Echinococcus multilocularis | serotonin transporter | 0.0722 | 0.0701 | 0.0695 |
Onchocerca volvulus | 0.0122 | 0.0099 | 0.1331 | |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.9975 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0122 | 0.0099 | 0.0093 |
Schistosoma mansoni | single-minded | 0.0117 | 0.0094 | 0.0088 |
Mycobacterium tuberculosis | Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) | 0.1352 | 0.1334 | 0.3477 |
Trypanosoma cruzi | 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative | 0.0349 | 0.0327 | 0.0528 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.0099 | 0.0096 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.0099 | 0.0096 |
Schistosoma mansoni | dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase | 0.0349 | 0.0327 | 0.0321 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0722 | 0.0701 | 0.0721 |
Toxoplasma gondii | carbamoylphosphate synthetase | 0.0859 | 0.0839 | 0.0833 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0047 | 0.0022 | 0.0017 |
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.0031 | 0.0006 | 0.001 |
Echinococcus granulosus | dihydrofolate reductase | 0.0047 | 0.0022 | 0.0017 |
Mycobacterium ulcerans | dihydrolipoamide acetyltransferase | 0.0349 | 0.0327 | 0.0807 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.0327 | 0.0333 |
Chlamydia trachomatis | dihydrolipoamide succinyltransferase | 0.0349 | 0.0327 | 0.0932 |
Chlamydia trachomatis | dihydrolipoamide acetyltransferase | 0.0349 | 0.0327 | 0.0932 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0031 | 0.0006 | 0.138 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.0327 | 0.0333 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0161 | 0.0137 | 0.0137 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0038 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0722 | 0.0701 | 0.0721 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0122 | 0.0099 | 0.0093 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0062 | 0.0038 | 0.0041 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.3799 | 0.3794 | 0.6137 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.0039 | 0.0033 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.3799 | 0.3794 | 0.6137 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0054 | 0.003 | 0.6763 |
Mycobacterium tuberculosis | Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 | 0.1352 | 0.1334 | 0.3477 |
Brugia malayi | dihydrofolate reductase family protein | 0.0047 | 0.0022 | 0.0017 |
Echinococcus multilocularis | thymidylate synthase | 0.0114 | 0.0091 | 0.0085 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0069 | 0.0045 | 1 |
Mycobacterium leprae | Probable biotinylated protein homolog TB7.3 | 0.0349 | 0.0327 | 0.0846 |
Brugia malayi | hypoxia-induced factor 1 | 0.0364 | 0.0341 | 0.0348 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0069 | 0.0045 | 0.0072 |
Mycobacterium leprae | Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB | 0.0349 | 0.0327 | 0.0846 |
Schistosoma mansoni | dihydrofolate reductase | 0.0047 | 0.0022 | 0.0017 |
Echinococcus granulosus | dihydrolipoyllysine residue succinyltransferase | 0.0349 | 0.0327 | 0.0321 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0122 | 0.0099 | 0.0093 |
Plasmodium falciparum | dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex | 0.0349 | 0.0327 | 0.0444 |
Onchocerca volvulus | 0.0122 | 0.0099 | 0.1331 | |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 4 AccD4 | 0.1352 | 0.1334 | 0.3477 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0047 | 0.0022 | 0.0043 |
Trypanosoma cruzi | dihydrolipoamide branched chain transacylase, putative | 0.0349 | 0.0327 | 0.0528 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.9625 | 0.9649 | 1 |
Trypanosoma cruzi | acetyl-CoA carboxylase, putative | 0.1352 | 0.1334 | 0.2158 |
Brugia malayi | N-terminal motif family protein | 0.0188 | 0.0165 | 0.0165 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0122 | 0.0099 | 0.0093 |
Leishmania major | protein kinase, putative | 0.0031 | 0.0006 | 0.0006 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0122 | 0.0099 | 0.0093 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0047 | 0.0022 | 0.0017 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 0.5 nM | Growth inhibition of human PANC1 cells | ChEMBL. | 18077159 |
GI50 (functional) | = 0.5 nM | Growth inhibition of human PANC1 cells | ChEMBL. | 18077159 |
GI50 (functional) | = 1.5 nM | Growth inhibition of human HepG cells | ChEMBL. | 18077159 |
GI50 (functional) | = 2 nM | Growth inhibition of human CEM cells | ChEMBL. | 18077159 |
GI50 (functional) | = 2 nM | Growth inhibition of human CEM cells | ChEMBL. | 18077159 |
IC50 (binding) | = 1.4 nM | Inhibition of NFkappaB-mediated transcription in human HepG cells | ChEMBL. | 18077159 |
IC50 (binding) | = 10 nM | Inhibition of GRE-mediated transcription in human HepG cells | ChEMBL. | 18077159 |
IC50 (binding) | = 18.6 nM | Inhibition of AP1-mediated transcription in human HepG cells | ChEMBL. | 18077159 |
IC50 (binding) | = 25 nM | Inhibition of CRE-mediated transcription in human HepG cells | ChEMBL. | 18077159 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.