Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0327 | 0.3677 | 0.106 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0327 | 0.3677 | 0.106 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0327 | 0.3677 | 0.106 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0273 | 0.2802 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0714 | 1 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0714 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0714 | 1 | 1 |
Plasmodium vivax | hexose transporter | 0.0327 | 0.3677 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0327 | 0.3677 | 0.106 |
Echinococcus granulosus | dihydrofolate reductase | 0.0714 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0273 | 0.2802 | 1 |
Toxoplasma gondii | facilitative glucose transporter GT1 | 0.0327 | 0.3677 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0327 | 0.3677 | 0.106 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0327 | 0.3677 | 0.106 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0714 | 1 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0327 | 0.3677 | 0.106 |
Brugia malayi | Dihydrofolate reductase | 0.0714 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0273 | 0.2802 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0327 | 0.3677 | 0.106 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0327 | 0.3677 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0714 | 1 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0714 | 1 | 0.5 |
Plasmodium falciparum | hexose transporter | 0.0327 | 0.3677 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0714 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.