Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0035 | 0.0351 | 0.5702 |
Toxoplasma gondii | thioredoxin reductase | 0.0048 | 0.0584 | 0.0963 |
Leishmania major | trypanothione reductase | 0.0048 | 0.0584 | 0.0963 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.034 | 0.6068 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0235 | 0.0145 |
Schistosoma mansoni | transcription factor btf3 | 0.0035 | 0.0351 | 0.0351 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0024 | 0.0132 | 0.0218 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0091 | 1 |
Schistosoma mansoni | ran | 0.0021 | 0.0091 | 0.0091 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0029 | 0.0235 | 0.0235 |
Trichomonas vaginalis | importin beta-1, putative | 0.0024 | 0.0132 | 0.2147 |
Entamoeba histolytica | hypothetical protein | 0.0024 | 0.0132 | 0.1572 |
Echinococcus multilocularis | thymidylate synthase | 0.0104 | 0.1636 | 0.1636 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0048 | 0.0584 | 0.0584 |
Echinococcus multilocularis | dihydrofolate reductase | 0.055 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.055 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.055 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.055 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.055 | 1 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0121 | 0.1957 | 0.1957 |
Loa Loa (eye worm) | thymidylate synthase | 0.0104 | 0.1636 | 0.1559 |
Toxoplasma gondii | NAC domain-containing protein | 0.0035 | 0.0351 | 0.0579 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0091 | 0.0091 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0091 | 0.0151 |
Leishmania major | importin beta-1 subunit, putative | 0.0024 | 0.0132 | 0.0218 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0091 | 0.0151 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0 | 0.5 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0029 | 0.0235 | 0.0388 |
Trichomonas vaginalis | ran, putative | 0.0021 | 0.0091 | 0.1484 |
Leishmania major | GTP-binding protein, putative | 0.0021 | 0.0091 | 0.0151 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0109 | 0.1729 | 0.1729 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0109 | 0.1729 | 0.1729 |
Leishmania major | basic transcription factor 3a, putative | 0.0035 | 0.0351 | 0.0579 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0021 | 0.0091 | 0.0151 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0104 | 0.1636 | 0.1636 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0121 | 0.1957 | 0.0384 |
Brugia malayi | RNA, U transporter 1 | 0.0083 | 0.124 | 0.124 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0048 | 0.0584 | 0.0963 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.055 | 1 | 1 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0035 | 0.0351 | 0.0579 |
Brugia malayi | Importin beta-1 subunit | 0.0029 | 0.0235 | 0.0235 |
Echinococcus granulosus | snurportin 1 | 0.031 | 0.5509 | 0.5509 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0035 | 0.0351 | 0.5702 |
Echinococcus granulosus | transcription factor btf3 | 0.0035 | 0.0351 | 0.0351 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0121 | 0.1957 | 0.1957 |
Echinococcus multilocularis | snurportin 1 | 0.031 | 0.5509 | 0.5509 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0035 | 0.0351 | 0.0579 |
Plasmodium vivax | glutathione reductase, putative | 0.0048 | 0.0584 | 0.0963 |
Entamoeba histolytica | transcription factor BTF3, putative | 0.0035 | 0.0351 | 1 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0021 | 0.0091 | 0.0151 |
Mycobacterium ulcerans | thymidylate synthase | 0.0104 | 0.1636 | 0.1636 |
Plasmodium vivax | importin-beta 2, putative | 0.0029 | 0.0235 | 0.0388 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0049 | 0.0616 | 0.1015 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0109 | 0.1729 | 0.1729 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.0132 | 0.2147 |
Chlamydia trachomatis | dihydrofolate reductase | 0.055 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.034 | 0.6068 | 1 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0091 | 0.0151 |
Schistosoma mansoni | importin beta-1 | 0.0029 | 0.0235 | 0.0235 |
Mycobacterium tuberculosis | Probable reductase | 0.0109 | 0.1729 | 0.1729 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.034 | 0.6068 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.034 | 0.6068 | 1 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.031 | 0.5509 | 0.5468 |
Echinococcus multilocularis | transcription factor btf3 | 0.0035 | 0.0351 | 0.0351 |
Plasmodium falciparum | importin beta, putative | 0.0029 | 0.0235 | 0.0388 |
Brugia malayi | Thioredoxin reductase | 0.0048 | 0.0584 | 0.0584 |
Schistosoma mansoni | ran | 0.0021 | 0.0091 | 0.0091 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0035 | 0.0351 | 0.5702 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0048 | 0.0584 | 0.0497 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.055 | 1 | 1 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0091 | 0.0151 |
Plasmodium falciparum | thioredoxin reductase | 0.0048 | 0.0584 | 0.0963 |
Brugia malayi | thymidylate synthase | 0.0104 | 0.1636 | 0.1636 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0049 | 0.0616 | 1 |
Treponema pallidum | NADH oxidase | 0.0017 | 0 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0048 | 0.0584 | 0.0584 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0235 | 0.0388 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0035 | 0.0351 | 0.0579 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.055 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0048 | 0.0584 | 0.0497 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0121 | 0.1957 | 0.1957 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.034 | 0.6068 | 1 |
Onchocerca volvulus | 0.0104 | 0.1636 | 0.5 | |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0104 | 0.1636 | 0.1636 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0021 | 0.0091 | 0.0091 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0048 | 0.0584 | 0.0963 |
Brugia malayi | hypothetical protein | 0.0049 | 0.0616 | 0.0616 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0035 | 0.0351 | 0.0579 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0351 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0049 | 0.0616 | 0.0616 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0109 | 0.1729 | 0.1729 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.0132 | 0.2147 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.034 | 0.6068 | 1 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0035 | 0.0351 | 0.0579 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0109 | 0.1729 | 0.0112 |
Brugia malayi | beta-NAC-like protein | 0.0035 | 0.0351 | 0.0351 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0021 | 0.0091 | 0.0091 |
Echinococcus granulosus | importin subunit beta 1 | 0.0029 | 0.0235 | 0.0235 |
Plasmodium falciparum | glutathione reductase | 0.0048 | 0.0584 | 0.0963 |
Loa Loa (eye worm) | ICD-1 protein | 0.0035 | 0.0351 | 0.0262 |
Echinococcus granulosus | thymidylate synthase | 0.0104 | 0.1636 | 0.1636 |
Brugia malayi | glutathione reductase | 0.0048 | 0.0584 | 0.0584 |
Trypanosoma brucei | trypanothione reductase | 0.0048 | 0.0584 | 0.0963 |
Schistosoma mansoni | hypothetical protein | 0.031 | 0.5509 | 0.5509 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0235 | 0.0388 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0109 | 0.1729 | 0.1729 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0048 | 0.0584 | 0.0584 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.46 nM | Displacement of [125I]TZDM from beta amyloid protein 42 (unknown origin) | ChEMBL. | 18226893 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.