Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transketolase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Probable 1-deoxy-D-xylulose 5-phosphate synthase Dxs1 (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS) | transketolase | 623 aa | 589 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | transketolase | 0.0032 | 0.0515 | 0.0515 |
Loa Loa (eye worm) | thymidylate synthase | 0.0211 | 0.6916 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0101 | 0.2951 | 0.2951 |
Echinococcus multilocularis | transketolase | 0.0032 | 0.0515 | 0.0745 |
Trypanosoma brucei | transketolase, putative | 0.0032 | 0.0515 | 0.0515 |
Brugia malayi | transketolase | 0.0032 | 0.0515 | 0.0745 |
Mycobacterium ulcerans | thymidylate synthase | 0.0211 | 0.6916 | 1 |
Echinococcus granulosus | transketolase | 0.0032 | 0.0515 | 0.0745 |
Onchocerca volvulus | 0.0211 | 0.6916 | 0.5 | |
Mycobacterium leprae | Probable transketolase Tkt (TK) | 0.0032 | 0.0515 | 0.0745 |
Schistosoma mansoni | transketolase | 0.0032 | 0.0515 | 0.0745 |
Entamoeba histolytica | transketolase, putative | 0.0032 | 0.0515 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0086 | 0.2437 | 1 |
Trypanosoma cruzi | transketolase, putative | 0.0032 | 0.0515 | 0.0515 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0101 | 0.2951 | 0.4267 |
Brugia malayi | hypothetical protein | 0.0101 | 0.2951 | 0.4267 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0298 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0211 | 0.6916 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0211 | 0.6916 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0298 | 1 | 1 |
Mycobacterium ulcerans | transketolase | 0.0032 | 0.0515 | 0.0745 |
Trypanosoma cruzi | transketolase, putative | 0.0032 | 0.0515 | 0.0515 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0298 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0086 | 0.2437 | 0.3524 |
Giardia lamblia | Transketolase | 0.0021 | 0.0091 | 0.5 |
Trichomonas vaginalis | transketolase, putative | 0.0032 | 0.0515 | 0.1483 |
Entamoeba histolytica | transketolase, putative | 0.0032 | 0.0515 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0298 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0086 | 0.2437 | 0.3524 |
Echinococcus granulosus | dihydrofolate reductase | 0.0086 | 0.2437 | 0.3524 |
Mycobacterium tuberculosis | Transketolase Tkt (TK) | 0.0032 | 0.0515 | 0.0745 |
Treponema pallidum | transketolase | 0.0021 | 0.0091 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0211 | 0.6916 | 1 |
Toxoplasma gondii | transketolase | 0.0032 | 0.0515 | 0.0515 |
Chlamydia trachomatis | transketolase | 0.0032 | 0.0515 | 0.2114 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0086 | 0.2437 | 0.3524 |
Brugia malayi | thymidylate synthase | 0.0211 | 0.6916 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0086 | 0.2437 | 0.3524 |
Wolbachia endosymbiont of Brugia malayi | transketolase | 0.0032 | 0.0515 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0086 | 0.2437 | 0.3524 |
Entamoeba histolytica | transketolase, putative | 0.0032 | 0.0515 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0298 | 1 | 1 |
Plasmodium falciparum | transketolase | 0.0021 | 0.0091 | 0.0091 |
Brugia malayi | dihydrofolate reductase family protein | 0.0086 | 0.2437 | 0.3524 |
Echinococcus multilocularis | thymidylate synthase | 0.0211 | 0.6916 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0086 | 0.2437 | 0.3524 |
Schistosoma mansoni | transketolase | 0.0032 | 0.0515 | 0.0745 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0211 | 0.6916 | 1 |
Entamoeba histolytica | transketolase, putative | 0.0021 | 0.0091 | 0.1768 |
Echinococcus granulosus | transketolase | 0.0032 | 0.0515 | 0.0745 |
Plasmodium vivax | transketolase, putative | 0.0021 | 0.0091 | 0.0091 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0101 | 0.2951 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0515 | 0.0745 |
Echinococcus multilocularis | transketolase | 0.0032 | 0.0515 | 0.0745 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0086 | 0.2437 | 0.3524 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 2.6 uM | Inhibition of transketolase in human HCT116 cells | ChEMBL. | 18182286 |
EC50 (binding) | = 2.6 uM | Inhibition of transketolase in human HCT116 cells | ChEMBL. | 18182286 |
Kcat/Km (binding) | = 2.4 10^-5/nM/s | Ratio of kcat to Km for thiamine pyrophosphokinase (unknown origin) | ChEMBL. | 18182286 |
Kcat/Km (binding) | = 2.4 10^-5/nM/s | Ratio of kcat to Km for thiamine pyrophosphokinase (unknown origin) | ChEMBL. | 18182286 |
Kd (binding) | = 64 nM | Inhibition of apo-transketolase (unknown origin) by coupled TPPK/Apo-TK enzymatic assay | ChEMBL. | 18182286 |
Kd (binding) | = 64 nM | Inhibition of apo-transketolase (unknown origin) by coupled TPPK/Apo-TK enzymatic assay | ChEMBL. | 18182286 |
Kd (binding) | > 500 uM | Inhibition of apo-transketolase (unknown origin) | ChEMBL. | 18182286 |
Kd (binding) | > 500 uM | Inhibition of apo-transketolase (unknown origin) | ChEMBL. | 18182286 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.