Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histamine receptor H3 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 4 | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0213 | 0.5625 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0213 | 0.5625 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0299 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0213 | 0.5625 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0213 | 0.5625 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0213 | 0.5625 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0299 | 1 | 0.5 |
Onchocerca volvulus | 0.0213 | 0.5625 | 1 | |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0299 | 1 | 0.5 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0146 | 0.2259 | 0.4016 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0146 | 0.2259 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0213 | 0.5625 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0213 | 0.5625 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0213 | 0.5625 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0299 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0101 | 0 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0299 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (functional) | = 9.6 | Antagonist activity at human histamine H3 receptor | ChEMBL. | 18060777 |
Ki (binding) | = 2.1 nM | Inhibition of human histamine H3 receptor | ChEMBL. | 18060777 |
Ki (binding) | = 2.1 nM | Inhibition of human histamine H3 receptor | ChEMBL. | 18060777 |
Ki (binding) | = 299 nM | Inhibition of rat SERT | ChEMBL. | 18060777 |
Ki (binding) | = 299 nM | Inhibition of rat SERT | ChEMBL. | 18060777 |
Ki (binding) | = 702 nM | Inhibition of human SERT | ChEMBL. | 18060777 |
Ki (binding) | = 702 nM | Inhibition of human SERT | ChEMBL. | 18060777 |
pA2 (functional) | = 9.6 | Antagonist activity at human histamine H3 receptor | ChEMBL. | 18060777 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.