Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nitric oxide synthase 1 (neuronal) | Starlite/ChEMBL | References |
Homo sapiens | nitric oxide synthase 3 (endothelial cell) | Starlite/ChEMBL | References |
Homo sapiens | nitric oxide synthase 2, inducible | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | dihydrofolate reductase | 0.0341 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0081 | 0.1186 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0341 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.013 | 0.2859 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0341 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.2859 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0091 | 0.1538 | 0.1229 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.013 | 0.2859 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0091 | 0.1538 | 0.1538 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0091 | 0.1538 | 0.1229 |
Brugia malayi | flavodoxin family protein | 0.0091 | 0.1538 | 0.1229 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0341 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0091 | 0.1538 | 0.1229 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0091 | 0.1538 | 0.2107 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0056 | 0.0352 | 0.0352 |
Brugia malayi | FAD binding domain containing protein | 0.0091 | 0.1538 | 0.1229 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.2859 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0091 | 0.1538 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0341 | 1 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0091 | 0.1538 | 0.2107 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0341 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0341 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0091 | 0.1538 | 0.1229 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.1538 | 0.1229 |
Echinococcus granulosus | dihydrofolate reductase | 0.0341 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0091 | 0.1538 | 0.1229 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.013 | 0.2859 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.013 | 0.2859 | 1 |
Giardia lamblia | Hypothetical protein | 0.0081 | 0.1186 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0341 | 1 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0091 | 0.1538 | 0.2107 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 330 nM | Inhibition of human iNOS expressed in human DLD1 cells after 1 hr | ChEMBL. | 18024030 |
IC50 (binding) | = 330 nM | Inhibition of human iNOS expressed in human DLD1 cells after 1 hr | ChEMBL. | 18024030 |
IC50 (binding) | = 350 nM | Inhibition of human nNOS expressed in insect SF9 cells after 1 hr | ChEMBL. | 18024030 |
IC50 (binding) | = 350 nM | Inhibition of human nNOS expressed in insect SF9 cells after 1 hr | ChEMBL. | 18024030 |
IC50 (binding) | = 1100 nM | Inhibition of human eNOS expressed in insect SF9 cells after 1 hr | ChEMBL. | 18024030 |
IC50 (binding) | = 1100 nM | Inhibition of human eNOS expressed in insect SF9 cells after 1 hr | ChEMBL. | 18024030 |
IC50 (binding) | = 5900 nM | Inhibition of cytokine-induced iNOS activity in human DLD1 cells after 24 hrs | ChEMBL. | 18024030 |
IC50 (binding) | = 5900 nM | Inhibition of cytokine-induced iNOS activity in human DLD1 cells after 24 hrs | ChEMBL. | 18024030 |
Ratio IC50 (binding) | = 1 | Selectivity for human nNOS to human iNOS | ChEMBL. | 18024030 |
Ratio IC50 (binding) | = 3 | Selectivity for human eNOS to human iNOS | ChEMBL. | 18024030 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.