Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1224 | 0.4893 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.2395 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.2395 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1224 | 0.4893 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.2395 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1224 | 0.4893 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0213 | 0.0488 | 0.0488 |
Onchocerca volvulus | 0.0213 | 0.0488 | 0.5 | |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.2395 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0213 | 0.0488 | 0.0269 |
Chlamydia trachomatis | dihydrofolate reductase | 0.2395 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0102 | 0 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1224 | 0.4893 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.2395 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.2395 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0213 | 0.0488 | 0.0269 |
Brugia malayi | thymidylate synthase | 0.0213 | 0.0488 | 0.0488 |
Schistosoma mansoni | dihydrofolate reductase | 0.2395 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0213 | 0.0488 | 0.0487 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1224 | 0.4893 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1224 | 0.4893 | 1 |
Brugia malayi | Matrixin family protein | 0.0102 | 0.0001 | 0.0001 |
Echinococcus multilocularis | dihydrofolate reductase | 0.2395 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 1000 nM | Inhibition of MMP2 (unknown origin) | ChEMBL. | 17980583 |
IC50 (binding) | > 1000 nM | Inhibition of MMP9 (unknown origin) | ChEMBL. | 17980583 |
IC50 (binding) | > 1000 nM | Inhibition of MMP2 (unknown origin) | ChEMBL. | 17980583 |
IC50 (binding) | > 1000 nM | Inhibition of MMP9 (unknown origin) | ChEMBL. | 17980583 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.