TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 459.558 | Formula: C23H29N3O5S
H donors: 2 H acceptors: 4 LogP: 2.1 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(CCNCC(CN(S(=O)(=O)c2cccc3c2ccnc3)C)O)ccc1OC
InChi: 1S/C23H29N3O5S/c1-26(32(28,29)23-6-4-5-18-14-24-12-10-20(18)23)16-19(27)15-25-11-9-17-7-8-21(30-2)22(13-17)31-3/h4-8,10,12-14,19,25,27H,9,11,15-16H2,1-3H3
InChiKey: LTHVOMFWHBXLDM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	ap endonuclease	0.0043	0.0231	0.0231
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0043	0.0231	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0065	0.0387	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0122	0.4944
Echinococcus granulosus	Nuclear hormone receptor HR96	0.003	0.0147	0.0147
Trichomonas vaginalis	hypothetical protein	0.0011	0.0017	0.047
Toxoplasma gondii	isocitrate dehydrogenase	0.0017	0.0054	0.0311
Schistosoma mansoni	nuclear hormone receptor	0.003	0.0147	0.0147
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0173	0.0173
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0108	0.0677	0.7002
Brugia malayi	hypothetical protein	0.003	0.0147	0.1516
Echinococcus granulosus	neuropeptide s receptor	0.0538	0.3621	0.3621
Echinococcus granulosus	dnaJ subfamily B	0.1325	0.8999	0.8999
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.015	0.0967	0.0967
Brugia malayi	ecdysteroid receptor	0.0064	0.0378	0.3908
Echinococcus multilocularis	lamin	0.0029	0.0139	0.0139
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0054	0.0054
Echinococcus granulosus	GPCR family 2	0.0034	0.0173	0.0173
Toxoplasma gondii	aldehyde dehydrogenase	0.0065	0.0387	0.3271
Brugia malayi	photoreceptor-specific nuclear receptor	0.0064	0.0378	0.3908
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0171	0.1772
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0084	0.3449
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0176	0.1145	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0021	0.0084	0.3449
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0108	0.0677	0.7002
Schistosoma mansoni	hypothetical protein	0.0074	0.0444	0.0444
Onchocerca volvulus		0.003	0.0147	0.0109
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0139	0.0139
Schistosoma mansoni	coup transcription factor	0.0064	0.0378	0.0378
Brugia malayi	hypothetical protein	0.0017	0.0058	0.0595
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.001	0.0007	0.0000000014506
Brugia malayi	Nuclear hormone receptor-like 1	0.0034	0.0171	0.1772
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0013	0.0031	0.0031
Brugia malayi	nuclear hormone receptor	0.0064	0.0378	0.3908
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0139	0.1435
Loa Loa (eye worm)	hypothetical protein	0.003	0.0147	0.1516
Brugia malayi	Muscleblind-like protein	0.0145	0.0933	0.9654
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0861	0.89
Loa Loa (eye worm)	DR-78	0.003	0.0147	0.1516
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.003	0.0147	0.1516
Toxoplasma gondii	LsmAD domain-containing protein	0.0027	0.0122	0.0914
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0122	0.513
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0173	0.1792
Trichomonas vaginalis	DNA helicase recq, putative	0.0028	0.0131	0.5543
Schistosoma mansoni	DNA helicase recq5	0.0012	0.0019	0.0019
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0016	0.0047	0.0481
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0122	0.513
Loa Loa (eye worm)	hypothetical protein	0.003	0.0147	0.1516
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0677	0.7002
Schistosoma mansoni	hypothetical protein	0.0034	0.0173	0.0173
Trichomonas vaginalis	DNA helicase recq, putative	0.0015	0.0042	0.1574
Brugia malayi	conserved hypotetical protein	0.003	0.0147	0.1516
Brugia malayi	MH2 domain containing protein	0.0128	0.0819	0.8468
Schistosoma mansoni	myst-related protein	0.0011	0.0015	0.0015
Brugia malayi	nuclear hormone receptor family member nhr-6	0.003	0.0147	0.1516
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0017	0.0054	0.0054
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0064	0.0378	0.0378
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0064	0.0378	0.3908
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0019	0.0197
Loa Loa (eye worm)	steroid hormone receptor	0.0064	0.0378	0.3908
Brugia malayi	nuclear receptor RXR	0.003	0.0147	0.1516
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0093	0.0576	0.5959
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0012	0.0019	0.0019
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0054	0.0344
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0084	0.3449
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0139	0.1435
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0064	0.0378	0.3908
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0064	0.0378	0.3908
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0064	0.0378	0.0378
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0017	0.0054	0.2104
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0012	0.0019	0.0177
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0065	0.0387	0.0387
Schistosoma mansoni	nuclear receptor nhr-48	0.003	0.0147	0.0147
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0043	0.0231	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0029	0.0137	0.0137
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0043	0.0231	0.5312
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0043	0.0231	0.0231
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0064	0.0378	0.3313
Loa Loa (eye worm)	hypothetical protein	0.003	0.0147	0.1516
Brugia malayi	nuclear hormone receptor	0.003	0.0147	0.1516
Brugia malayi	cytoplasmic intermediate filament protein	0.0016	0.0047	0.0481
Toxoplasma gondii	isocitrate dehydrogenase	0.0017	0.0054	0.0311
Brugia malayi	orphan nuclear receptor NR2E1	0.003	0.0147	0.1516
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0012	0.0019	0.0019
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.003	0.0147	0.0147
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0023	0.0098	0.0098
Schistosoma mansoni	hypothetical protein	0.0034	0.0173	0.0173
Brugia malayi	Bloom's syndrome protein homolog	0.0028	0.0131	0.1357
Echinococcus multilocularis	muscleblind protein	0.0145	0.0933	0.0933
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.003	0.0147	0.0147
Schistosoma mansoni	DNA helicase recq1	0.0012	0.0019	0.0019
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0017	0.0054	0.2104
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0054	0.2104
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0036	0.0372
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0064	0.0378	0.0378
Loa Loa (eye worm)	transcription factor SMAD2	0.0128	0.0819	0.8468
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0043	0.0231	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.003	0.0147	0.0147
Echinococcus granulosus	neuropeptide receptor A26	0.0538	0.3621	0.3621
Brugia malayi	steroid hormone receptor	0.0064	0.0378	0.3908
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0064	0.0378	0.3908
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0084	0.3449
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.015	0.0967	0.0967
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.003	0.0147	0.0147
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0064	0.0378	0.0378
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.003	0.0147	0.0147
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0065	0.0387	1
Echinococcus multilocularis	microtubule associated protein 2	0.1471	1	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0064	0.0378	0.3908
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0017	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.015	0.0967	1
Brugia malayi	intermediate filament protein	0.0029	0.0139	0.1435
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.003	0.0147	0.0109
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0043	0.0231	0.239
Loa Loa (eye worm)	hypothetical protein	0.003	0.0147	0.1516
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0064	0.0378	0.3908
Onchocerca volvulus		0.0093	0.0576	0.6061
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0378	0.3908
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0084	0.3449
Echinococcus granulosus	intermediate filament protein	0.0029	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0378	0.3908
Brugia malayi	nuclear receptor NHR-67	0.003	0.0147	0.1516
Schistosoma mansoni	retinoic acid receptor RXR	0.0064	0.0378	0.0378
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0014	0.0036	0.0036
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0043	0.0231	0.5473
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0064	0.0378	0.3908
Brugia malayi	hypothetical protein	0.003	0.0147	0.1516
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0064	0.0378	0.3908
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0171	0.1772
Schistosoma mansoni	aldehyde dehydrogenase	0.0065	0.0387	0.0387
Brugia malayi	latrophilin 2 splice variant baaae	0.0074	0.0444	0.4591
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0084	0.3449
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0378	0.3908
Onchocerca volvulus	Protein ultraspiracle homolog	0.0064	0.0378	0.3313
Echinococcus multilocularis	cpg binding protein	0.0098	0.0612	0.0612
Echinococcus multilocularis	neuropeptide s receptor	0.0538	0.3621	0.3621
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0023	0.0098	0.0098
Leishmania major	hypothetical protein, conserved	0.0027	0.0122	0.231
Echinococcus granulosus	nuclear receptor nhr 48	0.003	0.0147	0.0147
Echinococcus multilocularis	musashi	0.0029	0.0139	0.0139
Echinococcus granulosus	cpg binding protein	0.0098	0.0612	0.0612
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.003	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0378	0.3908
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0064	0.0378	0.0378
Brugia malayi	Nuclear hormone receptor-like 1	0.0064	0.0378	0.3908
Loa Loa (eye worm)	hypothetical protein	0.003	0.0147	0.1516
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0084	0.3449
Schistosoma mansoni	ap endonuclease	0.0043	0.0231	0.0231
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0084	0.3449
Echinococcus multilocularis	isocitrate dehydrogenase	0.0017	0.0054	0.0054
Loa Loa (eye worm)	nuclear receptor NHR-67	0.003	0.0147	0.1516
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0017	0.0054	0.0559
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.003	0.0147	0.0147
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0012	0.0019	0.0197
Brugia malayi	Nuclear hormone receptor-like 1	0.0034	0.0171	0.1772
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0034	0.0171	0.0171
Echinococcus multilocularis	geminin	0.0881	0.5966	0.5966
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0017	0.047
Schistosoma mansoni	RAR-like nuclear receptor	0.0064	0.0378	0.0378
Onchocerca volvulus	Bile acid receptor homolog	0.0064	0.0378	0.3313
Trichomonas vaginalis	ap endonuclease, putative	0.0043	0.0231	1
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0933	0.9654
Brugia malayi	isocitrate dehydrogenase	0.0017	0.0054	0.0559
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0012	0.0019	0.00000000031895
Schistosoma mansoni	thyroid hormone receptor	0.0064	0.0378	0.0378
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0023	0.0098	0.0098
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0065	0.0387	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0064	0.0378	0.0378
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0021	0.0084	0.3449
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0064	0.0378	0.3908
Schistosoma mansoni	myst-related protein	0.0011	0.0015	0.0015
Schistosoma mansoni	blooms syndrome DNA helicase	0.0022	0.0091	0.0091
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0012	0.0022	0.0022
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0064	0.0378	0.0378
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0135	0.1398
Brugia malayi	nuclear receptor NHR-88	0.0064	0.0378	0.3908
Brugia malayi	nuclear receptor NHR-88	0.003	0.0147	0.1516
Brugia malayi	Steroid receptor seven-up type 2	0.0064	0.0378	0.3908
Brugia malayi	hypothetical protein	0.0135	0.0861	0.89
Loa Loa (eye worm)	MH2 domain-containing protein	0.0128	0.0819	0.8468
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0043	0.0231	1
Echinococcus multilocularis	dnaJ subfamily B	0.1325	0.8999	0.8999
Brugia malayi	hypothetical protein	0.0034	0.0171	0.1772
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0012	0.0022	0.0022
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0173	0.1792
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0034	0.0171	0.0171
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0064	0.0378	0.0378
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0064	0.0378	0.0378
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.003	0.0147	0.0147
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0084	0.3449
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0171	0.1772
Loa Loa (eye worm)	hypothetical protein	0.003	0.0147	0.1516
Loa Loa (eye worm)	nuclear hormone receptor	0.003	0.0147	0.1516
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.003	0.0147	0.0109
Schistosoma mansoni	hypothetical protein	0.0086	0.0529	0.0529
Loa Loa (eye worm)	hypothetical protein	0.003	0.0147	0.1516
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0043	0.0231	1
Onchocerca volvulus		0.003	0.0147	0.0109
Schistosoma mansoni	hypothetical protein	0.0881	0.5966	0.5966
Schistosoma mansoni	nuclear hormone receptor	0.0064	0.0378	0.0378
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0017	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.003	0.0147	0.1516
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0054	0.0054
Echinococcus granulosus	FTZ F1 alpha	0.047	0.3152	0.3152
Echinococcus multilocularis	neuropeptide receptor A26	0.0538	0.3621	0.3621
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0933	0.9654
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.003	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0378	0.3908
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0173	0.0173
Echinococcus multilocularis	FTZ F1 alpha	0.015	0.0967	0.0967
Echinococcus granulosus	thyroid hormone receptor alpha	0.003	0.0147	0.0147
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0173	0.0173
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0122	0.4944
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0034	0.0171	0.0171
Schistosoma mansoni	hypothetical protein	0.0034	0.0173	0.0173
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0084	0.3449
Entamoeba histolytica	recQ family helicase, putative	0.0015	0.0042	0.1252
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0064	0.0378	0.3908
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0064	0.0378	0.0378
Onchocerca volvulus		0.0064	0.0378	0.3313
Schistosoma mansoni	hypothetical protein	0.0012	0.0022	0.0022
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0084	0.3449
Brugia malayi	tailless protein	0.003	0.0147	0.1516
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0139	0.1435
Loa Loa (eye worm)	hypothetical protein	0.003	0.0147	0.1516
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.015	0.0967	1
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0068	0.0433
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0043	0.0231	0.5
Onchocerca volvulus	Huntingtin homolog	0.0135	0.0861	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0064	0.0378	0.3908
Echinococcus multilocularis	ecdysone induced protein 78C	0.0064	0.0378	0.0378
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0015	0.0042	0.1574
Echinococcus granulosus	lamin dm0	0.0029	0.0139	0.0139
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.015	0.0967	0.0967
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0064	0.0378	0.0378
Echinococcus granulosus	lamin	0.0029	0.0139	0.0139
Schistosoma mansoni	microtubule-associated protein tau	0.1471	1	1
Schistosoma mansoni	zinc finger protein	0.003	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0032	0.0335
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0029	0.0137	0.0137
Schistosoma mansoni	lamin	0.0029	0.0139	0.0139
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0084	0.3449
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0043	0.0231	0.5
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0043	0.0231	1
Trichomonas vaginalis	helicase, putative	0.0021	0.0084	0.3449
Loa Loa (eye worm)	hypothetical protein	0.003	0.0147	0.1516
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0064	0.0378	0.3908
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0054	0.0054
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0034	0.0171	0.1772
Onchocerca volvulus	Huntingtin homolog	0.0135	0.0861	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0064	0.0378	0.3908
Loa Loa (eye worm)	hypothetical protein	0.003	0.0147	0.1516
Echinococcus granulosus	muscleblind protein	0.0145	0.0933	0.0933
Echinococcus granulosus	bloom syndrome protein	0.0028	0.0131	0.0131
Loa Loa (eye worm)	hypothetical protein	0.003	0.0147	0.1516
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.0122	0.3833
Brugia malayi	Nuclear hormone receptor E75	0.003	0.0147	0.1516
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0017	0.0054	0.1802
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0064	0.0378	0.0378
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0065	0.0387	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0084	0.3449
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0043	0.0231	1
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0054	0.2104
Schistosoma mansoni	hypothetical protein	0.0034	0.0173	0.0173
Echinococcus multilocularis	bloom syndrome protein	0.0028	0.0131	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0378	0.3908
Schistosoma mansoni	nuclear receptor	0.003	0.0147	0.0147
Schistosoma mansoni	cpg binding protein	0.0098	0.0612	0.0612
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0064	0.0378	0.3908
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0017	0.047
Brugia malayi	hypothetical protein	0.0027	0.0122	0.1261
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0444	0.4591
Brugia malayi	ecdysone receptor	0.003	0.0147	0.1516
Echinococcus multilocularis	muscleblind protein 1	0.0145	0.0933	0.0933
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0023	0.0098	0.0098
Brugia malayi	nuclear receptor RXR	0.0034	0.0171	0.1772
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0012	0.0019	0.0019
Schistosoma mansoni	hypothetical protein	0.0881	0.5966	0.5966
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0064	0.0378	0.0378
Loa Loa (eye worm)	hypothetical protein	0.003	0.0147	0.1516
Schistosoma mansoni	nuclear hormone receptor	0.003	0.0147	0.0147
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0065	0.0387	0.0387
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0034	0.0171	0.0171
Schistosoma mansoni	lamin	0.0029	0.0139	0.0139
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0012	0.0019	0.0197
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0064	0.0378	0.0378
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0084	0.3449
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0173	0.1792
Brugia malayi	hypothetical protein	0.0034	0.0171	0.1772
Schistosoma mansoni	cpg binding protein	0.0093	0.0576	0.0576
Schistosoma mansoni	nuclear receptor	0.003	0.0147	0.0147
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0012	0.0019	0.0197
Echinococcus granulosus	geminin	0.0881	0.5966	0.5966
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.015	0.0967	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0065	0.0387	0.0387
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0025	0.0108	0.4298
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0023	0.0098	0.0098
Schistosoma mansoni	thyroid hormone receptor	0.0064	0.0378	0.0378
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0173	0.1792
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.003	0.0147	0.0147
Trichomonas vaginalis	ap endonuclease, putative	0.0043	0.0231	1
Echinococcus multilocularis	nuclear receptor nhr 48	0.003	0.0147	0.0147
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0197	0.1289	0.1289
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0064	0.0378	0.3908
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0139	0.1435
Brugia malayi	exodeoxyribonuclease III family protein	0.0043	0.0231	0.239
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0171	0.1772
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0065	0.0387	1
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.0036	0.0036
Brugia malayi	F/Y-rich N-terminus family protein	0.0028	0.0134	0.139
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0171	0.1772
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0084	0.3449
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0378	0.3908
Toxoplasma gondii	exonuclease III APE	0.0043	0.0231	0.1883
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0173	0.0173
Trichomonas vaginalis	DNA helicase recq1, putative	0.0028	0.0131	0.5543
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.003	0.0147	0.1516
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0064	0.0378	0.3908
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0064	0.0378	0.0378
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0012	0.0019	0.0019
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0173	0.0173
Brugia malayi	nuclear hormone receptor family member odr-7	0.003	0.0147	0.1516
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0861	0.89
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0019	0.0069	0.0861
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0064	0.0378	0.0378
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0043	0.0231	0.0231
Echinococcus multilocularis	lamin dm0	0.0029	0.0139	0.0139
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0108	0.0677	0.7002
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0064	0.0378	0.0378
Brugia malayi	Isocitrate dehydrogenase	0.0017	0.0054	0.0559
Loa Loa (eye worm)	histone methyltransferase	0.0029	0.0137	0.1416
Schistosoma mansoni	hypothetical protein	0.1325	0.8999	0.8999
Brugia malayi	Nuclear hormone receptor E75	0.003	0.0147	0.1516
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0064	0.0378	0.0378
Schistosoma mansoni	cpg binding protein	0.0098	0.0612	0.0612
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0122	0.513
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0064	0.0378	0.3908
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0064	0.0378	0.0378
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0122	0.1261
Loa Loa (eye worm)	RecQ helicase	0.0028	0.0131	0.1357
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0015	0.0042	0.1574
Brugia malayi	CXXC zinc finger family protein	0.0093	0.0576	0.5959
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0084	0.3449
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0902	0.9327
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0064	0.0378	0.3908
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0032	0.0335

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	= 10 ug ml-1	Antimalarial activity against Plasmodium falciparum NF54 after 36 to 40 hrs	ChEMBL.	18039570
MIC (functional)	= 10 ug ml-1	Antimalarial activity against Plasmodium falciparum NF54 after 36 to 40 hrs	ChEMBL.	18039570

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 521279