Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0146548 | 0 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0243694 | 0.341391 | 0.341391 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0243694 | 0.341391 | 0.341391 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0243694 | 0.341391 | 0.445724 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0243694 | 0.341391 | 1 |
Brugia malayi | flavodoxin family protein | 0.0243694 | 0.341391 | 0.445724 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0243694 | 0.341391 | 1 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0364498 | 0.765923 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0243694 | 0.341391 | 0.445724 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0364498 | 0.765923 | 1 |
Schistosoma mansoni | amine GPCR | 0.0358961 | 0.746462 | 1 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0431107 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0157424 | 0.0382213 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0364498 | 0.765923 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0243694 | 0.341391 | 0.341391 |
Echinococcus granulosus | methionine synthase reductase | 0.0157424 | 0.0382213 | 0.0382213 |
Brugia malayi | FAD binding domain containing protein | 0.0157424 | 0.0382213 | 0.0499023 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0431107 | 1 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0364498 | 0.765923 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0243694 | 0.341391 | 0.14277 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0243694 | 0.341391 | 0.341391 |
Loa Loa (eye worm) | hypothetical protein | 0.0187166 | 0.142739 | 0.186362 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0157424 | 0.0382213 | 0.0512033 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0243694 | 0.341391 | 0.457345 |
Leishmania major | p450 reductase, putative | 0.0243694 | 0.341391 | 0.14277 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0364498 | 0.765923 | 1 |
Echinococcus multilocularis | methionine synthase reductase | 0.0157424 | 0.0382213 | 0.0382213 |
Loa Loa (eye worm) | hypothetical protein | 0.0243694 | 0.341391 | 0.445724 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0223574 | 0.270686 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0243694 | 0.341391 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0243694 | 0.341391 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0157424 | 0.0382213 | 0.0499023 |
Giardia lamblia | Hypothetical protein | 0.0223574 | 0.270686 | 0.5 |
Onchocerca volvulus | 0.0146548 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.84 uM | Antimalarial activity against Plasmodium falciparum by lactate dehydrogenase enzyme assay | ChEMBL. | 18078758 |
IC50 (functional) | = 0.84 uM | Antimalarial activity against Plasmodium falciparum by lactate dehydrogenase enzyme assay | ChEMBL. | 18078758 |
IC50 (ADMET) | = 6.3 uM | Toxicity in CHO cells | ChEMBL. | 18078758 |
Ratio IC50 (functional) | = 7.5 | Ratio of IC50 for CHO cells to IC50 for Plasmodium falciparum | ChEMBL. | 18078758 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 18078758 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.