Detailed information for compound 52160

Basic information

Technical information
  • TDR Targets ID: 52160
  • Name: (1-methylpyridin-1-ium-3-yl) N,N-dimethylcarb amate bromide
  • MW: 261.116 | Formula: C9H13BrN2O2
  • H donors: 0 H acceptors: 1 LogP: 1.72 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[n+]1cccc(c1)OC(=O)N(C)C.[Br-]
  • InChi: 1S/C9H13N2O2.BrH/c1-10(2)9(12)13-8-5-4-6-11(3)7-8;/h4-7H,1-3H3;1H/q+1;/p-1
  • InChiKey: VNYBTNPBYXSMOO-UHFFFAOYSA-M  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N,N-dimethylcarbamic acid (1-methyl-3-pyridin-1-iumyl) ester bromide
  • N,N-dimethylcarbamic acid (1-methylpyridin-1-ium-3-yl) ester bromide
  • Pyridostigmine Bromide
  • 101-26-8
  • D00487
  • Mestinon (TN)
  • Pyridostigmine bromide (JP15/USP/INN)
  • SMR000058605
  • NSC679759
  • EU-0101035
  • MLS000028385
  • SPECTRUM1503240
  • 3-{[(dimethylamino)carbonyl]oxy}-1-methylpyridinium bromide
  • 1-Methyl-3-hydroxypyridinium bromide dimethylcarbamate
  • 3-(((Dimethylamino)carbonyl)oxy)-1-methylpyridinium bromide
  • 3-(Dimethylcarbamyloxy)-1-methylpyridinium bromide
  • 3-Hydroxy-1-methylpyridinium bromide dimethylcarbamate
  • 3-Hydroxy-1-methylpyridinium bromide dimethylcarbamate (ester)
  • Bromure de pyridostigmine [INN-French]
  • Bromuro de piridostigmina [INN-Spanish]
  • CCRIS 6798
  • Carbamic acid, dimethyl-, ester with 3-hydroxy-1-methylpyridinium bromide
  • Dimethylcarbamic acid ester of 3-hydroxy-1-methylpyridinium bromide
  • EINECS 202-929-9
  • HSDB 3924
  • Kalimin
  • Kalymin
  • Mestinon
  • Mestinon bromide
  • Piridostigmina bromuro [DCIT]
  • Pyridinium, 3-(((dimethylamino)carbonyl)oxy)-1-methyl-, bromide
  • Pyridinium, 3-hydroxy-1-methyl-, bromide, dimethylcarbamate (ester)
  • Pyridinium, 3-hydroxyl-1-methyl-, bromide, dimethylcarbamate
  • Pyridostigmine bromide [USAN:BAN:INN:JAN]
  • Pyridostigmini bromidum [INN-Latin]
  • Regonal
  • Regonol
  • Ro 1-5130
  • 3-(Dimethylaminocarbonyloxy)-1-methylpyridinium bromide
  • P9797_SIGMA
  • NCGC00094324-02
  • NCGC00094324-03

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli endonuclease IV with intrinsic 3'-5' exonuclease activity Starlite/ChEMBL No references
Homo sapiens M-phase phosphoprotein 8 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens acetylcholinesterase (Yt blood group) Starlite/ChEMBL References
Homo sapiens peroxisome proliferator-activated receptor delta Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens butyrylcholinesterase Starlite/ChEMBL References
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens galactosidase, alpha Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_136365 All targets in OG5_136365
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Plasmodium yoelii AP endonuclease 1 Get druggable targets OG5_129467 All targets in OG5_129467
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans apurinic/apyrimidinic endonuclease/3'-repair diesterase Get druggable targets OG5_129467 All targets in OG5_129467
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus multilocularis carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative Get druggable targets OG5_129467 All targets in OG5_129467
Cryptosporidium parvum AP endonuclease of the TIM barrel fold, possible bacterial horizontal transfer Get druggable targets OG5_129467 All targets in OG5_129467
Brugia malayi Melibiase family protein Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Plasmodium knowlesi apurinic/apyrimidinic endonuclease Apn1, putative Get druggable targets OG5_129467 All targets in OG5_129467
Cryptosporidium hominis apurinic/apyrimidinic endonuclease Apn1 Get druggable targets OG5_129467 All targets in OG5_129467
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans endonuclease IV Get druggable targets OG5_129467 All targets in OG5_129467
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K01204 alpha-N-acetylgalactosaminidase [EC3.2.1.49], putative Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum Alpha-N-acetylgalactosaminidase precursor, putative Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus granulosus Ankyrin repeat domain containing protein Get druggable targets OG5_136365 All targets in OG5_136365
Neospora caninum hypothetical protein Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni multiple ankyrin repeats single kh domain protein Get druggable targets OG5_136365 All targets in OG5_136365
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum endonuclease V, putative Get druggable targets OG5_129467 All targets in OG5_129467
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis Ankyrin repeat domain containing protein Get druggable targets OG5_136365 All targets in OG5_136365
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis Alpha N acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Toxoplasma gondii endonuclease IV APN Get druggable targets OG5_129467 All targets in OG5_129467
Babesia bovis apurinic endonuclease (APN1) family protein Get druggable targets OG5_129467 All targets in OG5_129467
Echinococcus granulosus carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) acetylcholinesterase 1 Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum M-phase phosphoprotein 8, putative Get druggable targets OG5_136365 All targets in OG5_136365
Loa Loa (eye worm) carboxylesterase Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi M-phase phosphoprotein, mpp8 Get druggable targets OG5_136365 All targets in OG5_136365
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Chlamydia trachomatis endonuclease IV Get druggable targets OG5_129467 All targets in OG5_129467
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum expressed protein Get druggable targets OG5_127620 All targets in OG5_127620
Plasmodium berghei apurinic/apyrimidinic endonuclease Apn1, putative Get druggable targets OG5_129467 All targets in OG5_129467
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus Alpha N acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_136365 All targets in OG5_136365
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_129467 All targets in OG5_129467
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase Get druggable targets OG5_129467 All targets in OG5_129467
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) Get druggable targets OG5_129467 All targets in OG5_129467
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) Get druggable targets OG5_129467 All targets in OG5_129467
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Acetylcholinesterase 1 precursor, putative Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi hypothetical protein Get druggable targets OG5_136365 All targets in OG5_136365
Toxoplasma gondii melibiase subfamily protein Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus multilocularis Glycoside hydrolase, family 27 Get druggable targets OG5_127620 All targets in OG5_127620
Onchocerca volvulus Get druggable targets OG5_136365 All targets in OG5_136365
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129467 All targets in OG5_129467
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni multiple ankyrin repeats single kh domain protein Get druggable targets OG5_136365 All targets in OG5_136365
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_136365 All targets in OG5_136365
Schistosoma japonicum ko:K01049 acetylcholinesterase [EC3.1.1.7], putative Get druggable targets OG5_126875 All targets in OG5_126875
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative Get druggable targets OG5_129467 All targets in OG5_129467
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Carboxylesterase family protein acetylcholinesterase (Yt blood group) 614 aa 510 aa 26.5 %
Brugia malayi Carboxylesterase family protein butyrylcholinesterase 602 aa 546 aa 30.2 %
Brugia malayi ecdysteroid receptor peroxisome proliferator-activated receptor delta 441 aa 369 aa 24.7 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0122 0.3904 0.4483
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0259 0.0298
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0028 0.038 0.0272
Onchocerca volvulus 0.0028 0.038 0.0127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0259 0.0298
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0124 0.3955 0.5551
Loa Loa (eye worm) hypothetical protein 0.0024 0.0257 0.0295
Echinococcus multilocularis lamin dm0 0.0033 0.0563 0.0542
Loa Loa (eye worm) hypothetical protein 0.0028 0.038 0.0437
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0196 0.5
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0693 0.0733
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0693 0.1746
Echinococcus granulosus lamin 0.0033 0.0563 0.0542
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0024 0.0257 0.0233
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0259 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0259 0.0298
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0259 0.0369
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0259 0.0093
Echinococcus granulosus neuroligin 0.0028 0.038 0.0272
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0024 0.0259 0.0003
Brugia malayi Carboxylesterase family protein 0.0028 0.038 0.0437
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0259 0.0298
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0164 0.5446 0.7814
Echinococcus granulosus BC026374 protein S09 family 0.0028 0.038 0.0272
Echinococcus multilocularis para nitrobenzyl esterase 0.0028 0.038 0.0272
Schistosoma mansoni coup transcription factor 0.0024 0.0259 0.0369
Brugia malayi hypothetical protein 0.0122 0.3904 0.4483
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0259 0.0298
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0093 0.2796 0.3212
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0259 0.0093
Loa Loa (eye worm) acetylcholinesterase 1 0.0164 0.5446 0.6254
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0109 0.3391 0.4864
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0196 0.5
Schistosoma mansoni gliotactin 0.0028 0.038 0.0543
Brugia malayi nuclear hormone receptor 0.0024 0.0259 0.0298
Trichomonas vaginalis set domain proteins, putative 0.0286 1 1
Mycobacterium ulcerans epimerase 0.0024 0.0257 0.0233
Brugia malayi hypothetical protein 0.0028 0.038 0.0437
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0082 0.2421 0.3472
Brugia malayi Carboxylesterase family protein 0.0028 0.038 0.0437
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0259 0.0298
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0028 0.038 0.0543
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0259 0.0093
Loa Loa (eye worm) hypothetical protein 0.0028 0.038 0.0437
Echinococcus multilocularis geminin 0.0205 0.6969 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0563 0.0646
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0259 0.0298
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0259 0.0369
Loa Loa (eye worm) hypothetical protein 0.0082 0.2421 0.2781
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.005 0.1205 0.1727
Toxoplasma gondii exonuclease III APE 0.0023 0.0196 0.049
Echinococcus multilocularis acetylcholinesterase 0.0164 0.5446 0.7751
Onchocerca volvulus Protein ultraspiracle homolog 0.0024 0.0259 0.0003
Loa Loa (eye worm) hypothetical protein 0.0024 0.0259 0.0298
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0259 0.0093
Echinococcus multilocularis BC026374 protein (S09 family) 0.0028 0.038 0.0272
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0259 0.0093
Echinococcus granulosus intermediate filament protein 0.0033 0.0563 0.0542
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0124 0.3955 0.5551
Echinococcus granulosus acetylcholinesterase 0.0164 0.5446 0.7751
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.3955 0.5675
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0259 0.0298
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0124 0.3955 0.5551
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0259 0.0298
Loa Loa (eye worm) hypothetical protein 0.0122 0.3904 0.4483
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0259 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0259 0.0298
Brugia malayi steroid hormone receptor 0.0024 0.0259 0.0298
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0259 0.0369
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0259 0.0298
Onchocerca volvulus 0.0028 0.038 0.0127
Trichomonas vaginalis spcc417.12 protein, putative 0.0028 0.038 0.0188
Loa Loa (eye worm) hypothetical protein 0.0028 0.038 0.0437
Onchocerca volvulus 0.0122 0.3904 0.3743
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0259 0.0369
Onchocerca volvulus 0.0024 0.0259 0.0003
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0259 0.0369
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0028 0.038 0.0543
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0259 0.0093
Plasmodium vivax SET domain protein, putative 0.0036 0.0693 0.191
Schistosoma mansoni lamin 0.0033 0.0563 0.0805
Loa Loa (eye worm) hypothetical protein 0.0036 0.0693 0.0795
Loa Loa (eye worm) hypothetical protein 0.0032 0.0541 0.0621
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0563 0.0646
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0109 0.3391 0.4718
Echinococcus granulosus geminin 0.0205 0.6969 1
Brugia malayi Carboxylesterase family protein 0.0164 0.5446 0.6254
Loa Loa (eye worm) hypothetical protein 0.0093 0.2796 0.3212
Loa Loa (eye worm) hypothetical protein 0.0024 0.0259 0.0298
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0259 0.0369
Echinococcus multilocularis thyroid hormone receptor alpha 0.0024 0.0259 0.0093
Brugia malayi M-phase phosphoprotein, mpp8 0.0122 0.3904 0.4483
Loa Loa (eye worm) hypothetical protein 0.0164 0.5446 0.6254
Mycobacterium ulcerans carboxylesterase, LipT 0.0028 0.038 0.0709
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0196 0.0225
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0259 0.0369
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0563 0.0646
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.0259 0.0298
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0259 0.0093
Echinococcus multilocularis musashi 0.0033 0.0563 0.0542
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0259 0.0298
Loa Loa (eye worm) hypothetical protein 0.0024 0.0259 0.0298
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.8707 1
Echinococcus granulosus para nitrobenzyl esterase 0.0028 0.038 0.0272
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0028 0.038 0.0272
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0693 0.0991
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0259 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0259 0.0298
Echinococcus granulosus carboxylesterase 5A 0.0164 0.5446 0.7751
Loa Loa (eye worm) hypothetical protein 0.0024 0.0259 0.0298
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0259 0.0369
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0259 0.0298
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0093 0.2796 1
Brugia malayi Carboxylesterase family protein 0.0164 0.5446 0.6254
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0093 0.2796 1
Schistosoma mansoni hypothetical protein 0.0205 0.6969 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.038 0.0437
Onchocerca volvulus 0.0028 0.038 0.0127
Chlamydia trachomatis endonuclease IV 0.0093 0.2796 0.5
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0643 0.066
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0028 0.038 0.0709
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0563 0.0646
Mycobacterium tuberculosis Carboxylesterase LipT 0.0028 0.038 0.0709
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0093 0.2796 1
Onchocerca volvulus 0.0033 0.0563 0.0314
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0259 0.0298
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0259 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0259 0.0298
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0196 0.5
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0082 0.2421 0.227
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0028 0.038 0.0188
Echinococcus multilocularis acetylcholinesterase 0.0164 0.5446 0.7751
Brugia malayi ecdysteroid receptor 0.0024 0.0259 0.0298
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0259 0.0298
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0259 0.0093
Onchocerca volvulus 0.0122 0.3904 0.3743
Brugia malayi Pre-SET motif family protein 0.0036 0.0693 0.0795
Loa Loa (eye worm) hypothetical protein 0.0028 0.038 0.0437
Loa Loa (eye worm) hypothetical protein 0.0024 0.0259 0.0298
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0259 0.0093
Schistosoma mansoni BC026374 protein (S09 family) 0.0028 0.038 0.0543
Mycobacterium tuberculosis Conserved hypothetical protein 0.0024 0.0257 0.0233
Mycobacterium ulcerans hypothetical protein 0.0024 0.0257 0.0233
Schistosoma mansoni intermediate filament proteins 0.0033 0.0563 0.0805
Onchocerca volvulus 0.0028 0.038 0.0127
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0024 0.0257 0.0295
Schistosoma mansoni acetylcholinesterase 0.0028 0.038 0.0543
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0196 0.5
Echinococcus multilocularis neuroligin 0.0028 0.038 0.0272
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0259 0.0093
Onchocerca volvulus 0.005 0.1205 0.0973
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0693 0.0733
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0259 0.0298
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0259 0.0093
Loa Loa (eye worm) carboxylesterase 0.0028 0.038 0.0437
Brugia malayi Carboxylesterase family protein 0.0028 0.038 0.0437
Loa Loa (eye worm) hypothetical protein 0.0028 0.038 0.0437
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0109 0.3391 0.4864
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.0259 0.0298
Toxoplasma gondii endonuclease IV APN 0.0093 0.2796 0.7068
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0259 0.0093
Brugia malayi intermediate filament protein 0.0033 0.0563 0.0646
Loa Loa (eye worm) hypothetical protein 0.0028 0.038 0.0437
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0082 0.2421 0.3472
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0196 0.5
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0259 0.0369
Onchocerca volvulus Bile acid receptor homolog 0.0024 0.0259 0.0003
Brugia malayi Pre-SET motif family protein 0.0251 0.8707 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0693 0.0991
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0196 0.5
Toxoplasma gondii melibiase subfamily protein 0.0124 0.3955 1
Schistosoma mansoni hypothetical protein 0.0205 0.6969 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0693 0.0733
Loa Loa (eye worm) carboxylesterase 0.0028 0.038 0.0437
Schistosoma mansoni lamin 0.0033 0.0563 0.0805
Loa Loa (eye worm) carboxylesterase 0.0164 0.5446 0.6254
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0196 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0259 0.0298
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0028 0.038 0.0709
Loa Loa (eye worm) hypothetical protein 0.0024 0.0259 0.0298
Loa Loa (eye worm) hypothetical protein 0.0164 0.5446 0.6254
Brugia malayi nuclear receptor NHR-88 0.0024 0.0259 0.0298
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0093 0.2796 1
Onchocerca volvulus 0.0033 0.0563 0.0314
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0259 0.0369
Loa Loa (eye worm) hypothetical protein 0.0024 0.0259 0.0298
Schistosoma mansoni ap endonuclease 0.0023 0.0196 0.0278
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0259 0.0369
Schistosoma mansoni ap endonuclease 0.0023 0.0196 0.0278
Mycobacterium ulcerans endonuclease IV 0.0093 0.2796 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0028 0.038 0.0543
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0196 0.5
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0259 0.0369
Brugia malayi Melibiase family protein 0.0082 0.2421 0.2781
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.3955 0.5675
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.3955 0.5675
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0259 0.0298
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0259 0.0298
Echinococcus granulosus lamin dm0 0.0033 0.0563 0.0542
Echinococcus multilocularis carboxylesterase 5A 0.0164 0.5446 0.7751
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0109 0.3391 0.4718
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0693 0.0991
Echinococcus multilocularis lamin 0.0033 0.0563 0.0542
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0196 0.0225
Echinococcus granulosus acetylcholinesterase 0.0164 0.5446 0.7751
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0259 0.0298
Loa Loa (eye worm) hypothetical protein 0.0024 0.0259 0.0298
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0259 0.0093
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.3955 0.5675
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0028 0.038 0.0543
Brugia malayi Carboxylesterase family protein 0.0028 0.038 0.0437
Onchocerca volvulus 0.0028 0.038 0.0127

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 350 nM Inhibition of AChE from human erythrocytes ChEMBL. No reference
IC50 (binding) = 360 nM Inhibition of human whole RBC AChE pretreated for 30 mins by Ellman technique ChEMBL. 20627738
IC50 (binding) = 900 nM Inhibition of human plasma BChE pretreated for 30 mins by Ellman technique ChEMBL. 20627738
IC50 (binding) = 1000 nM Inhibition of BChE from human plasma ChEMBL. No reference
IC50 (binding) = 0.35 uM Inhibition of human AChE assessed as acetylthiocholine hydrolysis preincubated for 10 mins followed by addition of substrate measured after 2 mins by spectrophotometric method ChEMBL. 27377327
IC50 (binding) = 1 uM Inhibition of human plasma BChE assessed as butyrylthiocholine hydrolysis preincubated for 10 mins followed by addition of substrate measured after 2 mins by spectrophotometric method ChEMBL. 27377327
IC50 (binding) = 40 uM Inhibition of human erythrocyte AChE after 5 mins by Ellman's method ChEMBL. 20138518
IC50 (binding) = 16000 uM Inhibition of human plasma BChE after 5 mins by Ellman's method ChEMBL. 20138518
Inhibition (ADMET) = 96.48978353 % Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
Inhibition (ADMET) = 112.022441 % Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
LD50 (ADMET) = 2.6 mg kg-1 Acute toxicity of the compound was evaluated in mouse ChEMBL. 6827532
LD50 (ADMET) = 2.6 mg kg-1 Acute toxicity of the compound was evaluated in mouse ChEMBL. 6827532
LD50 (ADMET) = 3.1 mg kg-1 Acute toxicity of the compound was evaluated in rat ChEMBL. 6827532
LD50 (ADMET) = 3.3 mg kg-1 Acute toxicity in ip dosed mouse measured after 72 hrs ChEMBL. 27377327
Potency (functional) 0.0035 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.7943 uM PUBCHEM_BIOASSAY: qHTS Validation Assay for Inhibitors for MPP8 Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.8199 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.113 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays: 1472, 1467 ] ChEMBL. No reference
Potency (functional) 10.691 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: Counterscreen for APE1 Inhibitors: qHTS Validation Assay for Inhibitors of Endonuclease IV. (Class of assay: confirmatory) [Related pubchem assays: 1705, 1707 ] ChEMBL. No reference
Potency (functional) 29.8493 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) ChEMBL. No reference
Protective ratio (functional) = 3.1 Protective ratio of compound (10 mg/kg) against soman poisoning, given subcutaneously to mice 30 min prior to treatment by TAB ChEMBL. 6827532

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

6 literature references were collected for this gene.

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