TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 539.646 | Formula: C27H33N5O5S
H donors: 5 H acceptors: 4 LogP: 4.55 Rotable bonds: 16
Rule of 5 violations (Lipinski): 2
SMILES: CCc1ccccc1NC(=O)CSC(=O)NNC(=O)[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)OC(C)(C)C
InChi: 1S/C27H33N5O5S/c1-5-17-10-6-8-12-20(17)29-23(33)16-38-26(36)32-31-24(34)22(30-25(35)37-27(2,3)4)14-18-15-28-21-13-9-7-11-19(18)21/h6-13,15,22,28H,5,14,16H2,1-4H3,(H,29,33)(H,30,35)(H,31,34)(H,32,36)/t22-/m1/s1
InChiKey: OTIWAYTTYNFEKL-JOCHJYFZSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	dro:myosuppressin receptor	0.0098	0.1431	1
Schistosoma mansoni	amine GPCR	0.0098	0.1431	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0038	0.0449	0.3035
Echinococcus granulosus	neuropeptide Y receptor	0.0098	0.1431	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0098	0.1431	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0098	0.1431	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0027	0.0259	0.0218
Loa Loa (eye worm)	retinol dehydrogenase 12	0.0042	0.0501	0.3503
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0042	0.0501	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0098	0.1431	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0111	0.0775
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0098	0.1431	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Brugia malayi	Bromodomain containing protein	0.0048	0.0612	0.4103
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0098	0.1431	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0259	0.472
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0259	0.472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0221	0.1544
Brugia malayi	GnHR receptor homolog	0.0098	0.1431	1
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.0614	1	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Echinococcus multilocularis	serotonin receptor	0.0098	0.1431	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Brugia malayi	AKH receptor	0.0098	0.1431	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0098	0.1431	1
Brugia malayi	hypothetical protein	0.0098	0.1431	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0098	0.1431	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0098	0.1431	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0027	0.0259	0.1808
Schistosoma mansoni	myosin xvIII	0.0098	0.1431	1
Echinococcus granulosus	neuropeptide s receptor	0.0098	0.1431	1
Echinococcus granulosus	sex peptide receptor	0.0098	0.1431	1
Trypanosoma brucei	pteridine reductase 1	0.0042	0.0501	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0259	0.472
Echinococcus granulosus	7tm_1 domain containing protein	0.0098	0.1431	1
Brugia malayi	PHD-finger family protein	0.0016	0.0077	0.0255
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0098	0.1431	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0259	0.472
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0098	0.1431	1
Brugia malayi	Dopamine receptor protein 1	0.0098	0.1431	1
Echinococcus granulosus	neuropeptide Y receptor	0.0098	0.1431	1
Echinococcus multilocularis	g protein coupled receptor	0.0098	0.1431	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0027	0.0259	0.169
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0259	0.0218
Echinococcus multilocularis	neuropeptide receptor A26	0.0098	0.1431	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0098	0.1431	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0259	0.0218
Loa Loa (eye worm)	cysteine protease	0.0027	0.0259	0.1808
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0098	0.1431	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0098	0.1431	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0027	0.0259	0.0218
Onchocerca volvulus	Cathepsin F homolog	0.0027	0.0259	0.112
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Onchocerca volvulus		0.0098	0.1431	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0259	0.0218
Echinococcus granulosus	cysteine protease	0.0014	0.0042	0.0152
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0259	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0246	0.172
Onchocerca volvulus		0.0098	0.1431	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0098	0.1431	1
Schistosoma mansoni	adenoreceptor	0.0098	0.1431	1
Onchocerca volvulus		0.0098	0.1431	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0027	0.0259	0.0218
Echinococcus granulosus	3 oxoacyl acyl carrier protein reductase	0.0042	0.0501	0.3409
Brugia malayi	sulfakinin receptor protein	0.0098	0.1431	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0027	0.0259	0.472
Echinococcus multilocularis	neuropeptide Y receptor	0.0098	0.1431	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0098	0.1431	1
Brugia malayi	hypothetical protein	0.0098	0.1431	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0098	0.1431	1
Echinococcus granulosus	g protein coupled receptor	0.0098	0.1431	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0098	0.1431	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0098	0.1431	1
Schistosoma mansoni	hypothetical protein	0.0098	0.1431	1
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0259	0.1561
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0098	0.1431	1
Onchocerca volvulus		0.0098	0.1431	1
Echinococcus multilocularis	allatostatin A receptor	0.0098	0.1431	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0259	0.0218
Plasmodium vivax	vivapain-2	0.0027	0.0259	0.0218
Loa Loa (eye worm)	ctsf protein	0.0027	0.0259	0.1808
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0098	0.1431	1
Onchocerca volvulus		0.0027	0.0259	0.112
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0259	0.0218
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0259	0.1561
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0098	0.1431	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0098	0.1431	1
Entamoeba histolytica	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0042	0.0501	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0259	0.0218
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0098	0.1431	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0259	0.0218
Echinococcus multilocularis	sex peptide receptor	0.0098	0.1431	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0038	0.0449	0.3035
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0014	0.0042	0.0152
Onchocerca volvulus		0.0027	0.0259	0.112
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0098	0.1431	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0259	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Brugia malayi	G protein-coupled receptor	0.0098	0.1431	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0098	0.1431	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Plasmodium falciparum	3-oxoacyl-[acyl-carrier-protein] reductase	0.0042	0.0501	0.0462
Onchocerca volvulus		0.0098	0.1431	1
Echinococcus multilocularis	neuropeptide receptor	0.0098	0.1431	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0098	0.1431	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0259	0.472
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0098	0.1431	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0098	0.1431	1
Echinococcus granulosus	fetal alzheimer antigen falz	0.0015	0.0052	0.0224
Toxoplasma gondii	short chain dehydrogenase family protein, putative	0.0042	0.0501	0.0249
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0259	0.0218
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0098	0.1431	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0018	0.0111	0.0497
Onchocerca volvulus		0.0027	0.0259	0.112
Schistosoma mansoni	amine GPCR	0.0098	0.1431	1
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0111	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0259	0.472
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0259	0.472
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0259	0.0218
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0259	0.472
Echinococcus granulosus	neuropeptide FF receptor 2	0.0098	0.1431	1
Schistosoma mansoni	opsin-like receptor	0.0098	0.1431	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Onchocerca volvulus		0.0027	0.0259	0.112
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0014	0.0042	0.0152
Echinococcus granulosus	rhodopsin orphan GPCR	0.0098	0.1431	1
Echinococcus granulosus	allatostatin A receptor	0.0098	0.1431	1
Brugia malayi	Papain family cysteine protease containing protein	0.0027	0.0259	0.1561
Schistosoma mansoni	neuropeptide F-like receptor	0.0098	0.1431	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Brugia malayi	neuropeptide F receptor	0.0098	0.1431	1
Brugia malayi	hypothetical protein	0.0098	0.1431	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0098	0.1431	1
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.0614	1	1
Brugia malayi	Dopamine receptor protein 2	0.0098	0.1431	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0098	0.1431	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0259	0.472
Schistosoma mansoni	cathepsin F (C01 family)	0.0027	0.0259	0.169
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0111	0.0497
Echinococcus granulosus	dro:myosuppressin receptor	0.0098	0.1431	1
Echinococcus granulosus	neuropeptide receptor	0.0098	0.1431	1
Schistosoma mansoni	opsin-like receptor	0.0098	0.1431	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0098	0.1431	1
Echinococcus granulosus	somatostatin receptor	0.0098	0.1431	1
Onchocerca volvulus		0.0042	0.0501	0.2958
Echinococcus multilocularis	3 oxoacyl acyl carrier protein reductase	0.0042	0.0501	0.3409
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0098	0.1431	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0027	0.0259	0.1808
Onchocerca volvulus		0.0098	0.1431	1
Schistosoma mansoni	neuropeptide receptor	0.0098	0.1431	1
Loa Loa (eye worm)	TYRA-2 protein	0.0098	0.1431	1
Onchocerca volvulus		0.0027	0.0259	0.112
Echinococcus multilocularis	serotonin receptor	0.0098	0.1431	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0098	0.1431	1
Onchocerca volvulus		0.0098	0.1431	1
Brugia malayi	G-protein coupled receptor	0.0098	0.1431	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0098	0.1431	1
Loa Loa (eye worm)	fibroinase	0.0027	0.0259	0.1808
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0098	0.1431	1
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0042	0.0501	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0259	0.472
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0098	0.1431	1
Schistosoma mansoni	3-oxoacyl-[ACP] reductase	0.0042	0.0501	0.3409
Brugia malayi	putative neuropeptide receptor	0.0098	0.1431	1
Onchocerca volvulus	Cathepsin L homolog	0.0027	0.0259	0.112
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0098	0.1431	1
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.0259	0.472
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.0614	1	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0098	0.1431	1
Echinococcus multilocularis	g protein coupled receptor	0.0098	0.1431	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0027	0.0259	0.169
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Echinococcus granulosus	cathepsin L	0.0014	0.0042	0.0152
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0042	0.0501	1
Toxoplasma gondii	3-ketoacyl-(acyl-carrier-protein) reductase	0.0042	0.0501	0.0249
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0098	0.1431	1
Brugia malayi	hypothetical protein	0.0098	0.1431	1
Echinococcus multilocularis	cysteine protease	0.0027	0.0259	0.169
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0098	0.1431	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0098	0.1431	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0098	0.1431	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Brugia malayi	hypothetical protein	0.0098	0.1431	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0259	0.472
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0259	0.0218
Echinococcus granulosus	neuropeptide receptor A26	0.0098	0.1431	1
Schistosoma mansoni	amine GPCR	0.0098	0.1431	1
Schistosoma mansoni	neuropeptide receptor	0.0098	0.1431	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0259	0.0218
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0027	0.0259	0.0218
Schistosoma mansoni	growth hormone secretagogue receptor	0.0098	0.1431	1
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.0614	1	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0018	0.0111	0.1502
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0098	0.1431	1
Brugia malayi	Serotonin receptor	0.0098	0.1431	1
Trypanosoma brucei	beta-ketoacyl-ACP reductase	0.0042	0.0501	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0098	0.1431	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0111	0.0775
Brugia malayi	Serotonin receptor	0.0098	0.1431	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0098	0.1431	1
Onchocerca volvulus		0.0027	0.0259	0.112
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Echinococcus multilocularis	cysteine protease	0.0027	0.0259	0.169
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Onchocerca volvulus		0.0098	0.1431	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0098	0.1431	1
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0042	0.0501	1
Echinococcus granulosus	fmrfamide receptor	0.0098	0.1431	1
Leishmania major	oxidoreductase-like protein	0.0042	0.0501	1
Echinococcus granulosus	neuropeptides capa receptor	0.0098	0.1431	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0098	0.1431	1
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0259	0.1561
Echinococcus granulosus	neuropeptide receptor	0.0098	0.1431	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0501	0.3503
Plasmodium vivax	vivapain-2	0.0027	0.0259	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Echinococcus multilocularis	neuropeptide s receptor	0.0098	0.1431	1
Brugia malayi	hypothetical protein	0.0098	0.1431	1
Onchocerca volvulus		0.0098	0.1431	1
Schistosoma mansoni	hypothetical protein	0.0013	0.0032	0.008
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0098	0.1431	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0098	0.1431	1
Echinococcus multilocularis	fmrfamide receptor	0.0098	0.1431	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0098	0.1431	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0042	0.0501	0.3308
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0098	0.1431	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0098	0.1431	1
Onchocerca volvulus		0.0098	0.1431	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0259	0.0218
Brugia malayi	hypothetical protein	0.0098	0.1431	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0098	0.1431	1
Plasmodium falciparum	enoyl-acyl carrier reductase	0.0614	1	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0098	0.1431	1
Echinococcus granulosus	orexin receptor type 2	0.0098	0.1431	1
Brugia malayi	hypothetical protein	0.0098	0.1431	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0027	0.0259	0.0218
Schistosoma mansoni	biogenic amine receptor	0.0098	0.1431	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0259	0.472
Schistosoma mansoni	cathepsin F (C01 family)	0.0018	0.0111	0.0641
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0098	0.1431	1
Echinococcus granulosus	hypothetical protein	0.0098	0.1431	1
Schistosoma mansoni	amine GPCR	0.0098	0.1431	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0098	0.1431	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0098	0.1431	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0098	0.1431	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0111	0.0069
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0098	0.1431	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0098	0.1431	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0259	0.472
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0259	0.472
Schistosoma mansoni	opsin-like receptor	0.0098	0.1431	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0098	0.1431	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0098	0.1431	1
Brugia malayi	RE15519p	0.0098	0.1431	1
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.0614	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0027	0.0259	0.169
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0015	0.0052	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Onchocerca volvulus		0.0042	0.0501	0.2958
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0098	0.1431	1
Echinococcus granulosus	cathepsin l1	0.0027	0.0259	0.169
Onchocerca volvulus		0.0098	0.1431	1
Schistosoma mansoni	biogenic amine receptor	0.0098	0.1431	1
Plasmodium vivax	3-oxoacyl-[acyl-carrier-protein] reductase, putative	0.0042	0.0501	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Trypanosoma brucei	oxidoreductase-like protein	0.0042	0.0501	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0027	0.0259	0.169
Schistosoma mansoni	amine GPCR	0.0098	0.1431	1
Brugia malayi	follicle stimulating hormone receptor	0.0098	0.1431	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0111	0.0775
Echinococcus multilocularis	cathepsin L	0.0014	0.0042	0.0152
Leishmania major	pteridine reductase 1	0.0042	0.0501	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Schistosoma mansoni	hypothetical protein	0.0098	0.1431	1
Onchocerca volvulus		0.0098	0.1431	1
Onchocerca volvulus		0.0098	0.1431	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0098	0.1431	1
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0042	0.0501	0.3503
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0259	0.0218
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0098	0.1431	1
Echinococcus granulosus	cathepsin l1	0.0018	0.0111	0.0641
Echinococcus granulosus	G protein coupled receptor 139	0.0098	0.1431	1
Echinococcus multilocularis	fmrfamide receptor	0.0098	0.1431	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0098	0.1431	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0259	0.0218
Onchocerca volvulus		0.0098	0.1431	1
Schistosoma mansoni	histamine h1 receptor	0.0098	0.1431	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0098	0.1431	1
Onchocerca volvulus		0.0098	0.1431	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0098	0.1431	1
Schistosoma mansoni	hypothetical protein	0.0098	0.1431	1
Schistosoma mansoni	neuropeptide receptor	0.0098	0.1431	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Brugia malayi	Bromodomain containing protein	0.0025	0.022	0.1284
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0259	0.0218
Brugia malayi	larval opioid receptor	0.0098	0.1431	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0566	0.3956
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0098	0.1431	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0098	0.1431	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0023	0.0195	0.1237
Brugia malayi	ORL1-like opioid receptor	0.0098	0.1431	1
Brugia malayi	cathepsin L-like precursor	0.0018	0.0111	0.0497
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0098	0.1431	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0098	0.1431	1
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0259	0.1561
Schistosoma mansoni	biogenic amine receptor	0.0098	0.1431	1
Echinococcus granulosus	neuropeptides capa receptor	0.0098	0.1431	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0027	0.0259	0.169
Onchocerca volvulus		0.0098	0.1431	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0098	0.1431	1
Brugia malayi	hypothetical protein	0.0098	0.1431	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0098	0.1431	1
Brugia malayi	Dopamine receptor	0.0098	0.1431	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0259	0.1808
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0042	0.0501	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0027	0.0259	0.169
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0259	0.0218
Echinococcus multilocularis	somatostatin receptor	0.0098	0.1431	1
Echinococcus multilocularis	orexin receptor type 2	0.0098	0.1431	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0014	0.0042	0.0152
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0042	0.0501	0.0249
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0111	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Brugia malayi	G-protein coupled receptor	0.0098	0.1431	1
Echinococcus multilocularis	g protein coupled receptor	0.0098	0.1431	1
Brugia malayi	Melatonin receptor type 1A	0.0098	0.1431	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0098	0.1431	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0259	0.0218
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0259	0.1561
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0098	0.1431	1
Echinococcus multilocularis	neuropeptide receptor	0.0098	0.1431	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0098	0.1431	1
Schistosoma mansoni	dihydropteridine reductase	0.0042	0.0501	0.3409
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0259	0.1561
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0098	0.1431	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.0614	1	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0023	0.0195	0.1237
Loa Loa (eye worm)	oxidoreductase	0.0042	0.0501	0.3503
Echinococcus granulosus	serotonin receptor	0.0098	0.1431	1
Brugia malayi	hypothetical protein	0.0098	0.1431	1
Schistosoma mansoni	neuropeptide receptor	0.0098	0.1431	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0098	0.1431	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0259	0.0218
Echinococcus granulosus	7TM GPCR rhodopsin	0.0098	0.1431	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0098	0.1431	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0098	0.1431	1
Schistosoma mansoni	bromodomain containing protein	0.0041	0.0487	0.3306
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Brugia malayi	neuropeptide F receptor	0.0098	0.1431	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0014	0.0042	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0098	0.1431	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0027	0.0259	0.169
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0259	0.0218
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0098	0.1431	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0098	0.1431	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0098	0.1431	1
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.0259	0.472
Leishmania major	3-oxoacyl-ACP reductase, putative	0.0042	0.0501	1
Echinococcus granulosus	g protein coupled receptor	0.0098	0.1431	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0098	0.1431	1
Onchocerca volvulus		0.0027	0.0259	0.112
Echinococcus granulosus	rhodopsin orphan GPCR	0.0098	0.1431	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0098	0.1431	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0098	0.1431	1
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0015	0.0052	0.0224
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0042	0.0501	0.3308
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0259	0.472
Echinococcus granulosus	tm gpcr rhodopsin	0.0098	0.1431	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0259	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0267	0.1863
Onchocerca volvulus		0.0098	0.1431	1
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0111	0.1502
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0098	0.1431	1
Trichomonas vaginalis	hypothetical protein	0.0614	1	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0098	0.1431	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0259	0.472
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0098	0.1431	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0259	0.0218
Loa Loa (eye worm)	PHD-finger family protein	0.0013	0.0032	0.0221
Echinococcus multilocularis	g-protein coupled receptor	0.0098	0.1431	1
Schistosoma mansoni	hypothetical protein	0.0098	0.1431	1
Onchocerca volvulus	Cathepsin L homolog	0.0027	0.0259	0.112
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1431	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0098	0.1431	1
Echinococcus granulosus	g-protein coupled receptor	0.0098	0.1431	1
Echinococcus granulosus	g protein coupled receptor	0.0098	0.1431	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 34 uM	Inhibition of cathepsin L (unknown origin)	ChEMBL.	18060772
IC50 (binding)	= 34 uM	Inhibition of cathepsin L (unknown origin)	ChEMBL.	18060772

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 521775