Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0432 | 0.5055 | 1 |
Plasmodium falciparum | hexose transporter | 0.0432 | 0.5055 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0432 | 0.5055 | 0.1724 |
Toxoplasma gondii | facilitative glucose transporter GT1 | 0.0432 | 0.5055 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0432 | 0.5055 | 0.1724 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0432 | 0.5055 | 0.1724 |
Schistosoma mansoni | dihydrofolate reductase | 0.0724 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0724 | 1 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0432 | 0.5055 | 0.1724 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0277 | 0.242 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0724 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0432 | 0.5055 | 0.1724 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0277 | 0.242 | 1 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0432 | 0.5055 | 0.1724 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0432 | 0.5055 | 0.1724 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0277 | 0.242 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0724 | 1 | 1 |
Plasmodium vivax | hexose transporter | 0.0432 | 0.5055 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0432 | 0.5055 | 0.1724 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0724 | 1 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0724 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0724 | 1 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0724 | 1 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0724 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 120.01 uM | Antiproliferative activity against human K562 cells after 72 hrs by MTT assay | ChEMBL. | 18035542 |
IC50 (functional) | = 120.01 uM | Antiproliferative activity against human K562 cells after 72 hrs by MTT assay | ChEMBL. | 18035542 |
IC50 (functional) | = 140.02 uM | Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay | ChEMBL. | 18035542 |
IC50 (functional) | = 140.02 uM | Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay | ChEMBL. | 18035542 |
IC50 (functional) | > 200 uM | Antiproliferative activity against human SW620 cells after 72 hrs by MTT assay | ChEMBL. | 18035542 |
IC50 (functional) | > 200 uM | Antiproliferative activity against human C33 cells after 72 hrs by MTT assay | ChEMBL. | 18035542 |
IC50 (functional) | > 200 uM | Antiproliferative activity against human SW480 cells after 72 hrs by MTT assay | ChEMBL. | 18035542 |
IC50 (functional) | > 200 uM | Antiproliferative activity against human SW620 cells after 72 hrs by MTT assay | ChEMBL. | 18035542 |
IC50 (functional) | > 200 uM | Antiproliferative activity against human SW480 cells after 72 hrs by MTT assay | ChEMBL. | 18035542 |
Q50 (binding) | = 14.26 uM | Displacement of ethidium bromide from calf thymus DNA | ChEMBL. | 18035542 |
Ratio (binding) | = 0.9 | Ratio of Qmax for calf thymus DNA to Q50 for calf thymus DNA | ChEMBL. | 18035542 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.