Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0243694 | 0.341391 | 0.14277 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0243694 | 0.341391 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0243694 | 0.341391 | 0.5 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0431107 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0243694 | 0.341391 | 0.341391 |
Loa Loa (eye worm) | hypothetical protein | 0.0364498 | 0.765923 | 1 |
Leishmania major | p450 reductase, putative | 0.0243694 | 0.341391 | 0.14277 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0157424 | 0.0382213 | 0.0512033 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0146548 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0243694 | 0.341391 | 0.445724 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0364498 | 0.765923 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0243694 | 0.341391 | 0.445724 |
Brugia malayi | flavodoxin family protein | 0.0243694 | 0.341391 | 0.445724 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0223574 | 0.270686 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0187166 | 0.142739 | 0.186362 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0157424 | 0.0382213 | 0.0499023 |
Echinococcus granulosus | methionine synthase reductase | 0.0157424 | 0.0382213 | 0.0382213 |
Schistosoma mansoni | amine GPCR | 0.0358961 | 0.746462 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0243694 | 0.341391 | 0.341391 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0243694 | 0.341391 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0157424 | 0.0382213 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0223574 | 0.270686 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0243694 | 0.341391 | 0.341391 |
Brugia malayi | FAD binding domain containing protein | 0.0157424 | 0.0382213 | 0.0499023 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0243694 | 0.341391 | 0.445724 |
Echinococcus multilocularis | methionine synthase reductase | 0.0157424 | 0.0382213 | 0.0382213 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0364498 | 0.765923 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0243694 | 0.341391 | 0.457345 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0431107 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0243694 | 0.341391 | 0.341391 |
Onchocerca volvulus | 0.0146548 | 0 | 0.5 | |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0364498 | 0.765923 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0364498 | 0.765923 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0243694 | 0.341391 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.5 uM | Antimalarial activity against Plasmodium falciparum by lactate dehydrogenase enzyme assay | ChEMBL. | 18078758 |
IC50 (functional) | = 0.5 uM | Antimalarial activity against Plasmodium falciparum by lactate dehydrogenase enzyme assay | ChEMBL. | 18078758 |
IC50 (ADMET) | = 36 uM | Toxicity in CHO cells | ChEMBL. | 18078758 |
Ratio IC50 (functional) | = 72 | Ratio of IC50 for CHO cells to IC50 for Plasmodium falciparum | ChEMBL. | 18078758 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 18078758 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.