Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0416 | 0.5009 | 1 |
Plasmodium falciparum | hexose transporter | 0.0416 | 0.5009 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0416 | 0.5009 | 0.1698 |
Schistosoma mansoni | dihydrofolate reductase | 0.0703 | 1 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0416 | 0.5009 | 0.1698 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0269 | 0.2433 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0703 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0416 | 0.5009 | 0.1698 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0703 | 1 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0703 | 1 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0416 | 0.5009 | 0.1698 |
Plasmodium vivax | hexose transporter | 0.0416 | 0.5009 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0703 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0269 | 0.2433 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0703 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0703 | 1 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0416 | 0.5009 | 0.1698 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0703 | 1 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0703 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0416 | 0.5009 | 0.1698 |
Toxoplasma gondii | facilitative glucose transporter GT1 | 0.0416 | 0.5009 | 1 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0416 | 0.5009 | 0.1698 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0269 | 0.2433 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0416 | 0.5009 | 0.1698 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 78 % | Antitumor activity against human HCT116 cells xenografted in ip dosed nude mouse assessed as tumor volume inhibition | ChEMBL. | 18247554 |
Inhibition (functional) | = 78 % | Antitumor activity against human HCT116 cells xenografted in ip dosed nude mouse assessed as tumor volume inhibition | ChEMBL. | 18247554 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.