TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 384.039 | Formula: C23H42ClNO
H donors: 2 H acceptors: 1 LogP: 8.54 Rotable bonds: 16
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCCCCCCCCCN[C@H]([C@@H](c1ccccc1)O)C.Cl
InChi: 1S/C23H41NO.ClH/c1-3-4-5-6-7-8-9-10-11-12-13-17-20-24-21(2)23(25)22-18-15-14-16-19-22;/h14-16,18-19,21,23-25H,3-13,17,20H2,1-2H3;1H/t21-,23-;/m0./s1
InChiKey: QZAZSDKPNDNKNQ-IUQUCOCYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0542	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.1168	0.1303
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0004	0.0127	0.0127
Echinococcus granulosus	cpg binding protein	0.003	0.4688	0.6245
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0339	0.014
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.1168	0.1168
Schistosoma mansoni	nuclear receptor nhr-48	0.0005	0.024	0.024
Loa Loa (eye worm)	hypothetical protein	0.001	0.1168	0.1303
Loa Loa (eye worm)	hypothetical protein	0.001	0.1168	0.1303
Brugia malayi	Nuclear hormone receptor-like 1	0.0005	0.0339	0.014
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.1168	0.1303
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0542	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.1168	0.1303
Schistosoma mansoni	nuclear hormone receptor	0.001	0.1168	0.1168
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0956	0.1005
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.1168	0.1168
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0542	1
Brugia malayi	nuclear hormone receptor	0.001	0.1168	0.1303
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.1168	0.1303
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0542	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.1168	0.1303
Echinococcus multilocularis	cpg binding protein	0.003	0.4688	0.6245
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0005	0.024	0.024
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0542	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.1168	0.1303
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.1168	0.1303
Loa Loa (eye worm)	hypothetical protein	0.001	0.1168	0.1303
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.1168	0.1303
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.1168	0.1303
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.1168	0.1168
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.1168	0.1303
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.7362	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.7362	1
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.1168	0.1303
Loa Loa (eye worm)	hypothetical protein	0.001	0.1168	0.1303
Schistosoma mansoni	coup transcription factor	0.001	0.1168	0.1168
Brugia malayi	hypothetical protein	0.0005	0.0339	0.014
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.1168	0.1303
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.1168	0.1303
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.1168	0.1303
Brugia malayi	hypothetical protein	0.0005	0.0339	0.014
Schistosoma mansoni	thyroid hormone receptor	0.001	0.1168	0.1168
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.1168	0.1303
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.1168	0.1303
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.7362	1
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0339	0.014
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.1168	0.1303
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.1168	0.1303
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.1168	0.1303
Brugia malayi	ecdysteroid receptor	0.001	0.1168	0.1303
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0542	1
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0542	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.1168	0.1168
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.1168	0.1303
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.1168	0.1168
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.1168	0.1303
Schistosoma mansoni	zinc finger protein	0.0005	0.024	0.024
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.1168	0.1303
Onchocerca volvulus		0.0028	0.4403	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0005	0.0339	0.014
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0542	1
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.1168	0.1303
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0956	0.1005
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0005	0.0339	0.014
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0542	1
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0339	0.014
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.1168	0.1303
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0005	0.0339	0.0339
Loa Loa (eye worm)	hypothetical protein	0.001	0.1168	0.1303
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0956	0.1005
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.7362	0.7362
Plasmodium falciparum	zinc finger protein, putative	0.0003	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.1168	0.1303
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0005	0.0339	0.014
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.1168	0.1303
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.1168	0.1303
Brugia malayi	steroid hormone receptor	0.001	0.1168	0.1303
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0651	0.0651
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.1168	0.1303
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.7362	1
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0542	1
Schistosoma mansoni	cpg binding protein	0.003	0.4688	0.4688
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.1168	0.1168
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.1168	0.1303
Schistosoma mansoni	nuclear receptor	0.0005	0.024	0.024
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.1168	0.1303
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0542	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0651	0.0578
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.1168	0.1303
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0542	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.1168	0.1303
Schistosoma mansoni	nuclear hormone receptor	0.0005	0.024	0.024
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.1168	0.2229
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.1168	0.1303
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.7362	0.7362
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.4403	0.5846
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.1168	0.2229
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0339	0.014
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.1168	0.1303
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.1168	0.1168
Schistosoma mansoni	cpg binding protein	0.0028	0.4403	0.4403
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0542	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.1168	0.1303
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0542	1
Schistosoma mansoni	thyroid hormone receptor	0.001	0.1168	0.1168
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.1168	0.1303
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.7362	1
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0936	0.0977
Trichomonas vaginalis	helicase, putative	0.0006	0.0542	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.1168	0.1303
Echinococcus granulosus	FTZ F1 alpha	0.001	0.1168	0.1303
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.1168	0.1168
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0339	0.014
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0542	1
Entamoeba histolytica	hypothetical protein	0.0003	0	0.5
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0651	0.0578
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.1168	0.1303
Loa Loa (eye worm)	hypothetical protein	0.001	0.1168	0.1303
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0542	1
Schistosoma mansoni	cpg binding protein	0.003	0.4688	0.4688
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.1168	0.1303
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.1168	0.1303
Loa Loa (eye worm)	hypothetical protein	0.001	0.1168	0.1303
Onchocerca volvulus		0.001	0.1168	0.2229
Brugia malayi	CXXC zinc finger family protein	0.0028	0.4403	0.5846
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.7362	0.7362
Schistosoma mansoni	nuclear hormone receptor	0.0005	0.024	0.024
Brugia malayi	nuclear receptor NHR-88	0.001	0.1168	0.1303
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.1168	0.1303
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0005	0.024	0.024
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.1168	0.1303
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0542	1
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.1168	0.1168
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0651	0.0578
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0005	0.0339	0.014
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.8869	0.5
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0005	0.0339	0.0339
Brugia malayi	nuclear receptor RXR	0.0005	0.0339	0.014
Schistosoma mansoni	nuclear receptor	0.0005	0.024	0.024
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.7362	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.1168	0.2229
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0651	0.0578

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	= 4.88	Antiproliferative activity against human SKMEL5 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.62	Antiproliferative activity against human CCRF-CEM cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.63	Antiproliferative activity against human SKOV3 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.64	Antiproliferative activity against human MOLT4 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.66	Antiproliferative activity against human HS578T cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.68	Antiproliferative activity against human T47D cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.69	Antiproliferative activity against human SW620 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.69	Antiproliferative activity against human NCI-H322M cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.69	Antiproliferative activity against human NCI-H522 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.69	Antiproliferative activity against human MALME3M cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.69	Antiproliferative activity against human PC3 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.7	Antiproliferative activity against human RPMI8226 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.7	Antiproliferative activity against human OVCAR4 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.7	Antiproliferative activity against human TK10 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.71	Antiproliferative activity against human HOP62 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.71	Antiproliferative activity against human NCI-H226 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.71	Antiproliferative activity against human M14 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.71	Antiproliferative activity against human CAKI1 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.72	Antiproliferative activity against human HCT15 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.72	Antiproliferative activity against human A549 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.72	Antiproliferative activity against human NCI-H460 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.72	Antiproliferative activity against human SKMEL28 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.72	Antiproliferative activity against human OVCAR8 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.72	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.73	Antiproliferative activity against human HCT116 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.73	Antiproliferative activity against human HT29 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.73	Antiproliferative activity against human KM12 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.73	Antiproliferative activity against human UACC257 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.73	Antiproliferative activity against human DU145 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.74	Antiproliferative activity against human MCF7 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.74	Antiproliferative activity against human NCI-H23 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.74	Antiproliferative activity against human HCC2998 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.74	Antiproliferative activity against human U251 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.74	Antiproliferative activity against human UACC62 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.74	Antiproliferative activity against human SN12C cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.75	Antiproliferative activity against human SF268 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.75	Antiproliferative activity against human SF295 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.75	Antiproliferative activity against human SF539 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.75	Antiproliferative activity against human LOXIMVI cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.75	Antiproliferative activity against human SKMEL2 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.75	Antiproliferative activity against human ACHN cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.75	Antiproliferative activity against human MDA-MB-435 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.76	Antiproliferative activity against human COLO205 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.76	Antiproliferative activity against human UO31 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.77	Antiproliferative activity against human SNB19 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.77	Antiproliferative activity against human SNB75 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.77	Antiproliferative activity against human OVCAR5 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.78	Antiproliferative activity against human K562 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.78	Antiproliferative activity against human OVCAR3 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.78	Antiproliferative activity against human RXF393 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.8	Antiproliferative activity against human 786-0 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.82	Antiproliferative activity against human HOP92 cells after 48 hrs	ChEMBL.	17869115
GI50 (functional)	= 5.82	Antiproliferative activity against human BT549 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.55	Antiproliferative activity against human A498 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.43	Antiproliferative activity against human OVCAR4 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.31	Antiproliferative activity against human MOLT4 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.25	Antiproliferative activity against human KM12 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.24	Antiproliferative activity against human OVCAR5 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.24	Antiproliferative activity against human BT549 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.24	Antiproliferative activity against human HCC2998 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.24	Antiproliferative activity against human MDA-MB-435 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.23	Antiproliferative activity against human HCT15 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.23	Antiproliferative activity against human SNB19 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.23	Antiproliferative activity against human U251 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.23	Antiproliferative activity against human LOXIMVI cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.23	Antiproliferative activity against human 786-0 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.23	Antiproliferative activity against human CAKI1 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.22	Antiproliferative activity against human ACHN cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.22	Antiproliferative activity against human RXF393 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.21	Antiproliferative activity against human TK10 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.21	Antiproliferative activity against human HOP62 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.21	Antiproliferative activity against human COLO205 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.2	Antiproliferative activity against human KM12 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.2	Antiproliferative activity against human M14 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.2	Antiproliferative activity against human SKMEL28 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.2	Antiproliferative activity against human UACC62 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.2	Antiproliferative activity against human MCF7 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.2	Antiproliferative activity against human NCI-H460 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.2	Antiproliferative activity against human HCT15 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.19	Antiproliferative activity against human SF295 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.19	Antiproliferative activity against human MALME3M cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.19	Antiproliferative activity against human DU145 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.19	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.19	Antiproliferative activity against human HCT116 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.18	Antiproliferative activity against human SF268 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.18	Antiproliferative activity against human SNB75 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.18	Antiproliferative activity against human UO31 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.18	Antiproliferative activity against human NCI-H322M cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.17	Antiproliferative activity against human UACC257 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.17	Antiproliferative activity against human SN12C cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.17	Antiproliferative activity against human NCI-H23 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.17	Antiproliferative activity against human HT29 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.15	Antiproliferative activity against human A549 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.13	Antiproliferative activity against human K562 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.13	Antiproliferative activity against human NCI-H522 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.12	Antiproliferative activity against human T47D cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	= -5.01	Antiproliferative activity against human SKOV3 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	> -4	Antiproliferative activity against human CCRF-CEM cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	> -4	Antiproliferative activity against human SW620 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	> -4	Antiproliferative activity against human A498 cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	> -4	Antiproliferative activity against human HS578T cells after 48 hrs	ChEMBL.	17869115
LC50 (functional)	> -4	Antiproliferative activity against human SKMEL5 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	0	Antiproliferative activity against human MOLT4 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	0	Antiproliferative activity against human SF539 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	0	Antiproliferative activity against human SKMEL2 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	0	Antiproliferative activity against human IGROV1 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	0	Antiproliferative activity against human OVCAR3 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	0	Antiproliferative activity against human OVCAR8 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	0	Antiproliferative activity against human PC3 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	0	Antiproliferative activity against human NCI-ADR-RES cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	0	Antiproliferative activity against human RPMI8226 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	0	Antiproliferative activity against human EKVS cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	0	Antiproliferative activity against human HOP92 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	0	Antiproliferative activity against human NCI-H226 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	> 4	Antiproliferative activity against human CCRF-CEM cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	> 4	Antiproliferative activity against human SW620 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	> 4	Antiproliferative activity against human A498 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	> 4	Antiproliferative activity against human HS578T cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	> 4	Antiproliferative activity against human SKMEL5 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.01	Antiproliferative activity against human SKOV3 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.09	Antiproliferative activity against human HL60(TB) cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.12	Antiproliferative activity against human T47D cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.13	Antiproliferative activity against human K562 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.13	Antiproliferative activity against human NCI-H522 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.15	Antiproliferative activity against human A549 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.17	Antiproliferative activity against human UACC257 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.17	Antiproliferative activity against human SN12C cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.17	Antiproliferative activity against human NCI-H23 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.17	Antiproliferative activity against human HT29 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.18	Antiproliferative activity against human SF268 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.18	Antiproliferative activity against human SNB75 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.18	Antiproliferative activity against human UO31 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.18	Antiproliferative activity against human NCI-H322M cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.19	Antiproliferative activity against human SF295 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.19	Antiproliferative activity against human MALME3M cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.19	Antiproliferative activity against human DU145 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.19	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.19	Antiproliferative activity against human HCT116 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.2	Antiproliferative activity against human KM12 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.2	Antiproliferative activity against human M14 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.2	Antiproliferative activity against human SKMEL28 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.2	Antiproliferative activity against human UACC62 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.2	Antiproliferative activity against human MCF7 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.2	Antiproliferative activity against human NCI-H460 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.2	Antiproliferative activity against human HCT15 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.21	Antiproliferative activity against human TK10 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.21	Antiproliferative activity against human HOP62 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.21	Antiproliferative activity against human COLO205 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.22	Antiproliferative activity against human EKVS cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.22	Antiproliferative activity against human ACHN cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.22	Antiproliferative activity against human RXF393 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.23	Antiproliferative activity against human HCT15 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.23	Antiproliferative activity against human SNB19 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.23	Antiproliferative activity against human U251 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.23	Antiproliferative activity against human LOXIMVI cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.23	Antiproliferative activity against human 786-0 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.23	Antiproliferative activity against human CAKI1 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.24	Antiproliferative activity against human OVCAR5 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.24	Antiproliferative activity against human BT549 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.24	Antiproliferative activity against human HCC2998 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.24	Antiproliferative activity against human MDA-MB-435 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.25	Antiproliferative activity against human KM12 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.31	Antiproliferative activity against human MOLT4 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.43	Antiproliferative activity against human OVCAR4 cells after 48 hrs	ChEMBL.	17869115
Log LC50 (functional)	= 5.55	Antiproliferative activity against human A498 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5	Antiproliferative activity against human A498 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.16	Antiproliferative activity against human OVCAR4 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.26	Antiproliferative activity against human HS578T cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.29	Antiproliferative activity against human CCRF-CEM cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.32	Antiproliferative activity against human SKOV3 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.33	Antiproliferative activity against human MOLT4 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.36	Antiproliferative activity against human RPMI8226 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.39	Antiproliferative activity against human OVCAR8 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.4	Antiproliferative activity against human HL60(TB) cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.4	Antiproliferative activity against human T47D cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.41	Antiproliferative activity against human NCI-H522 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.42	Antiproliferative activity against human EKVS cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.42	Antiproliferative activity against human NCI-H226 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.43	Antiproliferative activity against human NCI-H322M cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.43	Antiproliferative activity against human SKMEL2 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.43	Antiproliferative activity against human PC3 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.44	Antiproliferative activity against human A549 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.44	Antiproliferative activity against human MALME3M cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.45	Antiproliferative activity against human K562 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.45	Antiproliferative activity against human NCI-H23 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.45	Antiproliferative activity against human HT29 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.45	Antiproliferative activity against human M14 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.45	Antiproliferative activity against human SKMEL5 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.45	Antiproliferative activity against human UACC257 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.45	Antiproliferative activity against human IGROV1 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.45	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.46	Antiproliferative activity against human HOP62 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.46	Antiproliferative activity against human NCI-H460 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.46	Antiproliferative activity against human HCT116 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.46	Antiproliferative activity against human SKMEL28 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.46	Antiproliferative activity against human SN12C cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.46	Antiproliferative activity against human TK10 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.46	Antiproliferative activity against human DU145 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.47	Antiproliferative activity against human MCF7 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.47	Antiproliferative activity against human SF268 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.47	Antiproliferative activity against human SF295 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.47	Antiproliferative activity against human SF539 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.47	Antiproliferative activity against human SNB75 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.47	Antiproliferative activity against human UACC62 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.47	Antiproliferative activity against human CAKI1 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.47	Antiproliferative activity against human UO31 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.47	Antiproliferative activity against human NCI-ADR-RES cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.48	Antiproliferative activity against human COLO205 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.48	Antiproliferative activity against human ACHN cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.49	Antiproliferative activity against human HCC2998 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.49	Antiproliferative activity against human U251 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.49	Antiproliferative activity against human LOXIMVI cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.49	Antiproliferative activity against human MDA-MB-435 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.5	Antiproliferative activity against human SNB19 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.5	Antiproliferative activity against human OVCAR3 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.5	Antiproliferative activity against human OVCAR5 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.5	Antiproliferative activity against human RXF393 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.51	Antiproliferative activity against human HOP92 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.51	Antiproliferative activity against human 786-0 cells after 48 hrs	ChEMBL.	17869115
Log TGI (functional)	= 5.53	Antiproliferative activity against human BT549 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 4.88	Antiproliferative activity against human SKMEL5 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.62	Antiproliferative activity against human CCRF-CEM cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.63	Antiproliferative activity against human SKOV3 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.64	Antiproliferative activity against human MOLT4 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.66	Antiproliferative activity against human HS578T cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.68	Antiproliferative activity against human T47D cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.69	Antiproliferative activity against human SW620 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.69	Antiproliferative activity against human NCI-H322M cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.69	Antiproliferative activity against human NCI-H522 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.69	Antiproliferative activity against human MALME3M cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.69	Antiproliferative activity against human PC3 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.7	Antiproliferative activity against human HL60(TB) cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.7	Antiproliferative activity against human RPMI8226 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.7	Antiproliferative activity against human EKVS cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.7	Antiproliferative activity against human OVCAR4 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.7	Antiproliferative activity against human TK10 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.71	Antiproliferative activity against human HOP62 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.71	Antiproliferative activity against human NCI-H226 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.71	Antiproliferative activity against human M14 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.71	Antiproliferative activity against human CAKI1 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.72	Antiproliferative activity against human HCT15 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.72	Antiproliferative activity against human A549 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.72	Antiproliferative activity against human NCI-H460 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.72	Antiproliferative activity against human SKMEL28 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.72	Antiproliferative activity against human OVCAR8 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.72	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.73	Antiproliferative activity against human HCT116 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.73	Antiproliferative activity against human HT29 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.73	Antiproliferative activity against human KM12 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.73	Antiproliferative activity against human UACC257 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.73	Antiproliferative activity against human DU145 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.74	Antiproliferative activity against human MCF7 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.74	Antiproliferative activity against human NCI-H23 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.74	Antiproliferative activity against human HCC2998 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.74	Antiproliferative activity against human U251 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.74	Antiproliferative activity against human UACC62 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.74	Antiproliferative activity against human SN12C cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.75	Antiproliferative activity against human SF268 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.75	Antiproliferative activity against human SF295 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.75	Antiproliferative activity against human SF539 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.75	Antiproliferative activity against human LOXIMVI cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.75	Antiproliferative activity against human SKMEL2 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.75	Antiproliferative activity against human ACHN cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.75	Antiproliferative activity against human MDA-MB-435 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.76	Antiproliferative activity against human COLO205 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.76	Antiproliferative activity against human UO31 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.77	Antiproliferative activity against human SNB19 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.77	Antiproliferative activity against human SNB75 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.77	Antiproliferative activity against human OVCAR5 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.77	Antiproliferative activity against human NCI-ADR-RES cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.78	Antiproliferative activity against human K562 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.78	Antiproliferative activity against human OVCAR3 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.78	Antiproliferative activity against human RXF393 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.8	Antiproliferative activity against human 786-0 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.82	Antiproliferative activity against human HOP92 cells after 48 hrs	ChEMBL.	17869115
pGI50 (functional)	= 5.82	Antiproliferative activity against human BT549 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.53	Antiproliferative activity against human BT549 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.51	Antiproliferative activity against human HOP92 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.51	Antiproliferative activity against human 786-0 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.5	Antiproliferative activity against human SNB19 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.5	Antiproliferative activity against human OVCAR3 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.5	Antiproliferative activity against human OVCAR5 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.5	Antiproliferative activity against human RXF393 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.49	Antiproliferative activity against human HCC2998 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.49	Antiproliferative activity against human U251 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.49	Antiproliferative activity against human LOXIMVI cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.49	Antiproliferative activity against human MDA-MB-435 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.48	Antiproliferative activity against human COLO205 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.48	Antiproliferative activity against human ACHN cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.47	Antiproliferative activity against human MCF7 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.47	Antiproliferative activity against human SF268 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.47	Antiproliferative activity against human SF295 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.47	Antiproliferative activity against human SF539 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.47	Antiproliferative activity against human SNB75 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.47	Antiproliferative activity against human UACC62 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.47	Antiproliferative activity against human CAKI1 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.47	Antiproliferative activity against human UO31 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.46	Antiproliferative activity against human HOP62 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.46	Antiproliferative activity against human NCI-H460 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.46	Antiproliferative activity against human HCT116 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.46	Antiproliferative activity against human SKMEL28 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.46	Antiproliferative activity against human SN12C cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.46	Antiproliferative activity against human TK10 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.46	Antiproliferative activity against human DU145 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.45	Antiproliferative activity against human K562 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.45	Antiproliferative activity against human NCI-H23 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.45	Antiproliferative activity against human HT29 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.45	Antiproliferative activity against human M14 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.45	Antiproliferative activity against human SKMEL5 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.45	Antiproliferative activity against human UACC257 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.45	Antiproliferative activity against human IGROV1 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.45	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.44	Antiproliferative activity against human A549 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.44	Antiproliferative activity against human MALME3M cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.43	Antiproliferative activity against human NCI-H322M cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.43	Antiproliferative activity against human SKMEL2 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.43	Antiproliferative activity against human PC3 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.42	Antiproliferative activity against human NCI-H226 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.41	Antiproliferative activity against human NCI-H522 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.4	Antiproliferative activity against human T47D cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.39	Antiproliferative activity against human OVCAR8 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.36	Antiproliferative activity against human RPMI8226 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.33	Antiproliferative activity against human MOLT4 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.32	Antiproliferative activity against human SKOV3 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.29	Antiproliferative activity against human CCRF-CEM cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.26	Antiproliferative activity against human HS578T cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5.16	Antiproliferative activity against human OVCAR4 cells after 48 hrs	ChEMBL.	17869115
TGI (functional)	= -5	Antiproliferative activity against human A498 cells after 48 hrs	ChEMBL.	17869115

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 522147