Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | larval opioid receptor | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0338 | 0.1953 | 0.1953 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0338 | 0.1953 | 0.5 |
Onchocerca volvulus | 0.0338 | 0.1953 | 0.5 | |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Echinococcus granulosus | carboxylesterase 5A | 0.0607 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Brugia malayi | RE15519p | 0.0338 | 0.1953 | 0.1953 |
Brugia malayi | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Brugia malayi | Carboxylesterase family protein | 0.0607 | 1 | 1 |
Onchocerca volvulus | 0.0338 | 0.1953 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0607 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Onchocerca volvulus | 0.0338 | 0.1953 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0338 | 0.1953 | 0.1953 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0338 | 0.1953 | 0.1953 |
Brugia malayi | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Onchocerca volvulus | 0.0338 | 0.1953 | 0.5 | |
Brugia malayi | ORL1-like opioid receptor | 0.0338 | 0.1953 | 0.1953 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Onchocerca volvulus | 0.0338 | 0.1953 | 0.5 | |
Onchocerca volvulus | 0.0338 | 0.1953 | 0.5 | |
Loa Loa (eye worm) | TYRA-2 protein | 0.0338 | 0.1953 | 0.1953 |
Brugia malayi | G-protein coupled receptor | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Echinococcus multilocularis | acetylcholinesterase | 0.0607 | 1 | 1 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0338 | 0.1953 | 0.1953 |
Brugia malayi | Serotonin receptor | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Brugia malayi | AKH receptor | 0.0338 | 0.1953 | 0.1953 |
Brugia malayi | G protein-coupled receptor | 0.0338 | 0.1953 | 0.1953 |
Brugia malayi | GnHR receptor homolog | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Onchocerca volvulus | 0.0338 | 0.1953 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0338 | 0.1953 | 0.5 |
Brugia malayi | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Onchocerca volvulus | 0.0338 | 0.1953 | 0.5 | |
Brugia malayi | Melatonin receptor type 1A | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Brugia malayi | Dopamine receptor | 0.0338 | 0.1953 | 0.1953 |
Onchocerca volvulus | 0.0338 | 0.1953 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0338 | 0.1953 | 0.1953 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Brugia malayi | neuropeptide F receptor | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Brugia malayi | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Brugia malayi | putative neuropeptide receptor | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Onchocerca volvulus | 0.0338 | 0.1953 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Onchocerca volvulus | 0.0338 | 0.1953 | 0.5 | |
Brugia malayi | neuropeptide F receptor | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0607 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Onchocerca volvulus | 0.0338 | 0.1953 | 0.5 | |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0338 | 0.1953 | 0.1953 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0607 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0607 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Brugia malayi | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Echinococcus granulosus | acetylcholinesterase | 0.0607 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Echinococcus multilocularis | acetylcholinesterase | 0.0607 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0607 | 1 | 1 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0338 | 0.1953 | 0.1953 |
Brugia malayi | Dopamine receptor protein 2 | 0.0338 | 0.1953 | 0.1953 |
Brugia malayi | sulfakinin receptor protein | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Brugia malayi | Dopamine receptor protein 1 | 0.0338 | 0.1953 | 0.1953 |
Brugia malayi | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Onchocerca volvulus | 0.0338 | 0.1953 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Onchocerca volvulus | 0.0338 | 0.1953 | 0.5 | |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Onchocerca volvulus | 0.0338 | 0.1953 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Brugia malayi | Serotonin receptor | 0.0338 | 0.1953 | 0.1953 |
Brugia malayi | G-protein coupled receptor | 0.0338 | 0.1953 | 0.1953 |
Brugia malayi | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Onchocerca volvulus | 0.0338 | 0.1953 | 0.5 | |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0338 | 0.1953 | 0.1953 |
Brugia malayi | follicle stimulating hormone receptor | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Onchocerca volvulus | 0.0338 | 0.1953 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0607 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1953 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0607 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
logP (ADMET) | = 4.82 | Partition coefficient (logP) | ChEMBL. | 6492079 |
pI50 (functional) | = 3.08 mM | Juvenile hormone mimetic activity in Aedes aegypti (yellow-fever mosquito) | ChEMBL. | 6492079 |
pI50 (functional) | = 5.51 uM pupa-1 | Juvenile hormone mimetic activity in Tenebrio molitor (yellow mealworm) | ChEMBL. | 6492079 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.