Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | 0.0157 | 0.9008 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0064 | 0.2813 | 0.3123 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0025 | 0.018 | 0.064 |
Giardia lamblia | Leucyl-tRNA synthetase | 0.0025 | 0.018 | 1 |
Treponema pallidum | leucyl-tRNA synthetase | 0.0025 | 0.018 | 0.018 |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | 0.0157 | 0.9008 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.9008 | 1 |
Loa Loa (eye worm) | multisynthetase complex auxiliary component p43 | 0.0147 | 0.8328 | 0.923 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0025 | 0.018 | 1 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0157 | 0.9008 | 1 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0025 | 0.018 | 0.02 |
Trypanosoma brucei | trypanothione reductase | 0.0064 | 0.2813 | 1 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0172 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0025 | 0.018 | 0.064 |
Schistosoma mansoni | leucyl-tRNA synthetase | 0.0025 | 0.018 | 0.02 |
Leishmania major | leucyl-tRNA synthetase, putative | 0.0025 | 0.018 | 0.064 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0064 | 0.2813 | 1 |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.0025 | 0.018 | 0.064 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0064 | 0.2813 | 0.2983 |
Toxoplasma gondii | thioredoxin reductase | 0.0064 | 0.2813 | 1 |
Schistosoma mansoni | glycyl-tRNA synthetase | 0.0052 | 0.2003 | 0.2224 |
Brugia malayi | glutathione reductase | 0.0064 | 0.2813 | 0.2813 |
Brugia malayi | bifunctional aminoacyl-tRNA synthetase | 0.0052 | 0.2003 | 0.2003 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.0157 | 0.9008 | 1 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.0025 | 0.018 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0064 | 0.2813 | 0.2813 |
Mycobacterium tuberculosis | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) | 0.0025 | 0.018 | 0.064 |
Leishmania major | methionyl-tRNA synthetase, putative | 0.0025 | 0.018 | 0.064 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0025 | 0.018 | 0.064 |
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.0025 | 0.018 | 1 |
Brugia malayi | glycyl-tRNA synthetase | 0.0052 | 0.2003 | 0.2003 |
Echinococcus granulosus | methionine tRNA synthetase | 0.0025 | 0.018 | 0.02 |
Mycobacterium leprae | Probable methionyl-tRNA synthase MetS | 0.0025 | 0.018 | 1 |
Toxoplasma gondii | tRNA ligases class I (M) protein | 0.0025 | 0.018 | 0.064 |
Leishmania major | trypanothione reductase | 0.0064 | 0.2813 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0064 | 0.2813 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0064 | 0.2813 | 1 |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.0025 | 0.018 | 1 |
Wolbachia endosymbiont of Brugia malayi | leucyl-tRNA synthetase | 0.0025 | 0.018 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0064 | 0.2813 | 1 |
Echinococcus granulosus | glycyl tRNA synthetase | 0.0052 | 0.2003 | 0.2224 |
Plasmodium vivax | glutathione reductase, putative | 0.0064 | 0.2813 | 1 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0172 | 1 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0064 | 0.2813 | 1 |
Echinococcus multilocularis | methionine tRNA synthetase | 0.0025 | 0.018 | 0.02 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0025 | 0.018 | 0.064 |
Plasmodium falciparum | methionine--tRNA ligase, putative | 0.0025 | 0.018 | 0.064 |
Echinococcus multilocularis | glycyl tRNA synthetase | 0.0052 | 0.2003 | 0.2224 |
Echinococcus multilocularis | leucyl tRNA synthetase | 0.0025 | 0.018 | 0.02 |
Mycobacterium ulcerans | leucyl-tRNA synthetase | 0.0025 | 0.018 | 1 |
Brugia malayi | protein ZK524.3 | 0.0025 | 0.018 | 0.018 |
Plasmodium falciparum | methionine--tRNA ligase | 0.0025 | 0.018 | 0.064 |
Loa Loa (eye worm) | glycyl-tRNA synthetase | 0.0052 | 0.2003 | 0.2065 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.004 | 0.1172 | 0.4166 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0064 | 0.2813 | 0.3123 |
Chlamydia trachomatis | leucine--tRNA ligase | 0.0025 | 0.018 | 0.02 |
Loa Loa (eye worm) | bifunctional aminoacyl-tRNA synthetase | 0.0052 | 0.2003 | 0.2065 |
Brugia malayi | methionyl-tRNA synthetase | 0.0025 | 0.018 | 0.018 |
Loa Loa (eye worm) | glutathione reductase | 0.0064 | 0.2813 | 0.2983 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 40 uM | Inhibition of CK2 in rat liver | ChEMBL. | 18251491 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.